glimepiride ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 1300 93479-97-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glimepiride
  • diameprid
  • glimax
  • glimperide
  • glirid
  • Molecular weight: 490.62
  • Formula: C24H34N4O5S
  • CLOGP: 3.96
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 124.68
  • ALOGS: -4.11
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.23 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.19 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 30, 1995 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 2120.46 11.09 961 42412 59104 63386545
Blood glucose increased 557.90 11.09 460 42913 83296 63362353
Lactic acidosis 481.08 11.09 309 43064 37978 63407671
Hypoglycaemic coma 380.21 11.09 118 43255 2457 63443192
Diabetes mellitus inadequate control 269.91 11.09 153 43220 14973 63430676
Glycosylated haemoglobin increased 250.21 11.09 136 43237 12262 63433387
Blood glucose decreased 221.66 11.09 152 43221 20800 63424849
Acute kidney injury 204.59 11.09 512 42861 262903 63182746
Hypoglycaemic encephalopathy 201.46 11.09 46 43327 266 63445383
Hyperglycaemia 149.48 11.09 163 43210 41704 63403945
Drug ineffective 134.04 11.09 326 43047 1044439 62401210
Systemic lupus erythematosus 114.83 11.09 7 43366 208911 63236738
Maternal exposure during pregnancy 110.80 11.09 11 43362 220051 63225598
Diabetic ketoacidosis 108.68 11.09 99 43274 20406 63425243
Pemphigus 107.90 11.09 4 43369 183722 63261927
Contraindicated product administered 106.70 11.09 12 43361 217636 63228013
Infusion related reaction 105.45 11.09 20 43353 245501 63200148
Drug intolerance 103.06 11.09 41 43332 308620 63137029
Euglycaemic diabetic ketoacidosis 102.13 11.09 50 43323 3624 63442025
Synovitis 97.70 11.09 8 43365 186910 63258739
Glossodynia 95.34 11.09 7 43366 178869 63266780
Hyperkalaemia 91.46 11.09 146 43227 54057 63391592
Joint swelling 90.58 11.09 56 43317 327610 63118039
Myocardial infarction 90.05 11.09 206 43167 99687 63345962
Pancreatitis 89.54 11.09 137 43236 48918 63396731
Diabetic metabolic decompensation 85.18 11.09 35 43338 1675 63443974
Cardiac failure congestive 82.63 11.09 190 43183 92243 63353406
Cerebral infarction 78.34 11.09 89 43284 23804 63421845
Renal failure 78.12 11.09 216 43157 117436 63328213
Off label use 77.32 11.09 222 43151 674240 62771409
Metabolic acidosis 74.12 11.09 120 43253 44949 63400700
Diabetes mellitus 72.66 11.09 134 43239 55676 63389973
Exposure during pregnancy 70.42 11.09 11 43362 155536 63290113
Eosinophilic myocarditis 69.30 11.09 23 43350 597 63445052
Alopecia 68.31 11.09 78 43295 337458 63108191
Pericarditis 67.73 11.09 6 43367 131573 63314076
Blood glucose fluctuation 65.11 11.09 40 43333 4536 63441113
Pancreatitis acute 64.48 11.09 86 43287 27080 63418569
Therapeutic product effect decreased 63.87 11.09 26 43347 193161 63252488
Rheumatoid arthritis 60.16 11.09 51 43322 253768 63191881
Altered state of consciousness 60.08 11.09 80 43293 25150 63420499
Dehydration 59.99 11.09 256 43117 173098 63272551
Decreased appetite 59.09 11.09 332 43041 250720 63194929
Hypersensitivity 58.81 11.09 68 43305 292617 63153032
Wound 55.56 11.09 21 43352 163242 63282407
Loss of consciousness 55.27 11.09 192 43181 117929 63327720
Pancreatic carcinoma 55.10 11.09 44 43329 7584 63438065
Renal impairment 54.51 11.09 158 43215 88197 63357452
Coronary artery disease 54.31 11.09 87 43286 32290 63413359
Swelling 53.17 11.09 66 43307 275312 63170337
Pain 51.79 11.09 296 43077 740332 62705317
MELAS syndrome 50.86 11.09 13 43360 128 63445521
Blood glucose abnormal 49.63 11.09 42 43331 7850 63437799
Helicobacter infection 48.38 11.09 4 43369 92781 63352868
Arthropathy 47.74 11.09 54 43319 234738 63210911
Discomfort 47.03 11.09 28 43345 167346 63278303
Treatment failure 45.93 11.09 41 43332 199002 63246647
Product use issue 45.62 11.09 50 43323 220470 63225179
Duodenal ulcer perforation 44.81 11.09 4 43369 87205 63358444
Musculoskeletal stiffness 43.84 11.09 37 43336 184581 63261068
Sopor 43.42 11.09 64 43309 22100 63423549
Cold sweat 43.14 11.09 47 43326 12000 63433649
Neuroglycopenia 42.74 11.09 15 43358 463 63445186
Abdominal discomfort 42.49 11.09 98 43275 320787 63124862
Diarrhoea 42.22 11.09 704 42669 714662 62730987
Hyperhidrosis 41.01 11.09 164 43209 107672 63337977
Drug interaction 38.95 11.09 279 43094 228852 63216797
Blood creatinine increased 38.68 11.09 140 43233 87704 63357945
Postprandial hypoglycaemia 37.93 11.09 9 43364 63 63445586
Fall 37.86 11.09 422 42951 391912 63053737
Cardiac failure 37.51 11.09 140 43233 89002 63356647
Ketoacidosis 35.41 11.09 27 43346 4351 63441298
Cholelithiasis 34.59 11.09 86 43287 43839 63401810
Weight decreased 34.52 11.09 314 43059 276484 63169165
Dermatitis exfoliative 34.22 11.09 29 43344 5430 63440219
Drug level increased 33.97 11.09 58 43315 22678 63422971
Blood urea increased 33.90 11.09 63 43310 26316 63419333
Insulin C-peptide increased 32.57 11.09 8 43365 66 63445583
Nasopharyngitis 31.78 11.09 80 43293 254177 63191472
Anuria 31.74 11.09 41 43332 12510 63433139
Arthralgia 31.05 11.09 245 43128 569465 62876184
Drug hypersensitivity 30.73 11.09 109 43264 310578 63135071
Sinusitis 30.15 11.09 69 43304 226584 63219065
Hyperinsulinaemia 29.28 11.09 8 43365 104 63445545
Hypoglycaemic unconsciousness 29.11 11.09 13 43360 764 63444885
Mobility decreased 29.10 11.09 24 43349 121135 63324514
Intentional product use issue 28.71 11.09 27 43346 127865 63317784
