latanoprost 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prostaglandins 1551 130209-82-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • roclanda
  • latanoprost
  • xalatan
  • (15R)-Latanoprost
  • PhXA41
A prostaglandin F analog used to treat OCULAR HYPERTENSION in patients with GLAUCOMA.
  • Molecular weight: 432.60
  • Formula: C26H40O5
  • CLOGP: 3.60
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 86.99
  • ALOGS: -4.53
  • ROTB: 14

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.05 mg/mL Benet LZ, Broccatelli F, Oprea TI
CL (Clearance) 6.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.10 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.28 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 7, 2021 EMA AERIE PHARMACEUTICALS IRELAND LIMITED
June 5, 1996 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Eye irritation 1289.46 12.28 479 35145 21492 63431906
Treatment failure 1013.05 12.28 859 34765 198184 63255214
Intraocular pressure increased 840.85 12.28 253 35371 5825 63447573
Eye pain 523.21 12.28 291 35333 33563 63419835
Glaucoma 516.80 12.28 239 35385 18666 63434732
Ocular hyperaemia 472.07 12.28 246 35378 24898 63428500
Visual acuity reduced 225.86 12.28 145 35479 21681 63431717
Eye pruritus 180.81 12.28 119 35505 18552 63434846
Colitis microscopic 174.10 12.28 91 35533 9248 63444150
Vision blurred 161.39 12.28 227 35397 91697 63361701
Foreign body sensation in eyes 154.27 12.28 55 35569 2179 63451219
Product container issue 154.19 12.28 52 35572 1741 63451657
Cataract 137.83 12.28 165 35459 56888 63396510
Product quality issue 112.75 12.28 119 35505 35746 63417652
Thyroid disorder 103.41 12.28 78 35546 15084 63438314
Skin reaction 102.63 12.28 77 35547 14772 63438626
Diverticulitis 96.50 12.28 115 35509 39442 63413956
Blindness 92.43 12.28 85 35539 21614 63431784
Intraocular pressure test abnormal 92.26 12.28 21 35603 150 63453248
Maternal exposure during pregnancy 91.09 12.28 9 35615 220053 63233345
Dry eye 85.74 12.28 110 35514 40651 63412747
Eye discharge 85.14 12.28 49 35575 6014 63447384
Visual impairment 82.27 12.28 160 35464 84286 63369112
Reaction to preservatives 81.70 12.28 20 35604 202 63453196
Eye disorder 78.01 12.28 79 35545 22606 63430792
Glossodynia 74.85 12.28 7 35617 178869 63274529
Ocular discomfort 72.54 12.28 39 35585 4194 63449204
Lacrimation increased 71.22 12.28 72 35552 20559 63432839
Conjunctival hyperaemia 71.01 12.28 32 35592 2347 63451051
Corneal disorder 65.84 12.28 28 35596 1786 63451612
Eye swelling 65.81 12.28 74 35550 23844 63429554
Systemic lupus erythematosus 61.99 12.28 20 35604 208898 63244500
Infusion related reaction 60.69 12.28 31 35593 245490 63207908
Choroidal effusion 58.06 12.28 18 35606 458 63452940
Blepharitis 57.88 12.28 29 35595 2696 63450702
Corneal opacity 57.84 12.28 20 35604 723 63452675
Growth of eyelashes 56.99 12.28 15 35609 207 63453191
Ocular surface disease 56.12 12.28 11 35613 33 63453365
Joint swelling 53.59 12.28 63 35561 327603 63125795
Toxic epidermal necrolysis 52.69 12.28 68 35556 25266 63428132
Visual field defect 52.08 12.28 37 35587 6524 63446874
Toxicity to various agents 51.67 12.28 38 35586 247212 63206186
Pericarditis 50.40 12.28 7 35617 131572 63321826
Product packaging quantity issue 49.40 12.28 21 35603 1338 63452060
Product delivery mechanism issue 49.33 12.28 15 35609 357 63453041
Arthropathy 49.17 12.28 36 35588 234756 63218642
Intraocular pressure fluctuation 48.40 12.28 10 35614 42 63453356
Corneal oedema 47.50 12.28 21 35603 1472 63451926
Contraindicated product administered 47.38 12.28 32 35592 217616 63235782
Bronchitis 45.61 12.28 164 35460 124771 63328627
Product packaging issue 45.05 12.28 19 35605 1187 63452211
Abnormal sensation in eye 44.32 12.28 21 35603 1728 63451670
Iridocyclitis 42.55 12.28 23 35601 2499 63450899
Trabeculectomy 41.88 12.28 8 35616 20 63453378
Eyelid margin crusting 40.41 12.28 17 35607 1055 63452343
Intraocular pressure decreased 39.75 12.28 10 35614 114 63453284
Blepharal pigmentation 39.70 12.28 9 35615 63 63453335
Erythema of eyelid 39.00 12.28 21 35603 2265 63451133
Normal tension glaucoma 38.64 12.28 8 35616 34 63453364
Infection 38.59 12.28 43 35581 229130 63224268
Hypersensitivity 38.22 12.28 288 35336 292397 63161001
Eye allergy 38.19 12.28 16 35608 983 63452415
Iris hyperpigmentation 38.09 12.28 8 35616 37 63453361
Iris atrophy 38.00 12.28 9 35615 78 63453320
Abdominal discomfort 36.95 12.28 78 35546 320807 63132591
Pain 36.89 12.28 254 35370 740374 62713024
Angle closure glaucoma 36.78 12.28 20 35604 2199 63451199
Product packaging difficult to open 36.49 12.28 9 35615 94 63453304
Burns second degree 36.08 12.28 19 35605 1959 63451439
Eye colour change 35.40 12.28 11 35613 282 63453116
Corneal deposits 35.22 12.28 11 35613 287 63453111
Discomfort 34.59 12.28 26 35598 167348 63286050
Product administration error 34.44 12.28 52 35572 22345 63431053
Macular oedema 33.42 12.28 23 35601 3854 63449544
Product use issue 33.31 12.28 45 35579 220475 63232923
Eyelash thickening 33.04 12.28 6 35618 10 63453388
Product container seal issue 32.34 12.28 9 35615 155 63453243
Lower respiratory tract infection 32.23 12.28 17 35607 132290 63321108
Conjunctival scar 31.81 12.28 7 35617 42 63453356
Dental restoration failure 31.78 12.28 14 35610 973 63452425
Eyelid oedema 31.56 12.28 34 35590 10445 63442953
