finasteride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| testosterone reductase inhibitors | 1171 | 98319-26-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | mg | O |
| 5 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
| S (Water solubility) | 0.01 mg/mL | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.19 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 63 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.10 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.10 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 6 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 19, 1992 | FDA | MERCK |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Exposure via body fluid | 312.91 | 24.64 | 44 | 1339 | 572 | 63487067 |
| Exposure during pregnancy | 125.83 | 24.64 | 63 | 1320 | 155484 | 63332155 |
| Abortion spontaneous | 89.92 | 24.64 | 35 | 1348 | 47160 | 63440479 |
| Product administration error | 70.19 | 24.64 | 24 | 1359 | 22373 | 63465266 |
| Abortion induced | 56.99 | 24.64 | 17 | 1366 | 10225 | 63477414 |
| Paternal drugs affecting foetus | 53.01 | 24.64 | 7 | 1376 | 54 | 63487585 |
| Exposure via father | 42.55 | 24.64 | 7 | 1376 | 265 | 63487374 |
| Hypertrichosis | 38.15 | 24.64 | 8 | 1375 | 1146 | 63486493 |
| Trans-sexualism | 36.71 | 24.64 | 4 | 1379 | 3 | 63487636 |
| Temporal lobe epilepsy | 33.07 | 24.64 | 6 | 1377 | 405 | 63487234 |
| No adverse event | 31.00 | 24.64 | 16 | 1367 | 41389 | 63446250 |
| Hidradenitis | 30.97 | 24.64 | 8 | 1375 | 2838 | 63484801 |
| Ophthalmoplegia | 30.79 | 24.64 | 7 | 1376 | 1457 | 63486182 |
| White matter lesion | 28.99 | 24.64 | 7 | 1376 | 1888 | 63485751 |
| Skin induration | 25.30 | 24.64 | 7 | 1376 | 3216 | 63484423 |
| Nystagmus | 24.78 | 24.64 | 8 | 1375 | 6212 | 63481427 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sexual dysfunction | 2882.85 | 10.68 | 919 | 82271 | 5384 | 34868357 |
| Erectile dysfunction | 2517.04 | 10.68 | 1145 | 82045 | 19492 | 34854249 |
| Libido decreased | 1504.99 | 10.68 | 524 | 82666 | 4172 | 34869569 |
| Loss of libido | 1240.24 | 10.68 | 390 | 82800 | 2162 | 34871579 |
| Semen volume decreased | 937.80 | 10.68 | 208 | 82982 | 148 | 34873593 |
| Ejaculation disorder | 886.33 | 10.68 | 244 | 82946 | 765 | 34872976 |
| Depression | 773.11 | 10.68 | 1049 | 82141 | 96049 | 34777692 |
| Cognitive disorder | 709.33 | 10.68 | 570 | 82620 | 28123 | 34845618 |
| Penile size reduced | 552.74 | 10.68 | 121 | 83069 | 74 | 34873667 |
| Anxiety | 551.07 | 10.68 | 907 | 82283 | 98521 | 34775220 |
| Ejaculation failure | 549.30 | 10.68 | 160 | 83030 | 649 | 34873092 |
| Testicular pain | 516.77 | 10.68 | 209 | 82981 | 2609 | 34871132 |
| Post 5-alpha-reductase inhibitor syndrome | 454.39 | 10.68 | 94 | 83096 | 22 | 34873719 |
| Organic erectile dysfunction | 446.70 | 10.68 | 107 | 83083 | 149 | 34873592 |
| Gynaecomastia | 427.43 | 10.68 | 279 | 82911 | 9901 | 34863840 |
| Hypogonadism | 405.77 | 10.68 | 165 | 83025 | 2090 | 34871651 |
| Blood testosterone decreased | 361.53 | 10.68 | 186 | 83004 | 4171 | 34869570 |
| Hormone level abnormal | 359.15 | 10.68 | 99 | 83091 | 312 | 34873429 |
| Testicular atrophy | 269.05 | 10.68 | 86 | 83104 | 506 | 34873235 |
| Penis injury | 263.99 | 10.68 | 71 | 83119 | 198 | 34873543 |
| Varicocele | 257.53 | 10.68 | 55 | 83135 | 24 | 34873717 |
| Painful ejaculation | 241.11 | 10.68 | 51 | 83139 | 19 | 34873722 |
| Genital hypoaesthesia | 226.83 | 10.68 | 61 | 83129 | 170 | 34873571 |
| Penis disorder | 214.92 | 10.68 | 89 | 83101 | 1184 | 34872557 |
| Off label use | 201.41 | 10.68 | 438 | 82752 | 419086 | 34454655 |
| Testicular failure | 192.27 | 10.68 | 42 | 83148 | 25 | 34873716 |
| Testicular disorder | 176.17 | 10.68 | 68 | 83122 | 743 | 34872998 |
| Semen analysis abnormal | 166.82 | 10.68 | 34 | 83156 | 5 | 34873736 |
| Orgasm abnormal | 166.64 | 10.68 | 43 | 83147 | 96 | 34873645 |
| Benign prostatic hyperplasia | 163.72 | 10.68 | 187 | 83003 | 14308 | 34859433 |
| Male orgasmic disorder | 162.94 | 10.68 | 41 | 83149 | 79 | 34873662 |
| Endocrine disorder | 155.97 | 10.68 | 49 | 83141 | 270 | 34873471 |
| Hypogonadism male | 155.59 | 10.68 | 50 | 83140 | 300 | 34873441 |
| Androgen deficiency | 153.95 | 10.68 | 44 | 83146 | 164 | 34873577 |
| Epididymal cyst | 150.57 | 10.68 | 34 | 83156 | 29 | 34873712 |
| Pyrexia | 149.56 | 10.68 | 360 | 82830 | 332653 | 34541088 |
| Infertility male | 148.78 | 10.68 | 42 | 83148 | 148 | 34873593 |
| Toxicity to various agents | 147.14 | 10.68 | 156 | 83034 | 200206 | 34673535 |
| Prostatitis | 143.61 | 10.68 | 113 | 83077 | 5394 | 34868347 |
| Hair transplant | 141.23 | 10.68 | 30 | 83160 | 12 | 34873729 |
| Panic attack | 140.64 | 10.68 | 141 | 83049 | 9291 | 34864450 |
| Male reproductive tract disorder | 140.33 | 10.68 | 37 | 83153 | 93 | 34873648 |
| Product administration error | 137.87 | 10.68 | 182 | 83008 | 16162 | 34857579 |
| Suicidal ideation | 137.84 | 10.68 | 300 | 82890 | 40088 | 34833653 |
| Sperm concentration decreased | 115.46 | 10.68 | 33 | 83157 | 123 | 34873618 |
| Drug ineffective | 109.19 | 10.68 | 640 | 82550 | 456111 | 34417630 |
| Anorgasmia | 108.83 | 10.68 | 49 | 83141 | 808 | 34872933 |
| Right atrial hypertrophy | 108.54 | 10.68 | 48 | 83142 | 757 | 34872984 |
| Reproductive tract disorder | 105.91 | 10.68 | 21 | 83169 | 0 | 34873741 |
| Drug abuse | 95.27 | 10.68 | 59 | 83131 | 99037 | 34774704 |
| Wrong technique in product usage process | 94.14 | 10.68 | 241 | 82949 | 35745 | 34837996 |
| Orgasmic sensation decreased | 93.81 | 10.68 | 24 | 83166 | 51 | 34873690 |
| Brain injury | 93.74 | 10.68 | 93 | 83097 | 6049 | 34867692 |
| Premature ejaculation | 93.57 | 10.68 | 27 | 83163 | 105 | 34873636 |
| Infertility | 92.11 | 10.68 | 30 | 83160 | 189 | 34873552 |
| Prostatic pain | 90.63 | 10.68 | 25 | 83165 | 79 | 34873662 |
| Male genital atrophy | 90.62 | 10.68 | 19 | 83171 | 6 | 34873735 |
| Muscle atrophy | 89.54 | 10.68 | 99 | 83091 | 7305 | 34866436 |
| Penile curvature | 88.36 | 10.68 | 25 | 83165 | 89 | 34873652 |
| Febrile neutropenia | 88.14 | 10.68 | 118 | 83072 | 136731 | 34737010 |
| Vomiting | 85.90 | 10.68 | 302 | 82888 | 247319 | 34626422 |
| Bronchial secretion retention | 84.46 | 10.68 | 50 | 83140 | 1486 | 34872255 |
| Urine flow decreased | 83.16 | 10.68 | 46 | 83144 | 1198 | 34872543 |
| Vasectomy | 82.22 | 10.68 | 20 | 83170 | 31 | 34873710 |
| Disturbance in sexual arousal | 81.92 | 10.68 | 25 | 83165 | 123 | 34873618 |
| Right ventricular hypertrophy | 81.91 | 10.68 | 49 | 83141 | 1485 | 34872256 |
| Urinary retention | 81.79 | 10.68 | 230 | 82960 | 36058 | 34837683 |
| Breast enlargement | 81.45 | 10.68 | 34 | 83156 | 462 | 34873279 |
| Gastrooesophageal reflux disease | 81.23 | 10.68 | 236 | 82954 | 37688 | 34836053 |
| Bronchial wall thickening | 76.45 | 10.68 | 45 | 83145 | 1323 | 34872418 |
| Intervertebral disc degeneration | 76.22 | 10.68 | 85 | 83105 | 6332 | 34867409 |
| Penile pain | 75.95 | 10.68 | 47 | 83143 | 1516 | 34872225 |
| Dizziness | 75.86 | 10.68 | 824 | 82366 | 217697 | 34656044 |
| Multiple organ dysfunction syndrome | 75.80 | 10.68 | 44 | 83146 | 76522 | 34797219 |
| Aortic valve stenosis | 71.63 | 10.68 | 56 | 83134 | 2647 | 34871094 |
| Obstruction | 71.34 | 10.68 | 56 | 83134 | 2663 | 34871078 |
| Disturbance in attention | 71.23 | 10.68 | 177 | 83013 | 25768 | 34847973 |
| Foetal exposure during pregnancy | 71.23 | 10.68 | 5 | 83185 | 38096 | 34835645 |
| Sleep apnoea syndrome | 70.50 | 10.68 | 152 | 83038 | 20169 | 34853572 |
| Tonsillectomy | 70.28 | 10.68 | 29 | 83161 | 382 | 34873359 |
| Insomnia | 69.99 | 10.68 | 455 | 82735 | 103452 | 34770289 |
| Interstitial lung disease | 69.79 | 10.68 | 34 | 83156 | 65248 | 34808493 |
| Breast cancer | 69.13 | 10.68 | 26 | 83164 | 263 | 34873478 |
| Hyperlipidaemia | 66.45 | 10.68 | 122 | 83068 | 14407 | 34859334 |
| Genital atrophy | 65.56 | 10.68 | 13 | 83177 | 0 | 34873741 |
| Breast tenderness | 64.20 | 10.68 | 33 | 83157 | 738 | 34873003 |
| Testicular cyst | 63.31 | 10.68 | 17 | 83173 | 47 | 34873694 |
| Major depression | 62.08 | 10.68 | 65 | 83125 | 4507 | 34869234 |
| Condition aggravated | 61.61 | 10.68 | 242 | 82948 | 191954 | 34681787 |
| Haematospermia | 61.37 | 10.68 | 25 | 83165 | 318 | 34873423 |
| Breast mass | 60.94 | 10.68 | 30 | 83160 | 610 | 34873131 |
| Melanocytic naevus | 60.90 | 10.68 | 48 | 83142 | 2296 | 34871445 |
| Fatigue | 60.77 | 10.68 | 1227 | 81963 | 369426 | 34504315 |
| Adverse event | 60.73 | 10.68 | 137 | 83053 | 18740 | 34855001 |
| Pollakiuria | 60.22 | 10.68 | 140 | 83050 | 19534 | 34854207 |
| Dysuria | 58.16 | 10.68 | 169 | 83021 | 26983 | 34846758 |
| Neutropenia | 57.84 | 10.68 | 186 | 83004 | 156592 | 34717149 |
| Spermatocele | 57.05 | 10.68 | 14 | 83176 | 23 | 34873718 |
| Pulmonary function test abnormal | 56.37 | 10.68 | 48 | 83142 | 2562 | 34871179 |
| Dihydrotestosterone decreased | 55.48 | 10.68 | 11 | 83179 | 0 | 34873741 |
| Lower urinary tract symptoms | 55.19 | 10.68 | 21 | 83169 | 220 | 34873521 |
| Nocturia | 54.82 | 10.68 | 92 | 83098 | 10118 | 34863623 |
