amcinonide indications/contra

Stem definitionDrug idCAS RN
steroids for topical use, acetal derivatives 150 51022-69-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amcinonide
  • amciderm
  • amcinonid
  • cyclocort
  • Molecular weight: 502.58
  • Formula: C28H35FO7
  • CLOGP: 2.88
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 99.13
  • ALOGS: -4.81
  • ROTB: 4

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 18, 1979 FDA ASTELLAS

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC D07AC11 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
FDA EPC N0000175576 Corticosteroid
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
MeSH PA D000305 Adrenal Cortex Hormones
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D006730 Hormones, Hormone Substitutes, and Hormone Antagonists
CHEBI has role CHEBI:35472 anti-inflammatory drug

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Glaucoma contraindication 23986001 DOID:1686
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Tuberculosis of skin contraindication 66986005
Bilateral cataracts contraindication 95722004
Atrophoderma contraindication 399979006 DOID:2733
Peripheral vascular disease contraindication 400047006

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.08 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

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IDSource
DB00288 DRUGBANK_ID
4017920 VUID
N0000146271 NUI
C0051556 UMLSCUI
7060 IUPHAR_LIGAND_ID
D01387 KEGG_DRUG
423W026MA9 UNII
3755 INN_ID
4017920 VANDF
420859004 SNOMEDCT_US
N0000005899 NDFRT
N0000146271 NDFRT
002202 NDDF
4163 MMSL
17652 RXNORM
44051 MMSL
67980007 SNOMEDCT_US
443958 PUBCHEM_CID
CHEMBL1200732 ChEMBL_ID
C012716 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:31199 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Amcinonide HUMAN PRESCRIPTION DRUG LABEL 1 0168-0278 CREAM 1 mg TOPICAL ANDA 11 sections
Amcinonide HUMAN PRESCRIPTION DRUG LABEL 1 0168-0279 OINTMENT 1 mg TOPICAL ANDA 11 sections
amcinonide HUMAN PRESCRIPTION DRUG LABEL 1 0168-0280 LOTION 1 mg TOPICAL ANDA 11 sections
Amcinonide HUMAN PRESCRIPTION DRUG LABEL 1 51672-4054 CREAM 1 mg TOPICAL ANDA 11 sections
Amcinonide HUMAN PRESCRIPTION DRUG LABEL 1 51672-4060 OINTMENT 1 mg TOPICAL ANDA 11 sections