All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

glimepiride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antihyperglycaemics	1300	93479-97-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: glimepiride diameprid glimax glimperide glirid	Molecular weight: 490.62 Formula: C24H34N4O5S CLOGP: 3.96 LIPINSKI: 0 HAC: 9 HDO: 3 TPSA: 124.68 ALOGS: -4.11 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
2	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.01 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	0 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.23 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	99 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.19 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.50 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.01 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	10 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Nov. 30, 1995	FDA	SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	2120.46	11.09	961	42412	59104	63386545
Blood glucose increased	557.90	11.09	460	42913	83296	63362353
Lactic acidosis	481.08	11.09	309	43064	37978	63407671
Hypoglycaemic coma	380.21	11.09	118	43255	2457	63443192
Diabetes mellitus inadequate control	269.91	11.09	153	43220	14973	63430676
Glycosylated haemoglobin increased	250.21	11.09	136	43237	12262	63433387
Blood glucose decreased	221.66	11.09	152	43221	20800	63424849
Acute kidney injury	204.59	11.09	512	42861	262903	63182746
Hypoglycaemic encephalopathy	201.46	11.09	46	43327	266	63445383
Hyperglycaemia	149.48	11.09	163	43210	41704	63403945
Drug ineffective	134.04	11.09	326	43047	1044439	62401210
Systemic lupus erythematosus	114.83	11.09	7	43366	208911	63236738
Maternal exposure during pregnancy	110.80	11.09	11	43362	220051	63225598
Diabetic ketoacidosis	108.68	11.09	99	43274	20406	63425243
Pemphigus	107.90	11.09	4	43369	183722	63261927
Contraindicated product administered	106.70	11.09	12	43361	217636	63228013
Infusion related reaction	105.45	11.09	20	43353	245501	63200148
Drug intolerance	103.06	11.09	41	43332	308620	63137029
Euglycaemic diabetic ketoacidosis	102.13	11.09	50	43323	3624	63442025
Synovitis	97.70	11.09	8	43365	186910	63258739
Glossodynia	95.34	11.09	7	43366	178869	63266780
Hyperkalaemia	91.46	11.09	146	43227	54057	63391592
Joint swelling	90.58	11.09	56	43317	327610	63118039
Myocardial infarction	90.05	11.09	206	43167	99687	63345962
Pancreatitis	89.54	11.09	137	43236	48918	63396731
Diabetic metabolic decompensation	85.18	11.09	35	43338	1675	63443974
Cardiac failure congestive	82.63	11.09	190	43183	92243	63353406
Cerebral infarction	78.34	11.09	89	43284	23804	63421845
Renal failure	78.12	11.09	216	43157	117436	63328213
Off label use	77.32	11.09	222	43151	674240	62771409
Metabolic acidosis	74.12	11.09	120	43253	44949	63400700
Diabetes mellitus	72.66	11.09	134	43239	55676	63389973
Exposure during pregnancy	70.42	11.09	11	43362	155536	63290113
Eosinophilic myocarditis	69.30	11.09	23	43350	597	63445052
Alopecia	68.31	11.09	78	43295	337458	63108191
Pericarditis	67.73	11.09	6	43367	131573	63314076
Blood glucose fluctuation	65.11	11.09	40	43333	4536	63441113
Pancreatitis acute	64.48	11.09	86	43287	27080	63418569
Therapeutic product effect decreased	63.87	11.09	26	43347	193161	63252488
Rheumatoid arthritis	60.16	11.09	51	43322	253768	63191881
Altered state of consciousness	60.08	11.09	80	43293	25150	63420499
Dehydration	59.99	11.09	256	43117	173098	63272551
Decreased appetite	59.09	11.09	332	43041	250720	63194929
Hypersensitivity	58.81	11.09	68	43305	292617	63153032
Wound	55.56	11.09	21	43352	163242	63282407
Loss of consciousness	55.27	11.09	192	43181	117929	63327720
Pancreatic carcinoma	55.10	11.09	44	43329	7584	63438065
Renal impairment	54.51	11.09	158	43215	88197	63357452
Coronary artery disease	54.31	11.09	87	43286	32290	63413359
Swelling	53.17	11.09	66	43307	275312	63170337
Pain	51.79	11.09	296	43077	740332	62705317
MELAS syndrome	50.86	11.09	13	43360	128	63445521
Blood glucose abnormal	49.63	11.09	42	43331	7850	63437799
Helicobacter infection	48.38	11.09	4	43369	92781	63352868
Arthropathy	47.74	11.09	54	43319	234738	63210911
Discomfort	47.03	11.09	28	43345	167346	63278303
Treatment failure	45.93	11.09	41	43332	199002	63246647
Product use issue	45.62	11.09	50	43323	220470	63225179
Duodenal ulcer perforation	44.81	11.09	4	43369	87205	63358444
Musculoskeletal stiffness	43.84	11.09	37	43336	184581	63261068
Sopor	43.42	11.09	64	43309	22100	63423549
Cold sweat	43.14	11.09	47	43326	12000	63433649
Neuroglycopenia	42.74	11.09	15	43358	463	63445186
Abdominal discomfort	42.49	11.09	98	43275	320787	63124862
Diarrhoea	42.22	11.09	704	42669	714662	62730987
Hyperhidrosis	41.01	11.09	164	43209	107672	63337977
Drug interaction	38.95	11.09	279	43094	228852	63216797
Blood creatinine increased	38.68	11.09	140	43233	87704	63357945
Postprandial hypoglycaemia	37.93	11.09	9	43364	63	63445586
Fall	37.86	11.09	422	42951	391912	63053737
Cardiac failure	37.51	11.09	140	43233	89002	63356647
Ketoacidosis	35.41	11.09	27	43346	4351	63441298
Cholelithiasis	34.59	11.09	86	43287	43839	63401810
Weight decreased	34.52	11.09	314	43059	276484	63169165
Dermatitis exfoliative	34.22	11.09	29	43344	5430	63440219
Drug level increased	33.97	11.09	58	43315	22678	63422971
Blood urea increased	33.90	11.09	63	43310	26316	63419333
Insulin C-peptide increased	32.57	11.09	8	43365	66	63445583
Nasopharyngitis	31.78	11.09	80	43293	254177	63191472
Anuria	31.74	11.09	41	43332	12510	63433139
Arthralgia	31.05	11.09	245	43128	569465	62876184
Drug hypersensitivity	30.73	11.09	109	43264	310578	63135071
