fexofenadine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1170 83799-24-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fexofenadine
  • terfenadine carboxylate
  • fexofenadine hydrochloride
  • fexofenadine HCl
a second generation antihistamine; metabolite of the antihistaminic drug terfenadine; ; RN refers to HCl
  • Molecular weight: 501.67
  • Formula: C32H39NO4
  • CLOGP: 1.96
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 3
  • TPSA: 81
  • ALOGS: -5.28
  • ROTB: 10

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.12 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.13 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 3.60 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
July 25, 1996 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Urticaria 140.11 10.93 298 35750 165504 63287470
Dermatitis atopic 128.87 10.93 76 35972 9648 63443326
Pruritus 108.58 10.93 449 35599 361004 63091970
Contraindicated product administered 106.05 10.93 4 36044 217644 63235330
Synovitis 92.58 10.93 3 36045 186915 63266059
Seasonal allergy 88.27 10.93 82 35966 20868 63432106
Angioedema 79.44 10.93 116 35932 47849 63405125
Lip swelling 79.34 10.93 93 35955 30970 63422004
Asthma 74.78 10.93 199 35849 127362 63325612
Systemic lupus erythematosus 72.75 10.93 15 36033 208903 63244071
Hand deformity 71.16 10.93 5 36043 159452 63293522
Toxicity to various agents 64.26 10.93 30 36018 247220 63205754
Glossodynia 64.05 10.93 12 36036 178864 63274110
COVID-19 62.83 10.93 173 35875 112930 63340044
Therapeutic product effect decreased 61.11 10.93 17 36031 193170 63259804
Completed suicide 58.50 10.93 7 36041 145666 63307308
Treatment failure 58.50 10.93 20 36028 199023 63253951
Sinusitis 58.30 10.93 269 35779 226384 63226590
Pharyngeal swelling 57.19 10.93 39 36009 6365 63446609
General physical health deterioration 53.00 10.93 24 36024 201378 63251596
Joint swelling 52.89 10.93 65 35983 327601 63125373
Anaphylactic reaction 50.27 10.93 114 35934 65986 63386988
Arthropathy 49.02 10.93 37 36011 234755 63218219
Dry skin 48.82 10.93 103 35945 56784 63396190
Eye pruritus 47.84 10.93 56 35992 18615 63434359
Product dose omission issue 47.47 10.93 260 35788 234053 63218921
Swelling face 44.46 10.93 106 35942 63369 63389605
Maternal exposure during pregnancy 44.26 10.93 36 36012 220026 63232948
Bronchitis 42.83 10.93 162 35886 124773 63328201
Headache 42.14 10.93 546 35502 632695 62820279
Wound 42.10 10.93 20 36028 163243 63289731
Feeling abnormal 41.79 10.93 181 35867 148211 63304763
Rheumatoid arthritis 41.31 10.93 50 35998 253769 63199205
Helicobacter infection 41.12 10.93 3 36045 92782 63360192
Drug intolerance 38.47 10.93 73 35975 308588 63144386
Mast cell activation syndrome 37.47 10.93 15 36033 810 63452164
Pre-existing condition improved 36.14 10.93 33 36015 8211 63444763
Illness 35.52 10.93 83 35965 48976 63403998
Rash 35.35 10.93 479 35569 560392 62892582
Hepatic enzyme increased 34.92 10.93 38 36010 202290 63250684
Hypotension 34.38 10.93 64 35984 272540 63180434
Throat tightness 33.90 10.93 55 35993 24832 63428142
Nasal pruritus 33.36 10.93 12 36036 482 63452492
Insomnia 32.27 10.93 221 35827 215031 63237943
Eczema 31.90 10.93 62 35986 32229 63420745
