isosorbide dinitrate ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
NO2 - derivatives 1505 87-33-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • r-isosorbide dinitrate
  • vascardin
  • astridine
  • isosorbide dinitrate
A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action.
  • Molecular weight: 236.14
  • Formula: C6H8N2O8
  • CLOGP: -0.08
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 0
  • TPSA: 128.56
  • ALOGS: -2.40
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
60 mg O
20 mg oral aerosol
20 mg SL
0.10 g TD

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.09 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 7.26 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 22 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.90 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 31 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.72 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 16, 1968 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 239.62 13.39 222 20252 99671 63368877
Cardiospasm 183.88 13.39 53 20421 1854 63466694
Subarachnoid haemorrhage 182.31 13.39 90 20384 14193 63454355
Palmoplantar keratoderma 181.20 13.39 53 20421 1954 63466594
Cardiac failure congestive 177.66 13.39 182 20292 92251 63376297
Pruritus genital 166.60 13.39 53 20421 2601 63465947
Sleep terror 166.09 13.39 53 20421 2627 63465921
Carotid artery occlusion 158.71 13.39 59 20415 4635 63463913
Atrial tachycardia 145.95 13.39 54 20420 4186 63464362
Tension headache 138.86 13.39 55 20419 5131 63463417
Anosmia 117.62 13.39 53 20421 6807 63461741
Immunisation 114.32 13.39 33 20441 1160 63467388
Ventricular tachycardia 113.20 13.39 74 20400 19905 63448643
Transient ischaemic attack 102.36 13.39 90 20384 37663 63430885
Facial pain 95.94 13.39 53 20421 10508 63458040
Chest pain 95.26 13.39 213 20261 215746 63252802
Pain of skin 93.82 13.39 54 20420 11580 63456968
Drug ineffective 83.22 13.39 131 20343 1044634 62423914
Vasculitis 83.07 13.39 59 20415 18150 63450398
Hallucination 82.58 13.39 95 20379 54722 63413826
Muscle twitching 79.00 13.39 59 20415 19609 63448939
Blindness 78.15 13.39 61 20413 21638 63446910
Eye pruritus 74.97 13.39 56 20418 18615 63449933
Intentional product misuse 74.51 13.39 95 20379 60822 63407726
Coronary artery disease 68.07 13.39 67 20407 32310 63436238
Acute myocardial infarction 66.65 13.39 66 20408 32058 63436490
Diplopia 65.17 13.39 57 20417 23671 63444877
Lip swelling 53.93 13.39 58 20416 31005 63437543
Blood glucose increased 52.87 13.39 96 20378 83660 63384888
Treatment failure 52.09 13.39 3 20471 199040 63269508
Contraindicated product administered 52.08 13.39 5 20469 217643 63250905
Generalised bullous fixed drug eruption 52.05 13.39 11 20463 100 63468448
Joint swelling 50.91 13.39 21 20453 327645 63140903
Infusion related reaction 50.73 13.39 9 20465 245512 63223036
Angina unstable 49.51 13.39 30 20444 7065 63461483
Systemic lupus erythematosus 49.46 13.39 5 20469 208913 63259635
Angioedema 48.23 13.39 68 20406 47897 63420651
Arthropathy 47.66 13.39 9 20465 234783 63233765
Bradycardia 47.57 13.39 85 20389 73142 63395406
Tinnitus 47.45 13.39 58 20416 35570 63432978
Visual impairment 47.34 13.39 92 20382 84354 63384194
Angina pectoris 46.75 13.39 53 20421 30025 63438523
Dry skin 46.24 13.39 73 20401 56814 63411734
Cardiac failure 46.22 13.39 94 20380 89048 63379500
Glossodynia 45.89 13.39 3 20471 178873 63289675
