almitrine indications/contra

Stem definitionDrug idCAS RN
127 27469-53-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • almitrine
  • almitrine mesylate
  • almitrine mesilate
  • duxil
  • almitrine dimesilate
  • almitrine dimesylate
A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.
  • Molecular weight: 477.56
  • Formula: C26H29F2N7
  • CLOGP: 6.33
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 2
  • TPSA: 69.21
  • ALOGS: -4.52
  • ROTB: 10

Drug dosage:

DoseUnitRoute
0.10 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC R07AB07 RESPIRATORY SYSTEM
OTHER RESPIRATORY SYSTEM PRODUCTS
OTHER RESPIRATORY SYSTEM PRODUCTS
Respiratory stimulants
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:35337 central nervous system stimulant

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Chronic obstructive lung disease indication 13645005 DOID:3083

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.0 Basic
pKa2 5.57 Basic
pKa3 3.77 Basic
pKa4 1.34 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
N0000167166 NUI
C0002164 UMLSCUI
D02822 KEGG_DRUG
6RY6V6XM8T UNII
29608-49-9 SECONDARY_CAS_RN
528 RXNORM
418600009 SNOMEDCT_US
N0000167166 NDFRT
003690 NDDF
4123 INN_ID
CHEMBL314610 ChEMBL_ID
33887 PUBCHEM_CID
CHEMBL1183717 ChEMBL_ID
C037558 MESH_SUPPLEMENTAL_RECORD_UI
DB01430 DRUGBANK_ID
D015765 MESH_DESCRIPTOR_UI
CHEBI:53778 CHEBI

Pharmaceutical products:

None