fluindione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1194	957-56-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: fluindione previscan	Molecular weight: 240.23 Formula: C15H9FO2 CLOGP: 2.95 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 34.14 ALOGS: -3.64 ROTB: 1

Molecule

Description

Molfile Inchi Smiles

Synonyms:

fluindione
previscan

Molecular weight: 240.23
Formula: C15H9FO2
CLOGP: 2.95
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 34.14
ALOGS: -3.64
ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
International normalised ratio increased	719.40	36.07	225	4584	46200	63438013
Drug interaction	464.61	36.07	259	4550	228872	63255341
Acute kidney injury	293.79	36.07	204	4605	263211	63221002
Haematoma	182.63	36.07	76	4733	34744	63449469
Shock haemorrhagic	178.02	36.07	54	4755	9841	63474372
Anaemia	170.12	36.07	155	4654	293275	63190938
Melaena	161.65	36.07	67	4742	30298	63453915
Cerebral haematoma	144.26	36.07	37	4772	3646	63480567
Hyperkalaemia	127.42	36.07	68	4741	54135	63430078
Bradycardia	116.01	36.07	71	4738	73156	63411057
Hyponatraemia	106.34	36.07	79	4730	111821	63372392
Subdural haematoma	77.47	36.07	32	4777	14296	63469917
Hepatocellular injury	71.82	36.07	37	4772	27344	63456869
Prothrombin time shortened	68.23	36.07	18	4791	1977	63482236
Abdominal wall haematoma	65.02	36.07	19	4790	3036	63481177
Overdose	60.89	36.07	58	4751	115020	63369193
Cholestasis	58.25	36.07	33	4776	29401	63454812
Cerebral haemorrhage	56.93	36.07	33	4776	30696	63453517
Muscle haemorrhage	55.64	36.07	17	4792	3162	63481051
Cardiac failure	53.07	36.07	48	4761	89094	63395119
Fall	52.81	36.07	101	4708	392233	63091980
Renal failure	52.41	36.07	54	4755	117598	63366615
Lactic acidosis	47.82	36.07	32	4777	38255	63445958
Drug ineffective	46.92	36.07	11	4798	1044754	62439459
Sinus node dysfunction	45.32	36.07	16	4793	4669	63479544
Retroperitoneal haematoma	44.34	36.07	14	4795	2899	63481314
Cardio-respiratory arrest	43.17	36.07	36	4773	59923	63424290
Pain	41.82	36.07	4	4805	740624	62743589
Interstitial lung disease	40.14	36.07	35	4774	61873	63422340
Toxic skin eruption	38.42	36.07	19	4790	12866	63471347
Haematoma muscle	37.64	36.07	10	4799	1127	63483086

