arginine hydrochloride indications/contra

Stem definitionDrug idCAS RN
1549 74-79-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • l-arginine
  • L-Arg
  • arginine
  • arginine hydrochloride
  • arginine HCl
An essential amino acid that is physiologically active in the L-form.
  • Molecular weight: 174.20
  • Formula: C6H14N4O2
  • CLOGP: -3.52
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 5
  • TPSA: 125.22
  • ALOGS: -1.88
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 28, 1973 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Parenteral nutrition associated liver disease 519.77 48.39 50 231 0 3385578
Foetal growth restriction 82.56 48.39 15 266 1854 3383724
Haematuria 77.52 48.39 19 262 9933 3375645
Infantile apnoea 50.45 48.39 8 273 433 3385145

Pharmacologic Action:

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SourceCodeDescription
ATC B05XB01 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Amino acids

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Diagnostic Test for Growth Hormone Secretion indication
Renal tubular acidosis contraindication 1776003 DOID:14219
Classical phenylketonuria contraindication 7573000
Poisoning by digitalis glycoside contraindication 12876009
Hyperkalemia contraindication 14140009
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:13404
Dehydration contraindication 34095006
End stage renal disease contraindication 46177005 DOID:784
Humoral hypercalcemia of malignancy contraindication 47709007
Heart disease contraindication 56265001 DOID:114
Metabolic acidosis contraindication 59455009
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Ventricular fibrillation contraindication 71908006
Hypercalciuria contraindication 71938000
Kidney disease contraindication 90708001 DOID:2527
Kidney stone contraindication 95570007
Hb SS disease contraindication 127040003 DOID:10923
Osteolysis contraindication 203522001
Myocardial infarction in recovery phase contraindication 418044006
Allergic Reactions contraindication

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.97 acidic
pKa2 11.72 Basic
pKa3 8.95 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Nitric oxide synthase, inducible Enzyme Kd 5.15 CHEMBL

External reference:

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IDSource
CHEBI:31235 CHEBI
DB00125 DRUGBANK_ID
4018668 VUID
N0000146979 NUI
C0003765 UMLSCUI
D02982 KEGG_DRUG
N0000147334 NDFRT
005095 NDDF
89918 RXNORM
63676001 SNOMEDCT_US
206 MMSL
4219 MMSL
4019067 VANDF
94ZLA3W45F UNII
1711 INN_ID
CHEMBL1485 ChEMBL_ID
CHEMBL1200381 ChEMBL_ID
1119-34-2 SECONDARY_CAS_RN
D001120 MESH_DESCRIPTOR_UI
66250 PUBCHEM_CID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
R-Gene HUMAN PRESCRIPTION DRUG LABEL 1 0009-0436 INJECTION, SOLUTION 10 g INTRAVENOUS NDA 12 sections
ProcalAmine HUMAN PRESCRIPTION DRUG LABEL 22 0264-1915 INJECTION 0.29 g INTRAVENOUS NDA 13 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3200 SOLUTION 1.47 g INTRAVENOUS ANDA 13 sections
Plenamine HUMAN PRESCRIPTION DRUG LABEL 17 0264-3205 SOLUTION 1.47 g INTRAVENOUS ANDA 13 sections
FreAmine III HUMAN PRESCRIPTION DRUG LABEL 16 0264-9010 INJECTION, SOLUTION 0.95 g INTRAVENOUS NDA 13 sections
FreAmine III HUMAN PRESCRIPTION DRUG LABEL 16 0264-9011 INJECTION, SOLUTION 0.95 g INTRAVENOUS NDA 13 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9341 SOLUTION 1.20 g INTRAVENOUS NDA 12 sections
FreAmine HBC HUMAN PRESCRIPTION DRUG LABEL 15 0264-9350 INJECTION, SOLUTION 0.58 g INTRAVENOUS NDA 13 sections
TrophAmine HUMAN PRESCRIPTION DRUG LABEL 20 0264-9361 SOLUTION 0.73 g INTRAVENOUS NDA 12 sections
HepatAmine HUMAN PRESCRIPTION DRUG LABEL 16 0264-9371 INJECTION, SOLUTION 0.60 g INTRAVENOUS NDA 13 sections
ProSol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0499 INJECTION, SOLUTION 1.96 g INTRAVENOUS NDA 12 sections
Clinisol HUMAN PRESCRIPTION DRUG LABEL 17 0338-0502 INJECTION, SOLUTION 1.47 g INTRAVENOUS ANDA 11 sections
Travasol HUMAN PRESCRIPTION DRUG LABEL 15 0338-0644 INJECTION 1.15 g INTRAVENOUS NDA 15 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1083 INJECTION 316 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1089 INJECTION 489 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1091 INJECTION 489 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1093 INJECTION 489 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1095 INJECTION 489 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1099 INJECTION 575 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1101 INJECTION 575 mg INTRAVENOUS NDA 14 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 15 0338-1103 INJECTION 575 mg INTRAVENOUS NDA 14 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1107 INJECTION 316 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1109 INJECTION 316 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1113 INJECTION 489 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1115 INJECTION 489 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1119 INJECTION 489 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1123 INJECTION 575 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1125 INJECTION 575 mg INTRAVENOUS NDA 15 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1127 INJECTION 575 mg INTRAVENOUS NDA 15 sections
Premasol - sulfite-free (Amino Acid) HUMAN PRESCRIPTION DRUG LABEL 19 0338-1130 INJECTION, SOLUTION 1.20 g INTRAVENOUS ANDA 12 sections