alpidem indications/contra

Stem definitionDrug idCAS RN
hypnotics/sedatives, zolpidem derivatives 134 82626-01-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alpidem
  • ananxyl
  • Molecular weight: 404.34
  • Formula: C21H23Cl2N3O
  • CLOGP: 5.58
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 37.61
  • ALOGS: -5.49
  • ROTB: 7

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1991 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.34 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bile salt export pump Transporter IC50 5.04 CHEMBL
Translocator protein Membrane receptor Ki 9.30 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 7.59 CHEMBL
Bile salt export pump Unclassified IC50 4.64 CHEMBL

External reference:

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IDSource
D02833 KEGG_DRUG
CHEMBL54349 ChEMBL_ID
54897 PUBCHEM_CID
C052036 MESH_SUPPLEMENTAL_RECORD_UI
I93SC245QZ UNII
5740 INN_ID
CHEBI:135649 CHEBI

Pharmaceutical products:

None