Fall 31.27 12.28 347 35277 391987 63061411
Arthralgia 31.06 12.28 190 35434 569520 62883878
Corneal neovascularisation 30.49 12.28 8 35616 109 63453289
Transient ischaemic attack 30.22 12.28 66 35558 37687 63415711
Angioplasty 30.11 12.28 15 35609 1377 63452021
Iris adhesions 30.05 12.28 10 35614 321 63453077
Exposure during pregnancy 29.85 12.28 26 35598 155521 63297877
Blindness unilateral 29.63 12.28 26 35598 6215 63447183
Product use complaint 29.52 12.28 18 35606 2456 63450942
Choroidal detachment 29.33 12.28 9 35615 221 63453177
Procollagen type I C-terminal propeptide increased 29.27 12.28 6 35618 24 63453374
Febrile neutropenia 29.17 12.28 15 35609 118434 63334964
Intestinal polyp 28.73 12.28 15 35609 1520 63451878
Catarrh 28.60 12.28 15 35609 1534 63451864
Serum procollagen type I N-terminal propeptide increased 28.53 12.28 6 35618 28 63453370
Psoriatic arthropathy 28.51 12.28 8 35616 91512 63361886
Cystoid macular oedema 28.36 12.28 15 35609 1560 63451838
Rheumatoid arthritis 28.12 12.28 63 35561 253756 63199642
Poor quality product administered 27.86 12.28 19 35605 3137 63450261
Cerebrovascular accident 27.61 12.28 127 35497 107897 63345501
Alopecia 27.61 12.28 97 35527 337439 63115959
Photophobia 27.19 12.28 41 35583 17594 63435804
Hyphaema 27.01 12.28 9 35615 290 63453108
Thyroxine decreased 26.79 12.28 11 35613 642 63452756
Steroid dependence 26.77 12.28 15 35609 1749 63451649
Metamorphopsia 26.55 12.28 13 35611 1150 63452248
Cataract operation 26.21 12.28 23 35601 5499 63447899
Phlebitis 26.06 12.28 25 35599 6699 63446699
Conjunctivitis allergic 26 12.28 12 35612 930 63452468
Nasal discharge discolouration 25.76 12.28 16 35608 2255 63451143
Ill-defined disorder 25.74 12.28 7 35617 81748 63371650
Therapeutic product effect decreased 25.70 12.28 43 35581 193144 63260254
Instillation site irritation 25.46 12.28 7 35617 115 63453283
Eye operation 25.12 12.28 16 35608 2356 63451042
Purpura senile 24.87 12.28 10 35614 553 63452845
Product package associated injury 24.81 12.28 5 35619 18 63453380
Tarsal tunnel syndrome 24.68 12.28 10 35614 564 63452834
Product formulation issue 24.61 12.28 10 35614 568 63452830
Duodenal ulcer haemorrhage 24.55 12.28 16 35608 2451 63450947
Peripheral vascular disorder 24.45 12.28 23 35601 6012 63447386
Limb injury 24.45 12.28 48 35576 25429 63427969
Product substitution issue 24.39 12.28 37 35587 15959 63437439
Irritable bowel syndrome 24.23 12.28 8 35616 82404 63370994
Hyperaesthesia 24.13 12.28 28 35596 9330 63444068
Foreign body in eye 23.99 12.28 7 35617 144 63453254
Eye inflammation 23.97 12.28 22 35602 5577 63447821
Punctate keratitis 23.92 12.28 10 35614 611 63452787
Gastrointestinal disorder 23.91 12.28 23 35601 131216 63322182
Hypotony of eye 23.76 12.28 7 35617 149 63453249
Musculoskeletal stiffness 23.73 12.28 42 35582 184576 63268822
Liver injury 23.69 12.28 3 35621 60517 63392881
Thermal burns of eye 23.59 12.28 7 35617 153 63453245
Product storage error 23.39 12.28 35 35589 14921 63438477
Instillation site pain 23.35 12.28 11 35613 893 63452505
Maculopathy 23.32 12.28 15 35609 2247 63451151
Eye oedema 23.27 12.28 13 35611 1507 63451891
Meniscus injury 23.05 12.28 24 35600 7090 63446308
Product complaint 22.99 12.28 32 35592 12777 63440621
Choking 22.90 12.28 28 35596 9851 63443547
Retinal detachment 22.77 12.28 22 35602 5947 63447451
Chronotropic incompetence 22.72 12.28 6 35618 84 63453314
Body height decreased 22.45 12.28 28 35596 10050 63443348
Instillation site erythema 22.15 12.28 6 35618 93 63453305
Haemorrhage intracranial 21.84 12.28 32 35592 13387 63440011
Corneal epithelium defect 21.81 12.28 8 35616 344 63453054
Eyelid irritation 21.78 12.28 9 35615 534 63452864
Suicide attempt 21.61 12.28 4 35620 60914 63392484
Off label use 21.42 12.28 259 35365 674203 62779195
Pupillary disorder 21.20 12.28 7 35617 219 63453179
Pyrexia 21.11 12.28 166 35458 470312 62983086
Retinopathy haemorrhagic 20.94 12.28 4 35620 10 63453388
Floppy iris syndrome 20.91 12.28 6 35618 116 63453282
Eyelid disorder 20.91 12.28 13 35611 1836 63451562
Product dose omission issue 20.85 12.28 212 35412 234101 63219297
Conjunctival erosion 20.81 12.28 6 35618 118 63453280
Eye complication associated with device 20.41 12.28 4 35620 12 63453386
Hypopnoea 20.41 12.28 17 35607 3789 63449609
Cardiac failure congestive 20.26 12.28 104 35520 92329 63361069
Conjunctival follicles 20.16 12.28 4 35620 13 63453385
Swelling 20.01 12.28 83 35541 275295 63178103
Conjunctivitis 19.74 12.28 39 35585 20757 63432641
Iris hypopigmentation 19.52 12.28 4 35620 16 63453382
Photocoagulation 19.46 12.28 3 35621 0 63453398
Scleral hyperaemia 19.29 12.28 7 35617 292 63453106
Injury corneal 18.67 12.28 5 35619 74 63453324
Hyponatraemia 18.65 12.28 117 35507 111783 63341615
Expired product administered 18.51 12.28 20 35604 6161 63447237
Blood albumin abnormal 18.51 12.28 8 35616 531 63452867
Visual field tests abnormal 18.32 12.28 4 35620 23 63453375
Macular hole 18.06 12.28 9 35615 827 63452571
Symblepharon 17.97 12.28 5 35619 86 63453312
Retinal vascular disorder 17.96 12.28 6 35618 195 63453203
Hypoacusis 17.95 12.28 41 35583 24110 63429288
Glaucoma surgery 17.87 12.28 5 35619 88 63453310
Corneal degeneration 17.76 12.28 5 35619 90 63453308
Keratitis 17.76 12.28 15 35609 3407 63449991
Dysgeusia 17.61 12.28 62 35562 46648 63406750
