inositol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1444 | 87-89-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Normal newborn | 58.80 | 51.51 | 12 | 245 | 8329 | 63480436 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Needle fatigue | 57.62 | 57.40 | 9 | 481 | 893 | 79743005 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A11HA07 | ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations |
| MeSH PA | D018977 | Micronutrients |
| MeSH PA | D014803 | Vitamin B Complex |
| MeSH PA | D014815 | Vitamins |
| CHEBI has role | CHEBI:33284 | nutrients |
| CHEBI has role | CHEBI:64763 | phosphatidylinositol-specific phospholipase C inhibitors |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:75772 | S. cerevisiae metabolites |
| CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:83056 | Daphnia magna metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypercholesterolemia | indication | 13644009 | |
| Hypoalphalipoproteinemia | indication | 190785000 | |
| Mixed hyperlipidemia | indication | 267434003 | |
| Hypertriglyceridemia | indication | 302870006 | |
| Pellagra | indication | 418186002 | DOID:8457 |
| Niacin deficiency | indication | 418279001 | |
| Slow Progression of Coronary Artery Disease | indication | ||
| Myocardial Reinfarction Prevention | indication | ||
| Hyperlipidemia | off-label use | 55822004 | DOID:1168 |
| Hypophosphatemia | contraindication | 4996001 | |
| Alcoholism | contraindication | 7200002 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Acute cerebrovascular insufficiency | contraindication | 29322000 | |
| Low blood pressure | contraindication | 45007003 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hyperglycemia | contraindication | 80394007 | DOID:4195 |
| Gout | contraindication | 90560007 | DOID:13189 |
| Liver function tests abnormal | contraindication | 166603001 | |
| Cerebrovascular accident | contraindication | 230690007 | |
| Arterial hemorrhage | contraindication | 234003006 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Pregnancy, function | contraindication | 289908002 | |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Acute coronary syndrome | contraindication | 394659003 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Cerebral infarction | contraindication | 432504007 | DOID:3526 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.21 | acidic |
| pKa2 | 13.31 | acidic |
| pKa3 | 13.71 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4017688 | VUID |
| N0000146062 | NUI |
| D08079 | KEGG_DRUG |
| 4017688 | VANDF |
| C0021547 | UMLSCUI |
| CHEBI:17268 | CHEBI |
| INS | PDB_CHEM_ID |
| CHEMBL1222251 | ChEMBL_ID |
| DB13178 | DRUGBANK_ID |
| D007294 | MESH_DESCRIPTOR_UI |
| 892 | PUBCHEM_CID |
| 10437 | INN_ID |
| 4L6452S749 | UNII |
| 5833 | RXNORM |
| 4879 | MMSL |
| 5751 | MMSL |
| d00496 | MMSL |
| 002057 | NDDF |
| 108960004 | SNOMEDCT_US |
| 72164009 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Lipovite | HUMAN PRESCRIPTION DRUG LABEL | 13 | 70104-128 | INJECTION | 1 mg | INTRAMUSCULAR | unapproved drug other | 1 sections |
| MIC B12 | HUMAN PRESCRIPTION DRUG LABEL | 4 | 70104-806 | INJECTION | 1 mg | INTRAMUSCULAR | unapproved drug other | 1 sections |
| NEONATAL PLUS VITAMIN | HUMAN PRESCRIPTION DRUG LABEL | 17 | 70898-115 | TABLET | 5 mg | ORAL | unapproved drug other | 9 sections |