hexestrol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
estrogens 1368 84-16-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dihydrodiethylstilbestrol
  • hexestrol
  • cycloestrol
  • erythrohexestrol
  • hexanoestrol
  • hexestrofen
  • hexoestrol
  • hormoestrol
  • mesohexestrol
A synthetic estrogen that has been used as a hormonal antineoplastic agent.
  • Molecular weight: 270.37
  • Formula: C18H22O2
  • CLOGP: 5.11
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -4.29
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D004967 Estrogens
MeSH PA D004968 Estrogens, Non-Steroidal
MeSH PA D006728 Hormones

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.8 acidic
pKa2 11.4 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Estrogen receptor Nuclear hormone receptor ANTAGONIST Ki 10.30 IUPHAR

External reference:

IDSource
D01641 KEGG_DRUG
C0019467 UMLSCUI
CHEBI:31669 CHEBI
HXS PDB_CHEM_ID
CHEMBL6615 ChEMBL_ID
CHEMBL9225 ChEMBL_ID
DB07931 DRUGBANK_ID
D006589 MESH_DESCRIPTOR_UI
3606 PUBCHEM_CID
2823 IUPHAR_LIGAND_ID
2074 INN_ID
10BI795R7D UNII
001282 NDDF
126069000 SNOMEDCT_US
26303005 SNOMEDCT_US

Pharmaceutical products:

None