| Male sexual dysfunction | 54.71 | 10.68 | 22 | 83168 | 270 | 34873471 |
| Prostatomegaly | 52.18 | 10.68 | 64 | 83126 | 5277 | 34868464 |
| Azoospermia | 52.17 | 10.68 | 24 | 83166 | 417 | 34873324 |
| Generalised anxiety disorder | 51.48 | 10.68 | 29 | 83161 | 783 | 34872958 |
| Epididymitis | 50.63 | 10.68 | 44 | 83146 | 2415 | 34871326 |
| Semen viscosity decreased | 50.43 | 10.68 | 10 | 83180 | 0 | 34873741 |
| Somatic symptom disorder | 50.21 | 10.68 | 27 | 83163 | 664 | 34873077 |
| Product use in unapproved indication | 50.19 | 10.68 | 130 | 83060 | 117369 | 34756372 |
| Haematuria | 50.14 | 10.68 | 244 | 82946 | 49822 | 34823919 |
| Blood oestrogen increased | 50.11 | 10.68 | 14 | 83176 | 47 | 34873694 |
| Oligospermia | 49.51 | 10.68 | 16 | 83174 | 98 | 34873643 |
| Fall | 48.88 | 10.68 | 715 | 82475 | 202170 | 34671571 |
| Wisdom teeth removal | 48.83 | 10.68 | 16 | 83174 | 103 | 34873638 |
| Marital problem | 48.41 | 10.68 | 14 | 83176 | 55 | 34873686 |
| Arthroscopy | 47.25 | 10.68 | 15 | 83175 | 86 | 34873655 |
| Orthostatic hypotension | 46.82 | 10.68 | 152 | 83038 | 25767 | 34847974 |
| Septic shock | 46.14 | 10.68 | 62 | 83128 | 71772 | 34801969 |
| Sepsis | 45.87 | 10.68 | 222 | 82968 | 166339 | 34707402 |
| C-reactive protein increased | 45.66 | 10.68 | 37 | 83153 | 54061 | 34819680 |
| Body fat disorder | 45.58 | 10.68 | 13 | 83177 | 48 | 34873693 |
| Amnesia | 45.50 | 10.68 | 153 | 83037 | 26410 | 34847331 |
| Dark circles under eyes | 45.37 | 10.68 | 13 | 83177 | 49 | 34873692 |
| Genital paraesthesia | 45.28 | 10.68 | 12 | 83178 | 31 | 34873710 |
| Nausea | 44.84 | 10.68 | 556 | 82634 | 339352 | 34534389 |
| Self esteem decreased | 44.68 | 10.68 | 23 | 83167 | 516 | 34873225 |
| Mucosal inflammation | 44.60 | 10.68 | 18 | 83172 | 38604 | 34835137 |
| Intentional product use issue | 44.44 | 10.68 | 46 | 83144 | 59770 | 34813971 |
| Breast cancer male | 44.24 | 10.68 | 21 | 83169 | 393 | 34873348 |
| Hypoacusis | 43.47 | 10.68 | 110 | 83080 | 16191 | 34857550 |
| Attention deficit hyperactivity disorder | 43.28 | 10.68 | 41 | 83149 | 2518 | 34871223 |
| Soft tissue injury | 43.15 | 10.68 | 17 | 83173 | 197 | 34873544 |
| Cardiac arrest | 42.92 | 10.68 | 104 | 83086 | 96055 | 34777686 |
| Overdose | 42.63 | 10.68 | 96 | 83094 | 90963 | 34782778 |
| Hepatic vein dilatation | 41.82 | 10.68 | 17 | 83173 | 215 | 34873526 |
| Hypospermia | 41.31 | 10.68 | 10 | 83180 | 15 | 34873726 |
| Hormone receptor positive breast cancer | 41.07 | 10.68 | 11 | 83179 | 30 | 34873711 |
| Breast pain | 40.94 | 10.68 | 31 | 83159 | 1397 | 34872344 |
| Prostatic disorder | 40.73 | 10.68 | 45 | 83145 | 3317 | 34870424 |
| Secondary hypogonadism | 40.69 | 10.68 | 18 | 83172 | 284 | 34873457 |
| Treatment failure | 40.59 | 10.68 | 31 | 83159 | 46666 | 34827075 |
| Intentional overdose | 40.58 | 10.68 | 27 | 83163 | 43647 | 34830094 |
| Terminal dribbling | 40.35 | 10.68 | 8 | 83182 | 0 | 34873741 |
| Androgens abnormal | 40.35 | 10.68 | 8 | 83182 | 0 | 34873741 |
| Teratospermia | 40.35 | 10.68 | 8 | 83182 | 0 | 34873741 |
| Osteoporosis | 39.70 | 10.68 | 91 | 83099 | 12577 | 34861164 |
| Anogenital warts | 39.70 | 10.68 | 22 | 83168 | 575 | 34873166 |
| Metabolic acidosis | 39.26 | 10.68 | 28 | 83162 | 43652 | 34830089 |
| Libido disorder | 39.15 | 10.68 | 17 | 83173 | 256 | 34873485 |
| Chest X-ray abnormal | 38.67 | 10.68 | 50 | 83140 | 4348 | 34869393 |
| Skin atrophy | 38.17 | 10.68 | 35 | 83155 | 2062 | 34871679 |
| Knee operation | 38.17 | 10.68 | 35 | 83155 | 2062 | 34871679 |
| Scrotal disorder | 37.73 | 10.68 | 14 | 83176 | 136 | 34873605 |
| Patellofemoral pain syndrome | 37.73 | 10.68 | 14 | 83176 | 136 | 34873605 |
| Spermatozoa abnormal | 37.68 | 10.68 | 11 | 83179 | 45 | 34873696 |
| Stress at work | 37.58 | 10.68 | 16 | 83174 | 229 | 34873512 |
| Partner stress | 37.46 | 10.68 | 14 | 83176 | 139 | 34873602 |
| Diastolic dysfunction | 37.35 | 10.68 | 59 | 83131 | 6168 | 34867573 |
| Radical prostatectomy | 37.30 | 10.68 | 11 | 83179 | 47 | 34873694 |
| Completed suicide | 37.20 | 10.68 | 115 | 83075 | 98053 | 34775688 |
| Respiratory failure | 37.15 | 10.68 | 133 | 83057 | 108439 | 34765302 |
| Tachycardia | 36.79 | 10.68 | 93 | 83097 | 84679 | 34789062 |
| Cytomegalovirus infection | 35.82 | 10.68 | 9 | 83181 | 26126 | 34847615 |
| Malignant neoplasm progression | 35.63 | 10.68 | 100 | 83090 | 87946 | 34785795 |
| Persistent depressive disorder | 35.53 | 10.68 | 17 | 83173 | 324 | 34873417 |
| Ascites | 35.52 | 10.68 | 35 | 83155 | 46536 | 34827205 |
| Feeling abnormal | 35.52 | 10.68 | 265 | 82925 | 62970 | 34810771 |
| Mole excision | 35.30 | 10.68 | 7 | 83183 | 0 | 34873741 |
| Apathy | 35.28 | 10.68 | 61 | 83129 | 6871 | 34866870 |
| Cytokine release syndrome | 35.22 | 10.68 | 6 | 83184 | 22871 | 34850870 |
| Cardio-respiratory arrest | 35.19 | 10.68 | 48 | 83142 | 55225 | 34818516 |
| Dehydroepiandrosterone decreased | 34.91 | 10.68 | 9 | 83181 | 20 | 34873721 |
| Leukopenia | 34.82 | 10.68 | 60 | 83130 | 62796 | 34810945 |
| Sexually transmitted disease | 34.60 | 10.68 | 9 | 83181 | 21 | 34873720 |
| Emotional distress | 34.59 | 10.68 | 96 | 83094 | 14930 | 34858811 |
| Blood thyroid stimulating hormone decreased | 34.56 | 10.68 | 32 | 83158 | 1909 | 34871832 |
| Chronic fatigue syndrome | 34.17 | 10.68 | 17 | 83173 | 354 | 34873387 |
| Arterial insufficiency | 34.01 | 10.68 | 13 | 83177 | 138 | 34873603 |
| Psychosexual disorder | 33.95 | 10.68 | 12 | 83178 | 100 | 34873641 |
| Infusion related reaction | 33.86 | 10.68 | 46 | 83144 | 53011 | 34820730 |
| Panic disorder | 33.27 | 10.68 | 26 | 83164 | 1228 | 34872513 |
| Blood luteinising hormone decreased | 33.14 | 10.68 | 12 | 83178 | 108 | 34873633 |
| Breast disorder male | 33.04 | 10.68 | 8 | 83182 | 12 | 34873729 |
| Disseminated intravascular coagulation | 32.98 | 10.68 | 6 | 83184 | 21810 | 34851931 |
| Perineal pain | 32.93 | 10.68 | 22 | 83168 | 811 | 34872930 |
| Nipple pain | 32.90 | 10.68 | 23 | 83167 | 914 | 34872827 |
| Nasal septal operation | 32.80 | 10.68 | 10 | 83180 | 49 | 34873692 |
| Hydrocele | 32.59 | 10.68 | 32 | 83158 | 2055 | 34871686 |
| Social anxiety disorder | 32.12 | 10.68 | 16 | 83174 | 334 | 34873407 |
| Nasal septum deviation | 31.82 | 10.68 | 24 | 83166 | 1075 | 34872666 |
| Spermatozoa progressive motility decreased | 31.68 | 10.68 | 12 | 83178 | 124 | 34873617 |
| Semen discolouration | 31.60 | 10.68 | 8 | 83182 | 16 | 34873725 |
| Liver palpable | 31.58 | 10.68 | 15 | 83175 | 281 | 34873460 |
| Muscle strain | 31.57 | 10.68 | 43 | 83147 | 3933 | 34869808 |
| Seizure | 31.07 | 10.68 | 136 | 83054 | 104721 | 34769020 |
| Hernia repair | 30.81 | 10.68 | 25 | 83165 | 1247 | 34872494 |
| Drug interaction | 30.71 | 10.68 | 367 | 82823 | 225579 | 34648162 |
| Alanine aminotransferase increased | 30.38 | 10.68 | 95 | 83095 | 80720 | 34793021 |
| Testicular microlithiasis | 30.37 | 10.68 | 8 | 83182 | 20 | 34873721 |
| Varicocele repair | 30.26 | 10.68 | 6 | 83184 | 0 | 34873741 |
| Granulomatous rosacea | 30.08 | 10.68 | 12 | 83178 | 144 | 34873597 |
| Renal failure | 29.88 | 10.68 | 185 | 83005 | 130372 | 34743369 |
| Macular hole | 29.40 | 10.68 | 13 | 83177 | 205 | 34873536 |
| Drug hypersensitivity | 29.33 | 10.68 | 96 | 83094 | 80433 | 34793308 |
| Sleep disorder | 29.29 | 10.68 | 151 | 83039 | 31537 | 34842204 |
| Ejaculation delayed | 29.20 | 10.68 | 14 | 83176 | 268 | 34873473 |
| Essential hypertension | 28.93 | 10.68 | 36 | 83154 | 3012 | 34870729 |
| Rhinitis allergic | 28.91 | 10.68 | 36 | 83154 | 3014 | 34870727 |
| Hypotrichosis | 28.60 | 10.68 | 8 | 83182 | 27 | 34873714 |
| Urinary tract obstruction | 28.51 | 10.68 | 39 | 83151 | 3581 | 34870160 |
| Irritable bowel syndrome | 28.32 | 10.68 | 39 | 83151 | 3604 | 34870137 |
| Saliva altered | 27.56 | 10.68 | 12 | 83178 | 182 | 34873559 |
| Platypnoea | 27.55 | 10.68 | 8 | 83182 | 32 | 34873709 |
| Genital pain | 27.44 | 10.68 | 16 | 83174 | 462 | 34873279 |
| Thrombocytopenia | 27.31 | 10.68 | 239 | 82951 | 156008 | 34717733 |
| Lid sulcus deepened | 27.20 | 10.68 | 9 | 83181 | 60 | 34873681 |
| Serotonin syndrome | 27.05 | 10.68 | 7 | 83183 | 19926 | 34853815 |
| Rotator cuff repair | 27.04 | 10.68 | 14 | 83176 | 318 | 34873423 |
| Acute respiratory distress syndrome | 27.03 | 10.68 | 14 | 83176 | 25955 | 34847786 |
| Adenotonsillectomy | 26.98 | 10.68 | 8 | 83182 | 35 | 34873706 |
| Emotional poverty | 26.59 | 10.68 | 17 | 83173 | 581 | 34873160 |
| Psychiatric symptom | 26.40 | 10.68 | 37 | 83153 | 3476 | 34870265 |
| Pelvic pain | 26.33 | 10.68 | 31 | 83159 | 2449 | 34871292 |
| Dermal cyst | 26.17 | 10.68 | 27 | 83163 | 1840 | 34871901 |
| Primary hypogonadism | 26.01 | 10.68 | 9 | 83181 | 70 | 34873671 |
| Renal impairment | 25.97 | 10.68 | 126 | 83064 | 94387 | 34779354 |
| Urinary tract infection | 25.88 | 10.68 | 310 | 82880 | 83771 | 34789970 |
| Skin irritation | 25.71 | 10.68 | 47 | 83143 | 5530 | 34868211 |
| Respiratory depression | 25.59 | 10.68 | 4 | 83186 | 16241 | 34857500 |
| Product use issue | 25.42 | 10.68 | 72 | 83118 | 63144 | 34810597 |
| Hypercholesterolaemia | 25.34 | 10.68 | 61 | 83129 | 8701 | 34865040 |
