aldosterone indications/contra

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 111 52-39-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aldosterone
  • aldocorten
  • aldocortene
  • aldocortin
  • electrocortin
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
  • Molecular weight: 360.45
  • Formula: C21H28O5
  • CLOGP: 1.76
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 91.67
  • ALOGS: -3.39
  • ROTB: 3

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC H02AA01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Mineralocorticoids

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.58 acidic
pKa2 13.29 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sex hormone-binding globulin Secreted Kd 5.32 CHEMBL
Mineralocorticoid receptor Nuclear hormone receptor EC50 8.42 CHEMBL
Corticosteroid-binding globulin Secreted Ki 6.28 CHEMBL
Mineralocorticoid receptor Transcription factor IC50 7.37 CHEMBL

External reference:

scroll-->
IDSource
2872 IUPHAR_LIGAND_ID
N0000167497 NUI
C0002006 UMLSCUI
D10528 KEGG_DRUG
CHEMBL273453 ChEMBL_ID
4964P6T9RB UNII
483 INN_ID
42605004 SNOMEDCT_US
22474002 SNOMEDCT_US
N0000167497 NDFRT
1312358 RXNORM
002206 NDDF
5839 PUBCHEM_CID
DB04630 DRUGBANK_ID
D000450 MESH_DESCRIPTOR_UI
CHEBI:27584 CHEBI
AS4 PDB_CHEM_ID

Pharmaceutical products:

None