gestrinone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 1292 16320-04-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gestrinone
  • dimetriose
  • dimetrose
  • nemestran
  • tridomose
A non-estrogenic contraceptive which is a weak progestin with strong anti-progesterone properties. It is effective if used once a week orally or can also be used in intravaginal devices.
  • Molecular weight: 308.42
  • Formula: C21H24O2
  • CLOGP: 2.44
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -4.50
  • ROTB: 1

Drug dosage:

DoseUnitRoute
0.70 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03XA02 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
Antigonadotropins and similar agents
MeSH PA D003270 Contraceptive Agents
MeSH PA D003271 Contraceptive Agents, Female
MeSH PA D000080066 Contraceptive Agents, Hormonal
MeSH PA D003278 Contraceptives, Oral, Hormonal
MeSH PA D006728 Hormones
MeSH PA D011372 Progestins
MeSH PA D012102 Reproductive Control Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.35 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sex hormone-binding globulin Secreted Kd 8.11 CHEMBL

External reference:

IDSource
N0000167403 NUI
D04317 KEGG_DRUG
C0017507 UMLSCUI
CHEBI:89642 CHEBI
CHEMBL1868702 ChEMBL_ID
DB11619 DRUGBANK_ID
D005867 MESH_DESCRIPTOR_UI
27812 PUBCHEM_CID
4285 INN_ID
1421533RCM UNII
4792 RXNORM
003973 NDDF
387589005 SNOMEDCT_US
96380003 SNOMEDCT_US

Pharmaceutical products:

None