isoflurane Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 1493 26675-46-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isoflurane
  • 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether
  • forane
  • forene
  • isoforine
  • isorrane
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
  • Molecular weight: 184.49
  • Formula: C3H2ClF5O
  • CLOGP: 1.76
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -1.72
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 18, 1979 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthermia malignant 320.15 108.14 44 457 650 4637841
Exposure during pregnancy 234.68 108.14 62 439 32909 4605582
Intestinal ischaemia 183.07 108.14 32 469 2331 4636160
Hypotension 166.44 108.14 56 445 67344 4571147
Congenital anomaly 164.82 108.14 29 472 2187 4636304
Necrosis ischaemic 129.99 108.14 17 484 163 4638328
Systemic inflammatory response syndrome 115.72 108.14 21 480 1872 4636619

Pharmacologic Action:

SourceCodeDescription
ATC N01AB06 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
FDA PE N0000175975 General Anesthesia
FDA EPC N0000175681 General Anesthetic
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
CHEBI has role CHEBI:38870 inhalation anaesthetic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Low blood pressure contraindication 45007003
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Disease of liver contraindication 235856003 DOID:409
Malignant hyperthermia contraindication 405501007

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycine receptor (alpha-1/beta) Ion channel POSITIVE MODULATOR CHEMBL CHEMBL
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL
5-hydroxytryptamine receptor 2B GPCR Ki 5.11 PDSP

External reference:

IDSource
D007530 MESH_DESCRIPTOR_UI
4019107 VUID
N0000147364 NUI
C0022180 UMLSCUI
D00545 KEGG_DRUG
66492008 SNOMEDCT_US
4326 MMSL
6026 RXNORM
387368002 SNOMEDCT_US
4926 MMSL
d00267 MMSL
4019107 VANDF
001391 NDDF
CYS9AKD70P UNII
3286 INN_ID
3763 PUBCHEM_CID
CHEBI:6015 CHEBI
CHEMBL1256 ChEMBL_ID
DB00753 DRUGBANK_ID
ICF PDB_CHEM_ID
2505 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FORANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-360 INHALANT 1 mL RESPIRATORY (INHALATION) NDA 12 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 12164-012 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Terrell HUMAN PRESCRIPTION DRUG LABEL 1 66794-011 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-017 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Terrell HUMAN PRESCRIPTION DRUG LABEL 1 66794-019 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 13 sections
Isoflurane HUMAN PRESCRIPTION DRUG LABEL 1 66794-020 LIQUID 1 mL RESPIRATORY (INHALATION) ANDA 12 sections