iproniazid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1480 54-92-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • marsilid
  • iproniazid phosphate
  • iproniazid
  • euphozid
  • iprazid
  • iprazide
  • iproniazide
  • iproniazide phosphate
An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.
  • Molecular weight: 179.22
  • Formula: C9H13N3O
  • CLOGP: 0.26
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 54.02
  • ALOGS: -2.43
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ
S (Water solubility) 35 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AF05 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Monoamine oxidase inhibitors, non-selective
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D008996 Monoamine Oxidase Inhibitors
MeSH PA D011619 Psychotropic Drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.67 acidic
pKa2 3.65 Basic
pKa3 0.76 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Amine oxidase [flavin-containing] B Enzyme INHIBITOR IC50 5.12 CHEMBL SCIENTIFIC LITERATURE
Amine oxidase [flavin-containing] A Enzyme INHIBITOR IC50 5.18 CHEMBL SCIENTIFIC LITERATURE
Amine oxidase [flavin-containing] B Enzyme IC50 5.12 CHEMBL
Amine oxidase [flavin-containing] A Enzyme IC50 5.30 CHEMBL

External reference:

IDSource
N0000167316 NUI
D02579 KEGG_DRUG
305-33-9 SECONDARY_CAS_RN
C0022059 UMLSCUI
CHEBI:5958 CHEBI
CHEMBL92401 ChEMBL_ID
DB04818 DRUGBANK_ID
CHEMBL1256361 ChEMBL_ID
D007490 MESH_DESCRIPTOR_UI
3748 PUBCHEM_CID
19 INN_ID
D892HFI3XA UNII
353560 RXNORM
005260 NDDF
005261 NDDF
1217172005 SNOMEDCT_US
387438007 SNOMEDCT_US
76962009 SNOMEDCT_US

Pharmaceutical products:

None