Therapeutic product effect decreased 44.77 13.39 5 20469 193182 63275366
Amnesia 44.72 13.39 71 20403 55514 63413034
Maternal exposure during pregnancy 43.48 13.39 9 20465 220053 63248495
Hepatic enzyme increased 42.70 13.39 7 20467 202321 63266227
Disturbance in attention 42.70 13.39 57 20417 38132 63430416
Drug intolerance 41.54 13.39 24 20450 308637 63159911
Rash papular 39.70 13.39 36 20438 15666 63452882
Dehydration 36.60 13.39 131 20343 173223 63295325
Myocardial ischaemia 35.53 13.39 31 20443 12828 63455720
Cerebrovascular accident 35.23 13.39 95 20379 107929 63360619
Swelling 33.51 13.39 24 20450 275354 63193194
Product use issue 32.85 13.39 15 20459 220505 63248043
Cognitive disorder 31.50 13.39 61 20413 55754 63412794
Discomfort 30.75 13.39 8 20466 167366 63301182
Renal failure 30.22 13.39 95 20379 117557 63350991
Hyperhidrosis 29.48 13.39 89 20385 107747 63360801
Palpitations 27.99 13.39 90 20384 112680 63355868
Hypersensitivity 27.87 13.39 32 20442 292653 63175895
Infection 27.83 13.39 20 20454 229153 63239395
Nasopharyngitis 27.38 13.39 25 20449 254232 63214316
Acute kidney injury 27.03 13.39 161 20313 263254 63205294
Haemorrhagic diathesis 26.59 13.39 17 20457 4398 63464150
Arteriospasm coronary 25.70 13.39 16 20458 3952 63464596
Rheumatoid arthritis 23.89 13.39 28 20446 253791 63214757
Lower respiratory tract infection 23.05 13.39 7 20467 132300 63336248
Red cell distribution width abnormal 22.78 13.39 6 20468 149 63468399
Coronary arterial stent insertion 22.45 13.39 13 20461 2816 63465732
Dysphoria 22.43 13.39 16 20458 4950 63463598
Mesenteric arterial occlusion 22.30 13.39 6 20468 162 63468386
Heart rate increased 22.29 13.39 74 20400 94164 63374384
Sinus bradycardia 21.53 13.39 25 20449 14526 63454022
Wound 21.51 13.39 13 20461 163250 63305298
Renal impairment 21.45 13.39 70 20404 88285 63380263
Tachycardia 21.36 13.39 85 20389 118071 63350477
Dyspnoea 20.60 13.39 313 20161 661000 62807548
Muscular weakness 20.52 13.39 86 20388 122267 63346281
Feeling abnormal 19.45 13.39 97 20377 148295 63320253
Left ventricular hypertrophy 19.26 13.39 15 20459 5300 63463248
Ischaemic cardiomyopathy 18.65 13.39 11 20463 2466 63466082
Electrocardiogram ST segment elevation 18.54 13.39 13 20461 3914 63464634
Exposure during pregnancy 18.33 13.39 14 20460 155533 63313015
Gamma-glutamyltransferase abnormal 18.14 13.39 6 20468 333 63468215
Lip erosion 18.07 13.39 8 20466 985 63467563
Hyperkalaemia 17.99 13.39 48 20426 54155 63414393
Chronic kidney disease 17.99 13.39 43 20431 45355 63423193
N-terminal prohormone brain natriuretic peptide abnormal 17.92 13.39 4 20470 48 63468500
Mucosal erosion 17.71 13.39 9 20465 1507 63467041
Blood urea increased 17.61 13.39 31 20443 26348 63442200
Psoriatic arthropathy 17.54 13.39 4 20470 91516 63377032
Genital erosion 17.48 13.39 5 20469 170 63468378
Memory impairment 17.26 13.39 73 20401 104185 63364363
Hypovolaemic shock 17.15 13.39 15 20459 6226 63462322
Blood pressure decreased 17.14 13.39 53 20421 64969 63403579
Irritable bowel syndrome 17.05 13.39 3 20471 82409 63386139
Insulin C-peptide increased 16.51 13.39 4 20470 70 63468478
Dizziness 16.38 13.39 211 20263 429714 63038834
COVID-19 16.31 13.39 76 20398 113027 63355521
BRASH syndrome 16.24 13.39 6 20468 463 63468085
Gynaecomastia 16.04 13.39 5 20469 229 63468319
Acute coronary syndrome 16.00 13.39 18 20456 10108 63458440
