fadrozole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
aromatase inhibitors, imidazole-triazole derivatives 1126 102676-47-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fadrozole
  • fadrozole hydrochloride
  • fadrozole HCl
  • fadrozole monohydrochloride
  • CGS 16949A
  • CGS-16949A
A selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer.
  • Molecular weight: 223.28
  • Formula: C14H13N3
  • CLOGP: 1.77
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 41.61
  • ALOGS: -2.81
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,EIF2AK3,GRK2,PDK1,PDK2,PDK4,PRKDC 7
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D004965 Estrogen Antagonists
MeSH PA D006727 Hormone Antagonists
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D047072 Aromatase Inhibitors
MeSH PA D065088 Steroid Synthesis Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.74 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Aromatase Enzyme INHIBITOR Ki 10.30 CHEMBL SCIENTIFIC LITERATURE
Cytochrome P450 11B1, mitochondrial Enzyme INHIBITOR IC50 8.20 CHEMBL
Cytochrome P450 11B2, mitochondrial Enzyme INHIBITOR IC50 9.10 CHEMBL
Cytochrome P450 11B2, mitochondrial Enzyme IC50 6.72 CHEMBL

External reference:

IDSource
D02451 KEGG_DRUG
C0117234 UMLSCUI
CHEBI:747936 CHEBI
0T3 PDB_CHEM_ID
CHEMBL9298 ChEMBL_ID
DB16832 DRUGBANK_ID
CHEMBL468419 ChEMBL_ID
D017316 MESH_DESCRIPTOR_UI
59693 PUBCHEM_CID
8311 IUPHAR_LIGAND_ID
6632 INN_ID
102676-31-3 SECONDARY_CAS_RN
H3988M64PU UNII
H3988M64PU INXIGHT DRUGS

Pharmaceutical products:

None