flumetasone pivalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 1198 2002-29-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • flumethasone pivalate
  • flumetasone pivalate
  • flumethasone 21-pivalate
  • locacorten
  • locorten
  • Molecular weight: 494.58
  • Formula: C27H36F2O6
  • CLOGP: 3.60
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -4.67
  • ROTB: 5
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Duodenal ulcer perforation 435.55 124.42 346 29404 86863 63372409
Anti-cyclic citrullinated peptide antibody positive 397.03 124.42 371 29379 115841 63343431
Helicobacter infection 385.76 124.42 331 29419 92454 63366818
Rheumatic fever 372.51 124.42 239 29511 42872 63416400
Wound 351.65 124.42 407 29343 162856 63296416
Blood cholesterol increased 336.15 124.42 308 29442 93724 63365548
Hand deformity 335.84 124.42 393 29357 159064 63300208
Glossodynia 328.09 124.42 411 29339 178465 63280807
Rheumatoid factor positive 326.37 124.42 289 29461 84117 63375155
Pericarditis 317.30 124.42 348 29402 131231 63328041
Swollen joint count increased 316.69 124.42 202 29548 35852 63423420
Liver injury 305.98 124.42 242 29508 60278 63398994
Pemphigus 303.73 124.42 401 29349 183325 63275947
Synovitis 298.30 124.42 401 29349 186517 63272755
Lip dry 285.02 124.42 141 29609 15329 63443943
Psoriatic arthropathy 283.55 124.42 277 29473 91243 63368029
Systemic lupus erythematosus 282.56 124.42 414 29336 208504 63250768
Prescribed overdose 279.39 124.42 183 29567 33970 63425302
Fibromyalgia 274.90 124.42 257 29493 80163 63379109
Folliculitis 270.23 124.42 240 29510 70077 63389195
Hepatic enzyme increased 267.89 124.42 397 29353 201931 63257341
Type 2 diabetes mellitus 267.60 124.42 229 29521 63639 63395633
Facet joint syndrome 245.72 124.42 118 29632 12020 63447252
Deep vein thrombosis postoperative 234.63 124.42 112 29638 11257 63448015
Injury 219.91 124.42 218 29532 73029 63386243
Peripheral venous disease 213.04 124.42 116 29634 15361 63443911
Arthropathy 212.34 124.42 388 29362 234404 63224868
Infusion related reaction 207.38 124.42 394 29356 245127 63214145
Blister 206.06 124.42 278 29472 129536 63329736
Muscle injury 197.09 124.42 195 29555 65150 63394122
C-reactive protein abnormal 192.43 124.42 165 29585 45931 63413341
Autoimmune disorder 191.12 124.42 112 29638 17065 63442207
Drug intolerance 183.44 124.42 429 29321 308232 63151040
Irritable bowel syndrome 179.65 124.42 207 29543 82205 63377067
Sciatica 174.96 124.42 138 29612 34186 63425086
Discomfort 171.05 124.42 292 29458 167082 63292190
Wheezing 162.82 124.42 212 29538 95383 63363889
Swelling 162.71 124.42 382 29368 274996 63184276
Impaired healing 161.73 124.42 219 29531 102323 63356949
Joint range of motion decreased 160.18 124.42 128 29622 32300 63426972
Bursitis 153.38 124.42 132 29618 36909 63422363
Abdominal discomfort 149.76 124.42 407 29343 320478 63138794
Alopecia 148.52 124.42 419 29331 337117 63122155
Death 146.36 124.42 7 29743 374374 63084898
Night sweats 142.22 124.42 143 29607 48671 63410601
Hip arthroplasty 141.43 124.42 141 29609 47505 63411767
Obesity 141.10 124.42 115 29635 29837 63429435
Contraindicated product administered 138.48 124.42 311 29439 217337 63241935
Maternal exposure during pregnancy 130.65 124.42 306 29444 219756 63239516
C-reactive protein 128.62 124.42 57 29693 4825 63454447
General physical health deterioration 128.33 124.42 288 29462 201114 63258158
Musculoskeletal stiffness 127.83 124.42 273 29477 184345 63274927
Joint swelling 127.10 124.42 389 29361 327277 63131995
Oedema 126.65 124.42 190 29560 97432 63361840
Grip strength decreased 125.32 124.42 95 29655 22192 63437080

