halazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	1348	23092-17-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

halazepam
paxipam

Molecular weight: 352.74
Formula: C17H12ClF3N2O
CLOGP: 3.94
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 32.67
ALOGS: -5.32
ROTB: 3

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.10	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 24, 1981	FDA	SCHERING

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05BA13	NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives
MeSH PA	D014151	Anti-Anxiety Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Anxiety	indication	48694002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.94	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN	POSITIVE ALLOSTERIC MODULATOR				CHEMBL	CHEMBL

External reference:

ID	Source
4018800	VUID
N0000147103	NUI
D00338	KEGG_DRUG
4018800	VANDF
C0062092	UMLSCUI
CHEBI:5603	CHEBI
CHEMBL970	ChEMBL_ID
DB00801	DRUGBANK_ID
C010175	MESH_SUPPLEMENTAL_RECORD_UI
31640	PUBCHEM_CID
7195	IUPHAR_LIGAND_ID
3339	INN_ID
320YC168LF	UNII
219119	RXNORM
3572	MMSL
4813	MMSL
d00904	MMSL
001465	NDDF
371367008	SNOMEDCT_US
63545000	SNOMEDCT_US

Pharmaceutical products:

None