Sinusitis	30.15	11.09	69	43304	226584	63219065
Hyperinsulinaemia	29.28	11.09	8	43365	104	63445545
Hypoglycaemic unconsciousness	29.11	11.09	13	43360	764	63444885
Mobility decreased	29.10	11.09	24	43349	121135	63324514
Intentional product use issue	28.71	11.09	27	43346	127865	63317784
Ketosis	28.68	11.09	12	43361	601	63445048
Product use in unapproved indication	28.57	11.09	49	43324	179031	63266618
Hepatic function abnormal	28.49	11.09	72	43301	37070	63408579
Shock hypoglycaemic	28.41	11.09	8	43365	117	63445532
Fatigue	28.34	11.09	432	42941	887596	62558053
Pyelonephritis acute	27.76	11.09	24	43349	4617	63441032
Hypoparathyroidism	27.52	11.09	12	43361	666	63444983
Irritable bowel syndrome	27.36	11.09	11	43362	82401	63363248
Thrombotic cerebral infarction	27.29	11.09	8	43365	136	63445513
Diabetic retinopathy	27.28	11.09	18	43355	2309	63443340
Ill-defined disorder	27.00	11.09	11	43362	81744	63363905
Psoriatic arthropathy	26.14	11.09	15	43358	91505	63354144
Bladder cancer	25.89	11.09	25	43348	5541	63440108
Hyponatraemia	25.62	11.09	147	43226	111753	63333896
Injection site nodule	25.33	11.09	21	43352	3814	63441835
Biopsy skin abnormal	25.14	11.09	7	43366	98	63445551
Hepatic enzyme increased	25.01	11.09	64	43309	202264	63243385
Rhabdomyolysis	24.63	11.09	76	43297	43875	63401774
Asthenia	24.56	11.09	383	42990	383221	63062428
Infection	24.29	11.09	78	43295	229095	63216554
Liver injury	23.78	11.09	6	43367	60514	63385135
Rash	23.71	11.09	257	43116	560614	62885035
Restlessness	23.54	11.09	58	43315	29395	63416254
Embolic cerebellar infarction	23.41	11.09	5	43368	20	63445629
Depressed level of consciousness	23.26	11.09	94	43279	61984	63383665
Hyperglycaemic hyperosmolar nonketotic syndrome	23.20	11.09	12	43361	977	63444672
Anaemia	23.17	11.09	304	43069	293126	63152523
Oedema peripheral	23.10	11.09	214	43159	189297	63256352
Blood insulin increased	22.91	11.09	7	43366	138	63445511
Nausea	22.80	11.09	753	42620	853718	62591931
Diabetic neuropathy	22.70	11.09	20	43353	3944	63441705
Cholecystitis	22.67	11.09	39	43334	15338	63430311
Blood potassium increased	22.62	11.09	43	43330	18266	63427383
Hip arthroplasty	22.41	11.09	3	43370	47643	63398006
Anaemia vitamin B12 deficiency	22.32	11.09	9	43364	410	63445239
Hypothermia	22.10	11.09	36	43337	13545	63432104
Impaired healing	21.46	11.09	23	43350	102519	63343130
Diabetic complication	21.19	11.09	11	43362	902	63444747
Pancreatic carcinoma metastatic	21.15	11.09	15	43358	2163	63443486
Electrolyte imbalance	21.02	11.09	44	43329	20032	63425617
Poverty of speech	20.83	11.09	8	43365	320	63445329
Oliguria	20.36	11.09	28	43345	9073	63436576
Hyperthyroidism	20.06	11.09	36	43337	14637	63431012
Differential white blood cell count abnormal	19.78	11.09	10	43363	776	63444873
Peripheral swelling	19.73	11.09	104	43269	265838	63179811
Contusion	19.68	11.09	46	43327	149998	63295651
Coagulation test abnormal	19.64	11.09	10	43363	788	63444861
Cardiac arrest	19.52	11.09	119	43254	92426	63353223
Pancreatitis necrotising	19.48	11.09	13	43360	1699	63443950
Urine ketone body present	19.29	11.09	15	43358	2488	63443161
Anti-insulin antibody increased	19.06	11.09	5	43368	55	63445594
Retinal haemorrhage	18.87	11.09	20	43353	4949	63440700
Ballismus	18.72	11.09	6	43367	139	63445510
Migraine	18.65	11.09	26	43347	103320	63342329
Bradypnoea	18.53	11.09	17	43356	3533	63442116
Urogenital haemorrhage	18.47	11.09	7	43366	270	63445379
Vomiting	18.04	11.09	505	42868	559112	62886537
Glycosylated haemoglobin abnormal	18.03	11.09	6	43367	157	63445492
Abortion spontaneous	17.93	11.09	5	43368	47190	63398459
Mixed anxiety and depressive disorder	17.88	11.09	7	43366	295	63445354
Drug abuse	17.86	11.09	14	43359	72504	63373145
Blood creatine phosphokinase increased	17.40	11.09	53	43320	30377	63415272
Ventricular fibrillation	17.37	11.09	30	43343	11837	63433812
Hepatic steatosis	17.30	11.09	51	43322	28718	63416931
Glomerular filtration rate decreased	17.14	11.09	32	43341	13409	63432240
Medication error	17.12	11.09	76	43297	52208	63393441
Hyperventilation	17.09	11.09	21	43352	6095	63439554
Muscle discomfort	16.89	11.09	6	43367	192	63445457
Musculoskeletal pain	16.87	11.09	23	43350	92254	63353395
Hyporesponsive to stimuli	16.60	11.09	10	43363	1094	63444555
Headache	16.27	11.09	320	43053	632921	62812728
Tachypnoea	15.92	11.09	36	43337	17266	63428383
Pregnancy	15.79	11.09	3	43370	36833	63408816
Urinary tract infection	15.69	11.09	261	43112	264423	63181226
Hypomagnesaemia	15.46	11.09	49	43324	28688	63416961
Arteriosclerosis	15.46	11.09	26	43347	10040	63435609
Macular oedema	15.43	11.09	16	43357	3861	63441788
Atrial fibrillation	15.37	11.09	134	43239	116502	63329147
Gastrointestinal disorder	15.09	11.09	43	43330	131196	63314453
Blood triglycerides increased	15.02	11.09	29	43344	12459	63433190
Gastroenteritis	14.91	11.09	46	43327	26544	63419105
Fibromyalgia	14.74	11.09	20	43353	80400	63365249
Hypoglycaemic seizure	14.59	11.09	7	43366	485	63445164
Retinopathy proliferative	14.43	11.09	4	43369	55	63445594
Myocardial ischaemia	14.42	11.09	29	43344	12830	63432819
Angina pectoris	14.14	11.09	49	43324	30029	63415620
Pemphigoid	14.09	11.09	21	43352	7323	63438326
Embolic cerebral infarction	14.06	11.09	7	43366	526	63445123
Carotid arteriosclerosis	14.05	11.09	9	43364	1097	63444552
Ectopic ACTH syndrome	14.02	11.09	5	43368	162	63445487
Dysarthria	13.92	11.09	62	43311	42649	63403000
Reperfusion injury	13.70	11.09	4	43369	67	63445582
Hypertriglyceridaemia	13.62	11.09	19	43354	6240	63439409
Azotaemia	13.55	11.09	16	43357	4455	63441194
Phobia	13.51	11.09	6	43367	348	63445301
Cerebral reperfusion injury	13.19	11.09	3	43370	17	63445632