Multiple organ dysfunction syndrome 17.60 12.28 5 35619 56747 63396651
Dacryostenosis acquired 17.57 12.28 8 35616 601 63452797
Product design issue 17.38 12.28 3 35621 3 63453395
Tubulointerstitial nephritis 17.31 12.28 36 35588 19867 63433531
Vitreous haemorrhage 17.29 12.28 12 35612 2038 63451360
Blister 17.16 12.28 29 35595 129785 63323613
Adenocarcinoma metastatic 17.13 12.28 5 35619 103 63453295
Epigastric discomfort 17 12.28 20 35604 6760 63446638
Retinal tear 16.95 12.28 10 35614 1284 63452114
Atrial flutter 16.92 12.28 24 35600 9748 63443650
Wound 16.89 12.28 42 35582 163221 63290177
Periorbital disorder 16.86 12.28 4 35620 35 63453363
Parosmia 16.72 12.28 19 35605 6187 63447211
Genital erythema 16.66 12.28 4 35620 37 63453361
Iritis 16.65 12.28 14 35610 3161 63450237
Hypertension 16.61 12.28 234 35390 279069 63174329
Corneal striae 16.52 12.28 3 35621 5 63453393
Incorrect dose administered 16.44 12.28 72 35552 59896 63393502
Ophthalmic herpes simplex 16.36 12.28 7 35617 453 63452945
Ocular hypertension 16.13 12.28 9 35615 1041 63452357
Instillation site reaction 16.05 12.28 7 35617 475 63452923
Palpitations 15.84 12.28 113 35511 112657 63340741
Reaction to excipient 15.82 12.28 10 35614 1454 63451944
Pulmonary congestion 15.74 12.28 32 35592 17386 63436012
Vitreous floaters 15.63 12.28 18 35606 5948 63447450
Eyelids pruritus 15.42 12.28 9 35615 1133 63452265
Achromotrichia acquired 15.31 12.28 3 35621 9 63453389
Subacute kidney injury 15.31 12.28 3 35621 9 63453389
Pharyngeal enanthema 15.21 12.28 4 35620 55 63453343
Liquid product physical issue 15.14 12.28 9 35615 1173 63452225
Corectopia 15.07 12.28 3 35621 10 63453388
Keratitis interstitial 15.07 12.28 3 35621 10 63453388
Chronic leukaemia 15.07 12.28 3 35621 10 63453388
Genital rash 14.99 12.28 7 35617 557 63452841
Stomatitis 14.89 12.28 35 35589 138690 63314708
Repetitive strain injury 14.86 12.28 5 35619 166 63453232
Fasciitis 14.78 12.28 7 35617 575 63452823
Resorption bone increased 14.51 12.28 9 35615 1265 63452133
Impaired healing 14.40 12.28 22 35602 102520 63350878
Haemorrhage 14.32 12.28 70 35554 60952 63392446
Ulcerative keratitis 14.31 12.28 12 35612 2698 63450700
Herpes ophthalmic 14.29 12.28 9 35615 1300 63452098
Product lot number issue 14.27 12.28 5 35619 188 63453210
Circumstance or information capable of leading to medication error 14.27 12.28 14 35610 3856 63449542
Glare 14.11 12.28 4 35620 74 63453324
Gingival pain 14.07 12.28 20 35604 8142 63445256
Tremor 13.91 12.28 124 35500 132115 63321283
Syncope 13.89 12.28 113 35511 117272 63336126
Chondropathy 13.86 12.28 11 35613 2289 63451109
Splenic haemorrhage 13.84 12.28 5 35619 206 63453192
Diabetic ulcer 13.74 12.28 5 35619 210 63453188
Uveitis 13.72 12.28 25 35599 12528 63440870
Hip fracture 13.69 12.28 42 35582 29432 63423966
Product closure removal difficult 13.63 12.28 3 35621 18 63453380
Vestibular disorder 13.55 12.28 9 35615 1422 63451976
Conjunctival oedema 13.54 12.28 7 35617 695 63452703
Eye haemorrhage 13.45 12.28 20 35604 8476 63444922
Sinus disorder 13.34 12.28 37 35587 24516 63428882
Rash 13.33 12.28 228 35396 560643 62892755
Injection site swelling 13.33 12.28 5 35619 47567 63405831
Injury 13.15 12.28 13 35611 73234 63380164
Ocular pemphigoid 13.12 12.28 4 35620 96 63453302
Type 2 diabetes mellitus 13.08 12.28 10 35614 63858 63389540
Superficial injury of eye 13.03 12.28 5 35619 244 63453154
Corneal abrasion 12.96 12.28 8 35616 1116 63452282
Crepitations 12.83 12.28 19 35605 8021 63445377
Corneal scar 12.64 12.28 4 35620 109 63453289
Weight increased 12.63 12.28 90 35534 260702 63192696
Injection site erythema 12.51 12.28 17 35607 83157 63370241
Cardiac amyloidosis 12.50 12.28 7 35617 815 63452583
Drug hypersensitivity 12.44 12.28 244 35380 310443 63142955
Paternal exposure during pregnancy 12.37 12.28 4 35620 117 63453281
Tinnitus 12.34 12.28 46 35578 35582 63417816
Laser therapy 12.28 12.28 3 35621 30 63453368

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Treatment failure 1037.11 12.65 521 20394 46176 34889840
Intraocular pressure increased 751.93 12.65 229 20686 5154 34930862
Eye irritation 570.84 12.65 202 20713 7359 34928657
Eye pain 217.94 12.65 122 20793 13340 34922676
Ocular hyperaemia 202.46 12.65 110 20805 11342 34924674
Visual acuity reduced 189.75 12.65 119 20796 16030 34919986
Glaucoma 173.23 12.65 84 20831 6828 34929188
Vision blurred 135.75 12.65 152 20763 45811 34890205
Foreign body sensation in eyes 114.78 12.65 33 20882 601 34935415
Product delivery mechanism issue 107.53 12.65 24 20891 144 34935872
Cataract 92.04 12.65 95 20820 26091 34909925
Corneal oedema 90.24 12.65 33 20882 1318 34934698
Corneal disorder 86.11 12.65 29 20886 905 34935111
Visual impairment 78.76 12.65 102 20813 35700 34900316
Product container issue 77.01 12.65 25 20890 694 34935322
Eye pruritus 75.14 12.65 50 20865 7439 34928577
Choroidal effusion 67.99 12.65 17 20898 176 34935840
Cystoid macular oedema 65.12 12.65 22 20893 693 34935323
Cataract operation 62.70 12.65 25 20890 1267 34934749
Corneal opacity 57.22 12.65 19 20896 567 34935449
Lacrimation increased 51.87 12.65 42 20873 8440 34927576
Blindness unilateral 49.65 12.65 32 20883 4510 34931506
Choroidal detachment 46.52 12.65 15 20900 407 34935609
Hypotony of eye 45.18 12.65 11 20904 101 34935915
Intraocular pressure fluctuation 44.90 12.65 8 20907 10 34936006