Ketosis 28.68 11.09 12 43361 601 63445048
Product use in unapproved indication 28.57 11.09 49 43324 179031 63266618
Hepatic function abnormal 28.49 11.09 72 43301 37070 63408579
Shock hypoglycaemic 28.41 11.09 8 43365 117 63445532
Fatigue 28.34 11.09 432 42941 887596 62558053
Pyelonephritis acute 27.76 11.09 24 43349 4617 63441032
Hypoparathyroidism 27.52 11.09 12 43361 666 63444983
Irritable bowel syndrome 27.36 11.09 11 43362 82401 63363248
Thrombotic cerebral infarction 27.29 11.09 8 43365 136 63445513
Diabetic retinopathy 27.28 11.09 18 43355 2309 63443340
Ill-defined disorder 27.00 11.09 11 43362 81744 63363905
Psoriatic arthropathy 26.14 11.09 15 43358 91505 63354144
Bladder cancer 25.89 11.09 25 43348 5541 63440108
Hyponatraemia 25.62 11.09 147 43226 111753 63333896
Injection site nodule 25.33 11.09 21 43352 3814 63441835
Biopsy skin abnormal 25.14 11.09 7 43366 98 63445551
Hepatic enzyme increased 25.01 11.09 64 43309 202264 63243385
Rhabdomyolysis 24.63 11.09 76 43297 43875 63401774
Asthenia 24.56 11.09 383 42990 383221 63062428
Infection 24.29 11.09 78 43295 229095 63216554
Liver injury 23.78 11.09 6 43367 60514 63385135
Rash 23.71 11.09 257 43116 560614 62885035
Restlessness 23.54 11.09 58 43315 29395 63416254
Embolic cerebellar infarction 23.41 11.09 5 43368 20 63445629
Depressed level of consciousness 23.26 11.09 94 43279 61984 63383665
Hyperglycaemic hyperosmolar nonketotic syndrome 23.20 11.09 12 43361 977 63444672
Anaemia 23.17 11.09 304 43069 293126 63152523
Oedema peripheral 23.10 11.09 214 43159 189297 63256352
Blood insulin increased 22.91 11.09 7 43366 138 63445511
Nausea 22.80 11.09 753 42620 853718 62591931
Diabetic neuropathy 22.70 11.09 20 43353 3944 63441705
Cholecystitis 22.67 11.09 39 43334 15338 63430311
Blood potassium increased 22.62 11.09 43 43330 18266 63427383
Hip arthroplasty 22.41 11.09 3 43370 47643 63398006
Anaemia vitamin B12 deficiency 22.32 11.09 9 43364 410 63445239
Hypothermia 22.10 11.09 36 43337 13545 63432104
Impaired healing 21.46 11.09 23 43350 102519 63343130
Diabetic complication 21.19 11.09 11 43362 902 63444747
Pancreatic carcinoma metastatic 21.15 11.09 15 43358 2163 63443486
Electrolyte imbalance 21.02 11.09 44 43329 20032 63425617
Poverty of speech 20.83 11.09 8 43365 320 63445329
Oliguria 20.36 11.09 28 43345 9073 63436576
Hyperthyroidism 20.06 11.09 36 43337 14637 63431012
Differential white blood cell count abnormal 19.78 11.09 10 43363 776 63444873
Peripheral swelling 19.73 11.09 104 43269 265838 63179811
Contusion 19.68 11.09 46 43327 149998 63295651
Coagulation test abnormal 19.64 11.09 10 43363 788 63444861
Cardiac arrest 19.52 11.09 119 43254 92426 63353223
Pancreatitis necrotising 19.48 11.09 13 43360 1699 63443950
Urine ketone body present 19.29 11.09 15 43358 2488 63443161
Anti-insulin antibody increased 19.06 11.09 5 43368 55 63445594
Retinal haemorrhage 18.87 11.09 20 43353 4949 63440700
Ballismus 18.72 11.09 6 43367 139 63445510
Migraine 18.65 11.09 26 43347 103320 63342329
Bradypnoea 18.53 11.09 17 43356 3533 63442116
Urogenital haemorrhage 18.47 11.09 7 43366 270 63445379
Vomiting 18.04 11.09 505 42868 559112 62886537
Glycosylated haemoglobin abnormal 18.03 11.09 6 43367 157 63445492
Abortion spontaneous 17.93 11.09 5 43368 47190 63398459
Mixed anxiety and depressive disorder 17.88 11.09 7 43366 295 63445354
Drug abuse 17.86 11.09 14 43359 72504 63373145
Blood creatine phosphokinase increased 17.40 11.09 53 43320 30377 63415272
Ventricular fibrillation 17.37 11.09 30 43343 11837 63433812
Hepatic steatosis 17.30 11.09 51 43322 28718 63416931
Glomerular filtration rate decreased 17.14 11.09 32 43341 13409 63432240
Medication error 17.12 11.09 76 43297 52208 63393441
Hyperventilation 17.09 11.09 21 43352 6095 63439554
Muscle discomfort 16.89 11.09 6 43367 192 63445457
Musculoskeletal pain 16.87 11.09 23 43350 92254 63353395
Hyporesponsive to stimuli 16.60 11.09 10 43363 1094 63444555
Headache 16.27 11.09 320 43053 632921 62812728
Tachypnoea 15.92 11.09 36 43337 17266 63428383
Pregnancy 15.79 11.09 3 43370 36833 63408816
Urinary tract infection 15.69 11.09 261 43112 264423 63181226
Hypomagnesaemia 15.46 11.09 49 43324 28688 63416961
Arteriosclerosis 15.46 11.09 26 43347 10040 63435609
Macular oedema 15.43 11.09 16 43357 3861 63441788
Atrial fibrillation 15.37 11.09 134 43239 116502 63329147
Gastrointestinal disorder 15.09 11.09 43 43330 131196 63314453
Blood triglycerides increased 15.02 11.09 29 43344 12459 63433190
Gastroenteritis 14.91 11.09 46 43327 26544 63419105
Fibromyalgia 14.74 11.09 20 43353 80400 63365249
Hypoglycaemic seizure 14.59 11.09 7 43366 485 63445164
Retinopathy proliferative 14.43 11.09 4 43369 55 63445594
Myocardial ischaemia 14.42 11.09 29 43344 12830 63432819
Angina pectoris 14.14 11.09 49 43324 30029 63415620
Pemphigoid 14.09 11.09 21 43352 7323 63438326
Embolic cerebral infarction 14.06 11.09 7 43366 526 63445123
Carotid arteriosclerosis 14.05 11.09 9 43364 1097 63444552
Ectopic ACTH syndrome 14.02 11.09 5 43368 162 63445487
Dysarthria 13.92 11.09 62 43311 42649 63403000
Reperfusion injury 13.70 11.09 4 43369 67 63445582
Hypertriglyceridaemia 13.62 11.09 19 43354 6240 63439409
Azotaemia 13.55 11.09 16 43357 4455 63441194
Phobia 13.51 11.09 6 43367 348 63445301
Jaundice 13.19 11.09 47 43326 29204 63416445
Cerebral reperfusion injury 13.19 11.09 3 43370 17 63445632
Metabolic encephalopathy 13.19 11.09 18 43355 5791 63439858
Lipase increased 13.16 11.09 24 43349 9876 63435773