| Disease progression | 25.32 | 10.68 | 152 | 83038 | 107925 | 34765816 |
| Liposuction | 25.22 | 10.68 | 5 | 83185 | 0 | 34873741 |
| Leydig cell tumour of the testis | 25.22 | 10.68 | 5 | 83185 | 0 | 34873741 |
| Psychogenic erectile dysfunction | 25.22 | 10.68 | 5 | 83185 | 0 | 34873741 |
| Shock | 25.22 | 10.68 | 13 | 83177 | 24166 | 34849575 |
| Suicide attempt | 24.87 | 10.68 | 34 | 83156 | 39082 | 34834659 |
| Respiratory distress | 24.75 | 10.68 | 29 | 83161 | 35636 | 34838105 |
| Vitamin D deficiency | 24.74 | 10.68 | 51 | 83139 | 6557 | 34867184 |
| Inguinal hernia repair | 24.69 | 10.68 | 13 | 83177 | 306 | 34873435 |
| Prostatic specific antigen increased | 24.65 | 10.68 | 84 | 83106 | 14596 | 34859145 |
| Penile vascular disorder | 24.40 | 10.68 | 6 | 83184 | 10 | 34873731 |
| Genital lesion | 24.29 | 10.68 | 12 | 83178 | 246 | 34873495 |
| Platelet distribution width increased | 24.08 | 10.68 | 10 | 83180 | 134 | 34873607 |
| Ligament sprain | 24.07 | 10.68 | 35 | 83155 | 3402 | 34870339 |
| Hepatic failure | 24.05 | 10.68 | 28 | 83162 | 34503 | 34839238 |
| Pneumonia | 23.88 | 10.68 | 669 | 82521 | 361958 | 34511783 |
| Prostatic operation | 23.83 | 10.68 | 14 | 83176 | 410 | 34873331 |
| Testicular mass | 23.59 | 10.68 | 9 | 83181 | 95 | 34873646 |
| Skin papilloma | 23.52 | 10.68 | 27 | 83163 | 2076 | 34871665 |
| Oestradiol increased | 23.48 | 10.68 | 8 | 83182 | 59 | 34873682 |
| Bone marrow failure | 23.46 | 10.68 | 21 | 83169 | 29232 | 34844509 |
| Diabetic ketoacidosis | 23.23 | 10.68 | 7 | 83183 | 18025 | 34855716 |
| Hallucination | 23.06 | 10.68 | 205 | 82985 | 51293 | 34822448 |
| Appendicectomy | 22.94 | 10.68 | 20 | 83170 | 1102 | 34872639 |
| Shoulder operation | 22.88 | 10.68 | 20 | 83170 | 1106 | 34872635 |
| Physical disability | 22.87 | 10.68 | 22 | 83168 | 1377 | 34872364 |
| Radiotherapy to prostate | 22.87 | 10.68 | 5 | 83185 | 3 | 34873738 |
| Seborrhoeic keratosis | 22.72 | 10.68 | 21 | 83169 | 1250 | 34872491 |
| Rheumatoid arthritis | 22.58 | 10.68 | 35 | 83155 | 38203 | 34835538 |
| Stomatitis | 22.27 | 10.68 | 42 | 83148 | 42472 | 34831269 |
| Asthenia | 22.15 | 10.68 | 751 | 82439 | 244500 | 34629241 |
| Anhedonia | 22.15 | 10.68 | 53 | 83137 | 7532 | 34866209 |
| Rash maculo-papular | 22.14 | 10.68 | 21 | 83169 | 28430 | 34845311 |
| Renal cyst | 21.83 | 10.68 | 59 | 83131 | 9034 | 34864707 |
| Injection site pain | 21.81 | 10.68 | 37 | 83153 | 38968 | 34834773 |
| Feminisation acquired | 21.78 | 10.68 | 7 | 83183 | 42 | 34873699 |
| Benign neoplasm of skin | 21.64 | 10.68 | 9 | 83181 | 121 | 34873620 |
| Orchitis | 21.60 | 10.68 | 23 | 83167 | 1626 | 34872115 |
| Epicondylitis | 21.55 | 10.68 | 14 | 83176 | 492 | 34873249 |
| Androgen insensitivity syndrome | 21.51 | 10.68 | 6 | 83184 | 20 | 34873721 |
| Lactic acidosis | 21.33 | 10.68 | 31 | 83159 | 34741 | 34839000 |
| Cerumen impaction | 21.32 | 10.68 | 13 | 83177 | 408 | 34873333 |
| Erythema | 21.25 | 10.68 | 124 | 83066 | 88656 | 34785085 |
| Bronchiectasis | 20.98 | 10.68 | 61 | 83129 | 9740 | 34864001 |
| Seborrhoeic dermatitis | 20.93 | 10.68 | 23 | 83167 | 1685 | 34872056 |
| Diverticulum | 20.88 | 10.68 | 50 | 83140 | 7109 | 34866632 |
| Blood follicle stimulating hormone decreased | 20.86 | 10.68 | 7 | 83183 | 49 | 34873692 |
| Mastectomy | 20.86 | 10.68 | 6 | 83184 | 23 | 34873718 |
| Blood testosterone increased | 20.78 | 10.68 | 20 | 83170 | 1253 | 34872488 |
| Inferior vena cava dilatation | 20.69 | 10.68 | 16 | 83174 | 744 | 34872997 |
| Toxic epidermal necrolysis | 20.62 | 10.68 | 13 | 83177 | 21633 | 34852108 |
| Agranulocytosis | 20.46 | 10.68 | 16 | 83174 | 23805 | 34849936 |
| Bladder neck obstruction | 20.35 | 10.68 | 9 | 83181 | 142 | 34873599 |
| Drug resistance | 20.33 | 10.68 | 19 | 83171 | 25908 | 34847833 |
| Drug ineffective for unapproved indication | 20.28 | 10.68 | 16 | 83174 | 23699 | 34850042 |
| Daydreaming | 20.26 | 10.68 | 14 | 83176 | 546 | 34873195 |
| Benign tumour excision | 20.17 | 10.68 | 4 | 83186 | 0 | 34873741 |
| Late onset hypogonadism syndrome | 20.17 | 10.68 | 4 | 83186 | 0 | 34873741 |
| Pelvic floor muscle weakness | 20.17 | 10.68 | 4 | 83186 | 0 | 34873741 |
| Oestrogenic effect | 20.17 | 10.68 | 4 | 83186 | 0 | 34873741 |
| Blood follicle stimulating hormone abnormal | 20.17 | 10.68 | 4 | 83186 | 0 | 34873741 |
| Sex hormone binding globulin increased | 20.09 | 10.68 | 5 | 83185 | 9 | 34873732 |
| Pneumocystis jirovecii pneumonia | 19.96 | 10.68 | 11 | 83179 | 19699 | 34854042 |
| Palpitations | 19.91 | 10.68 | 163 | 83027 | 39823 | 34833918 |
| Haemorrhoids | 19.91 | 10.68 | 78 | 83112 | 14497 | 34859244 |
| Acrochordon | 19.70 | 10.68 | 12 | 83178 | 376 | 34873365 |
| Memory impairment | 19.68 | 10.68 | 173 | 83017 | 43145 | 34830596 |
| Illusion | 19.50 | 10.68 | 16 | 83174 | 811 | 34872930 |
| Seminoma | 19.32 | 10.68 | 10 | 83180 | 227 | 34873514 |
| Cystitis | 19.22 | 10.68 | 59 | 83131 | 9706 | 34864035 |
| Lipoma | 19.03 | 10.68 | 22 | 83168 | 1704 | 34872037 |
| Bladder outlet obstruction | 19.03 | 10.68 | 9 | 83181 | 167 | 34873574 |
| Epilepsy | 19.02 | 10.68 | 14 | 83176 | 21481 | 34852260 |
| Seborrhoea | 18.85 | 10.68 | 10 | 83180 | 239 | 34873502 |
| Balance disorder | 18.80 | 10.68 | 163 | 83027 | 40491 | 34833250 |
| Prostatic calcification | 18.76 | 10.68 | 8 | 83182 | 115 | 34873626 |
| Blood testosterone free decreased | 18.68 | 10.68 | 7 | 83183 | 70 | 34873671 |
| Alveolar bone resorption | 18.57 | 10.68 | 5 | 83185 | 14 | 34873727 |
| Neutrophil count decreased | 18.55 | 10.68 | 61 | 83129 | 51043 | 34822698 |
| Extrapyramidal disorder | 18.51 | 10.68 | 4 | 83186 | 12876 | 34860865 |
| Anxiety disorder | 18.34 | 10.68 | 22 | 83168 | 1772 | 34871969 |
| Hepatic function abnormal | 18.22 | 10.68 | 50 | 83140 | 44313 | 34829428 |
| Pancreatitis | 18.19 | 10.68 | 41 | 83149 | 38850 | 34834891 |
| Ventricular enlargement | 18.12 | 10.68 | 14 | 83176 | 650 | 34873091 |
| Cardiogenic shock | 18.09 | 10.68 | 22 | 83168 | 26596 | 34847145 |
| Seasonal affective disorder | 18.08 | 10.68 | 5 | 83185 | 16 | 34873725 |
| Atrial enlargement | 17.97 | 10.68 | 14 | 83176 | 658 | 34873083 |
| Testis discomfort | 17.94 | 10.68 | 4 | 83186 | 3 | 34873738 |
| Blunted affect | 17.94 | 10.68 | 11 | 83179 | 349 | 34873392 |
| Atrial fibrillation | 17.91 | 10.68 | 399 | 82791 | 121994 | 34751747 |
| Nephropathy toxic | 17.91 | 10.68 | 4 | 83186 | 12584 | 34861157 |
| Inner ear disorder | 17.89 | 10.68 | 9 | 83181 | 192 | 34873549 |
| Genital burning sensation | 17.85 | 10.68 | 5 | 83185 | 17 | 34873724 |
| Ventricular fibrillation | 17.79 | 10.68 | 17 | 83173 | 22937 | 34850804 |
| Plica syndrome | 17.41 | 10.68 | 4 | 83186 | 4 | 34873737 |
| Genital cyst | 17.41 | 10.68 | 4 | 83186 | 4 | 34873737 |
| Melanocytic hyperplasia | 17.41 | 10.68 | 4 | 83186 | 4 | 34873737 |
| Keratomileusis | 17.41 | 10.68 | 4 | 83186 | 4 | 34873737 |
| Hypothalamo-pituitary disorder | 17.39 | 10.68 | 15 | 83175 | 815 | 34872926 |
| Back injury | 17.31 | 10.68 | 33 | 83157 | 4008 | 34869733 |
| Sex hormone binding globulin decreased | 17.22 | 10.68 | 5 | 83185 | 20 | 34873721 |
| Lymphadenectomy | 17.20 | 10.68 | 11 | 83179 | 376 | 34873365 |
| Malpositioned teeth | 17.02 | 10.68 | 5 | 83185 | 21 | 34873720 |
| Xanthopsia | 16.98 | 10.68 | 8 | 83182 | 147 | 34873594 |
| Thinking abnormal | 16.98 | 10.68 | 42 | 83148 | 6095 | 34867646 |
| Cholecystectomy | 16.94 | 10.68 | 27 | 83163 | 2843 | 34870898 |
| Flat affect | 16.87 | 10.68 | 15 | 83175 | 849 | 34872892 |
| Acute kidney injury | 16.79 | 10.68 | 576 | 82614 | 304412 | 34569329 |
| Affective disorder | 16.73 | 10.68 | 34 | 83156 | 4326 | 34869415 |
| Lung disorder | 16.70 | 10.68 | 36 | 83154 | 34660 | 34839081 |
| Facial bones fracture | 16.69 | 10.68 | 25 | 83165 | 2495 | 34871246 |
| Myocardial infarction | 16.67 | 10.68 | 196 | 82994 | 120889 | 34752852 |
| Bronchopulmonary aspergillosis | 16.65 | 10.68 | 7 | 83183 | 14652 | 34859089 |
| Sprue-like enteropathy | 16.65 | 10.68 | 12 | 83178 | 501 | 34873240 |
| Cardiac failure | 16.63 | 10.68 | 138 | 83052 | 91110 | 34782631 |
| Aspartate aminotransferase increased | 16.57 | 10.68 | 94 | 83096 | 67689 | 34806052 |
| Rhinoplasty | 16.52 | 10.68 | 4 | 83186 | 6 | 34873735 |
| Benign breast neoplasm | 16.52 | 10.68 | 4 | 83186 | 6 | 34873735 |
| Penile prosthesis insertion | 16.52 | 10.68 | 4 | 83186 | 6 | 34873735 |
| Pelvic discomfort | 16.52 | 10.68 | 4 | 83186 | 6 | 34873735 |
| Pudendal canal syndrome | 16.52 | 10.68 | 4 | 83186 | 6 | 34873735 |
| Decreased interest | 16.48 | 10.68 | 24 | 83166 | 2336 | 34871405 |
| Dissociation | 16.41 | 10.68 | 20 | 83170 | 1638 | 34872103 |
| Xerophthalmia | 16.39 | 10.68 | 7 | 83183 | 101 | 34873640 |
| Obsessive-compulsive disorder | 16.37 | 10.68 | 39 | 83151 | 5525 | 34868216 |
| Micturition urgency | 16.33 | 10.68 | 43 | 83147 | 6482 | 34867259 |
| Milia | 16.32 | 10.68 | 5 | 83185 | 25 | 34873716 |
| Rosacea | 16.27 | 10.68 | 17 | 83173 | 1176 | 34872565 |
| Fat tissue increased | 16.26 | 10.68 | 11 | 83179 | 414 | 34873327 |
