amidefrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 155 37571-84-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amidefrine mesilate
  • amidephrine
  • amidefrine
  • (+/-)-Amidephrine
  • amidephrine mesylate
  • amidefrine mesylate
  • amidephrine mesilate
  • Molecular weight: 244.31
  • Formula: C10H16N2O3S
  • CLOGP: -0.61
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 78.43
  • ALOGS: -1.74
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.57 acidic
pKa2 9.11 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenergic receptor alpha-2 GPCR IC50 4.72 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 4.40 CHEMBL

External reference:

IDSource
D02901 KEGG_DRUG
C0051584 UMLSCUI
CHEBI:134994 CHEBI
CHEMBL146408 ChEMBL_ID
DB16623 DRUGBANK_ID
C016980 MESH_SUPPLEMENTAL_RECORD_UI
C001998 MESH_SUPPLEMENTAL_RECORD_UI
514 IUPHAR_LIGAND_ID
1421-68-7 SECONDARY_CAS_RN
15010 PUBCHEM_CID
1751 INN_ID
7E2P22546V UNII

Pharmaceutical products:

None