gamolenic acid indications/contra

Stem definitionDrug idCAS RN
1276 506-26-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gamma-Linolenic Acid
  • gamolenic
  • gamolenic acid
An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed)
  • Molecular weight: 278.44
  • Formula: C18H30O2
  • CLOGP: 6.82
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -6.04
  • ROTB: 13

Drug dosage:

DoseUnitRoute
0.40 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC D11AX02 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
ATC D11AX52 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.6 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor IC50 5.66 CHEMBL
Peroxisome proliferator-activated receptor delta Nuclear hormone receptor IC50 6.12 CHEMBL
Peroxisome proliferator-activated receptor alpha Nuclear hormone receptor IC50 6.57 CHEMBL
Tissue factor Membrane receptor IC50 4.52 CHEMBL
3-oxo-5-alpha-steroid 4-dehydrogenase 2 Enzyme IC50 4.85 CHEMBL

External reference:

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IDSource
N0000168580 NUI
C0061078 UMLSCUI
4710 IUPHAR_LIGAND_ID
D07213 KEGG_DRUG
78YC2MAX4O UNII
2834 INN_ID
5280933 PUBCHEM_CID
427465009 SNOMEDCT_US
N0000168580 NDFRT
25605 RXNORM
13121007 SNOMEDCT_US
003969 NDDF
CHEBI:28661 CHEBI
CHEMBL464982 ChEMBL_ID
D017965 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None