Haematocrit abnormal 15.67 13.39 7 20467 880 63467668
Sinusitis 15.55 13.39 31 20443 226622 63241926
Coronary artery occlusion 15.47 13.39 16 20458 8175 63460373
Off label use 15.10 13.39 142 20332 674320 62794228
Cardiac failure chronic 15.00 13.39 12 20462 4406 63464142
Shock 14.92 13.39 27 20447 23436 63445112
Blood creatinine increased 14.92 13.39 62 20412 87782 63380766
Nephrogenic systemic fibrosis 14.67 13.39 12 20462 4544 63464004
Fibromyalgia 14.47 13.39 4 20470 80416 63388132
Respiratory acidosis 14.30 13.39 14 20460 6701 63461847
Coronary artery stenosis 14.25 13.39 12 20462 4732 63463816
Hypotension 14.07 13.39 142 20332 272462 63196086
Paraesthesia 14.03 13.39 18 20456 156948 63311600
Renal hypoplasia 13.94 13.39 3 20471 30 63468518
Cardiac disorder 13.93 13.39 42 20432 50774 63417774
Arrhythmia 13.92 13.39 35 20439 38105 63430443
Migraine 13.85 13.39 68 20406 103278 63365270
Therapeutic product effect incomplete 13.80 13.39 12 20462 125044 63343504
Silent myocardial infarction 13.69 13.39 5 20469 373 63468175
Rhabdomyolysis 13.66 13.39 38 20436 43913 63424635
Febrile neutropenia 13.52 13.39 11 20463 118438 63350110
Drug hypersensitivity 13.50 13.39 53 20421 310634 63157914

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 208.25 13.03 318 22195 120767 34813651
Cardiospasm 197.71 13.03 63 22450 1525 34932893
Palmoplantar keratoderma 181.00 13.03 62 22451 1891 34932527
Cardiac failure congestive 172.56 13.03 239 22274 83031 34851387
Pruritus genital 169.90 13.03 61 22452 2143 34932275
Sleep terror 166.89 13.03 61 22452 2257 34932161
Tension headache 161.17 13.03 64 22449 2978 34931440
Atrial tachycardia 156.64 13.03 66 22447 3579 34930839
Facial pain 152.30 13.03 65 22448 3639 34930779
Carotid artery occlusion 145.18 13.03 63 22450 3674 34930744
Anosmia 143.90 13.03 64 22449 3960 34930458
Immunisation 135.20 13.03 43 22470 1034 34933384
Chest pain 125.87 13.03 262 22251 126500 34807918
Pain of skin 112.97 13.03 62 22451 6047 34928371
Subarachnoid haemorrhage 97.60 13.03 74 22439 12561 34921857
Eye pruritus 96.15 13.03 60 22453 7429 34926989
Ventricular tachycardia 92.01 13.03 99 22414 26480 34907938
Vasculitis 91.34 13.03 68 22445 11228 34923190
Muscle twitching 87.79 13.03 64 22449 10234 34924184
Pericarditis 85.11 13.03 66 22447 11579 34922839
Blindness 82.43 13.03 72 22441 14914 34919504
Lip swelling 80.01 13.03 73 22440 16007 34918411
Acute myocardial infarction 78.22 13.03 131 22382 53588 34880830
Transient ischaemic attack 77.11 13.03 92 22421 27521 34906897
Drug ineffective 75.73 13.03 111 22402 456640 34477778
Coronary artery disease 67.94 13.03 116 22397 48189 34886229
Diplopia 67.74 13.03 68 22445 16775 34917643
Angina unstable 66.13 13.03 57 22456 11596 34922822
Tinnitus 64.52 13.03 72 22441 20046 34914372
Rash papular 61.85 13.03 52 22461 10226 34924192
Amnesia 59.06 13.03 79 22434 26484 34907934
Migraine 58.55 13.03 64 22449 17414 34917004
Angina pectoris 53.18 13.03 82 22431 31281 34903137
Dry skin 51.93 13.03 81 22432 31206 34903212
Blood glucose increased 50.53 13.03 124 22389 66594 34867824
Disturbance in attention 49.95 13.03 72 22441 25873 34908545
Alopecia 47.49 13.03 68 22445 24287 34910131
Dizziness 46.37 13.03 269 22244 218252 34716166
Silent myocardial infarction 46.01 13.03 15 22498 391 34934027
Palpitations 45.98 13.03 88 22425 39898 34894520
Angioedema 45.14 13.03 84 22429 37290 34897128
Myocardial ischaemia 43.73 13.03 55 22458 17353 34917065