| Scrotal pain | 16.25 | 10.68 | 15 | 83175 | 891 | 34872850 |
| Limb operation | 16.24 | 10.68 | 14 | 83176 | 760 | 34872981 |
| Impaired fasting glucose | 16.18 | 10.68 | 9 | 83181 | 237 | 34873504 |
| Drug reaction with eosinophilia and systemic symptoms | 16.10 | 10.68 | 34 | 83156 | 32978 | 34840763 |
| Retrograde ejaculation | 16.08 | 10.68 | 11 | 83179 | 422 | 34873319 |
| Blood pressure fluctuation | 15.99 | 10.68 | 22 | 83168 | 25227 | 34848514 |
| Agoraphobia | 15.98 | 10.68 | 9 | 83181 | 243 | 34873498 |
| Muscle disorder | 15.95 | 10.68 | 25 | 83165 | 2596 | 34871145 |
| Joint injury | 15.85 | 10.68 | 53 | 83137 | 9120 | 34864621 |
| Gingival recession | 15.81 | 10.68 | 11 | 83179 | 434 | 34873307 |
| Type V hyperlipidaemia | 15.78 | 10.68 | 14 | 83176 | 790 | 34872951 |
| Asthenospermia | 15.67 | 10.68 | 6 | 83184 | 64 | 34873677 |
| Mental impairment | 15.55 | 10.68 | 57 | 83133 | 10265 | 34863476 |
| Acute hepatic failure | 15.54 | 10.68 | 7 | 83183 | 14067 | 34859674 |
| Groin pain | 15.54 | 10.68 | 38 | 83152 | 5475 | 34868266 |
| Drug-induced liver injury | 15.53 | 10.68 | 28 | 83162 | 28804 | 34844937 |
| Penile exfoliation | 15.51 | 10.68 | 7 | 83183 | 116 | 34873625 |
| Product name confusion | 15.51 | 10.68 | 6 | 83184 | 66 | 34873675 |
| Hypoglycaemia | 15.49 | 10.68 | 72 | 83118 | 54568 | 34819173 |
| Chills | 15.49 | 10.68 | 121 | 83069 | 80922 | 34792819 |
| Hypertrophy | 15.46 | 10.68 | 11 | 83179 | 450 | 34873291 |
| Bladder disorder | 15.43 | 10.68 | 28 | 83162 | 3276 | 34870465 |
| Musculoskeletal stiffness | 15.41 | 10.68 | 58 | 83132 | 46622 | 34827119 |
| Peripheral coldness | 15.39 | 10.68 | 45 | 83145 | 7206 | 34866535 |
| Depression suicidal | 15.39 | 10.68 | 24 | 83166 | 2481 | 34871260 |
| Gout | 15.26 | 10.68 | 88 | 83102 | 19165 | 34854576 |
| Mammoplasty | 15.19 | 10.68 | 4 | 83186 | 10 | 34873731 |
| Exostosis of external ear canal | 15.19 | 10.68 | 4 | 83186 | 10 | 34873731 |
| Eyelid cyst | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Varicose vein operation | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Plastic surgery | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Penile repair | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Sigmoidectomy | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Psychophysiologic insomnia | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Urinary bladder suspension | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Benign breast lump removal | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Uvulopalatopharyngoplasty | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Semen liquefaction | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Genital injury | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Dermatitis artefacta | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Lipoma excision | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Interspinous osteoarthritis | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Penile wart | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Biotin deficiency | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Blood oestrogen abnormal | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Scar excision | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Sclerotherapy | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Cryotherapy | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Pseudohermaphroditism male | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Prostate tenderness | 15.13 | 10.68 | 3 | 83187 | 0 | 34873741 |
| Pancytopenia | 15.12 | 10.68 | 149 | 83041 | 95008 | 34778733 |
| Prostatic dysplasia | 14.91 | 10.68 | 4 | 83186 | 11 | 34873730 |
| Soft tissue mass | 14.76 | 10.68 | 15 | 83175 | 1004 | 34872737 |
| Arthroscopic surgery | 14.66 | 10.68 | 4 | 83186 | 12 | 34873729 |
| Urinary straining | 14.66 | 10.68 | 4 | 83186 | 12 | 34873729 |
| Anaphylactic shock | 14.61 | 10.68 | 10 | 83180 | 15931 | 34857810 |
| Drug dependence | 14.45 | 10.68 | 22 | 83168 | 24195 | 34849546 |
| Fixed eruption | 14.44 | 10.68 | 19 | 83171 | 1681 | 34872060 |
| Respiratory arrest | 14.43 | 10.68 | 28 | 83162 | 28015 | 34845726 |
| Meniscus injury | 14.42 | 10.68 | 22 | 83168 | 2231 | 34871510 |
| Post-traumatic stress disorder | 14.42 | 10.68 | 20 | 83170 | 1861 | 34871880 |
| Premature ageing | 14.41 | 10.68 | 6 | 83184 | 81 | 34873660 |
| Varicose vein | 14.41 | 10.68 | 17 | 83173 | 1346 | 34872395 |
| Genital herpes | 14.38 | 10.68 | 12 | 83178 | 623 | 34873118 |
| Dementia Alzheimer's type | 14.29 | 10.68 | 10 | 83180 | 398 | 34873343 |
| Hypoxia | 14.24 | 10.68 | 75 | 83115 | 55020 | 34818721 |
| Haemorrhoid operation | 14.22 | 10.68 | 5 | 83185 | 41 | 34873700 |
| Hair texture abnormal | 14.20 | 10.68 | 9 | 83181 | 303 | 34873438 |
| Pericarditis | 14.15 | 10.68 | 5 | 83185 | 11640 | 34862101 |
| Atrioventricular block first degree | 14.10 | 10.68 | 39 | 83151 | 6053 | 34867688 |
| Tinnitus | 14.07 | 10.68 | 89 | 83101 | 20029 | 34853712 |
| Adrenal disorder | 14.07 | 10.68 | 15 | 83175 | 1062 | 34872679 |
| Floppy iris syndrome | 14.07 | 10.68 | 9 | 83181 | 308 | 34873433 |
| Peritonitis | 14.04 | 10.68 | 11 | 83179 | 16354 | 34857387 |
| Therapy non-responder | 14.02 | 10.68 | 47 | 83143 | 39099 | 34834642 |
| Abdominal pain | 13.98 | 10.68 | 290 | 82900 | 163328 | 34710413 |
| Inguinal hernia | 13.96 | 10.68 | 45 | 83145 | 7596 | 34866145 |
| Thrombotic microangiopathy | 13.92 | 10.68 | 4 | 83186 | 10626 | 34863115 |
| General physical health deterioration | 13.91 | 10.68 | 218 | 82972 | 128051 | 34745690 |
| Prostate cancer | 13.91 | 10.68 | 150 | 83040 | 39499 | 34834242 |
| Exposure to communicable disease | 13.89 | 10.68 | 7 | 83183 | 150 | 34873591 |
| Depressed mood | 13.85 | 10.68 | 86 | 83104 | 19231 | 34854510 |
| Vitreous floaters | 13.81 | 10.68 | 28 | 83162 | 3557 | 34870184 |
| Eczema | 13.80 | 10.68 | 83 | 83107 | 18353 | 34855388 |
| Therapy partial responder | 13.79 | 10.68 | 3 | 83187 | 9613 | 34864128 |
| Madarosis | 13.78 | 10.68 | 8 | 83182 | 229 | 34873512 |
| Fear of crowded places | 13.77 | 10.68 | 4 | 83186 | 16 | 34873725 |
| Hyperglycaemia | 13.73 | 10.68 | 48 | 83142 | 39432 | 34834309 |
| Prostatic specific antigen decreased | 13.72 | 10.68 | 7 | 83183 | 154 | 34873587 |
| Creatinine urine decreased | 13.71 | 10.68 | 5 | 83185 | 46 | 34873695 |
| Body height decreased | 13.62 | 10.68 | 29 | 83161 | 3814 | 34869927 |
| Infusion site induration | 13.57 | 10.68 | 8 | 83182 | 236 | 34873505 |
| Invasive ductal breast carcinoma | 13.53 | 10.68 | 5 | 83185 | 48 | 34873693 |
| Abnormal loss of weight | 13.51 | 10.68 | 30 | 83160 | 4060 | 34869681 |
| Bradyphrenia | 13.44 | 10.68 | 33 | 83157 | 4765 | 34868976 |
| Electrocardiogram QT prolonged | 13.44 | 10.68 | 51 | 83139 | 40901 | 34832840 |
| Dyshidrotic eczema | 13.44 | 10.68 | 7 | 83183 | 161 | 34873580 |
| Beta globulin increased | 13.40 | 10.68 | 4 | 83186 | 18 | 34873723 |
| Chlamydial infection | 13.30 | 10.68 | 8 | 83182 | 245 | 34873496 |
| Sinus tachycardia | 13.29 | 10.68 | 13 | 83177 | 17347 | 34856394 |
| Genital rash | 13.25 | 10.68 | 11 | 83179 | 567 | 34873174 |
| Urinary tract disorder | 13.24 | 10.68 | 21 | 83169 | 2203 | 34871538 |
| Red blood cell analysis abnormal | 13.22 | 10.68 | 4 | 83186 | 19 | 34873722 |
| Reproductive tract hypoplasia, male | 13.22 | 10.68 | 4 | 83186 | 19 | 34873722 |
| Sexual relationship change | 13.22 | 10.68 | 4 | 83186 | 19 | 34873722 |
| Gingival disorder | 13.22 | 10.68 | 17 | 83173 | 1470 | 34872271 |
| Enterococcal infection | 13.15 | 10.68 | 3 | 83187 | 9303 | 34864438 |
| Oesophageal carcinoma | 13.15 | 10.68 | 3 | 83187 | 9301 | 34864440 |
| Neoplasm progression | 13.12 | 10.68 | 22 | 83168 | 23278 | 34850463 |
| Neuroleptic malignant syndrome | 13.08 | 10.68 | 14 | 83176 | 17920 | 34855821 |
| Coma | 13.06 | 10.68 | 60 | 83130 | 45618 | 34828123 |
| Otosalpingitis | 13.05 | 10.68 | 4 | 83186 | 20 | 34873721 |
| Alpha 2 globulin decreased | 13.05 | 10.68 | 4 | 83186 | 20 | 34873721 |
| Glomerular filtration rate abnormal | 13.04 | 10.68 | 13 | 83177 | 850 | 34872891 |
| Cystitis radiation | 13.00 | 10.68 | 6 | 83184 | 105 | 34873636 |
| COVID-19 | 12.92 | 10.68 | 120 | 83070 | 77430 | 34796311 |
| Prostatic haemorrhage | 12.90 | 10.68 | 8 | 83182 | 259 | 34873482 |
| Free androgen index decreased | 12.89 | 10.68 | 4 | 83186 | 21 | 34873720 |
| Dry eye | 12.88 | 10.68 | 51 | 83139 | 9524 | 34864217 |
| Blood follicle stimulating hormone increased | 12.88 | 10.68 | 7 | 83183 | 176 | 34873565 |
| Orchidectomy | 12.84 | 10.68 | 5 | 83185 | 56 | 34873685 |
| Social avoidant behaviour | 12.81 | 10.68 | 25 | 83165 | 3089 | 34870652 |
| Lymphopenia | 12.77 | 10.68 | 12 | 83178 | 16323 | 34857418 |
| Pneumothorax | 12.74 | 10.68 | 16 | 83174 | 19076 | 34854665 |
| Viral acanthoma | 12.74 | 10.68 | 4 | 83186 | 22 | 34873719 |
| Incorrect route of product administration | 12.71 | 10.68 | 10 | 83180 | 14835 | 34858906 |
| Vision blurred | 12.65 | 10.68 | 166 | 83024 | 45797 | 34827944 |
| Emotional disorder | 12.64 | 10.68 | 36 | 83154 | 5680 | 34868061 |