Anterior chamber disorder 43.85 12.65 10 20905 67 34935949
Eye disorder 43.66 12.65 40 20875 9488 34926528
Blindness 43.22 12.65 49 20866 14937 34921079
Product quality issue 42.97 12.65 52 20863 16983 34919033
Conjunctival hyperaemia 42.22 12.65 23 20892 2379 34933637
Hyphaema 41.67 12.65 15 20900 572 34935444
Dry eye 41.56 12.65 39 20876 9536 34926480
Completed suicide 41.49 12.65 5 20910 98163 34837853
Blepharitis 40.58 12.65 19 20896 1426 34934590
Eye discharge 40.31 12.65 21 20894 1985 34934031
Intraocular pressure test abnormal 38.41 12.65 9 20906 69 34935947
Iridocyclitis 38.16 12.65 19 20896 1633 34934383
Angle closure glaucoma 37.86 12.65 16 20899 941 34935075
Product packaging quantity issue 34.99 12.65 15 20900 914 34935102
Keratitis 34.44 12.65 17 20898 1434 34934582
Ectropion 34.19 12.65 9 20906 116 34935900
Thermal burns of eye 33.90 12.65 6 20909 7 34936009
Macular oedema 33.01 12.65 21 20894 2893 34933123
Ocular surface disease 33 12.65 8 20907 72 34935944
Conjunctival oedema 32.98 12.65 12 20903 472 34935544
Toxicity to various agents 32.93 12.65 43 20872 200319 34735697
Corneal infiltrates 31.93 12.65 9 20906 152 34935864
Corneal neovascularisation 31.22 12.65 7 20908 43 34935973
Growth of eyelashes 30.99 12.65 8 20907 95 34935921
Herpes ophthalmic 30.71 12.65 12 20903 576 34935440
Ocular hypertension 29.74 12.65 13 20902 831 34935185
Trabeculoplasty 29.17 12.65 5 20910 4 34936012
Visual field defect 29.12 12.65 23 20892 4460 34931556
Intraocular pressure decreased 28.58 12.65 7 20908 66 34935950
Reaction to preservatives 28.21 12.65 7 20908 70 34935946
Punctate keratitis 27.99 12.65 10 20905 373 34935643
Photocoagulation 27.74 12.65 5 20910 7 34936009
Eyelid margin crusting 27.71 12.65 9 20906 250 34935766
Eye inflammation 27.69 12.65 17 20898 2201 34933815
Instillation site pain 26.54 12.65 7 20908 91 34935925
Ulcerative keratitis 26.15 12.65 15 20900 1714 34934302
Ocular discomfort 25.73 12.65 16 20899 2118 34933898
Ophthalmic herpes simplex 25.58 12.65 9 20906 321 34935695
Pyelitis 25.25 12.65 7 20908 111 34935905
Erythema of eyelid 25.23 12.65 12 20903 933 34935083
Glaucoma surgery 25.19 12.65 5 20910 15 34936001
Eyelid irritation 24.91 12.65 7 20908 117 34935899
Product substitution issue 24.14 12.65 30 20885 10065 34925951
Product formulation issue 24.13 12.65 10 20905 560 34935456
Trabeculectomy 23.88 12.65 5 20910 21 34935995
Glaucomatous optic disc atrophy 23.45 12.65 4 20911 3 34936013
Burns second degree 23.21 12.65 12 20903 1117 34934899
Open angle glaucoma 22.97 12.65 7 20908 157 34935859
Dizziness 22.86 12.65 215 20700 218306 34717710
Eyelids pruritus 22.45 12.65 7 20908 170 34935846
Uveitis 22.34 12.65 25 20890 7510 34928506
Product container seal issue 22.03 12.65 4 20911 6 34936010
Hypersensitivity 21.72 12.65 83 20832 60952 34875064
Catarrh 21.61 12.65 11 20904 991 34935025
Parosmia 21.49 12.65 15 20900 2410 34933606
Eye swelling 21.22 12.65 28 20887 9967 34926049
Macular cyst 20.98 12.65 4 20911 9 34936007
Product use complaint 20.53 12.65 12 20903 1420 34934596
Photophobia 20.47 12.65 23 20892 6941 34929075
Instillation site erythema 20.41 12.65 4 20911 11 34936005
Visual acuity tests abnormal 20.24 12.65 5 20910 49 34935967
Optic nerve injury 20.02 12.65 6 20909 127 34935889
Steroid dependence 19.89 12.65 12 20903 1505 34934511
Bone marrow oedema 19.38 12.65 9 20906 663 34935353
Prostaglandin analogue periorbitopathy 19.27 12.65 3 20912 0 34936016
Iris hyperpigmentation 19.27 12.65 3 20912 0 34936016
Vitreous adhesions 19.26 12.65 4 20911 16 34936000
Corneal scar 18.89 12.65 6 20909 155 34935861
Off label use 18.26 12.65 162 20753 419362 34516654
Fall 18.01 12.65 193 20722 202692 34733324
Heart rate abnormal 17.82 12.65 12 20903 1819 34934197
Conjunctival disorder 17.82 12.65 5 20910 83 34935933
Hypopnoea 17.63 12.65 13 20902 2276 34933740
Corneal erosion 17.29 12.65 5 20910 93 34935923
Asthenopia 17.27 12.65 8 20907 586 34935430
Vitreous haemorrhage 17.21 12.65 13 20902 2360 34933656
Vitreous disorder 17.14 12.65 5 20910 96 34935920
Bronchiectasis 17.12 12.65 25 20890 9776 34926240
Eyelid ptosis 16.87 12.65 19 20896 5747 34930269
Drug interaction 16.68 12.65 74 20841 225872 34710144
Multiple organ dysfunction syndrome 16.46 12.65 13 20902 76553 34859463
Gingival pain 16.35 12.65 14 20901 3038 34932978
Corneal bleeding 15.97 12.65 3 20912 6 34936010
Eye haemorrhage 15.80 12.65 16 20899 4289 34931727
Tinnitus 15.49 12.65 36 20879 20082 34915934
Anterior chamber inflammation 15.39 12.65 6 20909 286 34935730
Funguria 14.89 12.65 4 20911 56 34935960
Choluria 14.61 12.65 5 20910 164 34935852
Optic nerve cupping 14.51 12.65 4 20911 62 34935954
Conjunctivitis 14.47 12.65 23 20892 9682 34926334
Myoclonic dystonia 14.34 12.65 4 20911 65 34935951
Suicide attempt 14.25 12.65 3 20912 39113 34896903
Scleral hyperaemia 14.17 12.65 4 20911 68 34935948
Diplopia 13.92 12.65 31 20884 16812 34919204
Keratopathy 13.67 12.65 7 20908 638 34935378
Eye laser surgery 13.59 12.65 3 20912 17 34935999
Product packaging issue 13.58 12.65 7 20908 647 34935369
Macular hole 13.36 12.65 5 20910 213 34935803
Swollen tongue 13.35 12.65 28 20887 14577 34921439
Keratitis interstitial 13.17 12.65 3 20912 20 34935996
Iris atrophy 13.07 12.65 4 20911 91 34935925
Iritis 12.97 12.65 9 20906 1432 34934584
Scleral disorder 12.92 12.65 3 20912 22 34935994