Multiple allergies 31.44 10.93 39 36009 13763 63439211
Cardiospasm 30.90 10.93 17 36031 1890 63451084
Pruritus genital 30.66 10.93 19 36029 2635 63450339
Migraine 30.58 10.93 128 35920 103218 63349756
Palmoplantar keratoderma 30.09 10.93 17 36031 1990 63450984
Dizziness 29.48 10.93 373 35675 429552 63023422
Anosmia 29.18 10.93 27 36021 6833 63446141
Hereditary angioedema 28.80 10.93 28 36020 7534 63445440
Cough 27.35 10.93 270 35778 292473 63160501
Upper respiratory tract infection 26.96 10.93 105 35943 81942 63371032
Folliculitis 26.74 10.93 4 36044 70313 63382661
Drug ineffective 26.55 10.93 426 35622 1044339 62408635
Chronic spontaneous urticaria 26.47 10.93 13 36035 1144 63451830
Chest discomfort 26.38 10.93 128 35920 109841 63343133
Impaired healing 25.76 10.93 13 36035 102529 63350445
Sleep terror 25.55 10.93 17 36031 2663 63450311
Sinus disorder 24.08 10.93 47 36001 24506 63428468
Skin exfoliation 23.98 10.93 66 35982 43036 63409938
Infusion site pain 23.96 10.93 38 36010 16831 63436143
Nausea 23.91 10.93 644 35404 853827 62599147
Hypohidrosis 23.81 10.93 6 36042 68 63452906
Muscle spasms 23.79 10.93 161 35887 155989 63296985
Infusion related reaction 22.66 10.93 68 35980 245453 63207521
Eye swelling 22.51 10.93 45 36003 23873 63429101
Pericarditis 22.38 10.93 25 36023 131554 63321420
Nasal disorder 22.21 10.93 16 36032 2848 63450126
Drug interaction 22.21 10.93 62 35986 229069 63223905
Rash macular 22.04 10.93 44 36004 23320 63429654
Pain of skin 22.01 10.93 30 36018 11604 63441370
Skin swelling 21.66 10.93 17 36031 3442 63449532
Genital rash 21.35 10.93 9 36039 555 63452419
Thrombocytopenia 21.32 10.93 33 36015 151124 63301850
Tension headache 21.26 10.93 20 36028 5166 63447808
Lip discolouration 20.93 10.93 9 36039 583 63452391
Nasal congestion 19.95 10.93 82 35966 65578 63387396
Diarrhoea 19.64 10.93 538 35510 714828 62738146
Oropharyngeal spasm 19.46 10.93 7 36041 281 63452693
Tinnitus 19.27 10.93 54 35994 35574 63417400
Eye haematoma 19.07 10.93 5 36043 67 63452907
Product quality issue 19.04 10.93 54 35994 35811 63417163
Acute kidney injury 18.95 10.93 81 35967 263334 63189640
Mucosal discolouration 18.87 10.93 8 36040 500 63452474
Atrial tachycardia 18.64 10.93 17 36031 4223 63448751
Therapeutic response unexpected 18.50 10.93 36 36012 18723 63434251
Essential tremor 18.46 10.93 10 36038 1078 63451896
Rash pruritic 18.42 10.93 75 35973 59724 63393250
Swollen tongue 18.09 10.93 52 35996 34748 63418226
Musculoskeletal stiffness 17.85 10.93 50 35998 184568 63268406
Cerebral disorder 17.69 10.93 17 36031 4509 63448465
Immunisation 17.60 10.93 10 36038 1183 63451791
Urticaria aquagenic 17.24 10.93 4 36044 31 63452943
Carotid artery occlusion 17.17 10.93 17 36031 4677 63448297
Urticaria cholinergic 17.13 10.93 4 36044 32 63452942
Diplopia 17.01 10.93 40 36008 23688 63429286
Rhinorrhoea 16.94 10.93 78 35970 65499 63387475
Death 16.82 10.93 134 35914 374247 63078727
Anxiety 16.72 10.93 193 35855 217348 63235626
Swelling 16.71 10.93 90 35958 275288 63177686
Exposure during pregnancy 16.67 10.93 40 36008 155507 63297467
Dry eye 16.64 10.93 56 35992 40705 63412269
Oropharyngeal pain 16.58 10.93 101 35947 94386 63358588
Mobility decreased 16.57 10.93 27 36021 121132 63331842