Cognitive disorder 41.77 13.03 70 22443 28623 34905795
Heart rate increased 40.38 13.03 91 22422 46252 34888166
Hallucination 40.36 13.03 97 22416 51401 34883017
Visual impairment 40.19 13.03 78 22435 35724 34898694
Feeling abnormal 40.13 13.03 110 22403 63125 34871293
Off label use 39.86 13.03 138 22375 419386 34515032
Cardiac failure 37.86 13.03 137 22376 91111 34843307
Drug abuse 37.26 13.03 9 22504 99087 34835331
Toxic epidermal necrolysis 35.85 13.03 56 22457 21590 34912828
Toxicity to various agents 33.72 13.03 48 22465 200314 34734104
Dyspnoea 33.07 13.03 379 22134 376403 34558015
Abdominal discomfort 32.09 13.03 98 22415 59737 34874681
Hyperhidrosis 31.69 13.03 114 22399 75578 34858840
Bradycardia 29.40 13.03 111 22402 75307 34859111
Memory impairment 29.13 13.03 77 22436 43241 34891177
Febrile neutropenia 28.11 13.03 28 22485 136821 34797597
Dehydration 27.50 13.03 160 22353 129809 34804609
Syncope 27.31 13.03 124 22389 91327 34843091
Cutaneous lupus erythematosus 26.73 13.03 12 22501 758 34933660
Hypotension 26.62 13.03 238 22275 221411 34713007
Product use in unapproved indication 26.56 13.03 22 22491 117477 34816941
Coronary artery occlusion 26.52 13.03 34 22479 10928 34923490
Normochromic normocytic anaemia 26.43 13.03 22 22491 4265 34930153
Hypoglycaemia 26.10 13.03 86 22427 54554 34879864
Prinzmetal angina 23.53 13.03 12 22501 1007 34933411
Muscular weakness 23.39 13.03 101 22412 72796 34861622
Neutropenia 23.10 13.03 41 22472 156737 34777681
Bleeding time prolonged 22.04 13.03 10 22503 648 34933770
Completed suicide 21.42 13.03 19 22494 98149 34836269
Malaise 20.01 13.03 195 22318 185630 34748788
Anxiety 19.47 13.03 120 22393 99308 34835110
Intentional product misuse 19.33 13.03 69 22444 45542 34888876
Pulmonary oedema 18.55 13.03 70 22443 47459 34886959
Cerebrovascular accident 18.30 13.03 105 22408 84706 34849712
Drug intolerance 17.84 13.03 8 22505 59562 34874856
Abdominal pain upper 17.78 13.03 92 22421 71398 34863020
Chronic kidney disease 17.17 13.03 62 22451 41148 34893270
Oesophageal ulcer haemorrhage 17.00 13.03 6 22507 200 34934218
Peripheral swelling 16.67 13.03 95 22418 76446 34857972
Arteriospasm coronary 16.13 13.03 15 22498 3367 34931051
Infusion related reaction 16.09 13.03 7 22506 53050 34881368
Malignant neoplasm progression 15.89 13.03 20 22493 88026 34846392
Occult blood positive 15.64 13.03 16 22497 4032 34930386
Myocardial depression 14.87 13.03 4 22509 52 34934366
Pruritus 14.78 13.03 148 22365 141833 34792585
Coronary artery stenosis 14.71 13.03 24 22489 9592 34924826
Renal failure 14.52 13.03 138 22375 130419 34803999
Cardiac failure acute 14.34 13.03 25 22488 10545 34923873
Ischaemia 14.01 13.03 16 22497 4564 34929854
Kounis syndrome 13.64 13.03 12 22501 2506 34931912
Supraventricular tachycardia 13.43 13.03 25 22488 11092 34923326
Therapeutic product effect incomplete 13.34 13.03 8 22505 50533 34883885
Cardiac disorder 13.25 13.03 59 22454 43067 34891351
Insomnia 13.17 13.03 113 22400 103794 34830624
Injury 13.12 13.03 36 22477 20651 34913767

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myocardial infarction 430.56 12.47 480 37036 183649 79523223
Cardiospasm 364.61 12.47 111 37405 3190 79703682
Palmoplantar keratoderma 347.51 12.47 110 37406 3606 79703266
Sleep terror 323.88 12.47 109 37407 4349 79702523
Cardiac failure congestive 323.67 12.47 366 37150 142036 79564836
Pruritus genital 323.21 12.47 109 37407 4377 79702495
