glycyrrhizic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1325 | 1405-86-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.
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Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.06 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.13 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 8.83 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A05BA08 | ALIMENTARY TRACT AND METABOLISM BILE AND LIVER THERAPY LIVER THERAPY, LIPOTROPICS Liver therapy |
| CHEBI has role | CHEBI:65232 | thrombin inhibitors |
| CHEBI has role | CHEBI:76924 | plant metabolites |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.84 | acidic |
| pKa2 | 3.48 | acidic |
| pKa3 | 4.89 | acidic |
| pKa4 | 10.8 | acidic |
| pKa5 | 11.96 | acidic |
| pKa6 | 12.18 | acidic |
| pKa7 | 12.79 | acidic |
| pKa8 | 13.33 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | IC50 | 9.40 | CHEMBL | |||||
| Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | IC50 | 8.22 | CHEMBL | |||||
| High mobility group protein B1 | Nuclear other | Kd | 4.06 | CHEMBL | |||||
| Beta-glucuronidase | Enzyme | IC50 | 4.01 | CHEMBL | |||||
| Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | IC50 | 8.52 | CHEMBL | |||||
| Beta-glucuronidase | Enzyme | IC50 | 4.92 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000166344 | NUI |
| D00157 | KEGG_DRUG |
| 68797-35-3 | SECONDARY_CAS_RN |
| C0061751 | UMLSCUI |
| CHEBI:15939 | CHEBI |
| CHEMBL441687 | ChEMBL_ID |
| CHEMBL1923952 | ChEMBL_ID |
| D019695 | MESH_DESCRIPTOR_UI |
| DB13751 | DRUGBANK_ID |
| 4688 | IUPHAR_LIGAND_ID |
| 14982 | PUBCHEM_CID |
| 1367264 | RXNORM |
| 008271 | NDDF |
| 715362002 | SNOMEDCT_US |
| 6FO62043WK | UNII |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| BAMBOO SALT Eunganggo Jook Yeom Toothpaste | HUMAN OTC DRUG LABEL | 7 | 53208-459 | PASTE | 0.04 g | DENTAL | OTC monograph not final | 8 sections |
| BAMBOO SALT Eunganggo Jook Yeom | HUMAN OTC DRUG LABEL | 7 | 53208-505 | PASTE | 0.04 g | DENTAL | OTC monograph not final | 8 sections |
| YOUNGGAKSAN | HUMAN OTC DRUG LABEL | 4 | 72689-0021 | POWDER | 8.30 mg | ORAL | unapproved drug other | 7 sections |
| YOUNGGAKSAN | HUMAN OTC DRUG LABEL | 4 | 72689-0022 | POWDER | 8.30 mg | ORAL | unapproved drug other | 7 sections |
| YOUNGGAKSAN | HUMAN OTC DRUG LABEL | 4 | 72988-0019 | POWDER | 8.30 mg | ORAL | unapproved drug other | 7 sections |
| YOUNGGAKSAN | HUMAN OTC DRUG LABEL | 4 | 72988-0020 | POWDER | 8.30 mg | ORAL | unapproved drug other | 7 sections |
| YOUNGGAKSAN | HUMAN OTC DRUG LABEL | 4 | 73442-0005 | POWDER | 8.30 mg | ORAL | unapproved drug other | 7 sections |
| YOUNGGAKSAN | HUMAN OTC DRUG LABEL | 4 | 73442-0006 | POWDER | 8.30 mg | ORAL | unapproved drug other | 7 sections |
| THE SKIN HOUSE EGF COLLAGEN AMPOULE | HUMAN OTC DRUG LABEL | 1 | 73590-0019 | LIQUID | 0.10 g | TOPICAL | unapproved drug other | 7 sections |
| BOP whiteningtoothpaste | HUMAN OTC DRUG LABEL | 2 | 82574-001 | GEL | 0.30 g | TOPICAL | unapproved drug other | 8 sections |
| Quick-Acting Wart Removal | HUMAN OTC DRUG LABEL | 4 | 83575-001 | LIQUID | 0.20 mg | CUTANEOUS | OTC monograph final | 12 sections |