Corneal infection 12.69 12.65 3 20912 24 34935992

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intraocular pressure increased 952.05 11.33 303 42235 8902 79692948
Eye irritation 841.32 11.33 341 42197 20340 79681510
Glaucoma 483.99 11.33 228 42310 19533 79682317
Eye pain 354.23 11.33 231 42307 37347 79664503
Visual acuity reduced 327.35 11.33 201 42337 29268 79672582
Ocular hyperaemia 314.88 11.33 193 42345 28013 79673837
Cataract 159.71 11.33 181 42357 61939 79639911
Vision blurred 155.44 11.33 234 42304 105664 79596186
Colitis microscopic 136.52 11.33 80 42458 10688 79691162
Corneal oedema 116.14 11.33 46 42492 2574 79699276
Foreign body sensation in eyes 113.87 11.33 43 42495 2114 79699736
Corneal disorder 107.80 11.33 42 42496 2249 79699601
Completed suicide 106.78 11.33 6 42532 245761 79456089
Blindness 104.01 11.33 100 42438 28283 79673567
Choroidal effusion 98.56 11.33 29 42509 648 79701202
Eye pruritus 93.96 11.33 82 42456 20488 79681362
Ocular surface disease 83.13 11.33 18 42520 105 79701745
Corneal opacity 82.90 11.33 28 42510 992 79700858
Visual impairment 81.73 11.33 163 42375 91968 79609882
Cystoid macular oedema 81.65 11.33 33 42505 1947 79699903
Product quality issue 80.66 11.33 95 42443 33845 79668005
Product delivery mechanism issue 76.71 11.33 18 42520 158 79701692
Diverticulitis 75.30 11.33 107 42431 45829 79656021
Angle closure glaucoma 74.86 11.33 35 42503 2941 79698909
Thyroid disorder 74.32 11.33 61 42477 14018 79687832
Visual field defect 74.11 11.33 51 42487 8994 79692856
Skin reaction 73.28 11.33 64 42474 16004 79685846
Blepharitis 73.24 11.33 35 42503 3089 79698761
Conjunctival hyperaemia 72.86 11.33 39 42499 4374 79697476
Toxicity to various agents 71.14 11.33 72 42466 421468 79280382
Intraocular pressure test abnormal 69.61 11.33 16 42522 127 79701723
Choroidal detachment 65.98 11.33 21 42517 615 79701235
Lacrimation increased 65.54 11.33 70 42468 22407 79679443
Trabeculectomy 65.34 11.33 13 42525 46 79701804
Iridocyclitis 61.90 11.33 33 42505 3671 79698179
Eye discharge 61.52 11.33 39 42499 5995 79695855
Intraocular pressure fluctuation 57.14 11.33 12 42526 59 79701791
Eye disorder 56.40 11.33 66 42472 23346 79678504
Reaction to preservatives 56.40 11.33 15 42523 228 79701622
Intraocular pressure decreased 55.70 11.33 14 42524 168 79701682
Burns second degree 54.28 11.33 27 42511 2601 79699249
Bronchitis 47.88 11.33 166 42372 130478 79571372
Corneal neovascularisation 47.14 11.33 12 42526 152 79701698
Fall 47.11 11.33 431 42107 487198 79214652
Blindness unilateral 46.61 11.33 37 42501 8109 79693741
Product formulation issue 46.37 11.33 18 42520 954 79700896
Hypotony of eye 46.27 11.33 13 42525 245 79701605
Maternal exposure during pregnancy 45.06 11.33 9 42529 136529 79565321
Product container issue 44.72 11.33 19 42519 1272 79700578
Hyphaema 44.05 11.33 17 42521 887 79700963
Infusion related reaction 43.97 11.33 35 42503 230202 79471648
Catarrh 43.87 11.33 22 42516 2156 79699694
Steroid dependence 42.74 11.33 23 42515 2607 79699243
Punctate keratitis 42.62 11.33 17 42521 969 79700881
Eye swelling 42.41 11.33 61 42477 26407 79675443
Iris atrophy 42.40 11.33 11 42527 151 79701699
Keratitis 41.75 11.33 27 42511 4295 79697555
Photocoagulation 40.91 11.33 7 42531 7 79701843
Eye inflammation 40.76 11.33 31 42507 6382 79695468
Iris hyperpigmentation 40.73 11.33 8 42530 26 79701824
Ulcerative keratitis 40.52 11.33 25 42513 3664 79698186
Dry eye 39.76 11.33 71 42467 36860 79664990
Instillation site pain 36.67 11.33 14 42524 709 79701141
Ophthalmic herpes simplex 36.54 11.33 14 42524 716 79701134
Pericarditis 36.27 11.33 6 42532 104230 79597620
Macular oedema 35.98 11.33 27 42511 5447 79696403
Instillation site erythema 34.64 11.33 8 42530 65 79701785
Infection 34.58 11.33 47 42491 241665 79460185
Hypopnoea 34.40 11.33 26 42512 5303 79696547
Corneal deposits 33.99 11.33 12 42526 486 79701364
Ocular discomfort 33.70 11.33 25 42513 4958 79696892
Conjunctival oedema 33.47 11.33 15 42523 1143 79700707
Anterior chamber disorder 32.90 11.33 9 42529 153 79701697
Cataract operation 32.81 11.33 25 42513 5160 79696690
Dental restoration failure 32.50 11.33 14 42524 970 79700880
Corneal scar 31.25 11.33 10 42528 298 79701552
Growth of eyelashes 31.11 11.33 9 42529 189 79701661
Thermal burns of eye 31.03 11.33 8 42530 107 79701743
Intestinal polyp 30.33 11.33 17 42521 2087 79699763
Parosmia 30.11 11.33 27 42511 6987 79694863
Normal tension glaucoma 30.08 11.33 7 42531 59 79701791
Product substitution issue 30.02 11.33 45 42493 20211 79681639
Procollagen type I C-terminal propeptide increased 29.58 11.33 6 42532 24 79701826
Angioplasty 29.46 11.33 16 42522 1847 79700003
Iris adhesions 29.24 11.33 11 42527 535 79701315
Dacryostenosis acquired 29.12 11.33 11 42527 541 79701309
Abnormal sensation in eye 28.89 11.33 16 42522 1919 79699931
Instillation site irritation 28.83 11.33 7 42531 72 79701778
Transient ischaemic attack 28.73 11.33 77 42461 52618 79649232
Serum procollagen type I N-terminal propeptide increased 28.66 11.33 6 42532 29 79701821
Glossodynia 28.08 11.33 10 42528 103327 79598523
Multiple organ dysfunction syndrome 27.38 11.33 15 42523 120231 79581619
Febrile neutropenia 27.29 11.33 51 42487 230948 79470902
Visual field tests abnormal 27.20 11.33 5 42533 10 79701840
Erythema of eyelid 27.18 11.33 17 42521 2553 79699297
