grepafloxacin indications/contra

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 1330 119914-60-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • grepafloxacin hydrochloride hydrate
  • grepafloxacin
  • tomefloxacin
  • grepafloxacin hydrochloride
  • grepafloxacin HCl
  • Molecular weight: 359.40
  • Formula: C19H22FN3O3
  • CLOGP: 0.29
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 72.88
  • ALOGS: -2.76
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.40 g O

Approvals:

DateAgencyCompanyOrphan
Nov. 6, 1997 FDA OTSUKA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC J01MA11 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Gonorrhea indication 15628003 DOID:7551
Acute gonococcal cervicitis indication 20943002 DOID:10615
Pneumonia due to Streptococcus indication 34020007
Pneumonia due to Mycoplasma pneumoniae indication 46970008
Haemophilus influenzae pneumonia indication 70036007
Urethritis due to Chlamydia trachomatis indication 179101003
Acute Moraxella catarrhalis bronchitis indication 195722003
Acute bacterial bronchitis indication 233598009
Haemophilus Influenzae Bronchitis indication
Moraxella Catarrhalis Pneumonia indication
Chlamydia Cervicitis indication
Streptococcus Pneumoniae Bronchitis indication

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.14 acidic
pKa2 8.66 Basic
pKa3 1.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.30 CHEMBL
DNA gyrase Enzyme INHIBITOR CHEMBL CHEMBL
DNA topoisomerase 4 Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

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IDSource
DB00365 DRUGBANK_ID
4024097 VUID
N0000022102 NUI
C0287721 UMLSCUI
D02178 KEGG_DRUG
CHEMBL583 ChEMBL_ID
5487J3Q1MN UNII
4024097 VANDF
N0000022102 NDFRT
N0000004859 NDFRT
d04246 MMSL
83719 RXNORM
108679003 SNOMEDCT_US
386892006 SNOMEDCT_US
007022 NDDF
161967-81-3 SECONDARY_CAS_RN
72474 PUBCHEM_CID
CHEMBL1200393 ChEMBL_ID
7024 INN_ID
C075375 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:5543 CHEBI

Pharmaceutical products:

None