Atrial tachycardia 294.96 12.47 115 37401 7018 79699854
Carotid artery occlusion 287.20 12.47 115 37401 7532 79699340
Tension headache 286.71 12.47 113 37403 7098 79699774
Subarachnoid haemorrhage 262.43 12.47 156 37360 24309 79682563
Anosmia 261.11 12.47 112 37404 8732 79698140
Immunisation 235.62 12.47 72 37444 2095 79704777
Facial pain 231.30 12.47 114 37402 12236 79694636
Pain of skin 204.79 12.47 111 37405 14502 79692370
Ventricular tachycardia 194.89 12.47 160 37356 41775 79665097
Eye pruritus 169.63 12.47 111 37405 20459 79686413
Vasculitis 167.88 12.47 119 37397 24983 79681889
Blindness 165.86 12.47 124 37392 28259 79678613
Transient ischaemic attack 165.26 12.47 161 37355 52534 79654338
Muscle twitching 164.70 12.47 117 37399 24647 79682225
Chest pain 162.73 12.47 389 37127 281915 79424957
Drug ineffective 138.89 12.47 184 37332 1080729 78626143
Acute myocardial infarction 137.05 12.47 175 37341 76861 79630011
Diplopia 133.55 12.47 117 37399 33349 79673523
Lip swelling 126.40 12.47 124 37392 40787 79666085
Coronary artery disease 123.24 12.47 153 37363 65321 79641551
Hallucination 122.39 12.47 175 37341 85570 79621302
Angina unstable 116.67 12.47 81 37435 16446 79690426
Blood glucose increased 114.60 12.47 199 37317 114776 79592096
Tinnitus 112.72 12.47 121 37395 44212 79662660
Disturbance in attention 104.19 12.47 124 37392 50677 79656195
Amnesia 103.97 12.47 138 37378 62919 79643953
Rash papular 102.59 12.47 84 37432 21832 79685040
Dry skin 100.30 12.47 141 37375 67854 79639018
Angioedema 95.28 12.47 146 37370 75889 79630983
Visual impairment 86.02 12.47 155 37361 91976 79614896
Intentional product misuse 84.93 12.47 157 37359 95008 79611864
Angina pectoris 83.41 12.47 112 37404 51620 79655252
Myocardial ischaemia 78.16 12.47 77 37439 25442 79681430
Infusion related reaction 72.28 12.47 11 37505 230226 79476646
Cognitive disorder 72.22 12.47 123 37393 69803 79637069
Bradycardia 70.73 12.47 180 37336 135377 79571495
Treatment failure 67.43 12.47 3 37513 170483 79536389
Cardiac failure 67.11 12.47 192 37324 154650 79552222
Joint swelling 65.34 12.47 27 37489 288619 79418253
Dehydration 65.18 12.47 260 37256 247927 79458945
Hyperhidrosis 64.84 12.47 187 37329 151305 79555567
Palpitations 62.83 12.47 165 37351 126445 79580427
Silent myocardial infarction 61.53 12.47 20 37496 714 79706158
Heart rate increased 58.55 12.47 156 37360 120568 79586304
Drug intolerance 56.17 12.47 27 37489 264092 79442780
Arthropathy 54.37 12.47 9 37507 177102 79529770
Migraine 54.00 12.47 124 37392 87369 79619503
Nasopharyngitis 50.93 12.47 28 37488 253853 79453019
Dizziness 49.90 12.47 420 37096 526021 79180851
Off label use 46.26 12.47 245 37271 906970 78799902
Therapeutic product effect decreased 44.73 12.47 11 37505 163852 79543020
Feeling abnormal 44.37 12.47 170 37346 159029 79547843
Toxic epidermal necrolysis 44.16 12.47 77 37439 44504 79662368
Muscular weakness 43.46 12.47 170 37346 160559 79546313
Swelling 43.32 12.47 24 37492 216687 79490185
Syncope 42.36 12.47 182 37334 179267 79527605
Rheumatoid arthritis 41.80 12.47 23 37493 208447 79498425
Generalised bullous fixed drug eruption 41.75 12.47 11 37505 184 79706688
Memory impairment 40.36 12.47 130 37386 111604 79595268
Hepatic enzyme increased 39.84 12.47 18 37498 182592 79524280
Cerebrovascular accident 39.38 12.47 161 37355 155131 79551741
Renal failure 38.69 12.47 192 37324 200776 79506096