Dysphonia 16.51 10.93 62 35986 47552 63405422
Neurosis 16.20 10.93 6 36042 262 63452712
Carcinoid syndrome 16.15 10.93 5 36043 125 63452849
Multiple organ dysfunction syndrome 16.15 10.93 6 36042 56746 63396228
Injection site rash 16.06 10.93 34 36014 18775 63434199
Vulvovaginal injury 15.48 10.93 7 36041 511 63452463
Endometriosis 15.40 10.93 17 36031 5303 63447671
Infusion site swelling 15.26 10.93 23 36025 9747 63443227
Palpitations 15.25 10.93 113 35935 112657 63340317
Eye discharge 15.22 10.93 18 36030 6045 63446929
Exposure to allergen 14.99 10.93 6 36042 324 63452650
Coma 14.94 10.93 9 36039 64355 63388619
Erythema 14.91 10.93 159 35889 175592 63277382
Infusion site erythema 14.81 10.93 25 36023 11654 63441320
Subarachnoid haemorrhage 14.81 10.93 28 36020 14255 63438719
Type 2 diabetes mellitus 14.73 10.93 9 36039 63859 63389115
Oropharyngeal oedema 14.66 10.93 6 36042 343 63452631
Sleep apnoea syndrome 14.63 10.93 43 36005 29090 63423884
Dermatitis contact 14.55 10.93 24 36024 10984 63441990
Inappropriate schedule of product administration 14.53 10.93 105 35943 103860 63349114
Sneezing 14.49 10.93 32 36016 18186 63434788
Infusion site haemorrhage 14.28 10.93 16 36032 5070 63447904
Burning feet syndrome 14.27 10.93 4 36044 70 63452904
Drug eruption 14.08 10.93 42 36006 28652 63424322
Depression 14.07 10.93 172 35876 196320 63256654
Product use issue 13.97 10.93 71 35977 220449 63232525
Facial pain 13.92 10.93 23 36025 10538 63442436
Nerve compression 13.64 10.93 21 36027 9066 63443908
Pulmonary fibrosis 13.55 10.93 3 36045 39806 63413168
Insurance issue 13.47 10.93 17 36031 6104 63446870
Product dose omission in error 13.46 10.93 19 36029 7593 63445381
Rhinitis allergic 13.44 10.93 24 36024 11703 63441271
Seborrhoeic dermatitis 12.89 10.93 8 36040 1113 63451861
Psoriasis 12.84 10.93 89 35959 86868 63366106
Laryngeal oedema 12.77 10.93 16 36032 5702 63447272
Respiratory failure 12.74 10.93 24 36024 101834 63351140
Paranasal sinus discomfort 12.69 10.93 14 36034 4362 63448612
Lower respiratory tract infection 12.66 10.93 36 36012 132271 63320703
Tongue discolouration 12.66 10.93 12 36036 3131 63449843
Upper-airway cough syndrome 12.61 10.93 23 36025 11395 63441579
Poor quality device used 12.58 10.93 10 36038 2061 63450913
Perfume sensitivity 12.56 10.93 7 36041 798 63452176
Ocular hyperaemia 12.52 10.93 37 36011 25107 63427867
Alopecia 12.45 10.93 127 35921 337409 63115565
Sinus congestion 12.40 10.93 30 36018 18093 63434881
Confusional state 12.35 10.93 81 35967 236299 63216675
Allergic bronchitis 12.16 10.93 3 36045 31 63452943
Trichoglossia 12.08 10.93 5 36043 294 63452680
Drug abuse 12.08 10.93 14 36034 72504 63380470
Alopecia universalis 12.04 10.93 4 36044 126 63452848
Overdose 12.01 10.93 30 36018 115048 63337926
Impaired quality of life 11.87 10.93 25 36023 13758 63439216
Injection site swelling 11.85 10.93 56 35992 47516 63405458
Leukopenia 11.75 10.93 16 36032 77274 63375700
Oropharyngeal swelling 11.68 10.93 7 36041 914 63452060
Product administration interrupted 11.55 10.93 14 36034 4822 63448152
Influenza 11.49 10.93 103 35945 108619 63344355
Throat irritation 11.42 10.93 47 36001 37600 63415374
Gastrooesophageal reflux disease 11.36 10.93 93 35955 95546 63357428
