guanidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1344 113-00-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • guanidine
  • aminoformamidine
  • iminourea
  • guanidin
  • carbamamidine
  • guanidine hydrochloride
  • guanidine HCl
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
  • Molecular weight: 59.07
  • Formula: CH5N3
  • CLOGP: -2.39
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 75.89
  • ALOGS: -0.71
  • ROTB: 0

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 592.51 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,FGFR1,FLT1,FLT3,GRK2,GSK3B,IKBKB,IRAK1,ITK,JAK1,JAK2,JAK3,KIT,MAP2K1,MAP2K6,MAP3K1,MAP3K10,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 80
kinase-selectivity-class AAK1,ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,CAMK2B,CAMK2D,CDK1,CDK9,CSF1R,DDR1,DYRK1B,EIF2AK3,FLT3,GRK2,IKBKB,IRAK1,JAK1,JAK2,MAP2K3,MAP2K6,MAP3K10,MAP3K11,MAP3K14,MAP3K21,MAP4K1,MAP4K3,MAPK7,MARK4,NTRK1,PRKCD,SIK2,SIK3,STK33,TEK,TTK,UHMK1,ULK1,ULK2 41
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Oct. 2, 1939 FDA MERCK SHARP DOHME

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Radiation inflammation 152.31 148.06 24 618 1024 42619669

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary pain 416.06 222.16 70 1153 6223 110581853
Amyloid arthropathy 275.38 222.16 41 1182 1639 110586437

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA PE N0000009079 Increased Acetylcholine Activity
FDA EPC N0000175772 Acetylcholine Releasing Agent
CHEBI has role CHEBI:35610 antineoplastic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Eaton-Lambert syndrome indication 56989000 DOID:0050214
Leukopenia contraindication 84828003 DOID:615
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-gated potassium channel Ion channel BLOCKER CHEMBL CHEMBL

External reference:

IDSource
JU58VJ6Y3B UNII
4019772 VUID
N0000147863 NUI
50-01-1 SECONDARY_CAS_RN
4018993 VANDF
4019772 VANDF
C0120446 UMLSCUI
CHEBI:42820 CHEBI
GAI PDB_CHEM_ID
CHEMBL821 ChEMBL_ID
3520 PUBCHEM_CID
DB00536 DRUGBANK_ID
CHEMBL1200728 ChEMBL_ID
D019791 MESH_DESCRIPTOR_UI
4783 IUPHAR_LIGAND_ID
50675 RXNORM
4810 MMSL
530 MMSL
72830 MMSL
d01422 MMSL
001698 NDDF
004685 NDDF
109108004 SNOMEDCT_US
409368007 SNOMEDCT_US
412195000 SNOMEDCT_US

Pharmaceutical products:

None