landiolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 1545 133242-30-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rapibloc
  • onoact
  • ONO-1101
  • ONO 1101
  • landiolol
  • landiolol hydrochloride
  • landiolol HCl
Landiolol (INN) is a drug which acts as a highly cardioselective, ultra short-acting beta blocker. It is used as an anti-arrhythmic agent.
  • Molecular weight: 509.60
  • Formula: C25H39N3O8
  • CLOGP: 1.83
  • LIPINSKI: 2
  • HAC: 11
  • HDO: 3
  • TPSA: 127.82
  • ALOGS: -3.18
  • ROTB: 14

Drug dosage:

None

ADMET properties:

PropertyValueReference
CL (Clearance) 36.33 mL/min/kg Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
Vd (Volume of distribution) 0.24 L/kg Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
June 29, 2016 EMA AOP Orphan Pharmaceuticals AG
July 5, 2002 PMDA Ono Pharmaceutical Co., Ltd

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AB14 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Atrial flutter indication 5370000
Tachyarrhythmia indication 6285003
Supraventricular tachycardia indication 6456007
Sinus tachycardia indication 11092001
Atrial fibrillation indication 49436004 DOID:0060224
Ventricular fibrillation indication 71908006
Hemodynamically unstable ventricular tachycardia indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.78 acidic
pKa2 7.77 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST KEGG DRUG KEGG DRUG

External reference:

IDSource
D01847 KEGG_DRUG
C0905464 UMLSCUI
CHEBI:31760 CHEBI
CHEMBL1742466 ChEMBL_ID
CHEMBL2362410 ChEMBL_ID
DB12212 DRUGBANK_ID
C077049 MESH_SUPPLEMENTAL_RECORD_UI
7516 INN_ID
144481-98-1 SECONDARY_CAS_RN
62NWQ924LH UNII
114905 PUBCHEM_CID
017430 NDDF
017431 NDDF

Pharmaceutical products:

None