Pylorus dilatation 13.04 11.09 3 43370 18 63445631
Metabolic alkalosis 12.85 11.09 13 43360 3048 63442601
Disorientation 12.66 11.09 57 43316 39395 63406254
Cerebral ischaemia 12.56 11.09 19 43354 6709 63438940
Toxic epidermal necrolysis 12.55 11.09 42 43331 25292 63420357
Ischaemic cerebral infarction 12.45 11.09 9 43364 1337 63444312
Capillary leak syndrome 12.40 11.09 11 43362 2189 63443460
Continuous haemodiafiltration 12.29 11.09 8 43365 1003 63444646
Hypophagia 12.24 11.09 48 43325 31211 63414438
Dizziness 12.20 11.09 382 42991 429543 63016106
Cerebrovascular accident 12.16 11.09 120 43253 107904 63337745
Neutropenia 12.11 11.09 70 43303 174935 63270714
Compartment syndrome 12.04 11.09 11 43362 2273 63443376
Colon cancer 11.95 11.09 23 43350 9855 63435794
Premature delivery 11.90 11.09 3 43370 30278 63415371
Adenocarcinoma pancreas 11.82 11.09 8 43365 1070 63444579
Transient ischaemic attack 11.70 11.09 54 43319 37699 63407950
Respiratory tract infection 11.56 11.09 7 43366 41476 63404173
Lymphocyte count increased 11.53 11.09 13 43360 3445 63442204
Head injury 11.49 11.09 43 43330 27353 63418296
Cardiac failure acute 11.31 11.09 22 43351 9501 63436148
Anti-insulin antibody 11.28 11.09 3 43370 35 63445614
C-reactive protein abnormal 11.22 11.09 9 43364 46087 63399562
Blood ketone body increased 11.18 11.09 5 43368 295 63445354

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 1644.70 11.31 974 45050 53666 34857241
Blood glucose increased 353.30 11.31 437 45587 66281 34844626
Hypoglycaemic coma 343.83 11.31 127 45897 2304 34908603
Lactic acidosis 306.70 11.31 298 45726 34474 34876433
Diabetes mellitus inadequate control 278.72 11.31 190 45834 13274 34897633
Glycosylated haemoglobin increased 213.29 11.31 151 45873 11209 34899698
Cerebral infarction 146.95 11.31 181 45843 27274 34883633
Off label use 131.04 11.31 220 45804 419304 34491603
Blood glucose decreased 113.89 11.31 112 45912 13125 34897782
Pancreatitis 111.86 11.31 191 45833 38700 34872207
Myocardial infarction 105.70 11.31 375 45649 120710 34790197
Pancreatitis acute 99.76 11.31 152 45872 27989 34882918
Hyperglycaemia 99.50 11.31 183 45841 39297 34871610
Coronary artery disease 98.75 11.31 205 45819 48100 34862807
Cardiac failure congestive 97.24 11.31 285 45739 82985 34827922
Hyperkalaemia 94.32 11.31 251 45773 69138 34841769
Drug abuse 87.64 11.31 13 46011 99083 34811824
Bladder cancer 78.63 11.31 102 45922 16176 34894731
Pancreatic carcinoma 77.85 11.31 76 45948 8825 34902082
Hypoglycaemic encephalopathy 75.05 11.31 24 46000 275 34910632
Product use in unapproved indication 74.03 11.31 31 45993 117468 34793439
Interstitial lung disease 73.86 11.31 221 45803 65061 34845846
Diabetic ketoacidosis 73.44 11.31 104 45920 17928 34892979
Acute kidney injury 64.33 11.31 648 45376 304340 34606567
Hepatic function abnormal 61.79 11.31 162 45862 44201 34866706
Drug ineffective 56.25 11.31 362 45662 456389 34454518
Toxicity to various agents 51.10 11.31 118 45906 200244 34710663
Blood lactic acid 48.64 11.31 18 46006 328 34910579
Diabetes mellitus 46.81 11.31 152 45872 46721 34864186
Altered state of consciousness 46.57 11.31 97 45927 22796 34888111
Diabetic neuropathy 42.75 11.31 39 45985 4158 34906749
Renal impairment 41.57 11.31 239 45785 94274 34816633
Febrile neutropenia 41.35 11.31 73 45951 136776 34774131
Decreased appetite 40.64 11.31 365 45659 166027 34744880
Foetal exposure during pregnancy 38.74 11.31 3 46021 38098 34872809
Diabetic retinopathy 38.43 11.31 26 45998 1791 34909116
Pemphigoid 38.30 11.31 52 45972 8614 34902293
Diabetic nephropathy 34.73 11.31 26 45998 2102 34908805
Blood glucose abnormal 33.05 11.31 40 45984 5912 34904995
Acute myocardial infarction 32.82 11.31 149 45875 53570 34857337
Diabetic metabolic decompensation 32.04 11.31 23 46001 1743 34909164
Cerebrovascular accident 31.91 11.31 206 45818 84605 34826302
Hepatocellular carcinoma 31.59 11.31 44 45980 7465 34903442
Treatment failure 31.58 11.31 11 46013 46686 34864221
Dyslalia 30.93 11.31 15 46009 545 34910362
Bladder transitional cell carcinoma 29.67 11.31 26 45998 2629 34908278
Blindness transient 29.40 11.31 24 46000 2202 34908705
Gastric cancer 28.87 11.31 39 45985 6430 34904477
Renal failure 28.64 11.31 280 45744 130277 34780630
Hypoglycaemic unconsciousness 28.62 11.31 16 46008 782 34910125
Urine ketone body present 28.11 11.31 18 46006 1130 34909777
Neutropenia 27.92 11.31 109 45915 156669 34754238
Diabetic gangrene 27.76 11.31 11 46013 243 34910664
Pancreatic carcinoma metastatic 27.40 11.31 26 45998 2914 34907993
Euglycaemic diabetic ketoacidosis 27.22 11.31 27 45997 3195 34907712
Cardiac failure 25.85 11.31 207 45817 91041 34819866
Myocardial ischaemia 25.70 11.31 65 45959 17343 34893564
Lipase increased 25.42 11.31 45 45979 9371 34901536
Liver disorder 25.20 11.31 98 45926 32899 34878008
Metabolic acidosis 25.09 11.31 119 45905 43561 34867346
Coronary artery stenosis 24.74 11.31 45 45979 9571 34901336
Shock 24.66 11.31 79 45945 24100 34886807
Mucosal inflammation 24.61 11.31 10 46014 38612 34872295
Drug resistance 23.85 11.31 3 46021 25924 34884983
Rhabdomyolysis 22.90 11.31 161 45863 68002 34842905
Lacunar infarction 22.67 11.31 24 46000 3066 34907841
Amylase increased 22.22 11.31 33 45991 5935 34904972
Blood glucose fluctuation 22.17 11.31 27 45997 4017 34906890
Joint swelling 21.89 11.31 28 45996 59862 34851045
Albumin urine present 20.35 11.31 10 46014 374 34910533