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
International normalised ratio increased	528.90	25.77	228	6205	47099	34903399
Acute kidney injury	333.15	25.77	339	6094	304649	34645849
Drug interaction	277.02	25.77	268	6165	225678	34724820
Hyperkalaemia	180.85	25.77	128	6305	69261	34881237
Cerebral haematoma	179.65	25.77	56	6377	4559	34945939
Shock haemorrhagic	178.26	25.77	70	6363	11284	34939214
Haematoma	134.88	25.77	74	6359	25531	34924967
Blood lactic acid	89.36	25.77	19	6414	327	34950171
Rectal haemorrhage	83.84	25.77	65	6368	40184	34910314
Melaena	75.56	25.77	58	6375	35322	34915176
Lactic acidosis	69.90	25.77	55	6378	34717	34915781
Bradycardia	69.13	25.77	77	6356	75341	34875157
Hepatocellular injury	62.40	25.77	43	6390	22168	34928330
Subdural haematoma	60.84	25.77	41	6392	20380	34930118
Granulomatous rosacea	60.47	25.77	12	6421	144	34950354
Toxic skin eruption	57.40	25.77	32	6401	11353	34939145
Interstitial lung disease	55.29	25.77	64	6369	65218	34885280
Eosinophilia	53.81	25.77	42	6391	26180	34924318
Intraventricular haemorrhage	52.67	25.77	21	6412	3510	34946988
Anaemia	52.03	25.77	125	6308	233210	34717288
Overdose	49.96	25.77	72	6361	90987	34859511
Coma	49.50	25.77	51	6382	45627	34904871
Drug reaction with eosinophilia and systemic symptoms	49.31	25.77	44	6389	32968	34917530
Traumatic haemothorax	47.23	25.77	11	6422	291	34950207
Blood loss anaemia	46.76	25.77	25	6408	8169	34942329
Cholestasis	46.48	25.77	39	6394	26909	34923589
Muscle haemorrhage	44.87	25.77	19	6414	3699	34946799
Brain stem haematoma	44.00	25.77	9	6424	127	34950371
Haematuria	43.91	25.77	50	6383	50016	34900482
Cardiogenic shock	42.79	25.77	37	6396	26581	34923917
Cardiorenal syndrome	42.17	25.77	12	6421	711	34949787
Subarachnoid haemorrhage	41.58	25.77	27	6406	12608	34937890
Ischaemic stroke	39.11	25.77	30	6403	18220	34932278
Haemorrhagic stroke	37.44	25.77	20	6413	6519	34943979
Purpura	36.32	25.77	23	6410	10288	34940210
Cerebral haemorrhage	34.25	25.77	37	6396	34900	34915598
Confusional state	33.95	25.77	79	6354	144081	34806417
International normalised ratio abnormal	33.57	25.77	15	6418	3320	34947178
Cardiac failure	32.07	25.77	59	6374	91189	34859309
Eczema	30.38	25.77	26	6407	18410	34932088
Nephroangiosclerosis	29.92	25.77	7	6426	189	34950309
Intracranial pressure increased	28.14	25.77	14	6419	3941	34946557
Pemphigoid	27.24	25.77	18	6415	8648	34941850
Drug ineffective	26.65	25.77	27	6406	456724	34493774
Nausea	26.31	25.77	15	6418	339893	34610605
Haemorrhagic ascites	26.28	25.77	6	6427	145	34950353
Limited symptom panic attack	26.12	25.77	5	6428	49	34950449

