gallopamil Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, verapamil derivatives 1275 16662-47-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gallopamil
  • methoxyverapamil
  • gallopamil hydrochloride
  • gallopamil HCl
Coronary vasodilator that is an analog of iproveratril (VERAPAMIL) with one more methoxy group on the benzene ring.
  • Molecular weight: 484.64
  • Formula: C28H40N2O5
  • CLOGP: 4.11
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 0
  • TPSA: 73.18
  • ALOGS: -4.95
  • ROTB: 14

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC C08DA02 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
Phenylalkylamine derivatives
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.91 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.44 CHEMBL

External reference:

IDSource
N0000166522 NUI
C0016986 UMLSCUI
D08009 KEGG_DRUG
39WPC8JHR8 UNII
4318 INN_ID
CHEMBL51149 ChEMBL_ID
4648 RXNORM
N0000166522 NDFRT
703433005 SNOMEDCT_US
004173 NDDF
1234 PUBCHEM_CID
CHEMBL523367 ChEMBL_ID
D005711 MESH_DESCRIPTOR_UI
16662-46-7 SECONDARY_CAS_RN
DB12923 DRUGBANK_ID
CHEBI:34772 CHEBI

Pharmaceutical products:

None