Glycosylated haemoglobin decreased 20.28 11.31 10 46014 377 34910530
Blood urea increased 19.88 11.31 86 45938 30278 34880629
Latent autoimmune diabetes in adults 19.50 11.31 6 46018 60 34910847
Brain stem infarction 19.46 11.31 15 46009 1267 34909640
Death 19.33 11.31 389 45635 397660 34513247
Product commingling 19.25 11.31 5 46019 25 34910882
Completed suicide 18.93 11.31 66 45958 98102 34812805
Intentional product use issue 18.88 11.31 31 45993 59785 34851122
Lower respiratory tract infection 18.88 11.31 9 46015 31628 34879279
Oedema peripheral 18.54 11.31 240 45784 119572 34791335
Infusion related reaction 18.18 11.31 26 45998 53031 34857876
Cytokine release syndrome 18.05 11.31 4 46020 22873 34888034
Pyrexia 17.83 11.31 320 45704 332693 34578214
Nephrogenic anaemia 17.71 11.31 18 46006 2193 34908714
Hyperglycaemic hyperosmolar nonketotic syndrome 17.33 11.31 14 46010 1266 34909641
Haemorrhagic cerebral infarction 17.32 11.31 12 46012 859 34910048
Blood creatinine increased 17.19 11.31 196 45828 94780 34816127
COVID-19 17.16 11.31 49 45975 77501 34833406
Product use issue 17.08 11.31 36 45988 63180 34847727
Loss of consciousness 17.00 11.31 175 45849 82492 34828415
Colon cancer 16.91 11.31 36 45988 8585 34902322
Ischaemic cardiomyopathy 16.56 11.31 30 45994 6359 34904548
Blood triglycerides increased 16.05 11.31 48 45976 14111 34896796
Ketonuria 16.01 11.31 10 46014 601 34910306
Hypothermia 15.72 11.31 40 45984 10708 34900199
Therapy non-responder 15.70 11.31 17 46007 39129 34871778
Hyperlipidaemia 15.30 11.31 48 45976 14481 34896426
Type 2 diabetes mellitus 15.11 11.31 51 45973 15981 34894926
Blood lactate dehydrogenase increased 14.96 11.31 65 45959 22925 34887982
Angina pectoris 14.89 11.31 81 45943 31282 34879625
Cytomegalovirus infection 14.75 11.31 8 46016 26127 34884780
Thrombotic cerebral infarction 14.68 11.31 8 46016 372 34910535
Cholangiocarcinoma 14.65 11.31 13 46011 1336 34909571
Cardiac disorder 14.55 11.31 102 45922 43024 34867883
Wheezing 14.47 11.31 20 46004 41382 34869525
Aggression 14.46 11.31 18 46006 38946 34871961
Pancreatitis necrotising 14.45 11.31 18 46006 2740 34908167
Anti-insulin antibody increased 14.41 11.31 5 46019 75 34910832
Cardiovascular disorder 14.27 11.31 37 45987 10019 34900888
Intentional product misuse 14.05 11.31 24 46000 45587 34865320
Arteriosclerosis 13.97 11.31 41 45983 11927 34898980
Arthralgia 13.87 11.31 150 45874 169891 34741016
Pain 13.86 11.31 188 45836 204487 34706420
Blood pressure fluctuation 13.85 11.31 8 46016 25241 34885666
Product odour abnormal 13.83 11.31 10 46014 766 34910141
Headache 13.69 11.31 184 45840 200451 34710456
Anxiety 13.61 11.31 76 45948 99352 34811555
Carotid artery stenosis 13.57 11.31 24 46000 4995 34905912
Blood ketone body increased 13.53 11.31 8 46016 435 34910472
Dehydration 13.40 11.31 243 45781 129726 34781181
Gastric adenoma 13.30 11.31 3 46021 7 34910900
Weight decreased 13.07 11.31 314 45710 175987 34734920
Ischaemic stroke 12.96 11.31 53 45971 18197 34892710
Insulin resistance 12.93 11.31 9 46015 649 34910258
Hyperuricaemia 12.89 11.31 31 45993 8012 34902895
Dialysis 12.71 11.31 38 45986 11170 34899737
Suicidal ideation 12.68 11.31 21 46003 40367 34870540
Bile duct cancer 12.61 11.31 9 46015 676 34910231
Hospitalisation 12.55 11.31 36 45988 56866 34854041
Adenocarcinoma pancreas 12.52 11.31 12 46012 1362 34909545
Toe amputation 12.47 11.31 16 46008 2508 34908399
Cholelithiasis 12.42 11.31 58 45966 21090 34889817
Blood creatine phosphokinase increased 12.27 11.31 101 45923 44756 34866151
Gamma-glutamyltransferase increased 12.23 11.31 73 45951 29158 34881749
Drug intolerance 12.20 11.31 39 45985 59531 34851376
Retinal aneurysm 12.12 11.31 5 46019 123 34910784
Retinal haemorrhage 12.07 11.31 23 46001 5066 34905841
Migraine 12.02 11.31 4 46020 17474 34893433
Diabetic ketosis 11.65 11.31 5 46019 136 34910771
Coagulation factor increased 11.65 11.31 4 46020 58 34910849
Leukopenia 11.62 11.31 43 45981 62813 34848094
Renal disorder 11.55 11.31 65 45959 25415 34885492
Tachycardia 11.49 11.31 65 45959 84707 34826200
Pancreatic neuroendocrine tumour 11.46 11.31 6 46018 257 34910650
Cerebral haemorrhage 11.42 11.31 82 45942 34855 34876052
Chronic kidney disease 11.39 11.31 93 45931 41117 34869790
Hemiplegia 11.31 11.31 27 45997 6945 34903962

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypoglycaemia 3545.07 10.55 1779 72897 99815 79569897
Lactic acidosis 784.34 10.55 596 74080 69763 79599949
Hypoglycaemic coma 685.75 10.55 231 74445 4529 79665183
Blood glucose increased 651.89 10.55 663 74013 114312 79555400
Diabetes mellitus inadequate control 494.79 10.55 299 74377 23965 79645747
Glycosylated haemoglobin increased 381.52 10.55 233 74443 19027 79650685
Acute kidney injury 263.08 10.55 1071 73605 518333 79151379
Hyperglycaemia 241.12 10.55 313 74363 70022 79599690
Hypoglycaemic encephalopathy 238.16 10.55 65 74611 596 79669116
Cerebral infarction 225.66 10.55 245 74431 45431 79624281
Blood glucose decreased 217.30 10.55 187 74489 26047 79643665
Hyperkalaemia 208.77 10.55 380 74296 114018 79555694
Myocardial infarction 195.93 10.55 491 74185 183638 79486074
Off label use 188.20 10.55 353 74323 906862 78762850
Drug ineffective 159.93 10.55 502 74174 1080411 78589301
Diabetic ketoacidosis 158.10 10.55 177 74499 33945 79635767
Cardiac failure congestive 158.04 10.55 386 74290 142016 79527696
Pancreatitis acute 145.96 10.55 205 74471 49399 79620313