Antibody test negative 11.32 10.93 3 36045 42 63452932
Immunisation reaction 11.28 10.93 6 36042 624 63452350
Renal failure 11.27 10.93 32 36016 117620 63335354
Myalgia 11.25 10.93 130 35918 146399 63306575
Loss of personal independence in daily activities 11.25 10.93 24 36024 97266 63355708
Product size issue 11.19 10.93 5 36043 355 63452619
Hallucination 11.18 10.93 61 35987 54756 63398218
Spider naevus 11.06 10.93 4 36044 163 63452811
Flatulence 11.06 10.93 44 36004 34658 63418316
Leukoplakia oral 10.97 10.93 4 36044 167 63452807

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pruritus 51.12 13.61 148 13793 141833 34801157
Dermatitis atopic 43.70 13.61 27 13914 5320 34937670
Toxicity to various agents 41.68 13.61 14 13927 200348 34742642
Sinusitis 37.95 13.61 63 13878 41339 34901651
Urticaria 37.27 13.61 79 13862 62298 34880692
Lip swelling 36.06 13.61 38 13903 16042 34926948
Anaphylactic reaction 34.91 13.61 53 13888 32248 34910742
Alopecia areata 32.07 13.61 9 13932 229 34942761
Skin texture abnormal 29.03 13.61 6 13935 38 34942952
Rash 28.76 13.61 169 13772 222583 34720407
General physical health deterioration 28.38 13.61 8 13933 128261 34814729
Hepatic function abnormal 24.00 13.61 54 13887 44309 34898681
Butterfly rash 23.66 13.61 6 13935 102 34942888
Headache 22.59 13.61 147 13794 200488 34742502
Pemphigoid 22.19 13.61 22 13919 8644 34934346
Drug eruption 21.99 13.61 33 13908 19865 34923125
Genital swelling 21.04 13.61 6 13935 162 34942828
Pharyngeal ulceration 20.06 13.61 7 13934 369 34942621
Rhinitis allergic 19.02 13.61 13 13928 3037 34939953
Mast cell activation syndrome 18.69 13.61 6 13935 244 34942746
Alopecia universalis 17.97 13.61 5 13936 123 34942867
Asthma 17.81 13.61 47 13894 42609 34900381
Pharyngeal swelling 17.37 13.61 11 13930 2261 34940729
Hypersensitivity 16.74 13.61 58 13883 60977 34882013
Eyelid skin dryness 15.51 13.61 4 13937 73 34942917
Allergy to plants 15.47 13.61 3 13938 13 34942977
Bronchitis 15.30 13.61 44 13897 41919 34901071
Myalgia 15.09 13.61 70 13871 84040 34858950
Renal failure 14.99 13.61 18 13923 130539 34812451
Overdose 14.79 13.61 9 13932 91050 34851940
Decreased appetite 14.68 13.61 115 13826 166277 34776713
Oropharyngeal swelling 14.59 13.61 6 13935 497 34942493
Sleep disorder 14.34 13.61 36 13905 31652 34911338
Therapeutic response decreased 14.01 13.61 34 13907 29279 34913711
Lacrimation increased 13.84 13.61 17 13924 8465 34934525
Interstitial lung disease 13.74 13.61 57 13884 65225 34877765

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Urticaria 163.93 11.10 312 38893 184889 79520294
Pruritus 141.73 11.10 471 38734 394177 79311006
Lip swelling 112.79 11.10 119 39086 40792 79664391
Dermatitis atopic 110.03 11.10 66 39139 9990 79695193
Toxicity to various agents 100.16 11.10 41 39164 421499 79283684
Pharyngeal swelling 75.09 11.10 47 39158 7672 79697511
General physical health deterioration 73.52 11.10 22 39183 275216 79429967
Rash 68.88 11.10 503 38702 577855 79127328
Swelling face 64.16 11.10 121 39084 71091 79634092
Anaphylactic reaction 61.90 11.10 131 39074 83612 79621571
Contraindicated product administered 61.67 11.10 4 39201 157534 79547649
Synovitis 61.55 11.10 3 39202 150731 79554452
