heparin indications/contra

Stem definitionDrug idCAS RN
heparin derivatives including low molecular mass heparins 1358 9005-49-6

Description:

MoleculeDescription

Synonyms:

  • heparin
  • heparin sodium
  • heparin calcium
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
10 TU P

Approvals:

DateAgencyCompanyOrphan
Feb. 9, 1939 FDA ORGANON USA INC

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heparin-induced thrombocytopenia 8790.26 42.54 1305 5985 651 3377918
Thrombocytopenia 1709.53 42.54 573 6717 34695 3343874
Haemorrhage 1205.16 42.54 384 6906 19537 3359032
Hypotension 1138.68 42.54 466 6824 49048 3329521
Activated partial thromboplastin time prolonged 935.19 42.54 204 7086 2228 3376341
Deep vein thrombosis 733.26 42.54 270 7020 21119 3357450
Pulmonary embolism 619.19 42.54 257 7033 27631 3350938
Haemoglobin decreased 615.27 42.54 262 7028 30032 3348537
Haematoma 596.04 42.54 179 7111 7360 3371209
Cerebral haemorrhage 581.50 42.54 187 7103 9667 3368902
Thrombosis in device 573.51 42.54 129 7161 1629 3376940
Haemorrhage intracranial 569.38 42.54 160 7130 5179 3373390
Thrombosis 549.91 42.54 196 7094 13894 3364675
Platelet count decreased 525.90 42.54 228 7062 27240 3351329
Blood pressure decreased 467.10 42.54 173 7117 13663 3364906
Retroperitoneal haematoma 463.08 42.54 94 7196 695 3377874
Retroperitoneal haemorrhage 442.13 42.54 95 7195 953 3377616
Haematocrit decreased 383.06 42.54 128 7162 7439 3371130
Post procedural haemorrhage 363.02 42.54 97 7193 2580 3375989
Gastrointestinal haemorrhage 360.02 42.54 169 7121 24205 3354364
Post procedural complication 352.89 42.54 109 7181 4908 3373661
Myocardial infarction 338.17 42.54 197 7093 43936 3334633
Disseminated intravascular coagulation 337.95 42.54 111 7179 6106 3372463
Drug ineffective 334.46 42.54 284 7006 115806 3262763
Multiple organ dysfunction syndrome 302.77 42.54 128 7162 14282 3364287
Dyspnoea 292.39 42.54 250 7040 102684 3275885
Cardiac arrest 289.01 42.54 151 7139 27168 3351401
Drug hypersensitivity 288.35 42.54 165 7125 35515 3343054
Nausea 278.39 42.54 269 7021 129376 3249193
Product quality issue 277.74 42.54 146 7144 26589 3351980

Pharmacologic Action:

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SourceCodeDescription
ATC B01AB01 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
ATC C05BA03 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Heparins or heparinoids for topical use
ATC S01XA14 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
ATC B01AB51 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
ATC C05BA53 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Heparins or heparinoids for topical use
MeSH PA D000925 Anticoagulants
MeSH PA D002317 Cardiovascular Agents
MeSH PA D050299 Fibrin Modulating Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
CHEBI has role CHEBI:50249 anticoagulant
FDA EPC N0000175980 Anti-coagulant
FDA Chemical/Ingredient N0000006341 Heparin
FDA EPC N0000175474 Unfractionated Heparin

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Disseminated intravascular coagulation indication 67406007 DOID:11247
Deep venous thrombosis indication 128053003
Pulmonary thromboembolism indication 233935004
Peripheral arterial embolism indication 286959000
Non-Q wave myocardial infarction indication 314207007
Prevention of deep vein thrombosis indication 439993001
Prevention of Ischemic Complications of Non-Q Wave MI indication
Prevention of Recurrent Venous Thrombosis Associated with Malignancy indication
Pulmonary Thromboembolism Prevention indication
Deep Vein Thrombosis with Pulmonary Embolism indication
Prevention of Cardiac Ischemia in Unstable Angina indication
Maintain Patency of Indwelling Vascular Catheter indication
Peripheral Arterial Thromboembolism Prevention indication
Intracranial hemorrhage contraindication 1386000
Diabetic retinopathy contraindication 4855003 DOID:8947
Hypertensive retinopathy contraindication 6962006 DOID:11561
Retinal disorder contraindication 29555009 DOID:5679
Antithrombin III deficiency contraindication 36351005 DOID:3755
Gastrointestinal ulcer contraindication 40845000
Threatened abortion contraindication 54048003 DOID:9667
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Osteoporosis contraindication 64859006 DOID:11476
Operation on brain contraindication 70586009
Heparin-induced thrombocytopenia contraindication 73397007
Gastrointestinal hemorrhage contraindication 74474003
Ulceration of intestine contraindication 85942002
Acute gastric ulcer with hemorrhage contraindication 89748001
Hemophilia contraindication 90935002
Disorder of biliary tract contraindication 105997008 DOID:9741
Procedure on central nervous system contraindication 118679007
Bleeding contraindication 131148009
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Hemorrhagic cerebral infarction contraindication 230706003
Local anesthetic intrathecal block contraindication 231249005
Infective endocarditis contraindication 233850007
Procedure on spine contraindication 238181003
Qualitative platelet disorder contraindication 267532001 DOID:11125
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral hemorrhage contraindication 274100004
Lumbar puncture contraindication 277762005
Bacterial endocarditis contraindication 301183007
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Dissection of aorta contraindication 308546005
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Surgical procedure on eye proper contraindication 373353005
Hypertensive urgency contraindication 443482000
Placement of Epidural Catheter contraindication
Significant Bleeding contraindication
Indwelling Vascular Catheter contraindication
Thrombosis in Heparin Induced Thrombocytopenia contraindication
Platelet Aggregation Inhibition contraindication
Spinal Epidural Hematoma contraindication
Myocardial infarction off-label use 22298006 DOID:5844
Acute coronary syndrome off-label use 394659003
Percutaneous coronary intervention off-label use 415070008