Contraindicated product administered 38.54 12.47 13 37503 157525 79549347
Arteriospasm coronary 38.46 12.47 29 37487 6687 79700185
Dyspnoea 38.28 12.47 590 36926 856435 78850437
Product use issue 38.10 12.47 26 37490 209796 79497076
Maternal exposure during pregnancy 37.59 12.47 9 37507 136529 79570343
Systemic lupus erythematosus 37.52 12.47 6 37510 121143 79585729
Coronary artery occlusion 35.78 12.47 40 37476 15275 79691597
Febrile neutropenia 32.97 12.47 36 37480 230963 79475909
Lower respiratory tract infection 32.78 12.47 10 37506 129210 79577662
Neutropenia 32.75 12.47 53 37463 287657 79419215
Prinzmetal angina 32.56 12.47 16 37500 1704 79705168
Product use in unapproved indication 32.55 12.47 42 37474 250317 79456555
Pericarditis 32.12 12.47 115 37401 104121 79602751
Hypotension 31.96 12.47 332 37184 439985 79266887
Tachycardia 30.84 12.47 165 37351 177603 79529269
Hypoglycaemia 30.38 12.47 111 37405 101483 79605389
Glossodynia 30.09 12.47 6 37510 103331 79603541
Anxiety 30.02 12.47 210 37306 248302 79458570
Drug abuse 29.74 12.47 20 37496 162671 79544201
Acute coronary syndrome 28.47 12.47 42 37474 21091 79685781
Infection 28.00 12.47 44 37472 241668 79465204
Hypersensitivity 27.39 12.47 51 37465 262188 79444684
Ischaemic cardiomyopathy 26.94 12.47 25 37491 7670 79699202
Coronary artery stenosis 26.45 12.47 31 37485 12453 79694419
Therapeutic product effect incomplete 25.11 12.47 18 37498 141627 79565245
Discomfort 24.96 12.47 14 37502 125603 79581269
Normochromic normocytic anaemia 24.94 12.47 24 37492 7703 79699169
Toxicity to various agents 24.18 12.47 109 37407 421431 79285441
Insomnia 23.89 12.47 197 37319 244973 79461899
Rhabdomyolysis 23.85 12.47 104 37412 103027 79603845
Drug interaction 23.35 12.47 298 37218 414885 79291987
Sinusitis 23.20 12.47 35 37481 195466 79511406
Weight increased 23.17 12.47 61 37455 277325 79429547
Chronic kidney disease 23.00 12.47 76 37440 66078 79640794
Gastrointestinal haemorrhage 22.88 12.47 133 37383 147586 79559286
COVID-19 21.90 12.47 138 37378 157536 79549336
Condition aggravated 21.88 12.47 142 37374 500982 79205890
Coronary arterial stent insertion 21.86 12.47 20 37496 6024 79700848
Cardiac failure acute 21.82 12.47 35 37481 18894 79687978
Psoriatic arthropathy 21.74 12.47 5 37511 77994 79628878
Bleeding time prolonged 21.55 12.47 11 37505 1270 79705602
Electrocardiogram ST segment elevation 21.47 12.47 23 37493 8374 79698498
Cardiac disorder 20.63 12.47 73 37443 65684 79641188
Ischaemia 20.44 12.47 22 37494 8053 79698819
Helicobacter infection 20.39 12.47 4 37512 69700 79637172
Abdominal pain upper 20.29 12.47 177 37339 223642 79483230
Wound 20.28 12.47 15 37501 116164 79590708
Musculoskeletal stiffness 20.13 12.47 32 37484 174976 79531896
International normalised ratio increased 20.02 12.47 86 37430 84635 79622237
Cutaneous lupus erythematosus 19.52 12.47 14 37502 2989 79703883
Drug hypersensitivity 19.17 12.47 74 37442 298842 79408030
Neuropathy peripheral 19.09 12.47 23 37493 141282 79565590
Pulmonary oedema 18.91 12.47 87 37429 88167 79618705
Atrial fibrillation 18.20 12.47 157 37359 197729 79509143
Red cell distribution width abnormal 18.13 12.47 6 37510 227 79706645
Haemorrhagic diathesis 17.96 12.47 18 37498 6066 79700806
Blood urea increased 17.82 12.47 57 37459 48733 79658139
Exposure during pregnancy 17.73 12.47 13 37503 101119 79605753
Hyperkalaemia 17.71 12.47 103 37413 114295 79592577
