glibornuride indications/contra

Stem definitionDrug idCAS RN
antihyperglycaemics 1298 26944-48-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glibornurid
  • glibornuride
  • gluboride
  • Ro-6-4563
was MH 1975-92 (see under SULFONYLUREA COMPOUNDS 1975-90); use SULFONYLUREA COMPOUNDS to search GLIBORNURIDE 1975-92; an oral, sulfonylurea hypoglycemic agent which stimulates insulin secretion
  • Molecular weight: 366.48
  • Formula: C18H26N2O4S
  • CLOGP: 3.70
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 95.50
  • ALOGS: -3.76
  • ROTB: 2

Drug dosage:

DoseUnitRoute
38 mg O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1969 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A10BB04 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Sulfonylureas
MeSH PA D007004 Hypoglycemic Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.65 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER Kd 7.05 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sulfonylurea receptor 2, Kir6.2 Ion channel BLOCKER Ki 5.17 WOMBAT-PK

External reference:

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IDSource
C0350998 UMLSCUI
D02427 KEGG_DRUG
419384001 SNOMEDCT_US
005328 NDDF
102846 RXNORM
325235002 SNOMEDCT_US
12818200 PUBCHEM_CID
CHEMBL529888 ChEMBL_ID
DB08962 DRUGBANK_ID
VP83E7434R UNII
2751 INN_ID
C073323 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135545 CHEBI

Pharmaceutical products:

None