alexidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
113 22573-93-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alexidine
  • bisguadine
  • bisguanidine
  • alexidine dihydrochloride
until June 1975 was mistakenly treated as synonym for chlorhexidine; RN given refers to parent cpd
  • Molecular weight: 508.80
  • Formula: C26H56N10
  • CLOGP: 6.15
  • LIPINSKI: 3
  • HAC: 10
  • HDO: 10
  • TPSA: 167.58
  • ALOGS: -4.27
  • ROTB: 19

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:33282 bactericides

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.68 Basic
pKa2 11.08 Basic
pKa3 2.68 Basic
pKa4 2.08 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Toll-like receptor 9 Membrane receptor IC50 5.21 CHEMBL
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 Enzyme INHIBITOR IC50 7.97 SCIENTIFIC LITERATURE
Replicase polyprotein 1ab Enzyme IC50 4.75 CHEMBL
Beta-lactamase Enzyme IC50 5.28 CHEMBL

External reference:

IDSource
D02804 KEGG_DRUG
C0051146 UMLSCUI
CHEBI:53661 CHEBI
CHEMBL1195210 ChEMBL_ID
C001570 MESH_SUPPLEMENTAL_RECORD_UI
2632 INN_ID
1715-30-6 SECONDARY_CAS_RN
GVN71CAL3G UNII
2090 PUBCHEM_CID
CHEMBL1487183 ChEMBL_ID
CHEMBL554041 ChEMBL_ID

Pharmaceutical products:

None