flopropione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1180	2295-58-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

ephtanon
flopropione
phloropropionone
profenon
propionylphloroglucinol
propiophloroglucine
cospanon

Molecular weight: 182.18
Formula: C9H10O4
CLOGP: 1.32
LIPINSKI: 0
HAC: 4
HDO: 3
TPSA: 77.76
ALOGS: -1.59
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Biliary dyskinesia	indication	197432008	DOID:4140
Calculus in biliary tract	indication	266474003

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.14	acidic
pKa2	10.28	acidic
pKa3	12.29	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Catechol O-methyltransferase	Enzyme	P21964	COMT_HUMAN	INHIBITOR				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D01259	KEGG_DRUG
C0060462	UMLSCUI
CHEBI:31614	CHEBI
CHEMBL1605835	ChEMBL_ID
3362	PUBCHEM_CID
2009	INN_ID
C014870	MESH_SUPPLEMENTAL_RECORD_UI
05V5NVB5Y1	UNII
25082	RXNORM
009821	NDDF

Pharmaceutical products:

None