glutathione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1312	70-18-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: glutathione GSH glutathion deltathione glutinal	A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. Molecular weight: 307.32 Formula: C10H17N3O6S CLOGP: -3.05 LIPINSKI: 0 HAC: 9 HDO: 5 TPSA: 158.82 ALOGS: -2.54 ROTB: 9 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

glutathione
GSH
glutathion
deltathione
glutinal

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

Molecular weight: 307.32
Formula: C10H17N3O6S
CLOGP: -3.05
LIPINSKI: 0
HAC: 9
HDO: 5
TPSA: 158.82
ALOGS: -2.54
ROTB: 9

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	65.76	22.52	27	1523	37115	63450357
Drug-induced liver injury	44.43	22.52	21	1529	40201	63447271
Eosinophilic pneumonia chronic	36.76	22.52	6	1544	192	63487280
Bowel movement irregularity	25.20	22.52	8	1542	5256	63482216
Chronic disease	23.64	22.52	4	1546	160	63487312
Defaecation urgency	22.72	22.52	7	1543	4168	63483304

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	74.95	28.94	35	1229	44328	34911339
Lymphocyte count decreased	58.13	28.94	24	1240	22598	34933069
Neutrophil count increased	53.76	28.94	21	1243	17125	34938542
Incision site pain	50.48	28.94	12	1252	1826	34953841
Platelet count decreased	49.33	28.94	38	1226	119679	34835988

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatic function abnormal	126.78	24.96	57	2549	73050	79668732
Incision site pain	71.79	24.96	17	2589	2813	79738969
Platelet count decreased	68.29	24.96	54	2552	194610	79547172
Lymphocyte count decreased	66.70	24.96	32	2574	47257	79694525
Drug-induced liver injury	64.84	24.96	35	2571	66082	79675700
Neutrophil count increased	60.84	24.96	26	2580	29370	79712412
Alanine aminotransferase increased	38.38	24.96	36	2570	162534	79579248
Red blood cells urine positive	35.57	24.96	11	2595	4952	79736830
White blood cell count increased	31.13	24.96	23	2583	74610	79667172
Blood albumin decreased	29.95	24.96	15	2591	24228	79717554

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FDA Adverse Event Reporting System (Pediatric)

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Pharmacologic Action:

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Source	Code	Description
ATC	V03AB32	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:85046	skin lightening agents
CHEBI has role	CHEBI:176497	geroprotectors
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites

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Drug Use | Suggest Off label Use Form| |View source of the data|

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🐶 Veterinary Drug Use

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🐶 Veterinary products

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Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.97	acidic
pKa2	3.3	acidic
pKa3	9.09	acidic
pKa4	11.82	acidic
pKa5	13.85	acidic
pKa6	9.79	Basic

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Orange Book patent data (new drug applications)

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Orange Book exclusivity data (new drug applications)

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Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glutathione S-transferase kappa 1	Enzyme	Q9Y2Q3	GSTK1_HUMAN		IC50	7.70		CHEMBL

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External reference:

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ID	Source
0P0	PDB_CHEM_ID
003447	NDDF
124886	PUBCHEM_CID
4020562	VUID
4020562	VANDF
423272009	SNOMEDCT_US
4890	RXNORM
55477000	SNOMEDCT_US
6737	IUPHAR_LIGAND_ID
C0017817	UMLSCUI

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Bio-7	HUMAN OTC DRUG LABEL	2	71583-1003	CREAM	3.26 g	TOPICAL	unapproved drug other	7 sections
Bio-7 Serum	HUMAN OTC DRUG LABEL	2	71583-1002	LIQUID	3 g	TOPICAL	unapproved drug other	7 sections
Deyanling(Cranberry Flavored Collagen Peptide)	HUMAN OTC DRUG LABEL	3	82570-004	POWDER	5 g	TOPICAL	unapproved drug other	8 sections
HARUTO HANGOVER DEFENCEPATCH	HUMAN OTC DRUG LABEL	1	80094-0001	PATCH	1.42 mg	TOPICAL	unapproved drug other	7 sections

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