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etifoxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1099 | 21715-46-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 90 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK2,PDK4,PIK3CB,PIK3CG,PRKDC,STK33,TEK,TTK | 22 | |||
| kinase-selectivity-class | AXL,GRK2,PDK4 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hepatic cytolysis | 85.46 | 49.78 | 30 | 1297 | 55023 | 110532949 |
| Somnolence | 55.90 | 49.78 | 38 | 1289 | 297411 | 110290561 |
| Cutaneous T-cell lymphoma | 50.71 | 49.78 | 11 | 1316 | 3373 | 110584599 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N05BX03 | NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Other anxiolytics |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014149 | Tranquilizing Agents |
| MeSH PA | D014151 | Anti-Anxiety Agents |
| CHEBI has role | CHEBI:35474 | anxiolytic drug |
Related Drugs by ATC class:
N05BX Other anxiolytics 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.57 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D07320 | KEGG_DRUG |
| 56776-32-0 | SECONDARY_CAS_RN |
| C0059678 | UMLSCUI |
| CHEBI:135272 | CHEBI |
| CHEMBL2106227 | ChEMBL_ID |
| DB08986 | DRUGBANK_ID |
| C002125 | MESH_SUPPLEMENTAL_RECORD_UI |
| 135413553 | PUBCHEM_CID |
| 5468 | IUPHAR_LIGAND_ID |
| 2846 | INN_ID |
| X24X82MX4X | UNII |
| 236215 | RXNORM |
| 005416 | NDDF |
| 005417 | NDDF |
| X24X82MX4X | INXIGHT DRUGS |
Pharmaceutical products:
None