fadrozole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| aromatase inhibitors, imidazole-triazole derivatives | 1126 | 102676-47-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018931 | Antineoplastic Agents, Hormonal |
| MeSH PA | D047072 | Aromatase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D004965 | Estrogen Antagonists |
| MeSH PA | D006727 | Hormone Antagonists |
| MeSH PA | D065088 | Steroid Synthesis Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.74 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Aromatase | Enzyme | INHIBITOR | Ki | 10.30 | CHEMBL | SCIENTIFIC LITERATURE | |||
| Cytochrome P450 11B1, mitochondrial | Enzyme | INHIBITOR | IC50 | 8.20 | CHEMBL | ||||
| Cytochrome P450 11B2, mitochondrial | Enzyme | INHIBITOR | IC50 | 9.10 | CHEMBL | ||||
| Cytochrome P450 11B2, mitochondrial | Enzyme | IC50 | 6.72 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02451 | KEGG_DRUG |
| 102676-31-3 | SECONDARY_CAS_RN |
| C0117234 | UMLSCUI |
| CHEBI:31589 | CHEBI |
| 0T3 | PDB_CHEM_ID |
| CHEMBL9298 | ChEMBL_ID |
| DB16832 | DRUGBANK_ID |
| D017316 | MESH_DESCRIPTOR_UI |
| 59693 | PUBCHEM_CID |
| 8311 | IUPHAR_LIGAND_ID |
| 6632 | INN_ID |
| H3988M64PU | UNII |
| CHEMBL468419 | ChEMBL_ID |
Pharmaceutical products:
None