Angioedema 58.60 11.10 121 39084 75914 79629269
Treatment failure 52.63 11.10 10 39195 170476 79534707
Headache 50.64 11.10 517 38688 653255 79051928
Asthma 49.88 11.10 163 39042 134932 79570251
Seasonal allergy 49.31 11.10 50 39155 16356 79688827
Completed suicide 49.14 11.10 30 39175 245737 79459446
Hypotension 46.81 11.10 91 39114 440226 79264957
Drug abuse 45.28 11.10 12 39193 162679 79542504
Eye pruritus 43.28 11.10 52 39153 20518 79684665
Feeling abnormal 41.81 11.10 172 39033 159027 79546156
COVID-19 41.13 11.10 170 39035 157504 79547679
Drug eruption 40.00 11.10 75 39130 43860 79661323
Sinusitis 38.49 11.10 194 39011 195307 79509876
Throat tightness 37.92 11.10 57 39148 27850 79677333
Dry skin 37.70 11.10 95 39110 67900 79637283
Therapeutic product effect decreased 35.64 11.10 18 39187 163845 79541338
Hand deformity 34.50 11.10 5 39200 103914 79601269
Drug interaction 34.36 11.10 98 39107 415085 79290098
Product dose omission issue 33.89 11.10 223 38982 247314 79457869
Systemic lupus erythematosus 31.75 11.10 10 39195 121139 79584044
Eye swelling 31.69 11.10 51 39154 26417 79678766
Joint swelling 31.22 11.10 59 39146 288587 79416596
Mast cell activation syndrome 30.64 11.10 12 39193 708 79704475
Hepatic function abnormal 30.45 11.10 92 39113 73015 79632168
Dizziness 29.78 11.10 392 38813 526049 79179134
Rash pruritic 28.77 11.10 89 39116 71540 79633643
Chest discomfort 28.58 11.10 139 39066 137905 79567278
Skin exfoliation 28.50 11.10 75 39130 55025 79650158
Rash macular 28.41 11.10 51 39154 28848 79676335
Insomnia 28.35 11.10 212 38993 244958 79460225
Alopecia universalis 28.21 11.10 9 39196 289 79704894
Drug intolerance 27.67 11.10 55 39150 264064 79441119
Migraine 27.42 11.10 100 39105 87393 79617790
Swollen tongue 27.38 11.10 63 39142 42507 79662676
Arthropathy 27.35 11.10 28 39177 177083 79528100
Acute kidney injury 26.78 11.10 148 39057 519256 79185927
Myalgia 26.47 11.10 169 39036 185472 79519711
Overdose 26.37 11.10 31 39174 184175 79521008
Nasal congestion 26.14 11.10 90 39115 76462 79628721
Thrombocytopenia 25.48 11.10 58 39147 265201 79439982
Bronchitis 24.55 11.10 128 39077 130516 79574667
Chronic spontaneous urticaria 24.52 11.10 12 39193 1212 79703971
Upper respiratory tract infection 24.31 11.10 99 39106 91069 79614114
Dry eye 24.13 11.10 55 39150 36876 79668307
Hepatic enzyme increased 23.79 11.10 33 39172 182577 79522606
Illness 23.74 11.10 63 39142 46448 79658735
Erythema 23.54 11.10 189 39016 223101 79482082
Oropharyngeal swelling 23.49 11.10 12 39193 1328 79703855
Pemphigoid 23.30 11.10 33 39172 15282 79689901
Diarrhoea 22.85 11.10 580 38625 879909 78825274
Nasal pruritus 22.63 11.10 9 39196 553 79704630
Alopecia areata 22.53 11.10 13 39192 1830 79703353
Glossodynia 21.51 11.10 12 39193 103325 79601858
Anosmia 21.35 11.10 24 39181 8820 79696363
Renal failure 20.92 11.10 42 39163 200926 79504257
Lip discolouration 20.62 11.10 9 39196 699 79704484
Eczema 20.54 11.10 55 39150 40763 79664420
Rheumatoid arthritis 20.49 11.10 45 39160 208425 79496758
Death 20.07 11.10 180 39025 566334 79138849
Dysphonia 19.53 11.10 67 39138 56805 79648378
Genital swelling 19.52 11.10 7 39198 323 79704860
Rhinitis allergic 19.51 11.10 27 39178 12242 79692941
