iproniazid indications/contra

Stem definitionDrug idCAS RN
1480 54-92-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • marsilid
  • iproniazid phosphate
  • iproniazid
  • euphozid
  • iprazid
  • iprazide
  • iproniazide
  • iproniazide phosphate
An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.
  • Molecular weight: 179.22
  • Formula: C9H13N3O
  • CLOGP: 0.26
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 54.02
  • ALOGS: -2.43
  • ROTB: 3

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N06AF05 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Monoamine oxidase inhibitors, non-selective
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D008996 Monoamine Oxidase Inhibitors
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007 DOID:2848

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.67 acidic
pKa2 3.65 Basic
pKa3 0.76 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Amine oxidase [flavin-containing] A Enzyme INHIBITOR IC50 5.18 CHEMBL SCIENTIFIC LITERATURE
Amine oxidase [flavin-containing] B Enzyme INHIBITOR IC50 5.12 CHEMBL SCIENTIFIC LITERATURE
Amine oxidase [flavin-containing] A Enzyme IC50 5.30 CHEMBL
Amine oxidase [flavin-containing] B Enzyme IC50 5.12 CHEMBL

External reference:

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IDSource
CHEBI:5958 CHEBI
N0000167316 NUI
C0022059 UMLSCUI
D02579 KEGG_DRUG
5981 RXNORM
387438007 SNOMEDCT_US
76962009 SNOMEDCT_US
N0000167316 NDFRT
005260 NDDF
8DE00V62TV UNII
305-33-9 SECONDARY_CAS_RN
CHEMBL92401 ChEMBL_ID
CHEMBL1256361 ChEMBL_ID
19 INN_ID
DB04818 DRUGBANK_ID
D007490 MESH_DESCRIPTOR_UI
3748 PUBCHEM_CID

Pharmaceutical products:

None