| Full blood count decreased | 12.64 | 10.68 | 80 | 83110 | 18008 | 34855733 |
| Plantar fascial fibromatosis | 12.60 | 10.68 | 3 | 83187 | 4 | 34873737 |
| Acne | 12.59 | 10.68 | 56 | 83134 | 11010 | 34862731 |
| Transurethral prostatectomy | 12.59 | 10.68 | 9 | 83181 | 371 | 34873370 |
| Posterior reversible encephalopathy syndrome | 12.58 | 10.68 | 4 | 83186 | 9950 | 34863791 |
| Intervertebral disc protrusion | 12.57 | 10.68 | 52 | 83138 | 9904 | 34863837 |
| Hyperbilirubinaemia | 12.45 | 10.68 | 13 | 83177 | 16830 | 34856911 |
| Umbilical hernia repair | 12.45 | 10.68 | 4 | 83186 | 24 | 34873717 |
| Cortisol increased | 12.43 | 10.68 | 7 | 83183 | 189 | 34873552 |
| Exposure via body fluid | 12.42 | 10.68 | 6 | 83184 | 117 | 34873624 |
| Pemphigoid | 12.34 | 10.68 | 47 | 83143 | 8619 | 34865122 |
| Temperature intolerance | 12.33 | 10.68 | 26 | 83164 | 3396 | 34870345 |
| Urine calcium/creatinine ratio increased | 12.31 | 10.68 | 4 | 83186 | 25 | 34873716 |
| Mitral valve prolapse | 12.30 | 10.68 | 11 | 83179 | 627 | 34873114 |
| Sinus polyp | 12.30 | 10.68 | 7 | 83183 | 193 | 34873548 |
| Brain oedema | 12.23 | 10.68 | 9 | 83181 | 13812 | 34859929 |
| Bladder trabeculation | 12.20 | 10.68 | 3 | 83187 | 5 | 34873736 |
| Motion sickness | 12.20 | 10.68 | 7 | 83183 | 196 | 34873545 |
| Hepatic cytolysis | 12.12 | 10.68 | 10 | 83180 | 14486 | 34859255 |
| Proteinuria | 12.05 | 10.68 | 16 | 83174 | 18626 | 34855115 |
| Bladder stenosis | 12.05 | 10.68 | 4 | 83186 | 27 | 34873714 |
| Nasal discomfort | 12.02 | 10.68 | 17 | 83173 | 1611 | 34872130 |
| N-terminal prohormone brain natriuretic peptide abnormal | 12.01 | 10.68 | 7 | 83183 | 202 | 34873539 |
| Rhabdomyolysis | 12.00 | 10.68 | 104 | 83086 | 68059 | 34805682 |
| Rales | 12.00 | 10.68 | 51 | 83139 | 9832 | 34863909 |
| Nipple disorder | 11.98 | 10.68 | 7 | 83183 | 203 | 34873538 |
| Device related infection | 11.98 | 10.68 | 14 | 83176 | 17223 | 34856518 |
| C-reactive protein abnormal | 11.93 | 10.68 | 3 | 83187 | 8707 | 34865034 |
| Prostatic obstruction | 11.89 | 10.68 | 6 | 83184 | 129 | 34873612 |
| Alpha globulin increased | 11.85 | 10.68 | 3 | 83187 | 6 | 34873735 |
| Blood testosterone free increased | 11.80 | 10.68 | 4 | 83186 | 29 | 34873712 |
| Hair growth abnormal | 11.80 | 10.68 | 12 | 83178 | 804 | 34872937 |
| Delusion of replacement | 11.64 | 10.68 | 6 | 83184 | 135 | 34873606 |
| Thyroid hormones increased | 11.59 | 10.68 | 5 | 83185 | 74 | 34873667 |
| Transplant rejection | 11.59 | 10.68 | 5 | 83185 | 10306 | 34863435 |
| Hepatocellular injury | 11.58 | 10.68 | 22 | 83168 | 22189 | 34851552 |
| Thyroid cyst | 11.57 | 10.68 | 4 | 83186 | 31 | 34873710 |
| Snoring | 11.57 | 10.68 | 25 | 83165 | 3321 | 34870420 |
| Hair colour changes | 11.55 | 10.68 | 18 | 83172 | 1859 | 34871882 |
| Spermatozoa morphology abnormal | 11.53 | 10.68 | 3 | 83187 | 7 | 34873734 |
| Mood altered | 11.50 | 10.68 | 47 | 83143 | 8905 | 34864836 |
| Hyposmia | 11.47 | 10.68 | 7 | 83183 | 220 | 34873521 |
| Radiotherapy | 11.44 | 10.68 | 9 | 83181 | 429 | 34873312 |
| Status epilepticus | 11.44 | 10.68 | 8 | 83182 | 12606 | 34861135 |
| Drug level increased | 11.42 | 10.68 | 22 | 83168 | 22074 | 34851667 |
| Dandruff | 11.28 | 10.68 | 7 | 83183 | 227 | 34873514 |
| Uterine haemorrhage | 11.25 | 10.68 | 3 | 83187 | 8 | 34873733 |
| Pneumonitis | 11.24 | 10.68 | 42 | 83148 | 33836 | 34839905 |
| Adverse drug reaction | 11.23 | 10.68 | 113 | 83077 | 29229 | 34844512 |
| Eosinophilia | 11.19 | 10.68 | 29 | 83161 | 26193 | 34847548 |
| Faeces discoloured | 11.15 | 10.68 | 67 | 83123 | 14811 | 34858930 |
| Colitis | 11.14 | 10.68 | 49 | 83141 | 37701 | 34836040 |
| Blood bilirubin increased | 11.13 | 10.68 | 50 | 83140 | 38246 | 34835495 |
| Adjustment disorder | 11.10 | 10.68 | 14 | 83176 | 1187 | 34872554 |
| Hepatic cancer | 11.05 | 10.68 | 3 | 83187 | 8272 | 34865469 |
| Pelvic fracture | 11.04 | 10.68 | 21 | 83169 | 2546 | 34871195 |
| Pituitary tumour benign | 11.03 | 10.68 | 12 | 83178 | 869 | 34872872 |
| Hair disorder | 11.03 | 10.68 | 6 | 83184 | 151 | 34873590 |
| Hospice care | 11.03 | 10.68 | 39 | 83151 | 6901 | 34866840 |
| Anti factor Xa activity decreased | 10.99 | 10.68 | 3 | 83187 | 9 | 34873732 |
| Eyelid operation | 10.99 | 10.68 | 3 | 83187 | 9 | 34873732 |
| Wrist surgery | 10.96 | 10.68 | 6 | 83184 | 153 | 34873588 |
| Hyponatraemia | 10.94 | 10.68 | 135 | 83055 | 82556 | 34791185 |
| Myoglobin blood increased | 10.93 | 10.68 | 23 | 83167 | 3000 | 34870741 |
| Febrile bone marrow aplasia | 10.92 | 10.68 | 3 | 83187 | 8206 | 34865535 |
| Phobia | 10.79 | 10.68 | 6 | 83184 | 158 | 34873583 |
| Hepatic enzyme increased | 10.78 | 10.68 | 52 | 83138 | 39028 | 34834713 |
| Anaphylactic reaction | 10.75 | 10.68 | 40 | 83150 | 32261 | 34841480 |
| Painful erection | 10.73 | 10.68 | 7 | 83183 | 248 | 34873493 |
| Cataract operation complication | 10.72 | 10.68 | 6 | 83184 | 160 | 34873581 |
| Listless | 10.69 | 10.68 | 16 | 83174 | 1596 | 34872145 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Erectile dysfunction | 666.01 | 10.66 | 281 | 54305 | 14383 | 79675419 |
| Post 5-alpha-reductase inhibitor syndrome | 477.38 | 10.66 | 79 | 54507 | 22 | 79689780 |
| Libido decreased | 363.76 | 10.66 | 137 | 54449 | 5184 | 79684618 |
| Loss of libido | 301.58 | 10.66 | 100 | 54486 | 2585 | 79687217 |
| Testicular pain | 264.69 | 10.66 | 85 | 54501 | 1980 | 79687822 |
| Penile size reduced | 229.15 | 10.66 | 40 | 54546 | 30 | 79689772 |
| Gynaecomastia | 199.89 | 10.66 | 100 | 54486 | 7581 | 79682221 |
| Right atrial hypertrophy | 160.06 | 10.66 | 46 | 54540 | 725 | 79689077 |
| Depression | 157.75 | 10.66 | 412 | 54174 | 216378 | 79473424 |
| Semen volume decreased | 156.41 | 10.66 | 29 | 54557 | 42 | 79689760 |
| Benign prostatic hyperplasia | 148.70 | 10.66 | 95 | 54491 | 11517 | 79678285 |
| Ejaculation disorder | 133.88 | 10.66 | 37 | 54549 | 502 | 79689300 |
| Right ventricular hypertrophy | 129.75 | 10.66 | 47 | 54539 | 1590 | 79688212 |
| Urinary retention | 123.21 | 10.66 | 172 | 54414 | 56458 | 79633344 |
| Sexual dysfunction | 118.41 | 10.66 | 71 | 54515 | 7692 | 79682110 |
| Organic erectile dysfunction | 116.23 | 10.66 | 24 | 54562 | 78 | 79689724 |
| Haematuria | 113.95 | 10.66 | 184 | 54402 | 68652 | 79621150 |
| Penis disorder | 113.73 | 10.66 | 37 | 54549 | 899 | 79688903 |
| Atrial fibrillation | 105.07 | 10.66 | 336 | 54250 | 197550 | 79492252 |
| Suicidal ideation | 100.03 | 10.66 | 184 | 54402 | 76156 | 79613646 |
| Infertility male | 97.52 | 10.66 | 21 | 54565 | 88 | 79689714 |
| Drug ineffective | 97.46 | 10.66 | 396 | 54190 | 1080517 | 78609285 |
| Obstruction | 96.89 | 10.66 | 52 | 54534 | 4558 | 79685244 |
| Bronchial wall thickening | 95.09 | 10.66 | 43 | 54543 | 2598 | 79687204 |
| Genital hypoaesthesia | 94.88 | 10.66 | 23 | 54563 | 178 | 79689624 |
| Bronchial secretion retention | 91.07 | 10.66 | 48 | 54538 | 4056 | 79685746 |
| Dizziness | 88.68 | 10.66 | 640 | 53946 | 525801 | 79164001 |
| Aortic valve stenosis | 87.50 | 10.66 | 51 | 54535 | 5243 | 79684559 |
| Pulmonary function test abnormal | 85.01 | 10.66 | 46 | 54540 | 4098 | 79685704 |
| Rheumatoid arthritis | 81.60 | 10.66 | 21 | 54565 | 208449 | 79481353 |
| Ejaculation failure | 81.27 | 10.66 | 23 | 54563 | 342 | 79689460 |
| Testicular atrophy | 80.90 | 10.66 | 23 | 54563 | 348 | 79689454 |
| Blood testosterone decreased | 80.23 | 10.66 | 37 | 54549 | 2340 | 79687462 |
| Male reproductive tract disorder | 76.14 | 10.66 | 16 | 54570 | 58 | 79689744 |
| Drug hypersensitivity | 73.69 | 10.66 | 58 | 54528 | 298858 | 79390944 |
| Orthostatic hypotension | 68.13 | 10.66 | 131 | 54455 | 56033 | 79633769 |
| Fall | 66.12 | 10.66 | 564 | 54022 | 487065 | 79202737 |
| Diastolic dysfunction | 64.76 | 10.66 | 56 | 54530 | 10755 | 79679047 |
| Exposure via body fluid | 64.12 | 10.66 | 19 | 54567 | 335 | 79689467 |
| Azoospermia | 63.37 | 10.66 | 16 | 54570 | 149 | 79689653 |
| Chest X-ray abnormal | 62.32 | 10.66 | 48 | 54538 | 7835 | 79681967 |
| Semen analysis abnormal | 60.25 | 10.66 | 10 | 54576 | 3 | 79689799 |
| Hallucination | 60.25 | 10.66 | 161 | 54425 | 85584 | 79604218 |
| Haematospermia | 60.06 | 10.66 | 17 | 54569 | 253 | 79689549 |
| Off label use | 59.99 | 10.66 | 370 | 54216 | 906845 | 78782957 |
| Maternal exposure during pregnancy | 58.99 | 10.66 | 11 | 54575 | 136527 | 79553275 |
| Systemic lupus erythematosus | 58.68 | 10.66 | 7 | 54579 | 121142 | 79568660 |
| Vomiting | 58.48 | 10.66 | 246 | 54340 | 665582 | 79024220 |
| Joint swelling | 58.28 | 10.66 | 67 | 54519 | 288579 | 79401223 |
| Breast cancer male | 56.53 | 10.66 | 17 | 54569 | 316 | 79689486 |
| Treatment failure | 56.43 | 10.66 | 23 | 54563 | 170463 | 79519339 |
| Infusion related reaction | 56.31 | 10.66 | 45 | 54541 | 230192 | 79459610 |
| Intervertebral disc degeneration | 55.41 | 10.66 | 61 | 54525 | 15724 | 79674078 |
| Cardiac failure congestive | 55.08 | 10.66 | 218 | 54368 | 142184 | 79547618 |
| Death | 55.03 | 10.66 | 611 | 53975 | 565903 | 79123899 |
| Hypoacusis | 54.58 | 10.66 | 84 | 54502 | 30066 | 79659736 |
