halothane indications/contra

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 1356 151-67-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • halothane
  • anestan
  • fluothane
  • ftorotan
  • narcotan
  • narcotane
  • rhodialothan
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
  • Molecular weight: 197.38
  • Formula: C2HBrClF3
  • CLOGP: 2.27
  • LIPINSKI: 0
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS: -1.71
  • ROTB: 1

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
March 12, 1958 FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N01AB01 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
CHEBI has role CHEBI:38870 inhalation anaesthetic
MeSH PA D000777 Anesthetics
MeSH PA D018681 Anesthetics, General
MeSH PA D018685 Anesthetics, Inhalation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Benign intracranial hypertension contraindication 68267002 DOID:11459
Disease of liver contraindication 235856003 DOID:409
Malignant hyperthermia contraindication 405501007 DOID:8545

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycine receptor (alpha-1/beta) Ion channel POSITIVE MODULATOR CHEMBL CHEMBL
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL

External reference:

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IDSource
CHEBI:5615 CHEBI
2401 IUPHAR_LIGAND_ID
4018499 VUID
N0000146821 NUI
C0018549 UMLSCUI
D00542 KEGG_DRUG
CHEMBL931 ChEMBL_ID
3562 PUBCHEM_CID
601 MMSL
5095 RXNORM
387351001 SNOMEDCT_US
63682003 SNOMEDCT_US
4820 MMSL
d00251 MMSL
4018499 VANDF
N0000006050 NDFRT
N0000146821 NDFRT
001394 NDDF
D006221 MESH_DESCRIPTOR_UI
DB01159 DRUGBANK_ID
UQT9G45D1P UNII
697 INN_ID

Pharmaceutical products:

None