Skin swelling 19.46 11.10 16 39189 3998 79701185
Eye discharge 19.25 11.10 19 39186 6015 79699168
Drug ineffective 19.18 11.10 396 38809 1080517 78624666
Cough 19.01 11.10 269 38936 366520 79338663
Off label use 18.33 11.10 325 38880 906890 78798293
Injection site rash 18.05 11.10 32 39173 17922 79687261
Metabolic acidosis 18.03 11.10 9 39196 82520 79622663
Stevens-Johnson syndrome 17.94 11.10 51 39154 39115 79666068
Pruritus genital 17.91 11.10 16 39189 4470 79700713
Palpitations 17.87 11.10 115 39090 126495 79578688
Helicobacter infection 17.82 11.10 6 39199 69698 79635485
Coma 17.82 11.10 14 39191 100635 79604548
Urticaria aquagenic 17.81 11.10 4 39201 31 79705152
Cardiospasm 17.79 11.10 14 39191 3287 79701896
Urticaria cholinergic 17.70 11.10 4 39201 32 79705151
Sinus disorder 17.59 11.10 36 39169 22428 79682755
Rhinorrhoea 17.50 11.10 79 39126 75995 79629188
Multiple organ dysfunction syndrome 17.46 11.10 20 39185 120226 79584957
Genital rash 17.42 11.10 9 39196 1019 79704164
Sneezing 17.17 11.10 33 39172 19650 79685533
White blood cell count decreased 17.00 11.10 154 39051 188134 79517049
Vision blurred 16.72 11.10 99 39106 105799 79599384
Endometriosis 16.50 11.10 14 39191 3654 79701529
Essential tremor 16.48 11.10 10 39195 1545 79703638
Mucosal discolouration 16.47 11.10 8 39197 795 79704388
Hypohidrosis 16.44 11.10 6 39199 291 79704892
Product quality issue 16.34 11.10 45 39160 33895 79671288
Palmoplantar keratoderma 16.34 11.10 14 39191 3702 79701481
Nasal disorder 16.17 11.10 14 39191 3755 79701428
Sleep disorder 16.13 11.10 84 39121 85593 79619590
Sleep terror 16.04 11.10 15 39190 4443 79700740
Tinnitus 15.90 11.10 53 39152 44280 79660903
Impaired healing 15.77 11.10 12 39193 87643 79617540
Eye haematoma 15.60 11.10 5 39200 163 79705020
Hereditary angioedema 15.56 11.10 16 39189 5319 79699864
Poor quality device used 15.22 11.10 11 39194 2274 79702909
Ocular hyperaemia 15.20 11.10 39 39166 28167 79677016
Tension headache 14.79 11.10 18 39187 7193 79697990
Maternal exposure during pregnancy 14.66 11.10 28 39177 136510 79568673
Nausea 14.66 11.10 592 38613 956604 78748579
Insurance issue 14.60 11.10 16 39189 5717 79699466
C-reactive protein abnormal 14.57 11.10 3 39202 48364 79656819
Carcinoid syndrome 14.50 11.10 5 39200 205 79704978
Infective pulmonary exacerbation of cystic fibrosis 14.35 11.10 24 39181 12827 79692356
Liver injury 14.26 11.10 5 39200 56609 79648574
Neurosis 14.19 11.10 6 39199 431 79704752
Oropharyngeal spasm 14.15 11.10 6 39199 434 79704749
Wound 14.14 11.10 22 39183 116157 79589026
Oropharyngeal pain 14.03 11.10 97 39108 109256 79595927
Pharyngeal ulceration 13.97 11.10 8 39197 1111 79704072
Cardiac arrest 13.93 11.10 41 39164 172055 79533128
Skin texture abnormal 13.75 11.10 6 39199 466 79704717
Multiple allergies 13.69 11.10 21 39184 10439 79694744
International normalised ratio increased 13.53 11.10 13 39192 84708 79620475
Lactic acidosis 13.48 11.10 9 39196 70350 79634833
Exposure during pregnancy 13.44 11.10 18 39187 101114 79604069
Pain of skin 13.36 11.10 25 39180 14588 79690595
Therapeutic response unexpected 13.36 11.10 30 39175 19916 79685267
Muscle spasms 13.35 11.10 138 39067 174592 79530591
Rash erythematous 13.29 11.10 60 39145 57709 79647474