Pancreatitis 144.82 10.55 243 74433 68332 79601380
Coronary artery disease 134.26 10.55 229 74447 65245 79604467
Joint swelling 124.89 10.55 57 74619 288589 79381123
Bladder cancer 118.51 10.55 117 74559 19409 79650303
Infusion related reaction 117.19 10.55 35 74641 230202 79439510
Euglycaemic diabetic ketoacidosis 115.92 10.55 75 74601 6769 79662943
Synovitis 113.25 10.55 7 74669 150727 79518985
Drug intolerance 112.94 10.55 53 74623 264066 79405646
Diabetic metabolic decompensation 111.73 10.55 57 74619 3275 79666437
Renal failure 106.53 10.55 421 74255 200547 79469165
Pancreatic carcinoma 104.82 10.55 93 74583 13484 79656228
Altered state of consciousness 102.96 10.55 163 74513 43659 79626053
Diabetes mellitus 97.23 10.55 222 74454 78168 79591544
Metabolic acidosis 96.10 10.55 228 74448 82301 79587411
Hepatic function abnormal 93.97 10.55 210 74466 72897 79596815
Maternal exposure during pregnancy 92.47 10.55 10 74666 136528 79533184
Product use in unapproved indication 86.26 10.55 65 74611 250294 79419418
Lower respiratory tract infection 86.16 10.55 10 74666 129210 79540502
Systemic lupus erythematosus 84.31 10.55 8 74668 121141 79548571
Decreased appetite 84.26 10.55 579 74097 341839 79327873
Drug abuse 84.11 10.55 24 74652 162667 79507045
Contraindicated product administered 80.05 10.55 24 74652 157514 79512198
Hypersensitivity 74.91 10.55 81 74595 262158 79407554
Renal impairment 73.70 10.55 318 74358 157465 79512247
Interstitial lung disease 71.41 10.55 250 74426 112350 79557362
Pain 69.24 10.55 382 74294 703420 78966292
Arthralgia 68.64 10.55 289 74387 571514 79098198
Pemphigus 68.18 10.55 7 74669 99575 79570137
Diabetic neuropathy 67.70 10.55 52 74624 6164 79663548
Exposure during pregnancy 66.98 10.55 8 74668 101124 79568588
Blood glucose abnormal 65.40 10.55 64 74612 10502 79659210
Cardiac failure 64.74 10.55 302 74374 154540 79515172
Rheumatoid arthritis 63.38 10.55 61 74615 208409 79461303
Glossodynia 61.90 10.55 11 74665 103326 79566386
Therapeutic product effect decreased 61.11 10.55 39 74637 163824 79505888
Dehydration 60.59 10.55 419 74257 247768 79421944
Alopecia 60.13 10.55 77 74599 231278 79438434
Loss of consciousness 59.16 10.55 312 74364 167631 79502081
Diabetic retinopathy 57.49 10.55 36 74640 3070 79666642
Rhabdomyolysis 55.35 10.55 217 74459 102914 79566798
Treatment failure 55.26 10.55 47 74629 170439 79499273
Acute myocardial infarction 52.29 10.55 175 74501 76861 79592851
Pemphigoid 52.19 10.55 68 74608 15247 79654465
Product use issue 51.31 10.55 73 74603 209749 79459963
Hepatocellular carcinoma 50.96 10.55 52 74624 8969 79660743
Musculoskeletal stiffness 50.02 10.55 54 74622 174954 79494758
Bladder transitional cell carcinoma 49.77 10.55 31 74645 2619 79667093
Blood lactic acid 49.51 10.55 18 74658 445 79669267
Arthropathy 49.13 10.55 56 74620 177055 79492657
Blood glucose fluctuation 48.09 10.55 44 74632 6638 79663074
Helicobacter infection 47.45 10.55 5 74671 69699 79600013
Eosinophilic myocarditis 47.16 10.55 23 74653 1199 79668513
Intentional product use issue 46.82 10.55 44 74632 152068 79517644
Sinusitis 45.86 10.55 70 74606 195431 79474281
Swelling 45.83 10.55 83 74593 216628 79453084
Fatigue 45.53 10.55 606 74070 929121 78740591
Blood creatinine increased 43.41 10.55 271 74405 154786 79514926
Drug hypersensitivity 43.05 10.55 140 74536 298776 79370936
Duodenal ulcer perforation 42.01 10.55 6 74670 66205 79603507
MELAS syndrome 41.81 10.55 13 74663 195 79669517
Cold sweat 41.78 10.55 68 74608 18631 79651081
Ill-defined disorder 41.73 10.55 6 74670 65869 79603843
Urine ketone body present 41.43 10.55 31 74645 3534 79666178
Pericarditis 41.40 10.55 23 74653 104213 79565499
Hypothermia 40.73 10.55 75 74601 22671 79647041
Wound 40.19 10.55 30 74646 116149 79553563
Febrile neutropenia 40.03 10.55 99 74577 230900 79438812
Angina pectoris 39.16 10.55 122 74554 51610 79618102
Headache 38.93 10.55 408 74268 653364 79016348
Hyperglycaemic hyperosmolar nonketotic syndrome 38.42 10.55 25 74651 2278 79667434
Neuroglycopenia 37.95 10.55 15 74661 469 79669243
Cholelithiasis 37.85 10.55 122 74554 52542 79617170
Cerebrovascular accident 37.75 10.55 262 74414 155030 79514682
Gastric cancer 37.53 10.55 47 74629 10132 79659580
Nasopharyngitis 37.18 10.55 118 74558 253763 79415949
Ketosis 36.99 10.55 19 74657 1107 79668605
Hypoglycaemic unconsciousness 36.11 10.55 19 74657 1164 79668548
Mobility decreased 35.68 10.55 37 74639 122138 79547574
Colon cancer 35.46 10.55 55 74621 14468 79655244
Ketoacidosis 35.10 10.55 40 74636 7814 79661898
Diabetic nephropathy 35.08 10.55 26 74650 2921 79666791
Blood creatine phosphokinase increased 34.59 10.55 138 74538 65952 79603760
Irritable bowel syndrome 34.42 10.55 8 74668 62233 79607479
Psoriatic arthropathy 34.32 10.55 15 74661 77984 79591728
Oedema peripheral 33.72 10.55 373 74303 251915 79417797
Pancreatic carcinoma metastatic 33.63 10.55 28 74648 3725 79665987
Myocardial ischaemia 33.56 10.55 74 74602 25445 79644267
Postprandial hypoglycaemia 33.43 10.55 9 74667 78 79669634
Shock 33.24 10.55 103 74573 43445 79626267
Infection 32.89 10.55 116 74560 241596 79428116
Blood urea increased 32.37 10.55 110 74566 48680 79621032
Thrombotic cerebral infarction 32.22 10.55 14 74662 558 79669154
Muscle injury 31.76 10.55 4 74672 48557 79621155
Lipase increased 30.37 10.55 55 74621 16411 79653301
Coronary artery stenosis 30.09 10.55 47 74629 12437 79657275
Migraine 29.74 10.55 23 74653 87470 79582242
