altizide indications/contra

Stem definitionDrug idCAS RN
diuretics, chlorothiazide derivatives 140 5588-16-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • altizide
  • aldactazine
  • althiazide
  • althizide
  • altizid
  • racemic althiazide
  • altizida
  • Molecular weight: 383.88
  • Formula: C11H14ClN3O4S3
  • CLOGP: 1.05
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 118.36
  • ALOGS: -2.96
  • ROTB: 5

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 135.41 49.41 29 110 18330 3367390
Acute kidney injury 92.53 49.41 26 113 49657 3336063
Hyperkalaemia 61.15 49.41 14 125 11280 3374440
Fall 58.02 49.41 19 120 58864 3326856

Pharmacologic Action:

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SourceCodeDescription
ATC C03EA04 CARDIOVASCULAR SYSTEM
DIURETICS
DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
Low-ceiling diuretics and potassium-sparing agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Edema indication 267038008

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.89 acidic
pKa2 10.88 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
C0051500 UMLSCUI
D02838 KEGG_DRUG
17599 RXNORM
005226 NDDF
717101002 SNOMEDCT_US
2122 PUBCHEM_CID
CHEMBL599870 ChEMBL_ID
C006480 MESH_SUPPLEMENTAL_RECORD_UI
GI8CB72B0D UNII
1382 INN_ID
B4D PDB_CHEM_ID

Pharmaceutical products:

None