hyoscyamine indications/contra

Stem definitionDrug idCAS RN
atropine derivatives 1402 101-31-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hyoscyamine hydrobromide
  • hyoscyamine
  • (-)-Atropine
  • (-)-Hyoscyamine
  • L-Hyoscyamin
  • L-Hyoscyamine
  • l-Atropine
  • hyoscyamine sulfate
The 3(S)-endo isomer of atropine.
  • Molecular weight: 289.38
  • Formula: C17H23NO3
  • CLOGP: 1.30
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.77
  • ALOGS: -2.06
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1.20 mg O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1869 YEAR INTRODUCED

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 174.59 45.78 42 157 31072 3354588
Drug hypersensitivity 138.62 45.78 36 163 35644 3350016
Anticholinergic syndrome 86.95 45.78 12 187 359 3385301
Vision blurred 86.20 45.78 22 177 19567 3366093
Dry mouth 73.70 45.78 17 182 9805 3375855
Apparent life threatening event 62.10 45.78 8 191 138 3385522
Cardio-respiratory arrest 61.16 45.78 16 183 15424 3370236
Serotonin syndrome 49.25 45.78 11 188 5412 3380248

Pharmacologic Action:

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SourceCodeDescription
ATC A03BA03 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
BELLADONNA AND DERIVATIVES, PLAIN
Belladonna alkaloids, tertiary amines
ATC A03CB31 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS
Belladonna and derivatives in combination with psycholeptics
MeSH PA D000759 Adjuvants, Anesthesia
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001337 Autonomic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D009184 Mydriatics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Dysuria indication 49650001
Sinus bradycardia indication 49710005
Excessive salivation indication 53827007
Gastrointestinal Radiography Adjunct indication
Cholinesterase Inhibitors Toxicity indication
Urinary Tract Irritation indication
Muscarine Toxicity indication
Brain damage contraindication 2470005
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hepatic encephalopathy contraindication 13920009 DOID:13413
Severe chronic ulcerative colitis contraindication 14311001
Disorder of autonomic nervous system contraindication 15241006
Cirrhosis of liver contraindication 19943007 DOID:5082
Hyperphosphatemia contraindication 20165001 DOID:0050459
Glaucoma contraindication 23986001 DOID:1686
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007 DOID:2848
Glomerulonephritis contraindication 36171008 DOID:2921
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Hypovolemic shock contraindication 39419009
Gastrointestinal ulcer contraindication 40845000
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Body fluid retention contraindication 43498006
Hyperactive behavior contraindication 44548000
Uremia contraindication 44730006 DOID:4676
Conduction disorder of the heart contraindication 44808001
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001 DOID:13976
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Poisoning by phenobarbital contraindication 64921004
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050848
Factor II deficiency contraindication 73975000
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Chronic idiopathic constipation contraindication 82934008
Hiatal hernia contraindication 84089009 DOID:12642
Kidney disease contraindication 90708001 DOID:2527
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Gastrointestinal obstruction contraindication 126765001
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Liver function tests abnormal contraindication 166603001
Myocardial dysfunction contraindication 233928007
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007 DOID:3122
Sleep automatism contraindication 247962006
Benign prostatic hyperplasia contraindication 266569009 DOID:2883
Dyspnea contraindication 267036007
Edema contraindication 267038008
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Drowsy contraindication 271782001
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Gastric ulcer contraindication 397825006 DOID:10808
Respiratory insufficiency contraindication 409623005
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Porphyria contraindication 418470004 DOID:13268
Fever greater than 100.4 Fahrenheit contraindication 426000000
Hypertensive urgency contraindication 443482000
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Irritable bowel syndrome off-label use 10743008 DOID:9778
Diarrhea off-label use 62315008
Urinary incontinence off-label use 165232002
Neurogenic bladder off-label use 398064005 DOID:12143

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.24 acidic
pKa2 9.26 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST Ki 9.80 WOMBAT-PK KEGG DRUG
Muscarinic acetylcholine receptor M2 GPCR ANTAGONIST Ki 9.30 WOMBAT-PK KEGG DRUG
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST Ki 9 WOMBAT-PK KEGG DRUG
Muscarinic acetylcholine receptor M5 GPCR Ki 9.20 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 9.90 WOMBAT-PK

External reference:

