halazepam Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 1348 23092-17-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • halazepam
  • paxipam
  • Molecular weight: 352.74
  • Formula: C17H12ClF3N2O
  • CLOGP: 3.75
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 32.67
  • ALOGS: -5.32
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.10 g O

Approvals:

DateAgencyCompanyOrphan
Sept. 24, 1981 FDA SCHERING

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug-induced liver injury 27.81 0 4 3 8587 4630398

Pharmacologic Action:

SourceCodeDescription
ATC N05BA13 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Anxiety indication 48694002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL

External reference:

IDSource
4018800 VUID
N0000147103 NUI
C0062092 UMLSCUI
D00338 KEGG_DRUG
320YC168LF UNII
3339 INN_ID
371367008 SNOMEDCT_US
d00904 MMSL
4813 MMSL
26412 RXNORM
63545000 SNOMEDCT_US
4018800 VANDF
001465 NDDF
CHEMBL970 ChEMBL_ID
DB00801 DRUGBANK_ID
CHEBI:5603 CHEBI
31640 PUBCHEM_CID
7195 IUPHAR_LIGAND_ID
C010175 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None