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Antithrombin-III Secreted ACTIVATOR Kd 7.85 IUPHAR CHEMBL

External reference:

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IDSource
4214 IUPHAR_LIGAND_ID
C0770546 UMLSCUI
D02112 KEGG_DRUG
DB01109 DRUGBANK_ID
372877000 SNOMEDCT_US
84812008 SNOMEDCT_US
4018538 VANDF
N0000146860 NDFRT
N0000006341 NDFRT
015153 NDDF
96382006 SNOMEDCT_US
5224 RXNORM
CHEMBL1201513 ChEMBL_ID
CHEMBL1201657 ChEMBL_ID
D006493 MESH_DESCRIPTOR_UI
CHEMBL1909300 ChEMBL_ID
772 PUBCHEM_CID
M4F288ZCTR UNII
37270-89-6 SECONDARY_CAS_RN
392 INN_ID
CHEBI:28304 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0043 INJECTION 1000 [USP'U] INTRAVENOUS NDA 16 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0058 INJECTION 1000 [USP'U] INTRAVENOUS NDA 16 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0059 INJECTION 5000 [USP'U] INTRAVENOUS NDA 16 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0062 INJECTION 10000 [USP'U] INTRAVENOUS NDA 16 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0069-0137 INJECTION 1000 [USP'U] INTRAVENOUS NDA 16 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9567 INJECTION 4000 [USP'U] INTRAVENOUS NDA 16 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9577 INJECTION 5000 [USP'U] INTRAVENOUS NDA 16 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9587 INJECTION 10000 [USP'U] INTRAVENOUS NDA 16 sections
Heparin Sodium in Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0264-9872 INJECTION 200 [USP'U] INTRAVENOUS NDA 16 sections
Heparin Sodium and Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0431 INJECTION, SOLUTION 200 [USP'U] INTRAVENOUS NDA 12 sections
Heparin Sodium and Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-0433 INJECTION, SOLUTION 200 [USP'U] INTRAVENOUS NDA 12 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-0549 INJECTION, SOLUTION 4000 [USP'U] INTRAVENOUS NDA 12 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-0550 INJECTION, SOLUTION 5000 [USP'U] INTRAVENOUS NDA 12 sections
Heparin Sodium in Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-0552 INJECTION, SOLUTION 10000 [USP'U] INTRAVENOUS NDA 12 sections
Heparin Sodium and Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-9552 INJECTION, SOLUTION 2000 [iU] INTRAVENOUS Unapproved drug for use in drug shortage 2 sections
Heparin Sodium and Sodium Chloride HUMAN PRESCRIPTION DRUG LABEL 1 0338-9556 INJECTION, SOLUTION 1000 [iU] INTRAVENOUS Unapproved drug for use in drug shortage 2 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-1316 INJECTION, SOLUTION 10000 [USP'U] SUBCUTANEOUS ANDA 13 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-1402 INJECTION, SOLUTION 5000 [USP'U] SUBCUTANEOUS ANDA 13 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2720 INJECTION, SOLUTION 1000 [USP'U] SUBCUTANEOUS ANDA 16 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2721 INJECTION, SOLUTION 10000 [USP'U] INTRAVENOUS ANDA 16 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-2723 INJECTION, SOLUTION 5000 [USP'U] SUBCUTANEOUS ANDA 16 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7620 INJECTION, SOLUTION 200 [USP'U] INTRAVENOUS NDA 16 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7650 INJECTION, SOLUTION 10000 [USP'U] INTRAVENOUS NDA 15 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0409-7651 INJECTION, SOLUTION 5000 [USP'U] INTRAVENOUS NDA 15 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0391 INJECTION 1000 [USP'U] INTRAVENOUS NDA 15 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0400 INJECTION 5000 [USP'U] INTRAVENOUS NDA 15 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0410 INJECTION 10000 [USP'U] INTRAVENOUS NDA 15 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-2450 INJECTION 1000 [USP'U] INTRAVENOUS NDA 15 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-2460 INJECTION 5000 [USP'U] INTRAVENOUS NDA 15 sections
Heparin Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0781-3327 INJECTION 5000 [USP'U] INTRAVENOUS ANDA 12 sections