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IDSource
DB00424 DRUGBANK_ID
4018400 VUID
N0000189428 NUI
C0596004 UMLSCUI
D00147 KEGG_DRUG
154417 PUBCHEM_CID
6292 MMSL
372757002 SNOMEDCT_US
48899009 SNOMEDCT_US
4860 MMSL
d00985 MMSL
4018400 VANDF
4949 MMSL
153970 RXNORM
N0000146727 NDFRT
N0000189428 NDFRT
001727 NDDF
CHEBI:17486 CHEBI
CHEMBL1257084 ChEMBL_ID
CHEMBL1331216 ChEMBL_ID
CHEMBL1697729 ChEMBL_ID
CHEMBL2106364 ChEMBL_ID
F2R8V82B84 UNII
6835-16-1 SECONDARY_CAS_RN
D064692 MESH_DESCRIPTOR_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
URELLE HUMAN PRESCRIPTION DRUG LABEL 5 0037-6321 TABLET 0.12 mg ORAL unapproved drug other 10 sections
Levsin HUMAN PRESCRIPTION DRUG LABEL 1 0037-9001 INJECTION, SOLUTION 0.50 mg SUBCUTANEOUS Unapproved drug other 11 sections
URIBEL HUMAN PRESCRIPTION DRUG LABEL 5 0076-0111 CAPSULE 0.12 mg ORAL unapproved drug other 12 sections
Hyophen HUMAN PRESCRIPTION DRUG LABEL 5 0076-0901 TABLET 0.12 mg ORAL unapproved drug other 12 sections
Phosphasal HUMAN PRESCRIPTION DRUG LABEL 5 0076-0902 TABLET 0.12 mg ORAL unapproved drug other 13 sections
Ustell HUMAN PRESCRIPTION DRUG LABEL 5 0076-0903 CAPSULE 0.12 mg ORAL unapproved drug other 13 sections
Belladonna Alkaloids with Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 4 0143-1140 TABLET 0.10 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Utira-C HUMAN PRESCRIPTION DRUG LABEL 5 0178-0513 TABLET 0.12 mg ORAL unapproved drug other 13 sections
DONNATAL HUMAN PRESCRIPTION DRUG LABEL 4 0179-0088 ELIXIR 0.10 mg ORAL unapproved drug other 12 sections
Donnatal HUMAN PRESCRIPTION DRUG LABEL 4 0179-0132 TABLET 0.10 mg ORAL unapproved drug other 15 sections
ANASPAZ HUMAN PRESCRIPTION DRUG LABEL 1 0225-0295 TABLET, ORALLY DISINTEGRATING 0.13 mg SUBLINGUAL unapproved drug other 12 sections
Belladonna Alkaloids with Phenobartbital HUMAN PRESCRIPTION DRUG LABEL 4 0440-7183 TABLET 0.10 mg ORAL UNAPPROVED DRUG OTHER 10 sections
ED-SPAZ HUMAN PRESCRIPTION DRUG LABEL 1 0485-0082 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL unapproved drug other 12 sections
UROGESIC BLUE HUMAN PRESCRIPTION DRUG LABEL 4 0485-0151 TABLET, COATED 0.12 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Urimar-T HUMAN PRESCRIPTION DRUG LABEL 5 0682-0334 TABLET 0.12 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Belladonna Alkaloids with Phenobartbital HUMAN PRESCRIPTION DRUG LABEL 4 15338-600 TABLET 0.10 mg ORAL Unapproved drug other 12 sections
Donnatal HUMAN PRESCRIPTION DRUG LABEL 4 17856-0423 ELIXIR 0.10 mg ORAL unapproved drug other 12 sections
Hyosyne HUMAN PRESCRIPTION DRUG LABEL 1 17856-0511 ELIXIR 0.13 mg ORAL unapproved drug other 11 sections
Hyosyne HUMAN PRESCRIPTION DRUG LABEL 1 17856-0514 ELIXIR 0.13 mg ORAL unapproved drug other 11 sections
Hyoscyamine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-442 TABLET 0.13 mg ORAL Unapproved drug other 12 sections
RE-PB HYOS ELIXIR HUMAN PRESCRIPTION DRUG LABEL 4 21695-594 ELIXIR 0.10 mg ORAL Unapproved drug other 11 sections
Belladonna Alkaloids with Phenobartbital HUMAN PRESCRIPTION DRUG LABEL 4 21695-890 TABLET 0.10 mg ORAL Unapproved drug other 12 sections
Hyoscyamine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 21695-926 TABLET 0.13 mg ORAL Unapproved drug other 12 sections
QUADRAPAX HUMAN PRESCRIPTION DRUG LABEL 4 21695-970 ELIXIR 0.10 mg ORAL Unapproved drug other 13 sections
UTA HUMAN PRESCRIPTION DRUG LABEL 4 24839-699 CAPSULE 0.12 mg ORAL unapproved drug other 13 sections
Hyoscyamine Sulfate Extended-Release HUMAN PRESCRIPTION DRUG LABEL 1 33261-907 TABLET 0.38 mg ORAL UNAPPROVED DRUG OTHER 12 sections
INDIOMIN MB HUMAN PRESCRIPTION DRUG LABEL 4 35573-315 CAPSULE 0.12 mg ORAL Unapproved drug other 14 sections
Hyoscyamine HUMAN PRESCRIPTION DRUG LABEL 1 39328-047 LIQUID 0.13 mg ORAL UNAPPROVED DRUG OTHER 12 sections
Hyoscyamine HUMAN PRESCRIPTION DRUG LABEL 1 39328-048 LIQUID 0.13 mg ORAL UNAPPROVED DRUG OTHER 12 sections
Hyoscyamine Sulfate ODT HUMAN PRESCRIPTION DRUG LABEL 1 42192-338 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL unapproved drug other 12 sections