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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
hesperetin 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
1362
520-33-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
hesperetin
hesperitin
aglycone of HESPERIDIN; structure
Molecular weight: 302.28
Formula: C16H14O6
CLOGP: 2.29
LIPINSKI: 0
HAC: 6
HDO: 3
TPSA: 96.22
ALOGS: -3.34
ROTB: 2
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
20 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
CHEBI has role
CHEBI:22586
antioxidants
CHEBI has role
CHEBI:35610
antineoplastic agents
CHEBI has role
CHEBI:76924
plant metabolites
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
7.78
acidic
pKa2
10.13
acidic
pKa3
10.68
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Carbonic anhydrase 4
Enzyme
P22748
CAH4_HUMAN
Ki
6.99
CHEMBL
Carbonic anhydrase 12
Enzyme
O43570
CAH12_HUMAN
Ki
6.34
CHEMBL
Carbonic anhydrase 7
Enzyme
P43166
CAH7_HUMAN
Ki
8.48
CHEMBL
Dipeptidyl peptidase 4
Enzyme
P27487
DPP4_HUMAN
IC50
6.55
CHEMBL
Glycogen synthase kinase-3 beta
Kinase
P49841
GSK3B_HUMAN
IC50
4.57
CHEMBL
Cytochrome P450 1B1
Enzyme
Q16678
CP1B1_HUMAN
IC50
6.29
CHEMBL
Lysine-specific histone demethylase 1A
Enzyme
O60341
KDM1A_HUMAN
IC50
4.10
CHEMBL
Replicase polyprotein 1ab
Enzyme
R1AB_CVHSA
IC50
5.08
CHEMBL
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External reference:
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ID
Source
10953
IUPHAR_LIGAND_ID
1314255
RXNORM
6JP
PDB_CHEM_ID
72281
PUBCHEM_CID
C0062585
UMLSCUI
C013015
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:28230
CHEBI
CHEMBL399121
ChEMBL_ID
DB01094
DRUGBANK_ID
Q9Q3D557F1
UNII
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Pharmaceutical products:
None
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hesperetin