hexylresorcinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1374	136-77-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

hexylresorcinol
4-Hexylresorcinol
antascarin
ascaricid
ascarinol

A substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.

Molecular weight: 194.27
Formula: C12H18O2
CLOGP: 3.90
LIPINSKI: 0
HAC: 2
HDO: 2
TPSA: 40.46
ALOGS: -2.63
ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R02AA12	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
MeSH PA	D000871	Anthelmintics
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000977	Antiparasitic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Methemoglobinemia	contraindication	38959009	DOID:10783
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Deficiency of cytochrome-b>5< reductase	contraindication	124184009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.32	acidic
pKa2	11.99	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Arachidonate 5-lipoxygenase	Enzyme	P09917	LOX5_HUMAN		IC50	5.55		CHEMBL
Tyrosinase	Enzyme	P14679	TYRO_HUMAN		IC50	6.25		CHEMBL
Polyphenol oxidase 2	Enzyme		PPO2_AGABI		IC50	6.01		CHEMBL

External reference:

ID	Source
N0000166594	NUI
D04441	KEGG_DRUG
C0019497	UMLSCUI
CHEBI:93749	CHEBI
CHEMBL443605	ChEMBL_ID
DB11254	DRUGBANK_ID
D006604	MESH_DESCRIPTOR_UI
3610	PUBCHEM_CID
R9QTB5E82N	UNII
5321	RXNORM
15077	MMSL
002976	NDDF
411201006	SNOMEDCT_US
54086007	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Myxcin-C	HUMAN OTC DRUG LABEL	1	52426-520	SOLUTION	1.10 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	14 sections
S.T.37	HUMAN OTC DRUG LABEL	1	69846-860	SOLUTION	1.10 mg	ORAL	unapproved drug other	16 sections
MUCINEX INSTASOOTHE SORE THROAT PLUS SOOTHING COMFORT	HUMAN OTC DRUG LABEL	1	72854-261	LOZENGE	2.40 mg	ORAL	OTC monograph not final	15 sections
MUCINEX INSTASOOTHE SORE THROAT PLUS PAIN RELIEF	HUMAN OTC DRUG LABEL	1	72854-262	LOZENGE	2 mg	ORAL	OTC MONOGRAPH NOT FINAL	15 sections
MUCINEX INSTASOOTHE SORE THROAT PLUS COUGH RELIEF	HUMAN OTC DRUG LABEL	2	72854-263	LOZENGE	2 mg	ORAL	OTC monograph not final	16 sections
AnubisMed	HUMAN OTC DRUG LABEL	14	83021-401	LIQUID	1 g	TOPICAL	OTC monograph final	9 sections