fenoldopam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
dopaminergic agents dopamine derivatives used as cardiac stimulant/antihypertensives/diuretics 1153 67227-56-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fenoldopam hydrobromide
  • fenoldopam
  • fenoldopam mesylate
  • corlopam
  • fenoldopam mesilate
A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
  • Molecular weight: 305.76
  • Formula: C16H16ClNO3
  • CLOGP: 2.40
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 72.72
  • ALOGS: -3.05
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 6 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 41.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 0.27 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Sept. 23, 1997 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CA19 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
FDA MoA N0000000117 Dopamine Agonists
FDA EPC N0000175580 Dopaminergic Agonist
CHEBI has role CHEBI:35569 alpha-adrenergic agonists
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:48561 dopaminergic antagonists
CHEBI has role CHEBI:51065 Dopamine receptor agonist
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018491 Dopamine Agonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014665 Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Malignant essential hypertension indication 78975002 DOID:10823
Hypertensive urgency indication 443482000
Open-angle glaucoma contraindication 84494001 DOID:1067




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.05 acidic
pKa2 10.45 acidic
pKa3 12.02 acidic
pKa4 7.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(1A) dopamine receptor GPCR AGONIST Kd 7.55 CHEMBL CHEMBL
D(2) dopamine receptor GPCR Ki 6.09 CHEMBL
D(1B) dopamine receptor GPCR Ki 6.96 PDSP
D(4) dopamine receptor GPCR AGONIST Ki 6.50 IUPHAR
Lysine-specific demethylase 4E Enzyme Ki 5.72 CHEMBL
Adrenergic receptor alpha-1 GPCR Kd 5.30 CHEMBL
FAD-linked sulfhydryl oxidase ALR Enzyme AC50 5.86 CHEMBL
D(2) dopamine receptor GPCR Kd 5.89 CHEMBL
D(1A) dopamine receptor GPCR Ki 8.52 CHEMBL
D(2) dopamine receptor GPCR Ki 6.10 CHEMBL
Adenosine A2b receptor GPCR Ki 7.45 CHEMBL

External reference:

IDSource
4021120 VUID
N0000148574 NUI
D00613 KEGG_DRUG
67287-54-1 SECONDARY_CAS_RN
67227-57-0 SECONDARY_CAS_RN
4021120 VANDF
4021121 VANDF
C0060180 UMLSCUI
CHEBI:5002 CHEBI
CHEMBL588 ChEMBL_ID
DB00800 DRUGBANK_ID
CHEMBL1026 ChEMBL_ID
D018818 MESH_DESCRIPTOR_UI
3341 PUBCHEM_CID
939 IUPHAR_LIGAND_ID
4673 INN_ID
INU8H2KAWG UNII
155091 RXNORM
11504 MMSL
4719 MMSL
47924 MMSL
d04257 MMSL
007356 NDDF
007357 NDDF
108590002 SNOMEDCT_US
108591003 SNOMEDCT_US
409138007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Corlopam HUMAN PRESCRIPTION DRUG LABEL 1 0409-3373 INJECTION, SOLUTION 10 mg INTRAVENOUS NDA 25 sections