Jaundice	13.19	11.09	47	43326	29204	63416445
Metabolic encephalopathy	13.19	11.09	18	43355	5791	63439858
Lipase increased	13.16	11.09	24	43349	9876	63435773
Pylorus dilatation	13.04	11.09	3	43370	18	63445631
Metabolic alkalosis	12.85	11.09	13	43360	3048	63442601
Disorientation	12.66	11.09	57	43316	39395	63406254
Cerebral ischaemia	12.56	11.09	19	43354	6709	63438940
Toxic epidermal necrolysis	12.55	11.09	42	43331	25292	63420357
Ischaemic cerebral infarction	12.45	11.09	9	43364	1337	63444312
Capillary leak syndrome	12.40	11.09	11	43362	2189	63443460
Continuous haemodiafiltration	12.29	11.09	8	43365	1003	63444646
Hypophagia	12.24	11.09	48	43325	31211	63414438
Dizziness	12.20	11.09	382	42991	429543	63016106
Cerebrovascular accident	12.16	11.09	120	43253	107904	63337745
Neutropenia	12.11	11.09	70	43303	174935	63270714
Compartment syndrome	12.04	11.09	11	43362	2273	63443376
Colon cancer	11.95	11.09	23	43350	9855	63435794
Premature delivery	11.90	11.09	3	43370	30278	63415371
Adenocarcinoma pancreas	11.82	11.09	8	43365	1070	63444579
Transient ischaemic attack	11.70	11.09	54	43319	37699	63407950
Respiratory tract infection	11.56	11.09	7	43366	41476	63404173
Lymphocyte count increased	11.53	11.09	13	43360	3445	63442204
Head injury	11.49	11.09	43	43330	27353	63418296
Cardiac failure acute	11.31	11.09	22	43351	9501	63436148
Anti-insulin antibody	11.28	11.09	3	43370	35	63445614
C-reactive protein abnormal	11.22	11.09	9	43364	46087	63399562
Blood ketone body increased	11.18	11.09	5	43368	295	63445354

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	1644.70	11.31	974	45050	53666	34857241
Blood glucose increased	353.30	11.31	437	45587	66281	34844626
Hypoglycaemic coma	343.83	11.31	127	45897	2304	34908603
Lactic acidosis	306.70	11.31	298	45726	34474	34876433
Diabetes mellitus inadequate control	278.72	11.31	190	45834	13274	34897633
Glycosylated haemoglobin increased	213.29	11.31	151	45873	11209	34899698
Cerebral infarction	146.95	11.31	181	45843	27274	34883633
Off label use	131.04	11.31	220	45804	419304	34491603
Blood glucose decreased	113.89	11.31	112	45912	13125	34897782
Pancreatitis	111.86	11.31	191	45833	38700	34872207
Myocardial infarction	105.70	11.31	375	45649	120710	34790197
Pancreatitis acute	99.76	11.31	152	45872	27989	34882918
Hyperglycaemia	99.50	11.31	183	45841	39297	34871610
Coronary artery disease	98.75	11.31	205	45819	48100	34862807
Cardiac failure congestive	97.24	11.31	285	45739	82985	34827922
Hyperkalaemia	94.32	11.31	251	45773	69138	34841769
Drug abuse	87.64	11.31	13	46011	99083	34811824
Bladder cancer	78.63	11.31	102	45922	16176	34894731
Pancreatic carcinoma	77.85	11.31	76	45948	8825	34902082
Hypoglycaemic encephalopathy	75.05	11.31	24	46000	275	34910632
Product use in unapproved indication	74.03	11.31	31	45993	117468	34793439
Interstitial lung disease	73.86	11.31	221	45803	65061	34845846
Diabetic ketoacidosis	73.44	11.31	104	45920	17928	34892979
Acute kidney injury	64.33	11.31	648	45376	304340	34606567
Hepatic function abnormal	61.79	11.31	162	45862	44201	34866706
Drug ineffective	56.25	11.31	362	45662	456389	34454518
Toxicity to various agents	51.10	11.31	118	45906	200244	34710663
Blood lactic acid	48.64	11.31	18	46006	328	34910579
Diabetes mellitus	46.81	11.31	152	45872	46721	34864186
Altered state of consciousness	46.57	11.31	97	45927	22796	34888111
Diabetic neuropathy	42.75	11.31	39	45985	4158	34906749
Renal impairment	41.57	11.31	239	45785	94274	34816633
Febrile neutropenia	41.35	11.31	73	45951	136776	34774131
Decreased appetite	40.64	11.31	365	45659	166027	34744880
Foetal exposure during pregnancy	38.74	11.31	3	46021	38098	34872809
Diabetic retinopathy	38.43	11.31	26	45998	1791	34909116
Pemphigoid	38.30	11.31	52	45972	8614	34902293
Diabetic nephropathy	34.73	11.31	26	45998	2102	34908805
Blood glucose abnormal	33.05	11.31	40	45984	5912	34904995
Acute myocardial infarction	32.82	11.31	149	45875	53570	34857337
Diabetic metabolic decompensation	32.04	11.31	23	46001	1743	34909164
Cerebrovascular accident	31.91	11.31	206	45818	84605	34826302
Hepatocellular carcinoma	31.59	11.31	44	45980	7465	34903442
Treatment failure	31.58	11.31	11	46013	46686	34864221
Dyslalia	30.93	11.31	15	46009	545	34910362
Bladder transitional cell carcinoma	29.67	11.31	26	45998	2629	34908278
Blindness transient	29.40	11.31	24	46000	2202	34908705
Gastric cancer	28.87	11.31	39	45985	6430	34904477
Renal failure	28.64	11.31	280	45744	130277	34780630
Hypoglycaemic unconsciousness	28.62	11.31	16	46008	782	34910125
Urine ketone body present	28.11	11.31	18	46006	1130	34909777
Neutropenia	27.92	11.31	109	45915	156669	34754238
Diabetic gangrene	27.76	11.31	11	46013	243	34910664
Pancreatic carcinoma metastatic	27.40	11.31	26	45998	2914	34907993
Euglycaemic diabetic ketoacidosis	27.22	11.31	27	45997	3195	34907712
Cardiac failure	25.85	11.31	207	45817	91041	34819866
Myocardial ischaemia	25.70	11.31	65	45959	17343	34893564
Lipase increased	25.42	11.31	45	45979	9371	34901536
Liver disorder	25.20	11.31	98	45926	32899	34878008
Metabolic acidosis	25.09	11.31	119	45905	43561	34867346
Coronary artery stenosis	24.74	11.31	45	45979	9571	34901336
Shock	24.66	11.31	79	45945	24100	34886807
Mucosal inflammation	24.61	11.31	10	46014	38612	34872295
Drug resistance	23.85	11.31	3	46021	25924	34884983
Rhabdomyolysis	22.90	11.31	161	45863	68002	34842905
Lacunar infarction	22.67	11.31	24	46000	3066	34907841
Amylase increased	22.22	11.31	33	45991	5935	34904972
Blood glucose fluctuation	22.17	11.31	27	45997	4017	34906890
Joint swelling	21.89	11.31	28	45996	59862	34851045
Albumin urine present	20.35	11.31	10	46014	374	34910533