Albumin urine present 29.69 10.55 14 74662 677 79669035
Hyperinsulinaemia 29.63 10.55 10 74666 197 79669515
Glycosylated haemoglobin decreased 29.48 10.55 14 74662 688 79669024
Diarrhoea 29.43 10.55 1053 73623 879436 78790276
Dyslalia 29.31 10.55 16 74660 1056 79668656
Diabetic gangrene 29.17 10.55 10 74666 207 79669505
Peripheral swelling 28.84 10.55 142 74534 269475 79400237
Blood pressure fluctuation 27.86 10.55 14 74662 67131 79602581
Drug interaction 27.69 10.55 544 74132 414639 79255073
Discomfort 27.55 10.55 47 74629 125570 79544142
Ischaemic cardiomyopathy 27.53 10.55 35 74641 7660 79662052
Retinal haemorrhage 27.25 10.55 36 74640 8181 79661531
Anuria 26.68 10.55 60 74616 20903 79648809
Drug resistance 26.38 10.55 4 74672 42209 79627503
Neutropenia 26.13 10.55 160 74516 287550 79382162
Fall 26.13 10.55 619 74057 487010 79182702
Insulin C-peptide increased 25.85 10.55 8 74668 118 79669594
Azotaemia 25.52 10.55 35 74641 8241 79661471
C-reactive protein abnormal 25.23 10.55 7 74669 48360 79621352
Abdominal discomfort 24.60 10.55 136 74540 250591 79419121
Completed suicide 24.28 10.55 133 74543 245634 79424078
Arteriosclerosis 24.13 10.55 53 74623 18174 79651538
Diabetic complication 24.11 10.55 15 74661 1264 79668448
Shock hypoglycaemic 23.84 10.55 9 74667 248 79669464
Hyperuricaemia 23.82 10.55 41 74635 11758 79657954
Liver disorder 23.76 10.55 132 74544 72285 79597427
Cardiac disorder 23.71 10.55 123 74553 65634 79604078
Therapy non-responder 23.67 10.55 31 74645 92274 79577438
Transient ischaemic attack 23.65 10.55 105 74571 52590 79617122
Hypoparathyroidism 23.59 10.55 14 74662 1084 79668628
Latent autoimmune diabetes in adults 23.58 10.55 7 74669 89 79669623
Drug level increased 23.38 10.55 86 74590 39565 79630147
Blood ketone body increased 23.19 10.55 12 74664 710 79669002
Mucosal inflammation 23.09 10.55 22 74654 75558 79594154
Pancreatitis necrotising 22.94 10.55 23 74653 3885 79665827
Lacunar infarction 22.75 10.55 28 74648 5929 79663783
Wheezing 22.63 10.55 47 74629 116617 79553095
Blindness transient 22.50 10.55 25 74651 4751 79664961
Sopor 22.40 10.55 75 74601 32935 79636777
Prerenal failure 22.14 10.55 22 74654 3676 79666036
Haemorrhagic cerebral infarction 22.12 10.55 15 74661 1464 79668248
Weight decreased 21.87 10.55 460 74216 354738 79314974
Contusion 21.87 10.55 69 74607 148707 79521005
Cardiac arrest 21.87 10.55 252 74424 171844 79497868
Embolic cerebellar infarction 21.84 10.55 5 74671 20 79669692
Hepatic cancer 21.80 10.55 37 74639 10492 79659220
Fibromyalgia 21.75 10.55 17 74659 64323 79605389
Injection site nodule 21.74 10.55 22 74654 3758 79665954
Ischaemic stroke 21.36 10.55 74 74602 33057 79636655
Atrial fibrillation 21.36 10.55 281 74395 197605 79472107
Macular oedema 21.35 10.55 26 74650 5448 79664264
Hyperthyroidism 21.28 10.55 57 74619 22152 79647560
Platelet count decreased 21.25 10.55 277 74399 194387 79475325
Toxicity to various agents 21.17 10.55 273 74403 421267 79248445
Condition aggravated 21.14 10.55 336 74340 500788 79168924
Hip arthroplasty 20.99 10.55 4 74672 35752 79633960
Blood insulin increased 20.90 10.55 9 74667 351 79669361
Gastrointestinal disorder 20.67 10.55 53 74623 122152 79547560
Blood potassium increased 20.30 10.55 67 74609 29208 79640504
Impaired healing 19.96 10.55 32 74644 87623 79582089
Hyperhidrosis 19.77 10.55 223 74453 151269 79518443
Anaemia 19.74 10.55 551 74125 444464 79225248
Angina unstable 19.59 10.55 46 74630 16481 79653231
Chorea 19.54 10.55 17 74659 2400 79667312
Pyelonephritis acute 19.38 10.55 26 74650 5997 79663715
Loss of personal independence in daily activities 19.33 10.55 42 74634 102538 79567174
Hyperlipidaemia 19.25 10.55 61 74615 26032 79643680
Hepatic enzyme increased 19.04 10.55 97 74579 182513 79487199
Amylase increased 18.87 10.55 36 74640 11173 79658539
Inflammation 18.84 10.55 37 74639 93716 79575996
Biopsy skin abnormal 18.57 10.55 7 74669 192 79669520
Ectopic ACTH syndrome 18.54 10.55 7 74669 193 79669519
Arthritis 18.53 10.55 51 74625 114829 79554883
Dermatitis exfoliative 18.50 10.55 35 74641 10794 79658918
Cholecystitis 18.33 10.55 54 74622 22158 79647554
Anxiety 18.24 10.55 147 74529 248365 79421347
Syncope 18.20 10.55 252 74424 179197 79490515
Acute coronary syndrome 18.03 10.55 52 74624 21081 79648631
Blood lactic acid increased 17.95 10.55 38 74638 12706 79657006
Anti-insulin antibody increased 17.83 10.55 6 74670 117 79669595
Joint stiffness 17.73 10.55 8 74668 40822 79628890
Nephrogenic anaemia 17.65 10.55 20 74656 3882 79665830
Cardiac failure acute 17.55 10.55 48 74628 18881 79650831
Ketonuria 17.47 10.55 12 74664 1196 79668516
Atrioventricular block complete 17.31 10.55 44 74632 16566 79653146
Blood triglycerides increased 17.21 10.55 51 74625 20989 79648723
Diabetic coma 17.09 10.55 12 74664 1239 79668473
Hemiplegia 17.08 10.55 41 74635 14898 79654814
Cholangiocarcinoma 17.06 10.55 16 74660 2490 79667222
Embolic cerebral infarction 16.92 10.55 12 74664 1259 79668453
Gastroenteritis 16.90 10.55 70 74606 34012 79635700
Cerebral haemorrhage 16.88 10.55 102 74574 57571 79612141
Gamma-glutamyltransferase increased 16.84 10.55 98 74578 54582 79615130
Jaundice 16.68 10.55 96 74580 53253 79616459
Poverty of speech 16.61 10.55 9 74667 585 79669127
Hypoglycaemic seizure 16.39 10.55 10 74666 814 79668898
Depressed level of consciousness 16.31 10.55 150 74526 96502 79573210
Bile duct stone 16.28 10.55 23 74653 5566 79664146
Sudden hearing loss 16.23 10.55 14 74662 1955 79667757
