imidapril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
angiotensin-converting enzyme inhibitors	1424	89371-37-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: imidapril hydrochloride tanatril imidapril TA-6366 imidapril HCl	Molecular weight: 405.45 Formula: C20H27N3O6 CLOGP: 1.53 LIPINSKI: 0 HAC: 9 HDO: 2 TPSA: 116.25 ALOGS: -2.96 ROTB: 10

Molecule

Description

Molfile Inchi Smiles

Synonyms:

imidapril hydrochloride
tanatril
imidapril
TA-6366
imidapril HCl

Molecular weight: 405.45
Formula: C20H27N3O6
CLOGP: 1.53
LIPINSKI: 0
HAC: 9
HDO: 2
TPSA: 116.25
ALOGS: -2.96
ROTB: 10

Drug dosage:

Dose	Unit	Route
10	mg	O

ADMET properties:

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Property	Value	Reference
S (Water solubility)	54 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	5 %	Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability)	20 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI

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Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1993	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	49.25	41.47	21	536	89121	63399344

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cerebral infarction	44.72	30.38	19	867	27436	34928609
Hepatic function abnormal	30.44	30.38	17	869	44346	34911699

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	67.67	28.38	41	1587	154801	79587959
Cerebral infarction	61.66	28.38	26	1602	45650	79697110
Hepatic function abnormal	55.80	28.38	28	1600	73079	79669681
Renal impairment	49.64	28.38	34	1594	157749	79585011
Altered state of consciousness	43.15	28.38	20	1608	43802	79698958
Interstitial lung disease	42.00	28.38	27	1601	112573	79630187
Embolic stroke	31.56	28.38	10	1618	7816	79734944

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	C09AA16	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain
CHEBI has role	CHEBI:35457	ACE inhibitor
CHEBI has role	CHEBI:35674	antihypertensive drugs
CHEBI has role	CHEBI:50266	Prodrugs
CHEBI has role	CHEBI:49103	drug metabolites
MeSH PA	D000806	Angiotensin-Converting Enzyme Inhibitors
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D011480	Protease Inhibitors

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.49	acidic
pKa2	4.83	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Angiotensin-converting enzyme	Enzyme	P12821	ACE_HUMAN	INHIBITOR	IC50	5		CHEMBL	SCIENTIFIC LITERATURE

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External reference:

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ID	Source
007791	NDDF
007792	NDDF
259335	RXNORM
395741003	SNOMEDCT_US
395984005	SNOMEDCT_US
426163004	SNOMEDCT_US
5464343	PUBCHEM_CID
5464344	PUBCHEM_CID
6377	IUPHAR_LIGAND_ID
6378	IUPHAR_LIGAND_ID

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Pharmaceutical products:

None