| Synovitis | 53.82 | 10.66 | 18 | 54568 | 150716 | 79539086 |
| Drug intolerance | 53.65 | 10.66 | 61 | 54525 | 264058 | 79425744 |
| Panic attack | 53.32 | 10.66 | 74 | 54512 | 24142 | 79665660 |
| Prostatic pain | 53.21 | 10.66 | 11 | 54575 | 36 | 79689766 |
| Pericarditis | 53.10 | 10.66 | 5 | 54581 | 104231 | 79585571 |
| Hepatic vein dilatation | 52.39 | 10.66 | 15 | 54571 | 233 | 79689569 |
| Testicular disorder | 51.47 | 10.66 | 15 | 54571 | 249 | 79689553 |
| Syncope | 51.35 | 10.66 | 251 | 54335 | 179198 | 79510604 |
| Muscle atrophy | 51.32 | 10.66 | 50 | 54536 | 11182 | 79678620 |
| Toxicity to various agents | 51.22 | 10.66 | 135 | 54451 | 421405 | 79268397 |
| Contraindicated product administered | 50.93 | 10.66 | 22 | 54564 | 157516 | 79532286 |
| Anxiety | 50.00 | 10.66 | 316 | 54270 | 248196 | 79441606 |
| Prostate cancer | 49.76 | 10.66 | 85 | 54501 | 33183 | 79656619 |
| Hypospermia | 48.97 | 10.66 | 9 | 54577 | 12 | 79689790 |
| Swelling | 48.58 | 10.66 | 46 | 54540 | 216665 | 79473137 |
| Acute kidney injury | 48.07 | 10.66 | 555 | 54031 | 518849 | 79170953 |
| Pain | 48.04 | 10.66 | 284 | 54302 | 703518 | 78986284 |
| Prostatitis | 47.98 | 10.66 | 32 | 54554 | 4170 | 79685632 |
| Penile pain | 47.97 | 10.66 | 20 | 54566 | 991 | 79688811 |
| Nausea | 47.61 | 10.66 | 423 | 54163 | 956773 | 78733029 |
| Pyrexia | 47.31 | 10.66 | 272 | 54314 | 678437 | 79011365 |
| Liver palpable | 46.84 | 10.66 | 15 | 54571 | 346 | 79689456 |
| Gout | 46.28 | 10.66 | 70 | 54516 | 24679 | 79665123 |
| International normalised ratio increased | 45.94 | 10.66 | 145 | 54441 | 84576 | 79605226 |
| Discomfort | 44.84 | 10.66 | 15 | 54571 | 125602 | 79564200 |
| Prostatic disorder | 44.37 | 10.66 | 24 | 54562 | 2136 | 79687666 |
| Hepatic enzyme increased | 44.26 | 10.66 | 36 | 54550 | 182574 | 79507228 |
| Breast tenderness | 43.27 | 10.66 | 24 | 54562 | 2244 | 79687558 |
| Sleep apnoea syndrome | 42.91 | 10.66 | 84 | 54502 | 36394 | 79653408 |
| Alopecia | 42.20 | 10.66 | 58 | 54528 | 231297 | 79458505 |
| Prostatic specific antigen increased | 41.51 | 10.66 | 43 | 54543 | 10343 | 79679459 |
| Granulomatous rosacea | 40.91 | 10.66 | 12 | 54574 | 204 | 79689598 |
| Anorgasmia | 40.71 | 10.66 | 19 | 54567 | 1235 | 79688567 |
| Musculoskeletal stiffness | 40.58 | 10.66 | 36 | 54550 | 174972 | 79514830 |
| Breast disorder male | 39.68 | 10.66 | 7 | 54579 | 6 | 79689796 |
| Asthenia | 39.67 | 10.66 | 529 | 54057 | 511160 | 79178642 |
| Therapeutic product effect decreased | 38.85 | 10.66 | 33 | 54553 | 163830 | 79525972 |
| Male orgasmic disorder | 38.56 | 10.66 | 9 | 54577 | 58 | 79689744 |
| Gastrointestinal haemorrhage | 38.30 | 10.66 | 201 | 54385 | 147518 | 79542284 |
| Arthropathy | 38.06 | 10.66 | 39 | 54547 | 177072 | 79512730 |
| Wrong technique in product usage process | 37.84 | 10.66 | 124 | 54462 | 73751 | 79616051 |
| Semen viscosity decreased | 37.73 | 10.66 | 6 | 54580 | 0 | 79689802 |
| Platypnoea | 37.45 | 10.66 | 8 | 54578 | 32 | 79689770 |
| Hypotension | 36.97 | 10.66 | 462 | 54124 | 439855 | 79249947 |
| Stomatitis | 36.73 | 10.66 | 28 | 54558 | 146729 | 79543073 |
| Helicobacter infection | 36.43 | 10.66 | 3 | 54583 | 69701 | 79620101 |
| Platelet distribution width increased | 36.23 | 10.66 | 10 | 54576 | 135 | 79689667 |
| Apathy | 35.30 | 10.66 | 44 | 54542 | 12933 | 79676869 |
| Hypersensitivity | 34.94 | 10.66 | 80 | 54506 | 262159 | 79427643 |
| Pemphigoid | 34.01 | 10.66 | 47 | 54539 | 15268 | 79674534 |
| Inferior vena cava dilatation | 33.98 | 10.66 | 15 | 54571 | 856 | 79688946 |
| Scrotal disorder | 33.96 | 10.66 | 8 | 54578 | 54 | 79689748 |
| Dehydroepiandrosterone decreased | 33.84 | 10.66 | 7 | 54579 | 23 | 79689779 |
| Sinusitis | 33.69 | 10.66 | 51 | 54535 | 195450 | 79494352 |
| Myoglobin blood increased | 33.60 | 10.66 | 23 | 54563 | 3128 | 79686674 |
| Spermatozoa abnormal | 33.57 | 10.66 | 6 | 54580 | 6 | 79689796 |
| Upper gastrointestinal haemorrhage | 33.52 | 10.66 | 82 | 54504 | 41298 | 79648504 |
| Plasma cell myeloma | 33.44 | 10.66 | 96 | 54490 | 53163 | 79636639 |
| Urine flow decreased | 33.37 | 10.66 | 16 | 54570 | 1105 | 79688697 |
| Ventricular enlargement | 33.12 | 10.66 | 14 | 54572 | 718 | 79689084 |
| Skin atrophy | 33.00 | 10.66 | 29 | 54557 | 5689 | 79684113 |
| Sperm concentration decreased | 32.88 | 10.66 | 8 | 54578 | 63 | 79689739 |
| Headache | 32.81 | 10.66 | 288 | 54298 | 653484 | 79036318 |
| Arrhythmia | 32.42 | 10.66 | 104 | 54482 | 61168 | 79628634 |
| Leydig cell tumour of the testis | 31.44 | 10.66 | 5 | 54581 | 0 | 79689802 |
| Dark circles under eyes | 31.34 | 10.66 | 12 | 54574 | 475 | 79689327 |
| Condition aggravated | 31.14 | 10.66 | 208 | 54378 | 500916 | 79188886 |
| Hormone receptor positive breast cancer | 30.83 | 10.66 | 11 | 54575 | 356 | 79689446 |
| Bronchiectasis | 30.63 | 10.66 | 55 | 54531 | 22331 | 79667471 |
| Lid sulcus deepened | 30.57 | 10.66 | 9 | 54577 | 155 | 79689647 |
| Emotional poverty | 30.54 | 10.66 | 14 | 54572 | 873 | 79688929 |
| Disturbance in attention | 30.39 | 10.66 | 90 | 54496 | 50711 | 79639091 |
| Dysuria | 30.22 | 10.66 | 90 | 54496 | 50861 | 79638941 |
| Daydreaming | 29.87 | 10.66 | 14 | 54572 | 919 | 79688883 |
| Genital paraesthesia | 29.74 | 10.66 | 7 | 54579 | 47 | 79689755 |
| Libido disorder | 29.74 | 10.66 | 10 | 54576 | 270 | 79689532 |
| Androgen deficiency | 29.62 | 10.66 | 8 | 54578 | 99 | 79689703 |
| Testis cancer | 29.36 | 10.66 | 15 | 54571 | 1188 | 79688614 |
| Hypogonadism male | 29.36 | 10.66 | 9 | 54577 | 179 | 79689623 |
| Blood thyroid stimulating hormone decreased | 29.07 | 10.66 | 27 | 54559 | 5689 | 79684113 |
| Abdominal discomfort | 28.40 | 10.66 | 83 | 54503 | 250644 | 79439158 |
| Atrial enlargement | 28.38 | 10.66 | 14 | 54572 | 1029 | 79688773 |
| Faeces discoloured | 28.29 | 10.66 | 62 | 54524 | 29065 | 79660737 |
| Pollakiuria | 28.18 | 10.66 | 72 | 54514 | 37245 | 79652557 |
| Glossodynia | 28.13 | 10.66 | 18 | 54568 | 103319 | 79586483 |
| Saliva altered | 27.51 | 10.66 | 11 | 54575 | 489 | 79689313 |
| Injection site pain | 27.43 | 10.66 | 29 | 54557 | 129809 | 79559993 |
| Rales | 27.18 | 10.66 | 49 | 54537 | 19952 | 79669850 |
| Body fat disorder | 26.91 | 10.66 | 9 | 54577 | 239 | 79689563 |
| Intentional product use issue | 26.86 | 10.66 | 39 | 54547 | 152073 | 79537729 |
| Psychiatric symptom | 26.11 | 10.66 | 28 | 54558 | 7007 | 79682795 |
| Hepatitis cholestatic | 25.64 | 10.66 | 39 | 54547 | 13813 | 79675989 |
| Hallucination, visual | 25.60 | 10.66 | 64 | 54522 | 32665 | 79657137 |
| Fixed eruption | 25.59 | 10.66 | 19 | 54567 | 2935 | 79686867 |
| Reproductive tract hypoplasia, male | 25.15 | 10.66 | 4 | 54582 | 0 | 79689802 |
| Late onset hypogonadism syndrome | 25.15 | 10.66 | 4 | 54582 | 0 | 79689802 |
| Teratospermia | 25.15 | 10.66 | 4 | 54582 | 0 | 79689802 |
| Perineal pain | 24.99 | 10.66 | 13 | 54573 | 1069 | 79688733 |
| Prostatomegaly | 24.93 | 10.66 | 20 | 54566 | 3463 | 79686339 |
| Orgasmic sensation decreased | 24.47 | 10.66 | 6 | 54580 | 49 | 79689753 |
| Penile exfoliation | 24.43 | 10.66 | 7 | 54579 | 109 | 79689693 |
| Seminoma | 24.26 | 10.66 | 8 | 54578 | 203 | 79689599 |
| Illusion | 24.18 | 10.66 | 15 | 54571 | 1726 | 79688076 |
| Fibromyalgia | 24.18 | 10.66 | 7 | 54579 | 64333 | 79625469 |
| Product use issue | 24.09 | 10.66 | 69 | 54517 | 209753 | 79480049 |
| Agitation | 24.02 | 10.66 | 133 | 54453 | 99582 | 79590220 |
| C-reactive protein increased | 23.86 | 10.66 | 32 | 54554 | 128995 | 79560807 |
| Confusional state | 23.86 | 10.66 | 327 | 54259 | 317670 | 79372132 |
| Floppy iris syndrome | 23.56 | 10.66 | 9 | 54577 | 354 | 79689448 |
| Haemoglobin decreased | 23.53 | 10.66 | 244 | 54342 | 221875 | 79467927 |
| Somatic symptom disorder | 23.52 | 10.66 | 17 | 54569 | 2520 | 79687282 |
| Wound | 23.39 | 10.66 | 27 | 54559 | 116152 | 79573650 |
| Cerebrovascular accident | 23.31 | 10.66 | 184 | 54402 | 155108 | 79534694 |
| Muscle injury | 23.03 | 10.66 | 3 | 54583 | 48558 | 79641244 |
| Trans-sexualism | 22.91 | 10.66 | 4 | 54582 | 3 | 79689799 |
| C-reactive protein abnormal | 22.91 | 10.66 | 3 | 54583 | 48364 | 79641438 |
| Atrioventricular block first degree | 22.89 | 10.66 | 35 | 54551 | 12456 | 79677346 |
| Testicular swelling | 22.66 | 10.66 | 13 | 54573 | 1297 | 79688505 |
| Product administration error | 22.56 | 10.66 | 60 | 54526 | 31786 | 79658016 |
| Myopathy | 22.56 | 10.66 | 46 | 54540 | 20517 | 79669285 |
| Plica syndrome | 22.38 | 10.66 | 4 | 54582 | 4 | 79689798 |
| Nasopharyngitis | 22.08 | 10.66 | 94 | 54492 | 253787 | 79436015 |
| On and off phenomenon | 21.91 | 10.66 | 18 | 54568 | 3222 | 79686580 |
| Testicular cyst | 21.59 | 10.66 | 5 | 54581 | 31 | 79689771 |
| Prostatic haemorrhage | 21.56 | 10.66 | 7 | 54579 | 169 | 79689633 |
| Hypogonadism | 21.55 | 10.66 | 14 | 54572 | 1746 | 79688056 |
| Intentional overdose | 20.92 | 10.66 | 25 | 54561 | 105935 | 79583867 |
| Malpositioned teeth | 20.59 | 10.66 | 5 | 54581 | 39 | 79689763 |
| Soft tissue mass | 20.21 | 10.66 | 12 | 54574 | 1276 | 79688526 |
| Xanthopsia | 20.20 | 10.66 | 8 | 54578 | 347 | 79689455 |