Glycosylated haemoglobin decreased	20.28	11.31	10	46014	377	34910530
Blood urea increased	19.88	11.31	86	45938	30278	34880629
Latent autoimmune diabetes in adults	19.50	11.31	6	46018	60	34910847
Brain stem infarction	19.46	11.31	15	46009	1267	34909640
Death	19.33	11.31	389	45635	397660	34513247
Product commingling	19.25	11.31	5	46019	25	34910882
Completed suicide	18.93	11.31	66	45958	98102	34812805
Intentional product use issue	18.88	11.31	31	45993	59785	34851122
Lower respiratory tract infection	18.88	11.31	9	46015	31628	34879279
Oedema peripheral	18.54	11.31	240	45784	119572	34791335
Infusion related reaction	18.18	11.31	26	45998	53031	34857876
Cytokine release syndrome	18.05	11.31	4	46020	22873	34888034
Pyrexia	17.83	11.31	320	45704	332693	34578214
Nephrogenic anaemia	17.71	11.31	18	46006	2193	34908714
Hyperglycaemic hyperosmolar nonketotic syndrome	17.33	11.31	14	46010	1266	34909641
Haemorrhagic cerebral infarction	17.32	11.31	12	46012	859	34910048
Blood creatinine increased	17.19	11.31	196	45828	94780	34816127
COVID-19	17.16	11.31	49	45975	77501	34833406
Product use issue	17.08	11.31	36	45988	63180	34847727
Loss of consciousness	17.00	11.31	175	45849	82492	34828415
Colon cancer	16.91	11.31	36	45988	8585	34902322
Ischaemic cardiomyopathy	16.56	11.31	30	45994	6359	34904548
Blood triglycerides increased	16.05	11.31	48	45976	14111	34896796
Ketonuria	16.01	11.31	10	46014	601	34910306
Hypothermia	15.72	11.31	40	45984	10708	34900199
Therapy non-responder	15.70	11.31	17	46007	39129	34871778
Hyperlipidaemia	15.30	11.31	48	45976	14481	34896426
Type 2 diabetes mellitus	15.11	11.31	51	45973	15981	34894926
Blood lactate dehydrogenase increased	14.96	11.31	65	45959	22925	34887982
Angina pectoris	14.89	11.31	81	45943	31282	34879625
Cytomegalovirus infection	14.75	11.31	8	46016	26127	34884780
Thrombotic cerebral infarction	14.68	11.31	8	46016	372	34910535
Cholangiocarcinoma	14.65	11.31	13	46011	1336	34909571
Cardiac disorder	14.55	11.31	102	45922	43024	34867883
Wheezing	14.47	11.31	20	46004	41382	34869525
Aggression	14.46	11.31	18	46006	38946	34871961
Pancreatitis necrotising	14.45	11.31	18	46006	2740	34908167
Anti-insulin antibody increased	14.41	11.31	5	46019	75	34910832
Cardiovascular disorder	14.27	11.31	37	45987	10019	34900888
Intentional product misuse	14.05	11.31	24	46000	45587	34865320
Arteriosclerosis	13.97	11.31	41	45983	11927	34898980
Arthralgia	13.87	11.31	150	45874	169891	34741016
Pain	13.86	11.31	188	45836	204487	34706420
Blood pressure fluctuation	13.85	11.31	8	46016	25241	34885666
Product odour abnormal	13.83	11.31	10	46014	766	34910141
Headache	13.69	11.31	184	45840	200451	34710456
Anxiety	13.61	11.31	76	45948	99352	34811555
Carotid artery stenosis	13.57	11.31	24	46000	4995	34905912
Blood ketone body increased	13.53	11.31	8	46016	435	34910472
Dehydration	13.40	11.31	243	45781	129726	34781181
Gastric adenoma	13.30	11.31	3	46021	7	34910900
Weight decreased	13.07	11.31	314	45710	175987	34734920
Ischaemic stroke	12.96	11.31	53	45971	18197	34892710
Insulin resistance	12.93	11.31	9	46015	649	34910258
Hyperuricaemia	12.89	11.31	31	45993	8012	34902895
Dialysis	12.71	11.31	38	45986	11170	34899737
Suicidal ideation	12.68	11.31	21	46003	40367	34870540
Bile duct cancer	12.61	11.31	9	46015	676	34910231
Hospitalisation	12.55	11.31	36	45988	56866	34854041
Adenocarcinoma pancreas	12.52	11.31	12	46012	1362	34909545
Toe amputation	12.47	11.31	16	46008	2508	34908399
Cholelithiasis	12.42	11.31	58	45966	21090	34889817
Blood creatine phosphokinase increased	12.27	11.31	101	45923	44756	34866151
Gamma-glutamyltransferase increased	12.23	11.31	73	45951	29158	34881749
Drug intolerance	12.20	11.31	39	45985	59531	34851376
Retinal aneurysm	12.12	11.31	5	46019	123	34910784
Retinal haemorrhage	12.07	11.31	23	46001	5066	34905841
Migraine	12.02	11.31	4	46020	17474	34893433
Diabetic ketosis	11.65	11.31	5	46019	136	34910771
Coagulation factor increased	11.65	11.31	4	46020	58	34910849
Leukopenia	11.62	11.31	43	45981	62813	34848094
Renal disorder	11.55	11.31	65	45959	25415	34885492
Tachycardia	11.49	11.31	65	45959	84707	34826200
Pancreatic neuroendocrine tumour	11.46	11.31	6	46018	257	34910650
Cerebral haemorrhage	11.42	11.31	82	45942	34855	34876052
Chronic kidney disease	11.39	11.31	93	45931	41117	34869790
Hemiplegia	11.31	11.31	27	45997	6945	34903962

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	3545.07	10.55	1779	72897	99815	79569897
Lactic acidosis	784.34	10.55	596	74080	69763	79599949
Hypoglycaemic coma	685.75	10.55	231	74445	4529	79665183
Blood glucose increased	651.89	10.55	663	74013	114312	79555400
Diabetes mellitus inadequate control	494.79	10.55	299	74377	23965	79645747
Glycosylated haemoglobin increased	381.52	10.55	233	74443	19027	79650685
Acute kidney injury	263.08	10.55	1071	73605	518333	79151379
Hyperglycaemia	241.12	10.55	313	74363	70022	79599690
Hypoglycaemic encephalopathy	238.16	10.55	65	74611	596	79669116
Cerebral infarction	225.66	10.55	245	74431	45431	79624281
Blood glucose decreased	217.30	10.55	187	74489	26047	79643665
Hyperkalaemia	208.77	10.55	380	74296	114018	79555694
Myocardial infarction	195.93	10.55	491	74185	183638	79486074
Off label use	188.20	10.55	353	74323	906862	78762850
Drug ineffective	159.93	10.55	502	74174	1080411	78589301
Diabetic ketoacidosis	158.10	10.55	177	74499	33945	79635767
Cardiac failure congestive	158.04	10.55	386	74290	142016	79527696
Pancreatitis acute	145.96	10.55	205	74471	49399	79620313
Pancreatitis	144.82	10.55	243	74433	68332	79601380
Coronary artery disease	134.26	10.55	229	74447	65245	79604467
Joint swelling	124.89	10.55	57	74619	288589	79381123