Corneal infiltrates 27.14 11.33 9 42529 301 79701549
Hyperaesthesia 27.04 11.33 33 42505 12189 79689661
Ocular hypertension 26.70 11.33 14 42524 1506 79700344
Joint swelling 26.57 11.33 73 42465 288573 79413277
Blepharal pigmentation 26.40 11.33 6 42532 45 79701805
Eyelid ptosis 26.38 11.33 31 42507 11013 79690837
Glaucoma surgery 26.28 11.33 7 42531 107 79701743
Product complaint 26.28 11.33 34 42504 13315 79688535
Suicide attempt 26.27 11.33 6 42532 82926 79618924
Poor quality product administered 26.26 11.33 19 42519 3626 79698224
Gingival pain 26.19 11.33 28 42510 8970 79692880
Dizziness 26.18 11.33 410 42128 526031 79175819
Vitreous haemorrhage 25.94 11.33 19 42519 3694 79698156
Floppy iris syndrome 25.75 11.33 9 42529 354 79701496
Maculopathy 25.70 11.33 17 42521 2808 79699042
Conjunctival follicles 25.52 11.33 5 42533 16 79701834
Eye oedema 25.29 11.33 15 42523 2048 79699802
Toxic epidermal necrolysis 25.17 11.33 66 42472 44515 79657335
Cerebrovascular accident 25.01 11.33 155 42383 155137 79546713
Nasal discharge discolouration 24.97 11.33 16 42522 2505 79699345
Duodenal ulcer perforation 24.93 11.33 3 42535 66208 79635642
Macular hole 24.90 11.33 11 42527 810 79701040
Mucosal inflammation 24.90 11.33 5 42533 75575 79626275
Limb injury 24.69 11.33 51 42487 29477 79672373
Thyroxine decreased 24.25 11.33 11 42527 862 79700988
Photophobia 24.09 11.33 41 42497 20487 79681363
Psoriatic arthropathy 24.00 11.33 6 42532 77993 79623857
Herpes ophthalmic 23.99 11.33 13 42525 1494 79700356
Open angle glaucoma 23.92 11.33 9 42529 438 79701412
Glaucomatous optic disc atrophy 23.91 11.33 4 42534 3 79701847
Keratitis interstitial 23.91 11.33 5 42533 24 79701826
Cornea verticillata 23.48 11.33 7 42531 164 79701686
Arrhythmia 23.43 11.33 79 42459 61193 79640657
Phlebitis 23.13 11.33 26 42512 8804 79693046
Corneal epithelium defect 22.99 11.33 10 42528 709 79701141
Metamorphopsia 22.97 11.33 12 42526 1281 79700569
Hyponatraemia 22.94 11.33 168 42370 177680 79524170
Arthralgia 22.92 11.33 195 42343 571608 79130242
Purpura senile 22.43 11.33 9 42529 521 79701329
Chronotropic incompetence 22.39 11.33 6 42532 94 79701756
Conjunctivitis allergic 22.38 11.33 13 42525 1707 79700143
Tarsal tunnel syndrome 22.33 11.33 9 42529 527 79701323
Eyelid margin crusting 22.23 11.33 11 42527 1048 79700802
Retinal detachment 22.16 11.33 26 42512 9221 79692629
Arthropathy 21.91 11.33 38 42500 177073 79524777
Uveitis 21.61 11.33 35 42503 16795 79685055
Heart rate abnormal 21.54 11.33 21 42517 6036 79695814
Sinus disorder 21.43 11.33 41 42497 22423 79679427
Meniscus injury 21.37 11.33 22 42516 6746 79695104
Conjunctivitis 21.01 11.33 44 42494 25671 79676179
Keratopathy 20.98 11.33 11 42527 1183 79700667
Eyelid disorder 20.70 11.33 13 42525 1965 79699885
Corneal degeneration 20.35 11.33 6 42532 135 79701715
Epigastric discomfort 20.26 11.33 23 42515 7873 79693977
Muscular weakness 20.25 11.33 151 42387 160578 79541272
Product use issue 20.11 11.33 52 42486 209770 79492080
Swollen tongue 20.06 11.33 59 42479 42511 79659339
Tubulointerstitial nephritis 19.97 11.33 55 42483 38180 79663670
Peripheral vascular disorder 19.95 11.33 23 42515 8007 79693843
Product packaging quantity issue 19.72 11.33 11 42527 1338 79700512
Eyelid oedema 19.70 11.33 30 42508 13657 79688193
Eye haemorrhage 19.44 11.33 25 42513 9732 79692118
Scleral hyperaemia 19.30 11.33 7 42531 307 79701543
Acute kidney injury 19.20 11.33 386 42152 519018 79182832
Atrial flutter 18.85 11.33 38 42500 21587 79680263
Pyelitis 18.69 11.33 7 42531 336 79701514
Meibomianitis 18.62 11.33 5 42533 79 79701771
Off label use 18.52 11.33 357 42181 906858 78794992
Gastrointestinal disorder 18.25 11.33 23 42515 122182 79579668
Choking 18.10 11.33 27 42511 12074 79689776
Cardiac failure congestive 18.06 11.33 134 42404 142268 79559582
Bronchiectasis 17.94 11.33 38 42500 22348 79679502
Conjunctival scar 17.80 11.33 6 42532 211 79701639
Cardiac murmur 17.77 11.33 31 42507 15793 79686057
Tinnitus 17.70 11.33 58 42480 44275 79657575
Contraindicated product administered 17.55 11.33 36 42502 157502 79544348
Eye colour change 17.46 11.33 7 42531 404 79701446
Body height decreased 17.12 11.33 22 42516 8558 79693292
Eye operation 17.01 11.33 12 42526 2201 79699649
Systemic lupus erythematosus 16.87 11.33 24 42514 121125 79580725
Rectal haemorrhage 16.87 11.33 83 42455 76217 79625633
Blood albumin abnormal 16.85 11.33 8 42530 696 79701154
Stomatitis 16.80 11.33 33 42505 146724 79555126
Atrioventricular block complete 16.69 11.33 31 42507 16579 79685271
Apathy 16.68 11.33 27 42511 12950 79688900
Lower respiratory tract infection 16.65 11.33 27 42511 129193 79572657
Rhinitis 16.62 11.33 29 42509 14778 79687072
Vertigo 16.61 11.33 77 42461 69005 79632845
Nightmare 16.39 11.33 40 42498 25821 79676029
Vitreous adhesions 16.15 11.33 4 42534 45 79701805
Product dose omission issue 15.98 11.33 202 42336 247335 79454515
Impaired quality of life 15.92 11.33 28 42510 14358 79687492
Macular cyst 15.84 11.33 4 42534 49 79701801
Ocular rosacea 15.72 11.33 3 42535 8 79701842
Repetitive strain injury 15.53 11.33 5 42533 152 79701698
Rheumatoid arthritis 15.48 11.33 58 42480 208412 79493438
Dysgeusia 15.46 11.33 66 42472 57111 79644739
Retinal tear 15.45 11.33 10 42528 1592 79700258
Asthma 15.39 11.33 124 42414 134971 79566879
Retinal vascular disorder 15.35 11.33 6 42532 324 79701526