| Exostosis of external ear canal | 20.15 | 10.66 | 4 | 54582 | 10 | 79689792 |
| Obstructive airways disorder | 20.03 | 10.66 | 57 | 54529 | 31402 | 79658400 |
| Sprue-like enteropathy | 19.96 | 10.66 | 12 | 54574 | 1306 | 79688496 |
| Splenomegaly | 19.96 | 10.66 | 44 | 54542 | 20710 | 79669092 |
| Glomerular filtration rate abnormal | 19.91 | 10.66 | 13 | 54573 | 1635 | 79688167 |
| Skin irritation | 19.90 | 10.66 | 31 | 54555 | 11209 | 79678593 |
| Melanocytic hyperplasia | 19.87 | 10.66 | 4 | 54582 | 11 | 79689791 |
| Drug abuse | 19.80 | 10.66 | 52 | 54534 | 162639 | 79527163 |
| Bradyphrenia | 19.76 | 10.66 | 30 | 54556 | 10610 | 79679192 |
| Interstitial lung disease | 19.75 | 10.66 | 29 | 54557 | 112571 | 79577231 |
| Irritable bowel syndrome | 19.62 | 10.66 | 9 | 54577 | 62232 | 79627570 |
| Varicocele | 19.61 | 10.66 | 4 | 54582 | 12 | 79689790 |
| Haemorrhage urinary tract | 19.48 | 10.66 | 15 | 54571 | 2446 | 79687356 |
| Hypertrophy | 19.48 | 10.66 | 10 | 54576 | 800 | 79689002 |
| Bradycardia | 19.46 | 10.66 | 159 | 54427 | 135398 | 79554404 |
| Injection site erythema | 19.46 | 10.66 | 15 | 54571 | 78182 | 79611620 |
| Balance disorder | 19.41 | 10.66 | 125 | 54461 | 98732 | 79591070 |
| Semen discolouration | 19.37 | 10.66 | 4 | 54582 | 13 | 79689789 |
| Parkinsonism | 19.27 | 10.66 | 38 | 54548 | 16546 | 79673256 |
| Depression suicidal | 19.25 | 10.66 | 18 | 54568 | 3824 | 79685978 |
| Subdural haemorrhage | 19.19 | 10.66 | 22 | 54564 | 5926 | 79683876 |
| Gastrointestinal disorder | 19.06 | 10.66 | 34 | 54552 | 122171 | 79567631 |
| Androgen insensitivity syndrome | 18.93 | 10.66 | 4 | 54582 | 15 | 79689787 |
| Fear of crowded places | 18.93 | 10.66 | 4 | 54582 | 15 | 79689787 |
| Haemorrhagic stroke | 18.91 | 10.66 | 30 | 54556 | 11016 | 79678786 |
| Androgens abnormal | 18.86 | 10.66 | 3 | 54583 | 0 | 79689802 |
| Biotin deficiency | 18.86 | 10.66 | 3 | 54583 | 0 | 79689802 |
| Arthralgia | 18.76 | 10.66 | 277 | 54309 | 571526 | 79118276 |
| Penile curvature | 18.72 | 10.66 | 4 | 54582 | 16 | 79689786 |
| Inflammation | 18.64 | 10.66 | 22 | 54564 | 93731 | 79596071 |
| N-terminal prohormone brain natriuretic peptide abnormal | 18.50 | 10.66 | 7 | 54579 | 268 | 79689534 |
| Nipple pain | 18.22 | 10.66 | 10 | 54576 | 916 | 79688886 |
| Suicide attempt | 18.11 | 10.66 | 18 | 54568 | 82914 | 79606888 |
| Impaired healing | 18.04 | 10.66 | 20 | 54566 | 87635 | 79602167 |
| Feeling abnormal | 17.87 | 10.66 | 177 | 54409 | 159022 | 79530780 |
| Brain natriuretic peptide increased | 17.82 | 10.66 | 26 | 54560 | 8874 | 79680928 |
| Delusion of replacement | 17.81 | 10.66 | 6 | 54580 | 163 | 79689639 |
| Alveolar bone resorption | 17.75 | 10.66 | 5 | 54581 | 73 | 79689729 |
| Muscular weakness | 17.70 | 10.66 | 178 | 54408 | 160551 | 79529251 |
| Blunted affect | 17.60 | 10.66 | 8 | 54578 | 489 | 79689313 |
| Stenosis | 17.53 | 10.66 | 14 | 54572 | 2408 | 79687394 |
| Coronary artery stenosis | 17.50 | 10.66 | 31 | 54555 | 12453 | 79677349 |
| Hyperkalaemia | 17.41 | 10.66 | 136 | 54450 | 114262 | 79575540 |
| Product name confusion | 17.41 | 10.66 | 6 | 54580 | 175 | 79689627 |
| Full blood count abnormal | 17.30 | 10.66 | 64 | 54522 | 40410 | 79649392 |
| Orgasm abnormal | 17.28 | 10.66 | 6 | 54580 | 179 | 79689623 |
| Ophthalmoplegia | 17.27 | 10.66 | 15 | 54571 | 2897 | 79686905 |
| Blood creatine phosphokinase increased | 17.16 | 10.66 | 90 | 54496 | 66000 | 79623802 |
| Haematemesis | 17.05 | 10.66 | 76 | 54510 | 52188 | 79637614 |
| Red blood cell analysis abnormal | 16.98 | 10.66 | 4 | 54582 | 27 | 79689775 |
| Ageusia | 16.84 | 10.66 | 36 | 54550 | 16596 | 79673206 |
| Blood oestrogen abnormal | 16.79 | 10.66 | 3 | 54583 | 3 | 79689799 |
| Dermatitis artefacta | 16.79 | 10.66 | 3 | 54583 | 3 | 79689799 |
| Weight increased | 16.76 | 10.66 | 116 | 54470 | 277270 | 79412532 |
| Blood creatinine increased | 16.73 | 10.66 | 171 | 54415 | 154886 | 79534916 |
| Muscle disorder | 16.57 | 10.66 | 20 | 54566 | 5687 | 79684115 |
| Iris disorder | 16.43 | 10.66 | 7 | 54579 | 366 | 79689436 |
| Nipple disorder | 16.42 | 10.66 | 6 | 54580 | 208 | 79689594 |
| Subdural haematoma | 16.30 | 10.66 | 53 | 54533 | 31381 | 79658421 |
| Arthritis | 16.15 | 10.66 | 34 | 54552 | 114846 | 79574956 |
| Cardiac failure chronic | 16.06 | 10.66 | 28 | 54558 | 11107 | 79678695 |
| Urinary tract obstruction | 16.01 | 10.66 | 18 | 54568 | 4747 | 79685055 |
| Cognitive disorder | 16.00 | 10.66 | 92 | 54494 | 69834 | 79619968 |
| Obsessive-compulsive disorder | 15.97 | 10.66 | 20 | 54566 | 5907 | 79683895 |
| Anhedonia | 15.96 | 10.66 | 33 | 54553 | 14865 | 79674937 |
| Ill-defined disorder | 15.93 | 10.66 | 13 | 54573 | 65862 | 79623940 |
| Migraine | 15.87 | 10.66 | 22 | 54564 | 87471 | 79602331 |
| Oligospermia | 15.59 | 10.66 | 4 | 54582 | 40 | 79689762 |
| Red blood cell sedimentation rate increased | 15.51 | 10.66 | 6 | 54580 | 45936 | 79643866 |
| Haemorrhage intracranial | 15.28 | 10.66 | 46 | 54540 | 26147 | 79663655 |
| Completed suicide | 15.23 | 10.66 | 102 | 54484 | 245665 | 79444137 |
| Flat affect | 15.20 | 10.66 | 12 | 54574 | 2029 | 79687773 |
| Insomnia | 15.20 | 10.66 | 244 | 54342 | 244926 | 79444876 |
| Bladder cancer | 15.08 | 10.66 | 38 | 54548 | 19488 | 79670314 |
| Serotonin syndrome | 15.01 | 10.66 | 6 | 54580 | 45021 | 79644781 |
| Blood glucose increased | 14.99 | 10.66 | 132 | 54454 | 114843 | 79574959 |
| Ludwig angina | 14.92 | 10.66 | 6 | 54580 | 271 | 79689531 |
| Dissociation | 14.92 | 10.66 | 16 | 54570 | 4005 | 79685797 |
| Mucosal inflammation | 14.74 | 10.66 | 18 | 54568 | 75562 | 79614240 |
| Dementia Alzheimer's type | 14.72 | 10.66 | 9 | 54577 | 1010 | 79688792 |
| Alcohol intolerance | 14.67 | 10.66 | 7 | 54579 | 478 | 79689324 |
| Lower respiratory tract infection | 14.46 | 10.66 | 43 | 54543 | 129177 | 79560625 |
| Cataract operation complication | 14.44 | 10.66 | 6 | 54580 | 295 | 79689507 |
| Phlebosclerosis | 14.43 | 10.66 | 5 | 54581 | 148 | 79689654 |
| Social avoidant behaviour | 14.19 | 10.66 | 17 | 54569 | 4797 | 79685005 |
| Renal atrophy | 14.18 | 10.66 | 11 | 54575 | 1814 | 79687988 |
| Retrograde ejaculation | 14.17 | 10.66 | 6 | 54580 | 309 | 79689493 |
| Genital cyst | 14.16 | 10.66 | 4 | 54582 | 59 | 79689743 |
| Iron metabolism disorder | 14.16 | 10.66 | 4 | 54582 | 59 | 79689743 |
| Infection | 14.15 | 10.66 | 102 | 54484 | 241610 | 79448192 |
| Mood altered | 14.06 | 10.66 | 35 | 54551 | 17812 | 79671990 |
| Spermatozoa progressive motility decreased | 14.04 | 10.66 | 4 | 54582 | 61 | 79689741 |
| Patellofemoral pain syndrome | 14.03 | 10.66 | 7 | 54579 | 527 | 79689275 |
| Ventricular extrasystoles | 13.83 | 10.66 | 37 | 54549 | 19667 | 79670135 |
| Febrile neutropenia | 13.76 | 10.66 | 97 | 54489 | 230902 | 79458900 |
| Blood luteinising hormone decreased | 13.75 | 10.66 | 5 | 54581 | 171 | 79689631 |
| Full blood count decreased | 13.71 | 10.66 | 45 | 54541 | 26774 | 79663028 |
| Listless | 13.69 | 10.66 | 15 | 54571 | 3846 | 79685956 |
| Hospice care | 13.66 | 10.66 | 25 | 54561 | 10299 | 79679503 |
| Epididymitis | 13.64 | 10.66 | 11 | 54575 | 1919 | 79687883 |
| Premature ejaculation | 13.64 | 10.66 | 4 | 54582 | 68 | 79689734 |
| Myalgia | 13.54 | 10.66 | 190 | 54396 | 185451 | 79504351 |
| Otosalpingitis | 13.50 | 10.66 | 3 | 54583 | 15 | 79689787 |
| Alpha 2 globulin decreased | 13.50 | 10.66 | 3 | 54583 | 15 | 79689787 |
| Sex hormone binding globulin decreased | 13.50 | 10.66 | 3 | 54583 | 15 | 79689787 |
| Paternal drugs affecting foetus | 13.50 | 10.66 | 3 | 54583 | 15 | 79689787 |
| Testicular microlithiasis | 13.50 | 10.66 | 3 | 54583 | 15 | 79689787 |
| Testicular mass | 13.37 | 10.66 | 4 | 54582 | 73 | 79689729 |
| Free androgen index decreased | 13.34 | 10.66 | 3 | 54583 | 16 | 79689786 |
| Bursitis | 13.28 | 10.66 | 4 | 54582 | 35840 | 79653962 |
| Immunodeficiency common variable | 13.28 | 10.66 | 6 | 54580 | 362 | 79689440 |
| Breast enlargement | 13.27 | 10.66 | 10 | 54576 | 1579 | 79688223 |
| Strangury | 13.25 | 10.66 | 5 | 54581 | 190 | 79689612 |
| Hip arthroplasty | 13.23 | 10.66 | 4 | 54582 | 35752 | 79654050 |
| Haematuria traumatic | 13.20 | 10.66 | 5 | 54581 | 192 | 79689610 |
| Anti factor Xa activity decreased | 13.04 | 10.66 | 3 | 54583 | 18 | 79689784 |
| Withdrawal hypertension | 13.03 | 10.66 | 6 | 54580 | 378 | 79689424 |
| Injection site reaction | 13.02 | 10.66 | 11 | 54575 | 54774 | 79635028 |
| Hypotrichosis | 12.91 | 10.66 | 5 | 54581 | 204 | 79689598 |
| Borderline personality disorder | 12.91 | 10.66 | 8 | 54578 | 919 | 79688883 |
| Multiple organ dysfunction syndrome | 12.75 | 10.66 | 41 | 54545 | 120205 | 79569597 |
| Blood oestrogen increased | 12.71 | 10.66 | 4 | 54582 | 87 | 79689715 |
| Mitochondrial cytopathy | 12.66 | 10.66 | 6 | 54580 | 404 | 79689398 |
| Fat tissue increased | 12.65 | 10.66 | 8 | 54578 | 952 | 79688850 |
| Bladder stenosis | 12.64 | 10.66 | 3 | 54583 | 21 | 79689781 |
| Atrial flutter | 12.63 | 10.66 | 38 | 54548 | 21587 | 79668215 |
| Exposure via father | 12.63 | 10.66 | 4 | 54582 | 89 | 79689713 |
