amidefrine indications/contra

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 155 37571-84-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amidefrine mesilate
  • amidephrine
  • amidefrine
  • (+/-)-Amidephrine
  • amidephrine mesylate
  • amidefrine mesylate
  • amidephrine mesilate
  • Molecular weight: 244.31
  • Formula: C10H16N2O3S
  • CLOGP: -0.61
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 78.43
  • ALOGS: -1.74
  • ROTB: 4

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.57 acidic
pKa2 9.11 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenergic receptor alpha-2 GPCR IC50 4.72 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 4.40 CHEMBL

External reference:

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IDSource
D02901 KEGG_DRUG
7E2P22546V UNII
15010 PUBCHEM_CID
CHEMBL146408 ChEMBL_ID
CHEBI:134994 CHEBI
C016980 MESH_SUPPLEMENTAL_RECORD_UI
C001998 MESH_SUPPLEMENTAL_RECORD_UI
1751 INN_ID
1421-68-7 SECONDARY_CAS_RN

Pharmaceutical products:

None