Ill-defined disorder 15.31 11.33 8 42530 65867 79635983
Corectopia 15.22 11.33 3 42535 10 79701840
Overdose 15.20 11.33 49 42489 184157 79517693
Pharyngeal enanthema 15.15 11.33 4 42534 59 79701791
Iritis 14.91 11.33 14 42524 3841 79698009
Intraocular pressure test 14.91 11.33 4 42534 63 79701787
Retinal artery occlusion 14.78 11.33 13 42525 3281 79698569
Prostaglandin analogue periorbitopathy 14.60 11.33 3 42535 13 79701837
Discomfort 14.59 11.33 28 42510 125589 79576261
Adenocarcinoma metastatic 14.57 11.33 5 42533 186 79701664
Eyelids pruritus 14.56 11.33 8 42530 945 79700905
International normalised ratio increased 14.55 11.33 86 42452 84635 79617215
Myoclonic dystonia 14.51 11.33 4 42534 70 79701780
Paternal exposure during pregnancy 14.51 11.33 4 42534 70 79701780
Corneal lesion 14.41 11.33 4 42534 72 79701778
Palpitations 14.31 11.33 116 42422 126494 79575356
Retinopathy haemorrhagic 14.31 11.33 4 42534 74 79701776
Superficial injury of eye 14.30 11.33 5 42533 197 79701653
Ageusia 14.22 11.33 29 42509 16603 79685247
Subacute kidney injury 14.08 11.33 3 42535 16 79701834
Haemorrhage intracranial 14.00 11.33 38 42500 26155 79675695
Genital rash 13.99 11.33 8 42530 1020 79700830
Hypertension 13.93 11.33 251 42287 330741 79371109
Ectropion 13.84 11.33 6 42532 422 79701428
Irritable bowel syndrome 13.82 11.33 8 42530 62233 79639617
Pigmentation disorder 13.80 11.33 16 42522 5602 79696248
Achromotrichia acquired 13.78 11.33 3 42535 18 79701832
Corneal pigmentation 13.78 11.33 3 42535 18 79701832
Conjunctivochalasis 13.78 11.33 3 42535 18 79701832
Ascites 13.78 11.33 12 42526 75550 79626300
Injury corneal 13.74 11.33 4 42534 86 79701764
Duodenal ulcer haemorrhage 13.72 11.33 18 42520 7145 79694705
Resorption bone increased 13.72 11.33 9 42529 1466 79700384
Eye allergy 13.63 11.33 7 42531 721 79701129
Product container seal issue 13.57 11.33 4 42534 90 79701760
Injection site erythema 13.57 11.33 13 42525 78184 79623666
Pyrexia 13.54 11.33 268 42270 678441 79023409
Corneal striae 13.51 11.33 3 42535 20 79701830
Chondropathy 13.50 11.33 11 42527 2501 79699349
Corneal thickening 13.38 11.33 3 42535 21 79701829
Red blood cell sedimentation rate increased 13.26 11.33 4 42534 45938 79655912
Blood magnesium decreased 13.20 11.33 28 42510 16484 79685366
Pain 13.13 11.33 281 42257 703521 78998329
Diabetic ulcer 13.12 11.33 5 42533 252 79701598
Reaction to excipient 13.11 11.33 9 42529 1580 79700270
Corneal infection 13.06 11.33 4 42534 103 79701747
Vitreous disorder 13.05 11.33 5 42533 256 79701594
Hyperkalaemia 13.03 11.33 105 42433 114293 79587557
Liquid product physical issue 13.01 11.33 8 42530 1166 79700684
Septic shock 12.89 11.33 29 42509 122772 79579078
Musculoskeletal stiffness 12.79 11.33 49 42489 174959 79526891
Abdominal pain 12.57 11.33 140 42398 389429 79312421
Therapeutic product effect decreased 12.55 11.33 45 42493 163818 79538032
Visual acuity tests abnormal 12.54 11.33 4 42534 118 79701732
Hypoacusis 12.54 11.33 40 42498 30110 79671740
Bone marrow oedema 12.51 11.33 9 42529 1702 79700148
Hepatotoxicity 12.29 11.33 6 42532 51346 79650504
Brain stem haematoma 12.26 11.33 4 42534 127 79701723
Injury 12.19 11.33 14 42524 77482 79624368
Bone marrow failure 12.19 11.33 6 42532 51101 79650749
Anterior chamber inflammation 12.16 11.33 6 42532 568 79701282
Bradycardia 12.12 11.33 118 42420 135439 79566411
Endophthalmitis 12.08 11.33 16 42522 6412 79695438
Hip fracture 12.06 11.33 40 42498 30721 79671129
Intracranial haematoma 11.96 11.33 7 42531 933 79700917
Anterior chamber cell 11.89 11.33 7 42531 942 79700908
Cytomegalovirus infection 11.80 11.33 4 42534 42640 79659210
Blood calcium abnormal 11.78 11.33 8 42530 1381 79700469
Leiomyoma 11.74 11.33 5 42533 337 79701513
Eczema 11.73 11.33 48 42490 40770 79661080
Corneal transplant 11.67 11.33 5 42533 342 79701508
Abortion 11.67 11.33 8 42530 1402 79700448
Optic nerve injury 11.67 11.33 6 42532 620 79701230
Vestibular disorder 11.64 11.33 10 42528 2445 79699405
Hallucination 11.62 11.33 82 42456 85663 79616187
Noninfective conjunctivitis 11.58 11.33 3 42535 41 79701809
Instillation site reaction 11.56 11.33 5 42533 350 79701500
Oral mucosal discolouration 11.54 11.33 5 42533 351 79701499
Eyelid pain 11.52 11.33 5 42533 353 79701497
Keratic precipitates 11.45 11.33 5 42533 358 79701492
Device deposit issue 11.44 11.33 3 42535 43 79701807
Flat anterior chamber of eye 11.43 11.33 4 42534 158 79701692

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01EE01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Prostaglandin analogues
ATC S01EE51 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Prostaglandin analogues
FDA CS M0017805 Prostaglandins
FDA EPC N0000175454 Prostaglandin Analog
MeSH PA D009883 Ophthalmic Solutions
MeSH PA D019999 Pharmaceutical Solutions
CHEBI has role CHEBI:23018 EC 4.2.1.1 inhibitor
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:39456 antiglaucoma agent
CHEBI has role CHEBI:50266 Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ocular hypertension indication 4210003 DOID:9282
Open-angle glaucoma indication 84494001 DOID:1067
Conjunctivitis contraindication 9826008 DOID:6195
Aphakia contraindication 24010005
Macular retinal edema contraindication 37231002 DOID:4449
Iritis contraindication 65074000 DOID:1406
Pseudophakia contraindication 95217000