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
International normalised ratio increased	1189.58	26.60	448	10966	84273	79648701
Drug interaction	676.83	26.60	520	10894	414663	79318311
Acute kidney injury	614.79	26.60	540	10874	518864	79214110
Shock haemorrhagic	346.44	26.60	124	11290	19936	79713038
Haematoma	305.30	26.60	149	11265	52046	79680928
Cerebral haematoma	304.93	26.60	90	11324	7852	79725122
Hyperkalaemia	303.36	26.60	194	11220	114204	79618770
Melaena	214.55	26.60	124	11290	60766	79672208
Anaemia	191.42	26.60	274	11140	444741	79288233
Bradycardia	172.84	26.60	148	11266	135409	79597565
Subdural haematoma	129.57	26.60	71	11343	31363	79701611
Hepatocellular injury	124.11	26.60	80	11334	47513	79685461
Rectal haemorrhage	111.02	26.60	90	11324	76210	79656764
Lactic acidosis	108.77	26.60	86	11328	70273	79662701
Overdose	101.06	26.60	128	11286	184078	79548896
Cholestasis	96.62	26.60	71	11343	52038	79680936
Muscle haemorrhage	94.01	26.60	35	11379	6265	79726709
Toxic skin eruption	93.64	26.60	51	11363	22242	79710732
Hyponatraemia	93.48	26.60	121	11293	177727	79555247
Blood lactic acid	88.59	26.60	19	11395	444	79732530
Interstitial lung disease	88.15	26.60	94	11320	112506	79620468
Cerebral haemorrhage	85.93	26.60	69	11345	57604	79675370
Cardiac failure	77.69	26.60	103	11311	154739	79578235
Cardiogenic shock	72.97	26.60	55	11359	41859	79691115
Pain	72.85	26.60	8	11406	703794	79029180
Blood loss anaemia	69.40	26.60	37	11377	15461	79717513
Drug reaction with eosinophilia and systemic symptoms	67.56	26.60	63	11351	64181	79668793
Drug ineffective	63.97	26.60	38	11376	1080875	78652099
Eosinophilia	62.79	26.60	52	11362	45293	79687681
Prothrombin time shortened	59.63	26.60	21	11393	3207	79729767
Granulomatous rosacea	59.57	26.60	12	11402	204	79732770
Nausea	58.96	26.60	32	11382	957164	78775810
Renal failure	57.39	26.60	103	11311	200865	79532109
Haematuria	56.56	26.60	59	11355	68777	79664197
Fatigue	54.50	26.60	33	11381	929694	78803280
Haemorrhagic stroke	54.09	26.60	28	11386	11018	79721956
Ischaemic stroke	52.24	26.60	41	11373	33090	79699884
Intraventricular haemorrhage	51.16	26.60	21	11393	4866	79728108
Retroperitoneal haematoma	49.53	26.60	21	11393	5276	79727698
Traumatic haemothorax	48.32	26.60	12	11402	542	79732432
Cardiorenal syndrome	48.07	26.60	15	11399	1574	79731400
Coma	47.46	26.60	65	11349	100584	79632390
Subarachnoid haemorrhage	46.83	26.60	34	11380	24431	79708543
Cardio-respiratory arrest	46.59	26.60	67	11347	108443	79624531
Abdominal wall haematoma	44.50	26.60	19	11395	4854	79728120
Brain stem haematoma	40.47	26.60	8	11406	123	79732851
Sinus node dysfunction	39.09	26.60	20	11394	7681	79725293
Vascular purpura	38.27	26.60	15	11399	3083	79729891
Epistaxis	38.19	26.60	62	11352	111453	79621521
Pemphigoid	38.07	26.60	25	11389	15290	79717684
Fall	37.98	26.60	154	11260	487475	79245499
Confusional state	37.32	26.60	115	11299	317882	79415092
Headache	37.13	26.60	24	11390	653748	79079226
Hepatitis	35.80	26.60	42	11372	55685	79677289
Purpura	34.81	26.60	26	11388	19501	79713473
Prothrombin time ratio decreased	33.38	26.60	10	11404	915	79732059
Nephroangiosclerosis	32.66	26.60	8	11406	341	79732633
Dermatitis exfoliative generalised	31.60	26.60	17	11397	7224	79725750
Intestinal haematoma	30.74	26.60	7	11407	217	79732757
Jaundice	30.66	26.60	38	11376	53311	79679663
Haematoma muscle	29.99	26.60	12	11402	2603	79730371
International normalised ratio abnormal	29.33	26.60	15	11399	5753	79727221
Pain in extremity	29.26	26.60	8	11406	364530	79368444
Lung disorder	29.23	26.60	46	11368	80511	79652463
Cardioactive drug level increased	29.11	26.60	13	11401	3696	79729278
Peripheral swelling	27.98	26.60	3	11411	269614	79463360
Acute pulmonary oedema	27.74	26.60	20	11394	14210	79718764
Dermatitis exfoliative	27.70	26.60	18	11396	10811	79722163
Limited symptom panic attack	27.37	26.60	5	11409	49	79732925
International normalised ratio decreased	27.22	26.60	16	11398	8054	79724920
Hypersensitivity	27.01	26.60	3	11411	262236	79470738
Sinus bradycardia	26.99	26.60	25	11389	25222	79707752
Anuria	26.86	26.60	23	11391	20940	79712034

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B01AA12	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Vitamin K antagonists
MeSH PA	D000925	Anticoagulants
MeSH PA	D006401	Hematologic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.43	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Arachidonate 5-lipoxygenase	Enzyme		LOX5_RAT		IC50	5.02		CHEMBL

External reference:

ID	Source
D07969	KEGG_DRUG
C0117899	UMLSCUI
CHEBI:134975	CHEBI
CHEMBL24924	ChEMBL_ID
DB13136	DRUGBANK_ID
68942	PUBCHEM_CID
C017673	MESH_SUPPLEMENTAL_RECORD_UI
4519	INN_ID
EQ35YMS20Q	UNII
50097	RXNORM
005420	NDDF
19351000122101	SNOMEDCT_US

Pharmaceutical products:

None