iproniazid indications/contra

Stem definitionDrug idCAS RN
1480 54-92-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • marsilid
  • iproniazid phosphate
  • iproniazid
  • euphozid
  • iprazid
  • iprazide
  • iproniazide
  • iproniazide phosphate
An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.
  • Molecular weight: 179.22
  • Formula: C9H13N3O
  • CLOGP: 0.26
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 54.02
  • ALOGS: -2.43
  • RINGS: 1
  • ROTB: 3

Drug dosage:

None

Approvals:

None

Pharmacologic Action:

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SourceCodeDescription
ATC N06AF05 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Monoamine oxidase inhibitors, non-selective
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D008996 Monoamine Oxidase Inhibitors
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007 DOID:2848

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Amine oxidase [flavin-containing] A Enzyme INHIBITOR IC50 5.18 CHEMBL SCIENTIFIC LITERATURE
Amine oxidase [flavin-containing] B Enzyme INHIBITOR IC50 5.12 CHEMBL SCIENTIFIC LITERATURE
Amine oxidase [flavin-containing] A Enzyme IC50 5.30 CHEMBL
Amine oxidase [flavin-containing] B Enzyme IC50 5.12 CHEMBL

External reference:

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IDSource
N0000167316 NDFRT
005260 NDDF
5981 RXNORM
387438007 SNOMEDCT_US
76962009 SNOMEDCT_US
DB04818 DRUGBANK_ID
D007490 MESH_DESCRIPTOR_UI
305-33-9 SECONDARY_CAS_RN
D02579 KEGG_DRUG
19 INN_ID
D892HFI3XA UNII
CHEBI:5958 CHEBI
3748 PUBCHEM_CID
CHEMBL92401 ChEMBL_ID
CHEMBL1256361 ChEMBL_ID
N0000167316 NUI
C0022059 UMLSCUI

Pharmaceutical products:

None