hesperetin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1362 | 520-33-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
aglycone of HESPERIDIN; structure
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 20 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:22586 | antioxidants |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:76924 | plant metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.78 | acidic |
| pKa2 | 10.13 | acidic |
| pKa3 | 10.68 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 4 | Enzyme | Ki | 6.99 | CHEMBL | |||||
| Carbonic anhydrase 12 | Enzyme | Ki | 6.34 | CHEMBL | |||||
| Carbonic anhydrase 7 | Enzyme | Ki | 8.48 | CHEMBL | |||||
| Dipeptidyl peptidase 4 | Enzyme | IC50 | 6.55 | CHEMBL | |||||
| Glycogen synthase kinase-3 beta | Kinase | IC50 | 4.57 | CHEMBL | |||||
| Cytochrome P450 1B1 | Enzyme | IC50 | 6.29 | CHEMBL | |||||
| Lysine-specific histone demethylase 1A | Enzyme | IC50 | 4.10 | CHEMBL | |||||
| Replicase polyprotein 1ab | Enzyme | IC50 | 5.08 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C0062585 | UMLSCUI |
| CHEBI:28230 | CHEBI |
| 6JP | PDB_CHEM_ID |
| CHEMBL399121 | ChEMBL_ID |
| DB01094 | DRUGBANK_ID |
| C013015 | MESH_SUPPLEMENTAL_RECORD_UI |
| 72281 | PUBCHEM_CID |
| 10953 | IUPHAR_LIGAND_ID |
| Q9Q3D557F1 | UNII |
| 1314255 | RXNORM |
Pharmaceutical products:
None