Renal disorder 16.04 10.55 80 74596 42025 79627687
Brain stem infarction 16.03 10.55 14 74662 1987 79667725
Toe amputation 15.94 10.55 19 74657 3892 79665820
Abortion spontaneous 15.91 10.55 4 74672 29503 79640209
Polyuria 15.89 10.55 40 74636 14974 79654738
Adenocarcinoma pancreas 15.84 10.55 14 74662 2019 79667693
Oliguria 15.77 10.55 42 74634 16267 79653445
Peripheral arterial occlusive disease 15.76 10.55 28 74648 8230 79661482
Gingival hypertrophy 15.76 10.55 17 74659 3125 79666587
COVID-19 15.74 10.55 85 74591 157589 79512123
Cytokine release syndrome 15.71 10.55 7 74669 35991 79633721
Rash 15.68 10.55 417 74259 577941 79091771
Bradycardia 15.68 10.55 195 74481 135362 79534350
Ballismus 15.66 10.55 7 74669 299 79669413
Ureteric cancer recurrent 15.37 10.55 4 74672 30 79669682
Hyperventilation 15.36 10.55 27 74649 7872 79661840
Dysarthria 15.21 10.55 112 74564 67510 79602202
Urine ketone body 14.99 10.55 6 74670 194 79669518
Reperfusion injury 14.96 10.55 6 74670 195 79669517
Therapeutic response decreased 14.67 10.55 25 74651 66828 79602884
Blood lactate dehydrogenase increased 14.63 10.55 74 74602 39096 79630616
Testicular swelling 14.36 10.55 11 74665 1299 79668413
Anaemia vitamin B12 deficiency 14.25 10.55 9 74667 779 79668933
Product commingling 14.17 10.55 5 74671 113 79669599
Brain stem haemorrhage 14.14 10.55 12 74664 1638 79668074
Ventricular tachycardia 14.13 10.55 77 74599 41858 79627854
Glycosylated haemoglobin abnormal 13.98 10.55 6 74670 232 79669480
Insulin resistance 13.86 10.55 11 74665 1368 79668344
Mixed anxiety and depressive disorder 13.66 10.55 7 74669 406 79669306
Generalised oedema 13.62 10.55 51 74625 23658 79646054
Hyporesponsive to stimuli 13.58 10.55 13 74663 2075 79667637
Glucose urine present 13.50 10.55 12 74664 1744 79667968
Foot deformity 13.50 10.55 3 74673 24071 79645641
Lymphocyte stimulation test positive 13.50 10.55 10 74666 1123 79668589
Chronic kidney disease 13.44 10.55 107 74569 66047 79603665
Sudden death 13.42 10.55 49 74627 22462 79647250
Carotid artery stenosis 13.38 10.55 27 74649 8731 79660981
Transitional cell carcinoma 13.19 10.55 14 74662 2527 79667185
Embolic stroke 13.01 10.55 25 74651 7801 79661911
Premature delivery 13.00 10.55 3 74673 23464 79646248
Night sweats 12.84 10.55 18 74658 52077 79617635
Sedation 12.73 10.55 18 74658 51877 79617835
Musculoskeletal pain 12.68 10.55 51 74625 102303 79567409
Aspartate aminotransferase increased 12.59 10.55 191 74485 138450 79531262
Dialysis 12.57 10.55 42 74634 18420 79651292
Peripheral vascular disorder 12.56 10.55 25 74651 8005 79661707
Diabetic ketosis 12.40 10.55 7 74669 493 79669219
Sleep disorder 12.40 10.55 40 74636 85637 79584075
Status epilepticus 12.38 10.55 4 74672 25037 79644675
Glomerular filtration rate decreased 12.36 10.55 48 74628 22654 79647058
Drug ineffective for unapproved indication 12.34 10.55 18 74658 51220 79618492
Asthma 12.32 10.55 75 74601 135020 79534692
Joint range of motion decreased 12.29 10.55 8 74668 33274 79636438
Cardiovascular disorder 12.27 10.55 41 74635 17984 79651728
Anti-insulin antibody 12.14 10.55 4 74672 73 79669639
Bronchiectasis 12.13 10.55 3 74673 22383 79647329
Bile duct cancer 12.11 10.55 9 74667 1015 79668697
Osteoporosis 12.09 10.55 20 74656 54092 79615620
Continuous haemodiafiltration 12.08 10.55 12 74664 2004 79667708
Thyroid adenoma 12.07 10.55 5 74671 177 79669535
Ear pain 12.00 10.55 8 74668 32861 79636851
Coagulation test abnormal 11.98 10.55 10 74666 1335 79668377
Blood insulin decreased 11.96 10.55 3 74673 19 79669693
Injection site swelling 11.91 10.55 16 74660 47116 79622596
Vitreous haemorrhage 11.90 10.55 16 74660 3697 79666015
Hepatic steatosis 11.85 10.55 68 74608 37670 79632042
Testicular pain 11.84 10.55 12 74664 2053 79667659
Hyponatraemia 11.81 10.55 233 74443 177615 79492097
Osteoarthritis 11.79 10.55 42 74634 87267 79582445
Grip strength decreased 11.72 10.55 3 74673 21866 79647846
Coagulation factor increased 11.70 10.55 4 74672 82 79669630
Bladder neoplasm 11.65 10.55 11 74665 1726 79667986
Stomatitis 11.61 10.55 85 74591 146672 79523040
Renal abscess 11.59 10.55 9 74667 1084 79668628
Disseminated intravascular coagulation 11.53 10.55 65 74611 35777 79633935
Leukopenia 11.52 10.55 63 74613 116450 79553262
Anaphylactic reaction 11.50 10.55 40 74636 83703 79586009
Haemorrhage subcutaneous 11.44 10.55 18 74658 4791 79664921
Pancreatic disorder 11.43 10.55 15 74661 3387 79666325
Diabetic hyperglycaemic coma 11.40 10.55 4 74672 89 79669623
Electrolyte imbalance 11.29 10.55 58 74618 30823 79638889
Cytomegalovirus infection 11.26 10.55 14 74662 42630 79627082
Blood sodium decreased 11.16 10.55 61 74615 33194 79636518
Respiratory depression 11.11 10.55 6 74670 27624 79642088
Cerebral ischaemia 10.99 10.55 29 74647 11166 79658546
Dry eye 10.99 10.55 11 74665 36920 79632792
Myelosuppression 10.89 10.55 13 74663 40283 79629429
Cholangitis acute 10.85 10.55 10 74666 1522 79668190
Chronic gastritis 10.77 10.55 16 74660 4052 79665660
Pylorus dilatation 10.76 10.55 3 74673 30 79669682
Therapeutic product effect incomplete 10.75 10.55 83 74593 141562 79528150
Progressive multifocal leukoencephalopathy 10.71 10.55 3 74673 20597 79649115
Vitamin B12 deficiency 10.68 10.55 22 74654 7219 79662493
Kussmaul respiration 10.65 10.55 6 74670 421 79669291
Blood pressure systolic increased 10.61 10.55 30 74646 66956 79602756
Cough 10.58 10.55 262 74414 366527 79303185
Illness 10.57 10.55 17 74659 46494 79623218