Bladder cancer	118.51	10.55	117	74559	19409	79650303
Infusion related reaction	117.19	10.55	35	74641	230202	79439510
Euglycaemic diabetic ketoacidosis	115.92	10.55	75	74601	6769	79662943
Synovitis	113.25	10.55	7	74669	150727	79518985
Drug intolerance	112.94	10.55	53	74623	264066	79405646
Diabetic metabolic decompensation	111.73	10.55	57	74619	3275	79666437
Renal failure	106.53	10.55	421	74255	200547	79469165
Pancreatic carcinoma	104.82	10.55	93	74583	13484	79656228
Altered state of consciousness	102.96	10.55	163	74513	43659	79626053
Diabetes mellitus	97.23	10.55	222	74454	78168	79591544
Metabolic acidosis	96.10	10.55	228	74448	82301	79587411
Hepatic function abnormal	93.97	10.55	210	74466	72897	79596815
Maternal exposure during pregnancy	92.47	10.55	10	74666	136528	79533184
Product use in unapproved indication	86.26	10.55	65	74611	250294	79419418
Lower respiratory tract infection	86.16	10.55	10	74666	129210	79540502
Systemic lupus erythematosus	84.31	10.55	8	74668	121141	79548571
Decreased appetite	84.26	10.55	579	74097	341839	79327873
Drug abuse	84.11	10.55	24	74652	162667	79507045
Contraindicated product administered	80.05	10.55	24	74652	157514	79512198
Hypersensitivity	74.91	10.55	81	74595	262158	79407554
Renal impairment	73.70	10.55	318	74358	157465	79512247
Interstitial lung disease	71.41	10.55	250	74426	112350	79557362
Pain	69.24	10.55	382	74294	703420	78966292
Arthralgia	68.64	10.55	289	74387	571514	79098198
Pemphigus	68.18	10.55	7	74669	99575	79570137
Diabetic neuropathy	67.70	10.55	52	74624	6164	79663548
Exposure during pregnancy	66.98	10.55	8	74668	101124	79568588
Blood glucose abnormal	65.40	10.55	64	74612	10502	79659210
Cardiac failure	64.74	10.55	302	74374	154540	79515172
Rheumatoid arthritis	63.38	10.55	61	74615	208409	79461303
Glossodynia	61.90	10.55	11	74665	103326	79566386
Therapeutic product effect decreased	61.11	10.55	39	74637	163824	79505888
Dehydration	60.59	10.55	419	74257	247768	79421944
Alopecia	60.13	10.55	77	74599	231278	79438434
Loss of consciousness	59.16	10.55	312	74364	167631	79502081
Diabetic retinopathy	57.49	10.55	36	74640	3070	79666642
Rhabdomyolysis	55.35	10.55	217	74459	102914	79566798
Treatment failure	55.26	10.55	47	74629	170439	79499273
Acute myocardial infarction	52.29	10.55	175	74501	76861	79592851
Pemphigoid	52.19	10.55	68	74608	15247	79654465
Product use issue	51.31	10.55	73	74603	209749	79459963
Hepatocellular carcinoma	50.96	10.55	52	74624	8969	79660743
Musculoskeletal stiffness	50.02	10.55	54	74622	174954	79494758
Bladder transitional cell carcinoma	49.77	10.55	31	74645	2619	79667093
Blood lactic acid	49.51	10.55	18	74658	445	79669267
Arthropathy	49.13	10.55	56	74620	177055	79492657
Blood glucose fluctuation	48.09	10.55	44	74632	6638	79663074
Helicobacter infection	47.45	10.55	5	74671	69699	79600013
Eosinophilic myocarditis	47.16	10.55	23	74653	1199	79668513
Intentional product use issue	46.82	10.55	44	74632	152068	79517644
Sinusitis	45.86	10.55	70	74606	195431	79474281
Swelling	45.83	10.55	83	74593	216628	79453084
Fatigue	45.53	10.55	606	74070	929121	78740591
Blood creatinine increased	43.41	10.55	271	74405	154786	79514926
Drug hypersensitivity	43.05	10.55	140	74536	298776	79370936
Duodenal ulcer perforation	42.01	10.55	6	74670	66205	79603507
MELAS syndrome	41.81	10.55	13	74663	195	79669517
Cold sweat	41.78	10.55	68	74608	18631	79651081
Ill-defined disorder	41.73	10.55	6	74670	65869	79603843
Urine ketone body present	41.43	10.55	31	74645	3534	79666178
Pericarditis	41.40	10.55	23	74653	104213	79565499
Hypothermia	40.73	10.55	75	74601	22671	79647041
Wound	40.19	10.55	30	74646	116149	79553563
Febrile neutropenia	40.03	10.55	99	74577	230900	79438812
Angina pectoris	39.16	10.55	122	74554	51610	79618102
Headache	38.93	10.55	408	74268	653364	79016348
Hyperglycaemic hyperosmolar nonketotic syndrome	38.42	10.55	25	74651	2278	79667434
Neuroglycopenia	37.95	10.55	15	74661	469	79669243
Cholelithiasis	37.85	10.55	122	74554	52542	79617170
Cerebrovascular accident	37.75	10.55	262	74414	155030	79514682
Gastric cancer	37.53	10.55	47	74629	10132	79659580
Nasopharyngitis	37.18	10.55	118	74558	253763	79415949
Ketosis	36.99	10.55	19	74657	1107	79668605
Hypoglycaemic unconsciousness	36.11	10.55	19	74657	1164	79668548
Mobility decreased	35.68	10.55	37	74639	122138	79547574
Colon cancer	35.46	10.55	55	74621	14468	79655244
Ketoacidosis	35.10	10.55	40	74636	7814	79661898
Diabetic nephropathy	35.08	10.55	26	74650	2921	79666791
Blood creatine phosphokinase increased	34.59	10.55	138	74538	65952	79603760
Irritable bowel syndrome	34.42	10.55	8	74668	62233	79607479
Psoriatic arthropathy	34.32	10.55	15	74661	77984	79591728
Oedema peripheral	33.72	10.55	373	74303	251915	79417797
Pancreatic carcinoma metastatic	33.63	10.55	28	74648	3725	79665987
Myocardial ischaemia	33.56	10.55	74	74602	25445	79644267
Postprandial hypoglycaemia	33.43	10.55	9	74667	78	79669634
Shock	33.24	10.55	103	74573	43445	79626267
Infection	32.89	10.55	116	74560	241596	79428116
Blood urea increased	32.37	10.55	110	74566	48680	79621032
Thrombotic cerebral infarction	32.22	10.55	14	74662	558	79669154
Muscle injury	31.76	10.55	4	74672	48557	79621155
Lipase increased	30.37	10.55	55	74621	16411	79653301
Coronary artery stenosis	30.09	10.55	47	74629	12437	79657275
Migraine	29.74	10.55	23	74653	87470	79582242
Albumin urine present	29.69	10.55	14	74662	677	79669035
Hyperinsulinaemia	29.63	10.55	10	74666	197	79669515
Glycosylated haemoglobin decreased	29.48	10.55	14	74662	688	79669024
Diarrhoea	29.43	10.55	1053	73623	879436	78790276
Dyslalia	29.31	10.55	16	74660	1056	79668656
Diabetic gangrene	29.17	10.55	10	74666	207	79669505
