gliquidone indications/contra

Stem definitionDrug idCAS RN
antihyperglycaemics 1302 33342-05-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gliquidone
  • glurenorm
  • beglynor
  • gliquidone calcium
  • gliquidone monosodium
  • gliquidone sodium
  • Molecular weight: 527.64
  • Formula: C27H33N3O6S
  • CLOGP: 5.06
  • LIPINSKI: 2
  • HAC: 9
  • HDO: 2
  • TPSA: 121.88
  • ALOGS: -5.38
  • ROTB: 6

Drug dosage:

DoseUnitRoute
60 mg O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC A10BB08 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
MeSH PA D007004 Hypoglycemic Agents

Drug Use (View source of the data)

scroll-->
DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.31 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Kd 9 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

scroll-->
IDSource
C0061328 UMLSCUI
D02430 KEGG_DRUG
25793 RXNORM
325249006 SNOMEDCT_US
395732008 SNOMEDCT_US
003974 NDDF
CHEMBL383634 ChEMBL_ID
91610 PUBCHEM_CID
C7C2QDD75P UNII
3308 INN_ID
C010969 MESH_SUPPLEMENTAL_RECORD_UI
DB01251 DRUGBANK_ID
CHEBI:93416 CHEBI

Pharmaceutical products:

None