ifenprodil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| vasodilators | 1419 | 23210-56-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
NMDA receptor antagonist; RN given refers to parent cpd without isomeric designation; structure
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 18.99 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 64.57 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 4.32 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C04AX28 | CARDIOVASCULAR SYSTEM PERIPHERAL VASODILATORS PERIPHERAL VASODILATORS Other peripheral vasodilators |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D000317 | Adrenergic alpha-Antagonists |
| MeSH PA | D018674 | Adrenergic Antagonists |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D018691 | Excitatory Amino Acid Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D014665 | Vasodilator Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.27 | acidic |
| pKa2 | 9.1 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2A | Ion channel | IC50 | 4.40 | CHEMBL | |||||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | IC50 | 8.41 | CHEMBL | |||||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 7 | CHEMBL | |||||
| Histamine H1 receptor | GPCR | IC50 | 6 | CHEMBL | |||||
| Glutamate receptor ionotropic, NMDA 2B | Ion channel | IC50 | 7.70 | CHEMBL | |||||
| Glutamate receptor ionotropic, NMDA 2C | Ion channel | IC50 | 4.54 | CHEMBL | |||||
| Glutamate receptor ionotropic, NMDA 2D | Ion channel | IC50 | 4.12 | CHEMBL | |||||
| Glutamate NMDA receptor; GRIN1/GRIN2B | Ion channel | Ki | 8 | CHEMBL | |||||
| Glutamate receptor ionotropic, NMDA 1 | Ion channel | IC50 | 7.14 | CHEMBL | |||||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 8.70 | CHEMBL | |||||
| Alpha-2A adrenergic receptor | GPCR | IC50 | 6.96 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | IC50 | 6.62 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | IC50 | 6.21 | CHEMBL | |||||
| Sigma non-opioid intracellular receptor 1 | Membrane other | Ki | 8.99 | CHEMBL | |||||
| Adrenergic receptor alpha-1 | GPCR | IC50 | 7 | CHEMBL | |||||
| Glutamate [NMDA] receptor subunit epsilon 2 | Ion channel | Ki | 7.96 | CHEMBL | |||||
| 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase | Unclassified | Ki | 8.57 | CHEMBL | |||||
| Sigma intracellular receptor 2 | Unclassified | Ki | 7.01 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01445 | KEGG_DRUG |
| C0063340 | UMLSCUI |
| CHEBI:31688 | CHEBI |
| QEL | PDB_CHEM_ID |
| CHEMBL305187 | ChEMBL_ID |
| DB08954 | DRUGBANK_ID |
| C010739 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3689 | PUBCHEM_CID |
| 5472 | IUPHAR_LIGAND_ID |
| 3236 | INN_ID |
| 23210-58-4 | SECONDARY_CAS_RN |
| R8OE3P6O5S | UNII |
| 27403 | RXNORM |
| 005790 | NDDF |
| 005791 | NDDF |
| 16291000122106 | SNOMEDCT_US |
| CHEMBL1256662 | ChEMBL_ID |
Pharmaceutical products:
None