fepradinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1168 36981-91-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fepradinol hydrochloride
  • fepradinol
  • Molecular weight: 209.29
  • Formula: C12H19NO2
  • CLOGP: 0.82
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 52.49
  • ALOGS: -1.40
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.411 Moderate 0.68
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.729 Moderate 0.68
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 5.383 10^-6 cm/s Moderate 0.68
dh-clint Dog hepatocyte intrinsic clearance 5.012 uL/min/10^6 cells Moderate 0.68
dppb Dog plasma protein binding (% unbound) 80.180 % Moderate 0.68
fcs-ppb Fetal calf serum protein binding (% unbound) 75.510 % Moderate 0.68
herg hERG pIC50 4.251 pIC50 Moderate 0.68
hh-clint Human hepatocyte intrinsic clearance 4.064 uL/min/10^6 cells Moderate 0.68
hlm-clint Human liver microsomal intrinsic clearance 3.681 uL/min/mg protein Moderate 0.68
hppb Human plasma protein binding (% unbound) 86.560 % Moderate 0.68
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKDC,SIK2,SIK3,SYK,TEK,TGFBR1,ZAP70 33
kinase-selectivity-class AXL,CDK4,GRK2,PDK4 4
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.507 Moderate 0.68
mh-clint Mouse hepatocyte intrinsic clearance 28.642 Moderate 0.68
mppb Mouse plasma protein binding (% unbound) 88.400 Moderate 0.68
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.600 Moderate 0.68
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 77.580 % Moderate 0.68
rh-clint Rat hepatocyte intrinsic clearance 40.832 uL/min/10^6 cells Moderate 0.68
rh-fuinc Rat hepatocyte fraction unbound in incubation 92.290 % Moderate 0.68
rppb Rat plasma protein binding (% unbound) 81.740 % Moderate 0.68
solubility-dd Solubility at pH 7.4 in DMSO 926.830 uM Moderate 0.68

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.99 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07954 KEGG_DRUG
67704-50-1 SECONDARY_CAS_RN
C0211039 UMLSCUI
CHEBI:134878 CHEBI
CHEMBL2106269 ChEMBL_ID
DB15902 DRUGBANK_ID
68819 PUBCHEM_CID
C078462 MESH_SUPPLEMENTAL_RECORD_UI
5456 INN_ID
860MHI4WBA UNII
717097006 SNOMEDCT_US

Pharmaceutical products:

None