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hexylcaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| local anaesthetics | 1373 | 532-77-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.867 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.516 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 35.400 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 51.523 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 44.330 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 59.160 | % | High | 1 |
| herg | hERG pIC50 | 4.680 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 35.892 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 49.774 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 44.550 | % | High | 1 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.266 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 258.226 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 67.630 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.492 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 78.480 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 289.734 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 91.920 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 63.530 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 790.679 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | MERCK |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Local anesthesia | indication | 386761002 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Decreased respiratory function | contraindication | 80954004 | |
| Open wound | contraindication | 125643001 | |
| Seizure disorder | contraindication | 128613002 | |
| Denuded skin | contraindication | 418242004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.06 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | BLOCKER | IC50 | 5.15 | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C0062686 | UMLSCUI |
| CHEBI:34791 | CHEBI |
| CHEMBL1197 | ChEMBL_ID |
| D02454 | KEGG_DRUG |
| DB00473 | DRUGBANK_ID |
| CHEMBL1200715 | ChEMBL_ID |
| C004954 | MESH_SUPPLEMENTAL_RECORD_UI |
| 10770 | PUBCHEM_CID |
| 7196 | IUPHAR_LIGAND_ID |
| 274 | INN_ID |
| 532-76-3 | SECONDARY_CAS_RN |
| 511IU0826Z | UNII |
| 1546032 | RXNORM |
| 001354 | NDDF |
| 004568 | NDDF |
| 16392005 | SNOMEDCT_US |
Pharmaceutical products:
None