Peripheral swelling	28.84	10.55	142	74534	269475	79400237
Blood pressure fluctuation	27.86	10.55	14	74662	67131	79602581
Drug interaction	27.69	10.55	544	74132	414639	79255073
Discomfort	27.55	10.55	47	74629	125570	79544142
Ischaemic cardiomyopathy	27.53	10.55	35	74641	7660	79662052
Retinal haemorrhage	27.25	10.55	36	74640	8181	79661531
Anuria	26.68	10.55	60	74616	20903	79648809
Drug resistance	26.38	10.55	4	74672	42209	79627503
Neutropenia	26.13	10.55	160	74516	287550	79382162
Fall	26.13	10.55	619	74057	487010	79182702
Insulin C-peptide increased	25.85	10.55	8	74668	118	79669594
Azotaemia	25.52	10.55	35	74641	8241	79661471
C-reactive protein abnormal	25.23	10.55	7	74669	48360	79621352
Abdominal discomfort	24.60	10.55	136	74540	250591	79419121
Completed suicide	24.28	10.55	133	74543	245634	79424078
Arteriosclerosis	24.13	10.55	53	74623	18174	79651538
Diabetic complication	24.11	10.55	15	74661	1264	79668448
Shock hypoglycaemic	23.84	10.55	9	74667	248	79669464
Hyperuricaemia	23.82	10.55	41	74635	11758	79657954
Liver disorder	23.76	10.55	132	74544	72285	79597427
Cardiac disorder	23.71	10.55	123	74553	65634	79604078
Therapy non-responder	23.67	10.55	31	74645	92274	79577438
Transient ischaemic attack	23.65	10.55	105	74571	52590	79617122
Hypoparathyroidism	23.59	10.55	14	74662	1084	79668628
Latent autoimmune diabetes in adults	23.58	10.55	7	74669	89	79669623
Drug level increased	23.38	10.55	86	74590	39565	79630147
Blood ketone body increased	23.19	10.55	12	74664	710	79669002
Mucosal inflammation	23.09	10.55	22	74654	75558	79594154
Pancreatitis necrotising	22.94	10.55	23	74653	3885	79665827
Lacunar infarction	22.75	10.55	28	74648	5929	79663783
Wheezing	22.63	10.55	47	74629	116617	79553095
Blindness transient	22.50	10.55	25	74651	4751	79664961
Sopor	22.40	10.55	75	74601	32935	79636777
Prerenal failure	22.14	10.55	22	74654	3676	79666036
Haemorrhagic cerebral infarction	22.12	10.55	15	74661	1464	79668248
Weight decreased	21.87	10.55	460	74216	354738	79314974
Contusion	21.87	10.55	69	74607	148707	79521005
Cardiac arrest	21.87	10.55	252	74424	171844	79497868
Embolic cerebellar infarction	21.84	10.55	5	74671	20	79669692
Hepatic cancer	21.80	10.55	37	74639	10492	79659220
Fibromyalgia	21.75	10.55	17	74659	64323	79605389
Injection site nodule	21.74	10.55	22	74654	3758	79665954
Ischaemic stroke	21.36	10.55	74	74602	33057	79636655
Atrial fibrillation	21.36	10.55	281	74395	197605	79472107
Macular oedema	21.35	10.55	26	74650	5448	79664264
Hyperthyroidism	21.28	10.55	57	74619	22152	79647560
Platelet count decreased	21.25	10.55	277	74399	194387	79475325
Toxicity to various agents	21.17	10.55	273	74403	421267	79248445
Condition aggravated	21.14	10.55	336	74340	500788	79168924
Hip arthroplasty	20.99	10.55	4	74672	35752	79633960
Blood insulin increased	20.90	10.55	9	74667	351	79669361
Gastrointestinal disorder	20.67	10.55	53	74623	122152	79547560
Blood potassium increased	20.30	10.55	67	74609	29208	79640504
Impaired healing	19.96	10.55	32	74644	87623	79582089
Hyperhidrosis	19.77	10.55	223	74453	151269	79518443
Anaemia	19.74	10.55	551	74125	444464	79225248
Angina unstable	19.59	10.55	46	74630	16481	79653231
Chorea	19.54	10.55	17	74659	2400	79667312
Pyelonephritis acute	19.38	10.55	26	74650	5997	79663715
Loss of personal independence in daily activities	19.33	10.55	42	74634	102538	79567174
Hyperlipidaemia	19.25	10.55	61	74615	26032	79643680
Hepatic enzyme increased	19.04	10.55	97	74579	182513	79487199
Amylase increased	18.87	10.55	36	74640	11173	79658539
Inflammation	18.84	10.55	37	74639	93716	79575996
Biopsy skin abnormal	18.57	10.55	7	74669	192	79669520
Ectopic ACTH syndrome	18.54	10.55	7	74669	193	79669519
Arthritis	18.53	10.55	51	74625	114829	79554883
Dermatitis exfoliative	18.50	10.55	35	74641	10794	79658918
Cholecystitis	18.33	10.55	54	74622	22158	79647554
Anxiety	18.24	10.55	147	74529	248365	79421347
Syncope	18.20	10.55	252	74424	179197	79490515
Acute coronary syndrome	18.03	10.55	52	74624	21081	79648631
Blood lactic acid increased	17.95	10.55	38	74638	12706	79657006
Anti-insulin antibody increased	17.83	10.55	6	74670	117	79669595
Joint stiffness	17.73	10.55	8	74668	40822	79628890
Nephrogenic anaemia	17.65	10.55	20	74656	3882	79665830
Cardiac failure acute	17.55	10.55	48	74628	18881	79650831
Ketonuria	17.47	10.55	12	74664	1196	79668516
Atrioventricular block complete	17.31	10.55	44	74632	16566	79653146
Blood triglycerides increased	17.21	10.55	51	74625	20989	79648723
Diabetic coma	17.09	10.55	12	74664	1239	79668473
Hemiplegia	17.08	10.55	41	74635	14898	79654814
Cholangiocarcinoma	17.06	10.55	16	74660	2490	79667222
Embolic cerebral infarction	16.92	10.55	12	74664	1259	79668453
Gastroenteritis	16.90	10.55	70	74606	34012	79635700
Cerebral haemorrhage	16.88	10.55	102	74574	57571	79612141
Gamma-glutamyltransferase increased	16.84	10.55	98	74578	54582	79615130
Jaundice	16.68	10.55	96	74580	53253	79616459
Poverty of speech	16.61	10.55	9	74667	585	79669127
Hypoglycaemic seizure	16.39	10.55	10	74666	814	79668898
Depressed level of consciousness	16.31	10.55	150	74526	96502	79573210
Bile duct stone	16.28	10.55	23	74653	5566	79664146
Sudden hearing loss	16.23	10.55	14	74662	1955	79667757
Renal disorder	16.04	10.55	80	74596	42025	79627687
Brain stem infarction	16.03	10.55	14	74662	1987	79667725
Toe amputation	15.94	10.55	19	74657	3892	79665820
Abortion spontaneous	15.91	10.55	4	74672	29503	79640209
Polyuria	15.89	10.55	40	74636	14974	79654738
Adenocarcinoma pancreas	15.84	10.55	14	74662	2019	79667693
Oliguria	15.77	10.55	42	74634	16267	79653445
Peripheral arterial occlusive disease	15.76	10.55	28	74648	8230	79661482