Pre-existing condition improved 13.27 11.10 15 39190 5548 79699635
Lacrimation increased 13.08 11.10 32 39173 22445 79682738
Skin oedema 13.03 11.10 9 39196 1732 79703451
Flatulence 12.68 11.10 48 39157 42676 79662507
Eczema herpeticum 12.64 11.10 5 39200 303 79704880
Urticarial vasculitis 12.53 11.10 6 39199 578 79704605
Haematoma 12.49 11.10 5 39200 52190 79652993
Cholestasis 12.46 11.10 5 39200 52104 79653079
Facial pain 12.40 11.10 22 39183 12328 79692855
Tongue discolouration 12.34 11.10 12 39193 3731 79701452
Mobility decreased 12.31 11.10 26 39179 122149 79583034
Interstitial lung disease 12.23 11.10 96 39109 112504 79592679
Confusional state 12.15 11.10 99 39106 317898 79387285
Exposure to allergen 12.15 11.10 5 39200 336 79704847
Sialoadenitis 11.91 11.10 9 39196 1992 79703191
Dermatitis allergic 11.84 11.10 27 39178 18103 79687080
Injection site urticaria 11.80 11.10 22 39183 12804 79692379
Skin weeping 11.79 11.10 7 39198 1040 79704143
Red blood cell sedimentation rate increased 11.67 11.10 4 39201 45938 79659245
Cerebral disorder 11.65 11.10 14 39191 5524 79699659
Injection site pain 11.62 11.10 106 39099 129732 79575451
Abdominal pain 11.59 11.10 129 39076 389440 79315743
Leukopenia 11.57 11.10 25 39180 116488 79588695
Concomitant disease aggravated 11.39 11.10 22 39183 13145 79692038
Drug dependence 11.35 11.10 3 39202 40766 79664417
Throat irritation 11.34 11.10 45 39160 40901 79664282
Impaired quality of life 11.20 11.10 23 39182 14363 79690820

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AX26 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Other antihistamines for systemic use
FDA MoA N0000000190 Histamine H1 Receptor Antagonists
FDA EPC N0000175587 Histamine-1 Receptor Antagonist
CHEBI has role CHEBI:37955 H1 receptor antagonists
CHEBI has role CHEBI:50857 anti-allergic drugs
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D039563 Histamine H1 Antagonists, Non-Sedating
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Allergic rhinitis indication 61582004
Sneezing indication 76067001
Chronic idiopathic urticaria indication 302162004
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Alopecia areata off-label use 68225006 DOID:986
Urticaria off-label use 126485001
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Hypertensive urgency contraindication 443482000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.66 acidic
pKa2 8.85 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 8 WOMBAT-PK CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.67 CHEMBL
Multidrug resistance protein 1 Transporter Km 5.70 WOMBAT-PK
Solute carrier organic anion transporter family member 1A2 Transporter Km 5.70 WOMBAT-PK

External reference:

IDSource
4024052 VUID
N0000022057 NUI
D00671 KEGG_DRUG
153439-40-8 SECONDARY_CAS_RN
4021012 VANDF
4024052 VANDF
C0296800 UMLSCUI
CHEBI:5050 CHEBI
CHEMBL914 ChEMBL_ID
CHEMBL1200618 ChEMBL_ID
DB00950 DRUGBANK_ID
C093230 MESH_SUPPLEMENTAL_RECORD_UI
4819 IUPHAR_LIGAND_ID
7469 INN_ID
E6582LOH6V UNII
3348 PUBCHEM_CID
236474 RXNORM
4726 MMSL
71159 MMSL
d04040 MMSL
006063 NDDF
006064 NDDF
108650005 SNOMEDCT_US
108653007 SNOMEDCT_US