Uveitis contraindication 128473001 DOID:13141
Cystoid macular edema contraindication 193387007 DOID:4447
Disorder of macula of retina contraindication 312999006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 10532993 July 11, 2026 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 10882840 July 11, 2026 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 11021456 July 11, 2026 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 8450344 July 11, 2026 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 9096569 July 11, 2026 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005% XELPROS SUN PHARM N206185 Sept. 12, 2018 RX EMULSION OPHTHALMIC 9539262 Oct. 15, 2028 REDUCING ELEVATED INTRAOCULAR PRESSURE IN PATIENTS WITH OPEN-ANGLE GLAUCOMA OR OCULAR HYPERTENSION
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 10174017 Jan. 27, 2030 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 10654844 Jan. 27, 2030 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 11028081 Jan. 27, 2030 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 11618748 Jan. 27, 2030 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 8394826 Nov. 10, 2030 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 10588901 March 14, 2034 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 9931336 March 14, 2034 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE
0.005%;EQ 0.02% BASE ROCKLATAN ALCON LABS INC N208259 March 12, 2019 RX SOLUTION/DROPS OPHTHALMIC 9993470 March 14, 2034 REDUCTION OF ELEVATED INTRAOCULAR PRESSURE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin F2-alpha receptor GPCR AGONIST Ki 6.30 IUPHAR CHEMBL
Prostaglandin E2 receptor EP1 subtype GPCR Ki 5.76 PDSP
Prostaglandin E2 receptor EP3 subtype GPCR Ki 5.19 PDSP
Prostaglandin F2-alpha receptor GPCR Ki 7.01 CHEMBL

External reference:

IDSource
4020967 VUID
N0000148440 NUI
D00356 KEGG_DRUG
4020967 VANDF
C0090306 UMLSCUI
CHEBI:6384 CHEBI
CHEBI:63925 CHEBI
CHEMBL1051 ChEMBL_ID
D000077338 MESH_DESCRIPTOR_UI
DB00654 DRUGBANK_ID
5311221 PUBCHEM_CID
6980 INN_ID
6Z5B6HVF6O UNII
153159 RXNORM
4959 MMSL
52442 MMSL
5860 MMSL
d04017 MMSL
006059 NDDF
108838001 SNOMEDCT_US
386926002 SNOMEDCT_US
CHEMBL1164123 ChEMBL_ID
CHEMBL1050 ChEMBL_ID
41639-83-2 SECONDARY_CAS_RN
6441636 PUBCHEM_CID
EJ85341990 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Xalatan HUMAN PRESCRIPTION DRUG LABEL 1 0013-8303 SOLUTION 50 ug OPHTHALMIC NDA 26 sections
Xalatan HUMAN PRESCRIPTION DRUG LABEL 1 0013-8303 SOLUTION 50 ug OPHTHALMIC NDA 26 sections
Xalatan HUMAN PRESCRIPTION DRUG LABEL 1 0013-8303 SOLUTION 50 ug OPHTHALMIC NDA 26 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 17478-625 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 25 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 21695-986 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 26 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 24208-463 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 24208-463 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 24208-463 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
XELPROS HUMAN PRESCRIPTION DRUG LABEL 1 47335-317 SOLUTION/ DROPS 0.05 mg OPHTHALMIC NDA 24 sections
XELPROS HUMAN PRESCRIPTION DRUG LABEL 1 47335-317 SOLUTION/ DROPS 0.05 mg OPHTHALMIC NDA 24 sections
XELPROS HUMAN PRESCRIPTION DRUG LABEL 1 47335-317 SOLUTION/ DROPS 0.05 mg OPHTHALMIC NDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 50090-1920 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 50090-1920 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 54868-6254 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 26 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 55545-1010 SOLUTION 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 59762-0333 SOLUTION 50 ug OPHTHALMIC NDA AUTHORIZED GENERIC 25 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 59762-0333 SOLUTION 50 ug OPHTHALMIC NDA AUTHORIZED GENERIC 25 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 61314-547 SOLUTION 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 61314-547 SOLUTION 50 ug OPHTHALMIC ANDA 24 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 61919-112 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 12 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 64980-516 SOLUTION 50 ug OPHTHALMIC ANDA 24 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 64980-516 SOLUTION 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost Human Prescription Drug Label 1 65862-872 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
Latanoprost Human Prescription Drug Label 1 65862-872 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 24 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 68071-2376 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 20 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 68071-4612 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 25 sections
Latanoprost HUMAN PRESCRIPTION DRUG LABEL 1 68071-4650 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 25 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 68071-4893 SOLUTION 50 ug OPHTHALMIC ANDA 24 sections
Xalatan HUMAN PRESCRIPTION DRUG LABEL 1 68258-8976 SOLUTION 50 ug OPHTHALMIC NDA 24 sections
LATANOPROST HUMAN PRESCRIPTION DRUG LABEL 1 70069-421 SOLUTION/ DROPS 50 ug OPHTHALMIC ANDA 20 sections