glycyrrhizic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1325 1405-86-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glycyrrhizin
  • glycyrrhizic acid
  • 18beta-Glycyrrhizic acid
  • glycyrrhizinic acid
  • glycyron
  • glycyrrhetinic acid glycoside
  • glycyrrhizinate dipotassium
A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.
  • Molecular weight: 822.94
  • Formula: C42H62O16
  • CLOGP: 3.03
  • LIPINSKI: 3
  • HAC: 16
  • HDO: 8
  • TPSA: 267.04
  • ALOGS: -4.18
  • ROTB: 7

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.06 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.13 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.83 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A05BA08 ALIMENTARY TRACT AND METABOLISM
BILE AND LIVER THERAPY
LIVER THERAPY, LIPOTROPICS
Liver therapy
CHEBI has role CHEBI:65232 thrombin inhibitors
CHEBI has role CHEBI:76924 plant metabolites
MeSH PA D000893 Anti-Inflammatory Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.84 acidic
pKa2 3.48 acidic
pKa3 4.89 acidic
pKa4 10.8 acidic
pKa5 11.96 acidic
pKa6 12.18 acidic
pKa7 12.79 acidic
pKa8 13.33 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme IC50 9.40 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 8.22 CHEMBL
High mobility group protein B1 Nuclear other Kd 4.06 CHEMBL
Beta-glucuronidase Enzyme IC50 4.01 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 8.52 CHEMBL
Beta-glucuronidase Enzyme IC50 4.92 CHEMBL

External reference:

IDSource
N0000166344 NUI
D00157 KEGG_DRUG
68797-35-3 SECONDARY_CAS_RN
C0061751 UMLSCUI
CHEBI:15939 CHEBI
CHEMBL441687 ChEMBL_ID
CHEMBL1923952 ChEMBL_ID
D019695 MESH_DESCRIPTOR_UI
DB13751 DRUGBANK_ID
4688 IUPHAR_LIGAND_ID
14982 PUBCHEM_CID
1367264 RXNORM
008271 NDDF
715362002 SNOMEDCT_US
6FO62043WK UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BAMBOO SALT Eunganggo Jook Yeom Toothpaste HUMAN OTC DRUG LABEL 7 53208-459 PASTE 0.04 g DENTAL OTC monograph not final 8 sections
BAMBOO SALT Eunganggo Jook Yeom HUMAN OTC DRUG LABEL 7 53208-505 PASTE 0.04 g DENTAL OTC monograph not final 8 sections
YOUNGGAKSAN HUMAN OTC DRUG LABEL 4 72689-0021 POWDER 8.30 mg ORAL unapproved drug other 7 sections
YOUNGGAKSAN HUMAN OTC DRUG LABEL 4 72689-0022 POWDER 8.30 mg ORAL unapproved drug other 7 sections
YOUNGGAKSAN HUMAN OTC DRUG LABEL 4 72988-0019 POWDER 8.30 mg ORAL unapproved drug other 7 sections
YOUNGGAKSAN HUMAN OTC DRUG LABEL 4 72988-0020 POWDER 8.30 mg ORAL unapproved drug other 7 sections
YOUNGGAKSAN HUMAN OTC DRUG LABEL 4 73442-0005 POWDER 8.30 mg ORAL unapproved drug other 7 sections
YOUNGGAKSAN HUMAN OTC DRUG LABEL 4 73442-0006 POWDER 8.30 mg ORAL unapproved drug other 7 sections
THE SKIN HOUSE EGF COLLAGEN AMPOULE HUMAN OTC DRUG LABEL 1 73590-0019 LIQUID 0.10 g TOPICAL unapproved drug other 7 sections
BOP whiteningtoothpaste HUMAN OTC DRUG LABEL 2 82574-001 GEL 0.30 g TOPICAL unapproved drug other 8 sections
Quick-Acting Wart Removal HUMAN OTC DRUG LABEL 4 83575-001 LIQUID 0.20 mg CUTANEOUS OTC monograph final 12 sections