Gingival hypertrophy	15.76	10.55	17	74659	3125	79666587
COVID-19	15.74	10.55	85	74591	157589	79512123
Cytokine release syndrome	15.71	10.55	7	74669	35991	79633721
Rash	15.68	10.55	417	74259	577941	79091771
Bradycardia	15.68	10.55	195	74481	135362	79534350
Ballismus	15.66	10.55	7	74669	299	79669413
Ureteric cancer recurrent	15.37	10.55	4	74672	30	79669682
Hyperventilation	15.36	10.55	27	74649	7872	79661840
Dysarthria	15.21	10.55	112	74564	67510	79602202
Urine ketone body	14.99	10.55	6	74670	194	79669518
Reperfusion injury	14.96	10.55	6	74670	195	79669517
Therapeutic response decreased	14.67	10.55	25	74651	66828	79602884
Blood lactate dehydrogenase increased	14.63	10.55	74	74602	39096	79630616
Testicular swelling	14.36	10.55	11	74665	1299	79668413
Anaemia vitamin B12 deficiency	14.25	10.55	9	74667	779	79668933
Product commingling	14.17	10.55	5	74671	113	79669599
Brain stem haemorrhage	14.14	10.55	12	74664	1638	79668074
Ventricular tachycardia	14.13	10.55	77	74599	41858	79627854
Glycosylated haemoglobin abnormal	13.98	10.55	6	74670	232	79669480
Insulin resistance	13.86	10.55	11	74665	1368	79668344
Mixed anxiety and depressive disorder	13.66	10.55	7	74669	406	79669306
Generalised oedema	13.62	10.55	51	74625	23658	79646054
Hyporesponsive to stimuli	13.58	10.55	13	74663	2075	79667637
Glucose urine present	13.50	10.55	12	74664	1744	79667968
Foot deformity	13.50	10.55	3	74673	24071	79645641
Lymphocyte stimulation test positive	13.50	10.55	10	74666	1123	79668589
Chronic kidney disease	13.44	10.55	107	74569	66047	79603665
Sudden death	13.42	10.55	49	74627	22462	79647250
Carotid artery stenosis	13.38	10.55	27	74649	8731	79660981
Transitional cell carcinoma	13.19	10.55	14	74662	2527	79667185
Embolic stroke	13.01	10.55	25	74651	7801	79661911
Premature delivery	13.00	10.55	3	74673	23464	79646248
Night sweats	12.84	10.55	18	74658	52077	79617635
Sedation	12.73	10.55	18	74658	51877	79617835
Musculoskeletal pain	12.68	10.55	51	74625	102303	79567409
Aspartate aminotransferase increased	12.59	10.55	191	74485	138450	79531262
Dialysis	12.57	10.55	42	74634	18420	79651292
Peripheral vascular disorder	12.56	10.55	25	74651	8005	79661707
Diabetic ketosis	12.40	10.55	7	74669	493	79669219
Sleep disorder	12.40	10.55	40	74636	85637	79584075
Status epilepticus	12.38	10.55	4	74672	25037	79644675
Glomerular filtration rate decreased	12.36	10.55	48	74628	22654	79647058
Drug ineffective for unapproved indication	12.34	10.55	18	74658	51220	79618492
Asthma	12.32	10.55	75	74601	135020	79534692
Joint range of motion decreased	12.29	10.55	8	74668	33274	79636438
Cardiovascular disorder	12.27	10.55	41	74635	17984	79651728
Anti-insulin antibody	12.14	10.55	4	74672	73	79669639
Bronchiectasis	12.13	10.55	3	74673	22383	79647329
Bile duct cancer	12.11	10.55	9	74667	1015	79668697
Osteoporosis	12.09	10.55	20	74656	54092	79615620
Continuous haemodiafiltration	12.08	10.55	12	74664	2004	79667708
Thyroid adenoma	12.07	10.55	5	74671	177	79669535
Ear pain	12.00	10.55	8	74668	32861	79636851
Coagulation test abnormal	11.98	10.55	10	74666	1335	79668377
Blood insulin decreased	11.96	10.55	3	74673	19	79669693
Injection site swelling	11.91	10.55	16	74660	47116	79622596
Vitreous haemorrhage	11.90	10.55	16	74660	3697	79666015
Hepatic steatosis	11.85	10.55	68	74608	37670	79632042
Testicular pain	11.84	10.55	12	74664	2053	79667659
Hyponatraemia	11.81	10.55	233	74443	177615	79492097
Osteoarthritis	11.79	10.55	42	74634	87267	79582445
Grip strength decreased	11.72	10.55	3	74673	21866	79647846
Coagulation factor increased	11.70	10.55	4	74672	82	79669630
Bladder neoplasm	11.65	10.55	11	74665	1726	79667986
Stomatitis	11.61	10.55	85	74591	146672	79523040
Renal abscess	11.59	10.55	9	74667	1084	79668628
Disseminated intravascular coagulation	11.53	10.55	65	74611	35777	79633935
Leukopenia	11.52	10.55	63	74613	116450	79553262
Anaphylactic reaction	11.50	10.55	40	74636	83703	79586009
Haemorrhage subcutaneous	11.44	10.55	18	74658	4791	79664921
Pancreatic disorder	11.43	10.55	15	74661	3387	79666325
Diabetic hyperglycaemic coma	11.40	10.55	4	74672	89	79669623
Electrolyte imbalance	11.29	10.55	58	74618	30823	79638889
Cytomegalovirus infection	11.26	10.55	14	74662	42630	79627082
Blood sodium decreased	11.16	10.55	61	74615	33194	79636518
Respiratory depression	11.11	10.55	6	74670	27624	79642088
Cerebral ischaemia	10.99	10.55	29	74647	11166	79658546
Dry eye	10.99	10.55	11	74665	36920	79632792
Myelosuppression	10.89	10.55	13	74663	40283	79629429
Cholangitis acute	10.85	10.55	10	74666	1522	79668190
Chronic gastritis	10.77	10.55	16	74660	4052	79665660
Pylorus dilatation	10.76	10.55	3	74673	30	79669682
Therapeutic product effect incomplete	10.75	10.55	83	74593	141562	79528150
Progressive multifocal leukoencephalopathy	10.71	10.55	3	74673	20597	79649115
Vitamin B12 deficiency	10.68	10.55	22	74654	7219	79662493
Kussmaul respiration	10.65	10.55	6	74670	421	79669291
Blood pressure systolic increased	10.61	10.55	30	74646	66956	79602756
Cough	10.58	10.55	262	74414	366527	79303185
Illness	10.57	10.55	17	74659	46494	79623218

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A10BB12	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Sulfonylureas
ATC	A10BD04	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Combinations of oral blood glucose lowering drugs
ATC	A10BD06	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Combinations of oral blood glucose lowering drugs
FDA CS	M0020795	Sulfonylurea Compounds
CHEBI has role	CHEBI:35526	antidiabetic
CHEBI has role	CHEBI:90415	insulin secretagogues
MeSH PA	D000889	Anti-Arrhythmia Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D007004	Hypoglycemic Agents