372522002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Good Sense Aller Ease HUMAN OTC DRUG LABEL 1 0113-0425 TABLET, FILM COATED 60 mg ORAL ANDA 15 sections
good sense aller ease HUMAN OTC DRUG LABEL 1 0113-0571 TABLET, FILM COATED 180 mg ORAL ANDA 15 sections
good sense aller ease HUMAN OTC DRUG LABEL 1 0113-0847 TABLET, FILM COATED 180 mg ORAL ANDA 15 sections
basic care allergy HUMAN OTC DRUG LABEL 1 0113-7425 TABLET, FILM COATED 60 mg ORAL ANDA 15 sections
basic care allergy HUMAN OTC DRUG LABEL 1 0113-7571 TABLET, FILM COATED 180 mg ORAL ANDA 15 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 2 0363-0044 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 14 sections
Fexofenadine HCl and Pseudoephedrine HCl HUMAN OTC DRUG LABEL 2 0363-0049 TABLET, EXTENDED RELEASE 180 mg ORAL ANDA 15 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride Human OTC Drug Label 2 0363-0094 TABLET, FILM COATED, EXTENDED RELEASE 60 mg ORAL ANDA 11 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride Human OTC Drug Label 2 0363-0094 TABLET, FILM COATED, EXTENDED RELEASE 60 mg ORAL ANDA 11 sections
Fexofenadine hydrochloride Human OTC Drug Label 1 0363-0095 TABLET, FILM COATED 60 mg ORAL ANDA 13 sections
Fexofenadine hydrochloride Human OTC Drug Label 1 0363-0097 TABLET, FILM COATED 180 mg ORAL ANDA 13 sections
Wal fex Allergy HUMAN OTC DRUG LABEL 1 0363-0425 TABLET, FILM COATED 60 mg ORAL ANDA 15 sections
Wal Fex 24 Hour Allergy HUMAN OTC DRUG LABEL 1 0363-0600 TABLET, FILM COATED 180 mg ORAL ANDA 15 sections
Fexofenadine hydrochloride HUMAN OTC DRUG LABEL 1 0363-0783 TABLET 60 mg ORAL ANDA 15 sections
Fexofenadine hydrochloride HUMAN OTC DRUG LABEL 1 0363-0783 TABLET 60 mg ORAL ANDA 15 sections
Wal-Fex HUMAN OTC DRUG LABEL 1 0363-0784 TABLET 180 mg ORAL ANDA 16 sections
Wal-Fex HUMAN OTC DRUG LABEL 1 0363-0784 TABLET 180 mg ORAL ANDA 16 sections
Indoor Outdoor Allergy Relief HUMAN OTC DRUG LABEL 1 0363-0904 TABLET, COATED 180 mg ORAL ANDA 15 sections
Indoor Outdoor Allergy Relief HUMAN OTC DRUG LABEL 1 0363-0904 TABLET, COATED 180 mg ORAL ANDA 15 sections
Fexofenadine HCl and Pseudoephedrine HCI HUMAN OTC DRUG LABEL 2 0363-1606 TABLET, EXTENDED RELEASE 60 mg ORAL ANDA 16 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride HUMAN OTC DRUG LABEL 2 0363-2110 TABLET, FILM COATED, EXTENDED RELEASE 60 mg ORAL ANDA 14 sections
Allergy Relief HUMAN OTC DRUG LABEL 1 0363-8010 TABLET, COATED 180 mg ORAL ANDA 15 sections
Allergy Relief HUMAN OTC DRUG LABEL 1 0363-8010 TABLET, COATED 180 mg ORAL ANDA 15 sections
Allergy Relief HUMAN OTC DRUG LABEL 1 0363-8010 TABLET, COATED 180 mg ORAL ANDA 15 sections
Dye Free Wal Fexchildrens allergy HUMAN OTC DRUG LABEL 1 0363-9230 SUSPENSION 30 mg ORAL ANDA 15 sections
Dye Free Wal Fexchildrens allergy HUMAN OTC DRUG LABEL 1 0363-9230 SUSPENSION 30 mg ORAL ANDA 15 sections
Dye Free Wal Fexchildrens allergy HUMAN OTC DRUG LABEL 1 0363-9230 SUSPENSION 30 mg ORAL ANDA 15 sections
Fexofenadine Hydrochloride HUMAN OTC DRUG LABEL 1 0363-9898 TABLET, FILM COATED 180 mg ORAL ANDA 14 sections
Fexofenadine Hydrochloride HUMAN OTC DRUG LABEL 1 0378-0781 TABLET, FILM COATED 60 mg ORAL ANDA 15 sections
Fexofenadine Hydrochloride HUMAN OTC DRUG LABEL 1 0378-0782 TABLET, FILM COATED 180 mg ORAL ANDA 15 sections