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BB12 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
ATC A10BD04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Combinations of oral blood glucose lowering drugs
ATC A10BD06 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Combinations of oral blood glucose lowering drugs
FDA CS M0020795 Sulfonylurea Compounds
CHEBI has role CHEBI:35526 antidiabetic
CHEBI has role CHEBI:90415 insulin secretagogues
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D007004 Hypoglycemic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
FDA EPC N0000175608 Sulfonylurea

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352
Treatment Refractory Type 2 Diabetes Mellitus indication
Alcoholism contraindication 7200002
Weight gain finding contraindication 8943002
Asthenia contraindication 13791008
Pulmonary edema contraindication 19242006 DOID:11396
Myocardial infarction contraindication 22298006 DOID:5844
Macular retinal edema contraindication 37231002 DOID:4449
Infectious disease contraindication 40733004
Body fluid retention contraindication 43498006
Chronic heart failure contraindication 48447003
Hepatic porphyria contraindication 55056006 DOID:3133
Hemolytic anemia contraindication 61261009 DOID:583
Glucose-6-phosphate dehydrogenase deficiency anemia contraindication 62403005
Osteoporosis contraindication 64859006 DOID:11476
Hypopituitarism contraindication 74728003 DOID:9406
Kidney disease contraindication 90708001 DOID:557
Fracture of bone contraindication 125605004
Autonomic dysreflexia contraindication 129618003
Liver function tests abnormal contraindication 166603001
Angina pectoris contraindication 194828000
Decompensated cardiac failure contraindication 195111005
Cerebrovascular accident contraindication 230690007
Disease of liver contraindication 235856003 DOID:409
Drug-induced hepatitis contraindication 235876009
Hypoglycemic disorder contraindication 237630007
Edema contraindication 267038008
Osteopenia contraindication 312894000
Primary adrenocortical insufficiency contraindication 373662000
Fever contraindication 386661006
Surgical procedure contraindication 387713003
Malignant tumor of urinary bladder contraindication 399326009 DOID:11054
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic injury contraindication 417746004
Fever greater than 100.4 Fahrenheit contraindication 426000000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.31 acidic
pKa2 13.98 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Ki 9.24 WOMBAT-PK CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 6.07 CHEMBL
Sulfonylurea receptor 2, Kir6.2 Ion channel BLOCKER Ki 7.98 WOMBAT-PK

External reference:

IDSource
4020945 VUID
N0000148425 NUI
D00593 KEGG_DRUG
4020945 VANDF
C0061323 UMLSCUI
CHEBI:5383 CHEBI
GMR PDB_CHEM_ID
CHEMBL1481 ChEMBL_ID
DB00222 DRUGBANK_ID
C057619 MESH_SUPPLEMENTAL_RECORD_UI
6820 IUPHAR_LIGAND_ID
5718 INN_ID
6KY687524K UNII
3476 PUBCHEM_CID
25789 RXNORM
4782 MMSL
72042 MMSL
d03864 MMSL
005624 NDDF
109079009 SNOMEDCT_US
386966003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
AMARYL HUMAN PRESCRIPTION DRUG LABEL 1 0039-0221 TABLET 1 mg ORAL NDA 26 sections
AMARYL HUMAN PRESCRIPTION DRUG LABEL 1 0039-0222 TABLET 2 mg ORAL NDA 26 sections
AMARYL HUMAN PRESCRIPTION DRUG LABEL 1 0039-0223 TABLET 4 mg ORAL NDA 26 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0440-6564 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0440-6565 TABLET 2 mg ORAL ANDA 26 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0440-6566 TABLET 4 mg ORAL ANDA 26 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8332 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8333 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8334 TABLET 4 mg ORAL ANDA 25 sections
Pioglitazone hydrochloride and glimepiride HUMAN PRESCRIPTION DRUG LABEL 2 0781-5634 TABLET 2 mg ORAL ANDA 28 sections
Pioglitazone hydrochloride and glimepiride HUMAN PRESCRIPTION DRUG LABEL 2 0781-5635 TABLET 4 mg ORAL ANDA 28 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 10544-217 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 10544-219 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-773 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-773 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-774 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-774 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-775 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride Human Prescription Drug Label 1 16571-775 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-001 TABLET 1 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-002 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 16729-003 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 21695-746 TABLET 2 mg ORAL ANDA 20 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 21695-747 TABLET 4 mg ORAL ANDA 20 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 21695-993 TABLET 1 mg ORAL ANDA 20 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 33261-831 TABLET 2 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 33261-892 TABLET 4 mg ORAL ANDA 25 sections
Glimepiride HUMAN PRESCRIPTION DRUG LABEL 1 33261-961 TABLET 1 mg ORAL ANDA 26 sections
GLIMEPIRIDE HUMAN PRESCRIPTION DRUG LABEL 1 42549-498 TABLET 4 mg ORAL ANDA 28 sections
GLIMEPIRIDE HUMAN PRESCRIPTION DRUG LABEL 1 42549-499 TABLET 2 mg ORAL ANDA 24 sections