irofulven 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antineoplastics, acylfulvene derivatives | 1483 | 158440-71-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 3.10 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 140 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.30 hours | Lombardo F, Berellini G, Obach RS |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000477 | Alkylating Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018906 | Antineoplastic Agents, Alkylating |
| MeSH PA | D009676 | Noxae |
| MeSH PA | D011838 | Radiation-Sensitizing Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.82 | acidic |
| pKa2 | 13.67 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk2 | Kinase | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| D04614 | KEGG_DRUG |
| C0532362 | UMLSCUI |
| CHEBI:135002 | CHEBI |
| CHEMBL118218 | ChEMBL_ID |
| DB05786 | DRUGBANK_ID |
| C102714 | MESH_SUPPLEMENTAL_RECORD_UI |
| 148189 | PUBCHEM_CID |
| 7889 | INN_ID |
| 6B799IH05A | UNII |
Pharmaceutical products:
None