MeSH PA	D007155	Immunologic Factors
MeSH PA	D007166	Immunosuppressive Agents
FDA EPC	N0000175608	Sulfonylurea

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diabetes mellitus type 2	indication	44054006	DOID:9352
Treatment Refractory Type 2 Diabetes Mellitus	indication
Alcoholism	contraindication	7200002
Weight gain finding	contraindication	8943002
Asthenia	contraindication	13791008
Pulmonary edema	contraindication	19242006	DOID:11396
Myocardial infarction	contraindication	22298006	DOID:5844
Macular retinal edema	contraindication	37231002	DOID:4449
Infectious disease	contraindication	40733004
Body fluid retention	contraindication	43498006
Chronic heart failure	contraindication	48447003
Hepatic porphyria	contraindication	55056006	DOID:3133
Hemolytic anemia	contraindication	61261009	DOID:583
Glucose-6-phosphate dehydrogenase deficiency anemia	contraindication	62403005
Osteoporosis	contraindication	64859006	DOID:11476
Hypopituitarism	contraindication	74728003	DOID:9406
Kidney disease	contraindication	90708001	DOID:557
Fracture of bone	contraindication	125605004
Autonomic dysreflexia	contraindication	129618003
Liver function tests abnormal	contraindication	166603001
Angina pectoris	contraindication	194828000
Decompensated cardiac failure	contraindication	195111005
Cerebrovascular accident	contraindication	230690007
Disease of liver	contraindication	235856003	DOID:409
Drug-induced hepatitis	contraindication	235876009
Hypoglycemic disorder	contraindication	237630007
Edema	contraindication	267038008
Osteopenia	contraindication	312894000
Primary adrenocortical insufficiency	contraindication	373662000
Fever	contraindication	386661006
Surgical procedure	contraindication	387713003
Malignant tumor of urinary bladder	contraindication	399326009	DOID:11054
Breastfeeding (mother)	contraindication	413712001
Disorder of coronary artery	contraindication	414024009
Myocardial ischemia	contraindication	414795007	DOID:3393
Traumatic injury	contraindication	417746004
Fever greater than 100.4 Fahrenheit	contraindication	426000000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	5.31	acidic
pKa2	13.98	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sulfonylurea receptor 1, Kir6.2	Ion channel	Q09428 Q14654	ABCC8_HUMAN KCJ11_HUMAN	BLOCKER	Ki	9.24		WOMBAT-PK	CHEMBL
Aldo-keto reductase family 1 member C3	Enzyme	P42330	AK1C3_HUMAN		IC50	6.07		CHEMBL
Sulfonylurea receptor 2, Kir6.2	Ion channel	O60706 Q14654	ABCC9_HUMAN KCJ11_HUMAN	BLOCKER	Ki	7.98		WOMBAT-PK

External reference:

ID	Source
4020945	VUID
N0000148425	NUI
D00593	KEGG_DRUG
4020945	VANDF
C0061323	UMLSCUI
CHEBI:5383	CHEBI
GMR	PDB_CHEM_ID
CHEMBL1481	ChEMBL_ID
DB00222	DRUGBANK_ID
C057619	MESH_SUPPLEMENTAL_RECORD_UI
6820	IUPHAR_LIGAND_ID
5718	INN_ID
6KY687524K	UNII
3476	PUBCHEM_CID
25789	RXNORM
4782	MMSL
72042	MMSL
d03864	MMSL
005624	NDDF
109079009	SNOMEDCT_US
386966003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
AMARYL	HUMAN PRESCRIPTION DRUG LABEL	1	0039-0221	TABLET	1 mg	ORAL	NDA	26 sections
AMARYL	HUMAN PRESCRIPTION DRUG LABEL	1	0039-0222	TABLET	2 mg	ORAL	NDA	26 sections
AMARYL	HUMAN PRESCRIPTION DRUG LABEL	1	0039-0223	TABLET	4 mg	ORAL	NDA	26 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	0440-6564	TABLET	1 mg	ORAL	ANDA	25 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	0440-6565	TABLET	2 mg	ORAL	ANDA	26 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	0440-6566	TABLET	4 mg	ORAL	ANDA	26 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8332	TABLET	1 mg	ORAL	ANDA	25 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8333	TABLET	2 mg	ORAL	ANDA	25 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8334	TABLET	4 mg	ORAL	ANDA	25 sections
Pioglitazone hydrochloride and glimepiride	HUMAN PRESCRIPTION DRUG LABEL	2	0781-5634	TABLET	2 mg	ORAL	ANDA	28 sections
Pioglitazone hydrochloride and glimepiride	HUMAN PRESCRIPTION DRUG LABEL	2	0781-5635	TABLET	4 mg	ORAL	ANDA	28 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	10544-217	TABLET	2 mg	ORAL	ANDA	25 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	10544-219	TABLET	4 mg	ORAL	ANDA	25 sections
Glimepiride	Human Prescription Drug Label	1	16571-773	TABLET	1 mg	ORAL	ANDA	25 sections
Glimepiride	Human Prescription Drug Label	1	16571-773	TABLET	1 mg	ORAL	ANDA	25 sections
Glimepiride	Human Prescription Drug Label	1	16571-774	TABLET	2 mg	ORAL	ANDA	25 sections
Glimepiride	Human Prescription Drug Label	1	16571-774	TABLET	2 mg	ORAL	ANDA	25 sections
Glimepiride	Human Prescription Drug Label	1	16571-775	TABLET	4 mg	ORAL	ANDA	25 sections
Glimepiride	Human Prescription Drug Label	1	16571-775	TABLET	4 mg	ORAL	ANDA	25 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	16729-001	TABLET	1 mg	ORAL	ANDA	25 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	16729-002	TABLET	2 mg	ORAL	ANDA	25 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	16729-003	TABLET	4 mg	ORAL	ANDA	25 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-746	TABLET	2 mg	ORAL	ANDA	20 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-747	TABLET	4 mg	ORAL	ANDA	20 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-993	TABLET	1 mg	ORAL	ANDA	20 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	33261-831	TABLET	2 mg	ORAL	ANDA	25 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	33261-892	TABLET	4 mg	ORAL	ANDA	25 sections
Glimepiride	HUMAN PRESCRIPTION DRUG LABEL	1	33261-961	TABLET	1 mg	ORAL	ANDA	26 sections
GLIMEPIRIDE	HUMAN PRESCRIPTION DRUG LABEL	1	42549-498	TABLET	4 mg	ORAL	ANDA	28 sections
GLIMEPIRIDE	HUMAN PRESCRIPTION DRUG LABEL	1	42549-499	TABLET	2 mg	ORAL	ANDA	24 sections