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Duodenal ulcer perforation 493.92 166.31 292 25483 65919 79652694
Rheumatic fever 478.46 166.31 217 25558 28308 79690305
Helicobacter infection 436.80 166.31 275 25500 69429 79649184
Glossodynia 422.30 166.31 313 25462 103024 79615589
Hand deformity 416.25 166.31 311 25464 103608 79615005
Pemphigus 414.51 166.31 305 25470 99277 79619336
Blood cholesterol increased 409.65 166.31 283 25492 83437 79635176
Swollen joint count increased 399.01 166.31 179 25596 22748 79695865
Anti-cyclic citrullinated peptide antibody positive 394.96 166.31 276 25499 82867 79635746
Systemic lupus erythematosus 386.61 166.31 317 25458 120832 79597781
Wound 385.49 166.31 311 25464 115868 79602745
Rheumatoid factor positive 374.63 166.31 236 25539 59603 79659010
Pericarditis 371.40 166.31 291 25484 103945 79614668
Psoriatic arthropathy 358.99 166.31 254 25521 77745 79640868
Fibromyalgia 358.96 166.31 236 25539 64104 79654509
Liver injury 346.19 166.31 220 25555 56394 79662219
Folliculitis 338.11 166.31 215 25560 55165 79663448
Lip dry 328.97 166.31 139 25636 15279 79703334
Type 2 diabetes mellitus 307.63 166.31 205 25570 56917 79661696
Synovitis 304.44 166.31 305 25470 150429 79568184
Arthropathy 289.30 166.31 320 25455 176791 79541822
Facet joint syndrome 289.03 166.31 116 25659 11186 79707427
Prescribed overdose 276.84 166.31 165 25610 37718 79680895
Deep vein thrombosis postoperative 270.27 166.31 109 25666 10643 79707970
Maternal exposure during pregnancy 255.11 166.31 265 25510 136273 79582340
Blister 252.69 166.31 248 25527 119228 79599385
Muscle injury 251.17 166.31 170 25605 48391 79670222
Hepatic enzyme increased 244.65 166.31 298 25477 182312 79536301
Peripheral venous disease 241.53 166.31 113 25662 15796 79702817
Irritable bowel syndrome 239.47 166.31 182 25593 62059 79656554
Discomfort 238.60 166.31 246 25529 125371 79593242
Injury 232.85 166.31 196 25579 77300 79641313
C-reactive protein abnormal 232.84 166.31 162 25613 48205 79670408
Swelling 226.78 166.31 313 25462 216398 79502215
Autoimmune disorder 224.74 166.31 109 25666 16503 79702110
Alopecia 221.17 166.31 320 25455 231035 79487578
Sciatica 215.26 166.31 134 25641 33088 79685525
Contraindicated product administered 212.42 166.31 258 25517 157280 79561333
Impaired healing 208.10 166.31 194 25581 87461 79631152
Drug intolerance 202.74 166.31 330 25445 263789 79454824
Bursitis 193.75 166.31 129 25646 35715 79682898
Joint range of motion decreased 192.60 166.31 125 25650 33157 79685456
Infusion related reaction 190.84 166.31 298 25477 229939 79488674
Abdominal discomfort 185.27 166.31 308 25467 250419 79468194
Therapeutic product effect decreased 182.40 166.31 244 25531 163619 79554994
Musculoskeletal stiffness 175.83 166.31 248 25527 174760 79543853
Night sweats 173.65 166.31 140 25635 51955 79666658
Treatment failure 170.39 166.31 241 25534 170245 79548368

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:59683 antipruritic drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 13.41 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST DRUGBANK CHEMBL

External reference:

IDSource
D01464 KEGG_DRUG
C0060494 UMLSCUI
CHEBI:31620 CHEBI
CHEBI:34764 CHEBI
CHEMBL1200877 ChEMBL_ID
C005565 MESH_SUPPLEMENTAL_RECORD_UI
7075 IUPHAR_LIGAND_ID
443980 PUBCHEM_CID
25113 RXNORM
002198 NDDF
004949 NDDF
116598007 SNOMEDCT_US
3037004 SNOMEDCT_US
395944001 SNOMEDCT_US
C0016294 UMLSCUI
DB00663 DRUGBANK_ID
16490 PUBCHEM_CID
0DV09X6F21 UNII

Pharmaceutical products:

None