| Mental impairment | 12.62 | 10.66 | 35 | 54551 | 19001 | 79670801 |
| Fatigue | 12.54 | 10.66 | 766 | 53820 | 928961 | 78760841 |
| Urogenital haemorrhage | 12.52 | 10.66 | 8 | 54578 | 969 | 79688833 |
| Testicular germ cell tumour mixed | 12.52 | 10.66 | 3 | 54583 | 22 | 79689780 |
| Internal haemorrhage | 12.46 | 10.66 | 22 | 54564 | 8811 | 79680991 |
| Blood urea increased | 12.37 | 10.66 | 66 | 54520 | 48724 | 79641078 |
| Altered state of consciousness | 12.30 | 10.66 | 61 | 54525 | 43761 | 79646041 |
| Viral acanthoma | 12.29 | 10.66 | 3 | 54583 | 24 | 79689778 |
| Peyronie's disease | 12.29 | 10.66 | 3 | 54583 | 24 | 79689778 |
| Gastrooesophageal reflux disease | 12.23 | 10.66 | 117 | 54469 | 104129 | 79585673 |
| Cytomegalovirus infection | 12.20 | 10.66 | 7 | 54579 | 42637 | 79647165 |
| Overdose | 12.15 | 10.66 | 75 | 54511 | 184131 | 79505671 |
| Bundle branch block right | 12.14 | 10.66 | 25 | 54561 | 11226 | 79678576 |
| Peritoneal neoplasm | 12.11 | 10.66 | 4 | 54582 | 102 | 79689700 |
| Blood testosterone abnormal | 12.08 | 10.66 | 5 | 54581 | 243 | 79689559 |
| Basosquamous carcinoma | 12.07 | 10.66 | 4 | 54582 | 103 | 79689699 |
| Nocturia | 12.04 | 10.66 | 28 | 54558 | 13653 | 79676149 |
| Myxoedema coma | 11.92 | 10.66 | 7 | 54579 | 730 | 79689072 |
| Product use in unapproved indication | 11.77 | 10.66 | 112 | 54474 | 250247 | 79439555 |
| Renal cyst | 11.72 | 10.66 | 29 | 54557 | 14703 | 79675099 |
| Prostatic operation | 11.67 | 10.66 | 5 | 54581 | 265 | 79689537 |
| Disseminated intravascular coagulation | 11.59 | 10.66 | 5 | 54581 | 35837 | 79653965 |
| Blood cholesterol increased | 11.58 | 10.66 | 25 | 54561 | 83695 | 79606107 |
| Product dispensing error | 11.51 | 10.66 | 27 | 54559 | 13236 | 79676566 |
| Vitreous floaters | 11.46 | 10.66 | 19 | 54567 | 7237 | 79682565 |
| Asbestosis | 11.43 | 10.66 | 4 | 54582 | 122 | 79689680 |
| Infusion site induration | 11.43 | 10.66 | 8 | 54578 | 1127 | 79688675 |
| Dyspnoea at rest | 11.37 | 10.66 | 19 | 54567 | 7283 | 79682519 |
| Feminisation acquired | 11.35 | 10.66 | 3 | 54583 | 34 | 79689768 |
| Myasthenia gravis | 11.10 | 10.66 | 23 | 54563 | 10376 | 79679426 |
| Cryptorchism | 11.04 | 10.66 | 3 | 54583 | 38 | 79689764 |
| Sexually inappropriate behaviour | 11.04 | 10.66 | 6 | 54580 | 539 | 79689263 |
| Nasal discomfort | 10.95 | 10.66 | 16 | 54570 | 5467 | 79684335 |
| Heparin-induced thrombocytopenia test positive | 10.94 | 10.66 | 4 | 54582 | 139 | 79689663 |
| Gingival disorder | 10.94 | 10.66 | 13 | 54573 | 3638 | 79686164 |
| Sinus rhythm | 10.93 | 10.66 | 7 | 54579 | 851 | 79688951 |
| Gingivitis | 10.88 | 10.66 | 21 | 54565 | 9000 | 79680802 |
| Affective disorder | 10.82 | 10.66 | 20 | 54566 | 8299 | 79681503 |
| Bladder dilatation | 10.76 | 10.66 | 10 | 54576 | 2109 | 79687693 |
| Genital burning sensation | 10.74 | 10.66 | 5 | 54581 | 323 | 79689479 |
| Mesenteric vascular insufficiency | 10.73 | 10.66 | 4 | 54582 | 147 | 79689655 |
| Parkinson's disease | 10.71 | 10.66 | 9 | 54577 | 1662 | 79688140 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D11AX10 | DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals |
| ATC | G04CA51 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Alpha-adrenoreceptor antagonists |
| ATC | G04CA55 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Alpha-adrenoreceptor antagonists |
| ATC | G04CB01 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Testosterone-5-alpha reductase inhibitors |
| ATC | G04CB51 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Testosterone-5-alpha reductase inhibitors |
| FDA MoA | N0000000126 | 5-alpha Reductase Inhibitors |
| CHEBI has role | CHEBI:35497 | antiandrogen |
| CHEBI has role | CHEBI:50781 | 5alpha-reductase inhibitors |
| CHEBI has role | CHEBI:59844 | antihyperplasia drugs |
| FDA EPC | N0000175836 | 5-alpha Reductase Inhibitor |
| MeSH PA | D058891 | 5-alpha Reductase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D006727 | Hormone Antagonists |
| MeSH PA | D065088 | Steroid Synthesis Inhibitors |
| MeSH PA | D064804 | Urological Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Benign prostatic hyperplasia | indication | 266569009 | |
| Male Patterned Baldness | indication | ||
| Hidradenitis suppurativa | off-label use | 59393003 | DOID:2280 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Pregnancy, function | contraindication | 289908002 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| High-Grade Prostate Cancer | contraindication | ||
| Breast Carcinoma in Males | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.26 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Enzyme | INHIBITOR | IC50 | 8.26 | WOMBAT-PK | DRUG LABEL | |||
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Enzyme | INHIBITOR | IC50 | 7.58 | WOMBAT-PK | DRUG LABEL | |||
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | Enzyme | Ki | 4.96 | CHEMBL | |||||
| Cytochrome P450 2C9 | Enzyme | IC50 | 5.70 | DRUG MATRIX | |||||
| Cytochrome P450 2C19 | Enzyme | IC50 | 6 | DRUG MATRIX | |||||
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | Enzyme | Ki | 8.17 | CHEMBL | |||||
| Steroid 5-alpha-reductase | Enzyme | Ki | 7.26 | CHEMBL | |||||
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | Enzyme | IC50 | 9.55 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020167 | VUID |
| N0000148118 | NUI |
| D00321 | KEGG_DRUG |
| 4020167 | VANDF |
| C0060389 | UMLSCUI |
| CHEBI:5062 | CHEBI |
| FIT | PDB_CHEM_ID |
| CHEMBL710 | ChEMBL_ID |
| DB01216 | DRUGBANK_ID |
| D018120 | MESH_DESCRIPTOR_UI |
| 57363 | PUBCHEM_CID |
| 6818 | IUPHAR_LIGAND_ID |
| 6539 | INN_ID |
| 57GNO57U7G | UNII |
| 219462 | RXNORM |
| 11509 | MMSL |
| 4728 | MMSL |
| 82773 | MMSL |
| d00563 | MMSL |
| 003665 | NDDF |
| 109035006 | SNOMEDCT_US |
| 386963006 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| PROPECIA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0006-0071 | TABLET, FILM COATED | 1 mg | ORAL | NDA | 28 sections |
| PROSCAR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0006-0072 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 28 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7355 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 27 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7355 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 27 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6830 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6830 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-089 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 28 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-089 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 28 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-089 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 28 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-090 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 27 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-090 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 27 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-090 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 27 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0090 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-525 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 22 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-525 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 22 sections |
| Finasteride | Human Prescription Drug Label | 1 | 31722-526 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 26 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-833 | TABLET | 5 mg | ORAL | ANDA | 27 sections |
| Finasteride | Human Prescription Drug Label | 1 | 35573-400 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 26 sections |
| Finasteride | Human Prescription Drug Label | 1 | 35573-400 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 26 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-303 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-390 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 25 sections |
| Finasteride | Human Prescription Drug Label | 1 | 47335-714 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 26 sections |
| Finasteride | Human Prescription Drug Label | 1 | 47335-714 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 26 sections |
| FINASTERIDE | Human Prescription Drug Label | 1 | 47335-715 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1718 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
| Finasteride | Human Prescription Drug Label | 1 | 50090-1936 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
| Finasteride | Human Prescription Drug Label | 1 | 50090-1936 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
| Finasteride | Human Prescription Drug Label | 1 | 50090-1936 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |
| Finasteride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3942 | TABLET, FILM COATED | 1 mg | ORAL | ANDA | 27 sections |
| Finasteride | Human Prescription Drug Label | 1 | 50090-4648 | TABLET, COATED | 1 mg | ORAL | ANDA | 25 sections |