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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
alfacalcidol ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
Vitamin D analogues/derivatives
130
41294-56-8
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
alfacalcidol
1alpha-Hydroxycholecalciferol
alfarol
alphacalcidol
einsalpha
alpha-calcidol
1-hydroxycholecalciferol
Molecular weight: 400.65
Formula: C27H44O2
CLOGP: 8.24
LIPINSKI: 1
HAC: 2
HDO: 2
TPSA: 40.46
ALOGS: -5.39
ROTB: 6
Drug dosage:
Dose
Unit
Route
1
mcg
O
1
mcg
P
10
mg
O
ADMET properties:
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Property
Value
Reference
EoM (Fraction excreted unchanged in urine)
8 %
Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability)
71 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
t_half (Half-life)
48.60 hours
Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)
1
Benet LZ, Broccatelli F, Oprea TI
CL (Clearance)
0.82 mL/min/kg
Lombardo F, Berellini G, Obach RS
MRTD (Maximum Recommended Therapeutic Daily Dose)
0.00 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Showing 1 to 6 of 6 entries
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Approvals:
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Date
Agency
Company
Orphan
Jan. 1, 1978
YEAR INTRODUCED
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1
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Muscle spasticity
476.39
14.88
191
17340
21603
63449888
Respiratory disorder
401.60
14.88
202
17329
38880
63432611
Ear pain
392.73
14.88
194
17337
35924
63435567
Body temperature increased
381.45
14.88
192
17339
37000
63434491
Night sweats
359.34
14.88
202
17329
48612
63422879
Urticaria
167.28
14.88
217
17314
165585
63305906
Lower respiratory tract infection
163.81
14.88
192
17339
132115
63339376
Hypocalcaemia
152.53
14.88
100
17431
31613
63439878
Insomnia
144.24
14.88
232
17299
215020
63256471
Back pain
129.33
14.88
248
17283
263897
63207594
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1
2
3
4
5
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11
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Shunt stenosis
148.16
17.20
35
8378
747
34947771
Oesophageal perforation
119.02
17.20
32
8381
1167
34947351
Hypocalcaemia
117.42
17.20
73
8340
24216
34924302
Soft tissue mass
114.50
17.20
30
8383
989
34947529
Multimorbidity
111.97
17.20
29
8384
913
34947605
Shunt occlusion
109.34
17.20
28
8385
842
34947676
Immunosuppressant drug level increased
97.37
17.20
41
8372
6014
34942504
Superinfection
87.71
17.20
30
8383
2489
34946029
Transplant failure
81.22
17.20
31
8382
3522
34944996
Myocardial ischaemia
68.51
17.20
46
8367
17362
34931156
Showing 1 to 10 of 61 entries
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6
7
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Hypocalcaemia
235.60
13.24
160
23567
49764
79670897
Shunt stenosis
224.22
13.24
57
23670
1334
79719327
Muscle spasticity
203.97
13.24
108
23619
21367
79699294
Ear pain
166.21
13.24
110
23617
32759
79687902
Respiratory disorder
152.75
13.24
118
23609
44738
79675923
Body temperature increased
145.07
13.24
114
23613
44306
79676355
Shunt occlusion
144.71
13.24
41
23686
1463
79719198
Hypercalcaemia
139.44
13.24
105
23622
38325
79682336
Night sweats
137.24
13.24
118
23609
51977
79668684
Osteonecrosis of jaw
130.62
13.24
106
23621
43120
79677541
Showing 1 to 10 of 157 entries
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5
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16
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
A11CC03
ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC
M05BB06
MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
CHEBI has role
CHEBI:50646
antiosteoporotic
MeSH PA
D050071
Bone Density Conservation Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Renal osteodystrophy
indication
16726004
DOID:13068
Hypoparathyroidism
indication
36976004
DOID:11199
Hyperparathyroidism
indication
66999008
DOID:13543
Neonatal hypocalcemia
indication
268846006
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๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
13.7
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Vitamin D3 receptor
Nuclear hormone receptor
P11473
VDR_HUMAN
AGONIST
WOMBAT-PK
KEGG DRUG
Sodium-dependent noradrenaline transporter
Transporter
P23975
SC6A2_HUMAN
Ki
6
DRUG MATRIX
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External reference:
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ID
Source
003501
NDDF
11984007
SNOMEDCT_US
12062
RXNORM
329325000
SNOMEDCT_US
4489
INN_ID
5282181
PUBCHEM_CID
C0044410
UMLSCUI
C008088
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:31186
CHEBI
CHEMBL1601669
ChEMBL_ID
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Pharmaceutical products:
None
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L1000
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alfacalcidol