hymecromone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1401 | 90-33-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A05AX02 | ALIMENTARY TRACT AND METABOLISM BILE AND LIVER THERAPY BILE THERAPY Other drugs for bile therapy |
| MeSH PA | D007202 | Indicators and Reagents |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:131561 | HA synthesis inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.16 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] B | Enzyme | IC50 | 4.09 | CHEMBL | |||||
| Aldose reductase | Enzyme | IC50 | 4.61 | CHEMBL | |||||
| Carbonic anhydrase 9 | Enzyme | Ki | 6.25 | CHEMBL | |||||
| Carbonic anhydrase 12 | Enzyme | Ki | 5.09 | CHEMBL | |||||
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Cytosolic other | Ki | 4.66 | CHEMBL | |||||
| Testosterone 17-beta-dehydrogenase 3 | Enzyme | IC50 | 6 | CHEMBL | |||||
| Aldose reductase | Enzyme | IC50 | 4.21 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167012 | NUI |
| D00170 | KEGG_DRUG |
| C0020411 | UMLSCUI |
| CHEBI:17224 | CHEBI |
| 4MU | PDB_CHEM_ID |
| CHEMBL12208 | ChEMBL_ID |
| DB07118 | DRUGBANK_ID |
| D006923 | MESH_DESCRIPTOR_UI |
| 5280567 | PUBCHEM_CID |
| 1891 | INN_ID |
| 3T5NG4Q468 | UNII |
| 5556 | RXNORM |
| 005482 | NDDF |
Pharmaceutical products:
None