Blood pressure decreased 17.70 12.47 93 37423 99373 79607499
Mesenteric arterial occlusion 17.64 12.47 6 37510 247 79706625
General physical health deterioration 17.10 12.47 69 37447 275169 79431703
Back pain 16.52 12.47 217 37299 303963 79402909
Anhedonia 16.43 12.47 27 37489 14871 79692001
Fibromyalgia 16.27 12.47 5 37511 64335 79642537
Cardiac failure chronic 16.27 12.47 23 37493 11112 79695760
Flushing 15.93 12.47 11 37505 88257 79618615
Impaired healing 15.71 12.47 11 37505 87644 79619228
Injection site pain 15.64 12.47 23 37493 129815 79577057
Fear 15.64 12.47 33 37483 21953 79684919
Peripheral vascular disorder 15.47 12.47 19 37497 8011 79698861
Arthritis 15.20 12.47 19 37497 114861 79592011
Sedation 15.13 12.47 3 37513 51892 79654980
Renal hypoplasia 14.97 12.47 3 37513 13 79706859
Delirium 14.97 12.47 79 37437 84548 79622324
Pulseless electrical activity 14.73 12.47 25 37491 14135 79692737
Left ventricular hypertrophy 14.73 12.47 22 37494 11169 79695703
Occult blood positive 14.43 12.47 17 37499 6866 79700006
Atrioventricular block complete 14.30 12.47 27 37489 16583 79690289
Blood creatinine increased 14.24 12.47 123 37393 154934 79551938
Mucosal inflammation 14.20 12.47 9 37507 75571 79631301
Stomatitis 14.06 12.47 30 37486 146727 79560145
Dysphoria 13.97 12.47 14 37502 4720 79702152
Rash 13.95 12.47 190 37326 578168 79128704
Muscle injury 13.76 12.47 3 37513 48558 79658314
Hepatic function abnormal 13.45 12.47 69 37447 73038 79633834
Renal impairment 13.38 12.47 123 37393 157660 79549212
Inappropriate schedule of product administration 13.06 12.47 27 37489 133601 79573271
Pruritus 12.96 12.47 259 37257 394389 79312483
Inflammation 12.94 12.47 15 37501 93738 79613134
Ephelides 12.91 12.47 4 37512 122 79706750
Sinus node dysfunction 12.91 12.47 17 37499 7684 79699188
Leukopenia 12.74 12.47 22 37494 116491 79590381
Acute kidney injury 12.71 12.47 327 37189 519077 79187795
Red blood cell sedimentation rate increased 12.69 12.47 3 37513 45939 79660933
Sinus bradycardia 12.61 12.47 33 37483 25214 79681658
Injection site reaction 12.58 12.47 5 37511 54780 79652092
Gamma-glutamyltransferase abnormal 12.57 12.47 6 37510 600 79706272
Oropharyngeal pain 12.56 12.47 20 37496 109333 79597539
Oesophageal ulcer haemorrhage 12.48 12.47 6 37510 609 79706263

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01DA08 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Organic nitrates
ATC C01DA58 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Organic nitrates
ATC C05AE02 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Muscle relaxants
FDA CS M0014874 Nitrates
FDA PE N0000009909 Vasodilation
FDA EPC N0000175415 Nitrate Vasodilator
MeSH PA D002317 Cardiovascular Agents
MeSH PA D020030 Nitric Oxide Donors
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:50566 nitric oxide generators

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Chronic heart failure indication 48447003
Angina pectoris indication 194828000
Angina Pectoris Prevention indication
Prevention of Bleeding Esophageal Varices off-label use
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Hyperthyroidism contraindication 34486009 DOID:7998
Low blood pressure contraindication 45007003
Benign intracranial hypertension contraindication 68267002 DOID:11459
Injury of head contraindication 82271004
Increased intestinal motility contraindication 102624003
Cerebrovascular accident contraindication 230690007
