inositol indications/contra

Stem definitionDrug idCAS RN
1444 87-89-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • inositol
  • myo-Inositol
  • cyclohexanehexol
  • cyclohexitol
  • inosital
  • inositene
  • inositina
  • mesoinositol
  • myoinosite
  • myoinositol
An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
  • Molecular weight: 180.16
  • Formula: C6H12O6
  • CLOGP: -0.12
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 6
  • TPSA: 121.38
  • ALOGS: 0.43
  • ROTB: 0

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A11HA07 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D006133 Growth Substances
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins
MeSH PA D014803 Vitamin B Complex

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Hypoalphalipoproteinemia indication 190785000
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Pellagra indication 418186002 DOID:8457
Niacin deficiency indication 418279001 DOID:8457
Slow Progression of Coronary Artery Disease indication
Myocardial Reinfarction Prevention indication
Hypophosphatemia contraindication 4996001
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Acute cerebrovascular insufficiency contraindication 29322000
Low blood pressure contraindication 45007003
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Gout contraindication 90560007 DOID:13189
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007 DOID:6713
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Acute coronary syndrome contraindication 394659003
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Cerebral infarction contraindication 432504007 DOID:3526
Hyperlipidemia off-label use 55822004 DOID:1168

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.21 acidic
pKa2 13.31 acidic
pKa3 13.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
CHEBI:17268 CHEBI
4017688 VUID
N0000146062 NUI
C0021547 UMLSCUI
D08079 KEGG_DRUG
4L6452S749 UNII
10437 INN_ID
5751 MMSL
5833 RXNORM
72164009 SNOMEDCT_US
4879 MMSL
d00496 MMSL
108960004 SNOMEDCT_US
4017688 VANDF
N0000007204 NDFRT
N0000146062 NDFRT
002057 NDDF
CHEMBL1222251 ChEMBL_ID
D007294 MESH_DESCRIPTOR_UI
DB13178 DRUGBANK_ID
892 PUBCHEM_CID
INS PDB_CHEM_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Lipovite HUMAN PRESCRIPTION DRUG LABEL 11 70104-128 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections
MIC B12 HUMAN PRESCRIPTION DRUG LABEL 3 70104-806 INJECTION 1 mg INTRAMUSCULAR unapproved drug other 1 sections