alizapride indications/contra

Stem definitionDrug idCAS RN
sulpiride derivatives 120 59338-93-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alizapride
  • alizapride hydrochloride
  • alizapride HCl
  • Molecular weight: 315.38
  • Formula: C16H21N5O2
  • CLOGP: 2.53
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 83.14
  • ALOGS: -2.84
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1981 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A03FA05 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
PROPULSIVES
Propulsives
MeSH PA D000932 Antiemetics
MeSH PA D001337 Autonomic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.11 acidic
pKa2 13.45 acidic
pKa3 8.72 Basic
pKa4 0.34 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-2C adrenergic receptor GPCR Ki 7 WOMBAT-PK
D(2) dopamine receptor GPCR Ki 7.15 WOMBAT-PK
D(2) dopamine receptor GPCR IC50 6.70 CHEMBL

External reference:

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IDSource
C0051162 UMLSCUI
D07102 KEGG_DRUG
41BT72BOQ7 UNII
59338-87-3 SECONDARY_CAS_RN
CHEMBL290194 ChEMBL_ID
005228 NDDF
17311 RXNORM
724156007 SNOMEDCT_US
43008 PUBCHEM_CID
DB01425 DRUGBANK_ID
4823 INN_ID
C033968 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:94316 CHEBI

Pharmaceutical products:

None