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Lupus erythematosus and erythema multiforme-like syndrome contraindication 238926009
Anemia contraindication 271737000 DOID:2355
Cerebral hemorrhage contraindication 274100004
Disorder of coronary artery contraindication 414024009
Myocardial infarction in recovery phase contraindication 418044006
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005
Malabsorption States contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Soluble guanylate cyclase Enzyme ACTIVATOR CHEMBL CHEMBL
Atrial natriuretic peptide receptor 1 Enzyme WOMBAT-PK

External reference:

IDSource
4017825 VUID
N0000146183 NUI
D00516 KEGG_DRUG
4017825 VANDF
C0022252 UMLSCUI
CHEBI:6061 CHEBI
CHEMBL6622 ChEMBL_ID
D007548 MESH_DESCRIPTOR_UI
DB00883 DRUGBANK_ID
7051 IUPHAR_LIGAND_ID
996 INN_ID
IA7306519N UNII
6883 PUBCHEM_CID
379630 RXNORM
2988 MMSL
2996 MMSL
4934 MMSL
d00268 MMSL
000688 NDDF
387332007 SNOMEDCT_US
5924003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-1765 TABLET 2.50 mg SUBLINGUAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-1767 TABLET 5 mg SUBLINGUAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-1769 TABLET 5 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-1769 TABLET 5 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-1771 TABLET 10 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-1771 TABLET 10 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-1772 TABLET 20 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-1772 TABLET 20 mg ORAL ANDA 21 sections
IsordilTitradose HUMAN PRESCRIPTION DRUG LABEL 1 0187-0152 TABLET 5 mg ORAL NDA 20 sections
IsordilTitradose HUMAN PRESCRIPTION DRUG LABEL 1 0187-0192 TABLET 40 mg ORAL NDA 20 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-1560 TABLET 10 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-1575 TABLET 20 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8157 TABLET 10 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8157 TABLET 10 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8193 TABLET 30 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8193 TABLET 30 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8294 TABLET 20 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8294 TABLET 20 mg ORAL ANDA 21 sections
ISOSORBIDE DINITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8463 TABLET 10 mg ORAL ANDA 21 sections
ISOSORBIDE DINITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8464 TABLET 20 mg ORAL ANDA 21 sections
ISOSORBIDE DINITRATE HUMAN PRESCRIPTION DRUG LABEL 1 0615-8465 TABLET 30 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-1556 TABLET 10 mg ORAL ANDA 23 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-1556 TABLET 10 mg ORAL ANDA 23 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-1635 TABLET 5 mg ORAL ANDA 23 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-1635 TABLET 5 mg ORAL ANDA 23 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-1695 TABLET 20 mg ORAL ANDA 23 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-1695 TABLET 20 mg ORAL ANDA 23 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6619 TABLET 10 mg ORAL ANDA 21 sections
Isosorbide Dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6620 TABLET 20 mg ORAL ANDA 21 sections
Isosorbide dinitrate HUMAN PRESCRIPTION DRUG LABEL 1 16714-007 TABLET 5 mg ORAL ANDA 17 sections