alfacalcidol indications/contra

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 130 41294-56-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alfacalcidol
  • 1alpha-Hydroxycholecalciferol
  • alfarol
  • alphacalcidol
  • einsalpha
  • alpha-calcidol
  • 1-hydroxycholecalciferol
  • Molecular weight: 400.65
  • Formula: C27H44O2
  • CLOGP: 8.24
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -5.39
  • ROTB: 6

Drug dosage:

DoseUnitRoute
1 mcg O
1 mcg P
10 mg O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1978 YEAR INTRODUCED

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypercalcaemia 123.36 56.18 22 170 3715 3381952
Follicular mucinosis 57.27 56.18 6 186 13 3385654

Pharmacologic Action:

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SourceCodeDescription
ATC A11CC03 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC M05BB06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
MeSH PA D050071 Bone Density Conservation Agents
CHEBI has role CHEBI:50646 bone density conservation agent

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Renal osteodystrophy indication 16726004 DOID:13068
Hypoparathyroidism indication 36976004 DOID:11199
Hyperparathyroidism indication 66999008 DOID:13543
Neonatal hypocalcemia indication 268846006

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST WOMBAT-PK KEGG DRUG
Sodium-dependent noradrenaline transporter Transporter Ki 6 DRUG MATRIX

External reference:

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IDSource
C0044410 UMLSCUI
D01518 KEGG_DRUG
11984007 SNOMEDCT_US
329325000 SNOMEDCT_US
12062 RXNORM
003501 NDDF
5282181 PUBCHEM_CID
CHEMBL1601669 ChEMBL_ID
DB01436 DRUGBANK_ID
URQ2517572 UNII
4489 INN_ID
C008088 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:31186 CHEBI

Pharmaceutical products:

None